Tag: M.W=700-800

Related Products of 144690-33-5,Some common heterocyclic compound, 144690-33-5, name is Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2′-(1-trityl-1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate, molecular formula is C45H44N6O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

123.2g of compound and 2.5g of potassium hydroxide solid were added to a 500ml four-necked flask.DMAC76g, heated to 50 C, stirred for about 6h,The TLC dot plate showed that the compound 1 point disappeared, that is, the end of the hydrolysis reaction was judged.Cool to 15 ¡À 5 C, add KBr 0.64g, add DMDO-C16.5g, DMAC 10g,After about 40 minutes, the temperature was raised to 25¡À5C for 2h, then the temperature was raised to 50C, the reaction was about 6h, and the temperature was lowered again to 20¡À5C for 5h. The reaction solution was added with 324g water and 208g of dichloromethane.Shake well and let the layers separate. The aqueous layer was extracted with 70 g of dichloromethane and combined with several layers.It was washed twice with 206 g of water, and the last aqueous layer was extracted with 100 g of dichloromethane.The organic layers were combined and dried under reduced pressure at 45 C.After adding 100g of the upper batch of crystallization, the mother liquid is heated and refluxed for 25¡À5 minutes, and then naturally cooled.Then crystallization at 0 C for 6 h,Drying by suction filtration to obtain 23.2 g of trityl olmesartan medoxomil white solid powder.The yield was 93.4%. HPLC analysis, purity 99.7%, acid miscellaneous <0.05%,The olefinic impurity is <0.1%, and the other unknown single impurities are <0.1%. The synthetic route of 144690-33-5 has been constantly updated, and we look forward to future research findings. Reference:
Patent; Zhejiang Huahai Pharmaceutical Co., Ltd.; Xiong Xueqiang; Li Guoxiang; Wang Jiquan; (6 pag.)CN103880825; (2019); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 144690-33-5, The chemical industry reduces the impact on the environment during synthesis 144690-33-5, name is Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2′-(1-trityl-1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate, I believe this compound will play a more active role in future production and life.

To a 10 L reaction flask was added 257 gPhenyl) methylimidazol-1-yl) phenyl] propan-1- {4- [2- (triphenylmethyl- Carboxylic acid ethyl ester (Compound II) and 2.8 L 1,4-dioxane were added and dissolved by mechanical stirring,Heating to 45 C, adding 28.6g of sodium hydroxide solution, the reaction 4.5h. To the reaction mixture, 1.5 L of ethyl acetate was added,Stirring, standing layered, separate the organic phase. The aqueous phase was extracted with 1 L of ethyl acetate. The organic phases were combined and the organic phase was chlorinated with 4.5 LSodium aqueous solution. The organic phase was cooled in an ice bath and adjusted to pH 3 to 5 with 20% aqueous acetic acid. The filter cake was washed with 5 L of ethyl acetateEster. The filter cake was dried in a dry oven to constant weight to give 198.6 g of product as a white solid. The yield was 80.4% by weight.The product was 98.5% by HPLC.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2′-(1-trityl-1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bengbu Tu Shan Fengyuan Pharmaceutical Co., Ltd.; Ma, Qisheng; Li, Baoqin; Sun, Peng; (18 pag.)CN105418593; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem