Tag: M.W=50-100

Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Category: imidazoles-derivatives.

Du, Xiaoyu;Li, Mengwen;Du, Man;Shen, Ao;Hao, Xiaohui;Yuan, Jiaxin;Ma, Shufeng;Zhao, Yongwei;Hou, Lala;Li, Ziqi;Yang, Yunxu research published 《 A one-pot strategic construction of functionalized nanomaterial ZIF-90-Rhn for stepwise detection and capturing of Ag⁺ and formaldehyde from an aqueous solution》, the research content is summarized as follows. In this work, a new functionalized nanomaterial, ZIF-90-Rhn, was designed, synthesized and characterized. The synthesis was performed by one-pot strategic construction, post-modification and pre-modification synthesis methods. After encapsulating cyanine dye, Cy-N, into ZIF-90-Rhn, a multi-functional complex of ZIF-90-Rhn@Cy-N was successfully obtained and could be used to detect Ag⁺ in dual-signals (fluorescence signal and visual color signal) by forming an intermedial product of ZIF-90-Rhn@Ag⁺/Cy-N in an aqueous solution Subsequently, the intermediate product ZIF-90-Rhn@Ag⁺/Cy-N could detect formaldehyde (FA) via a stepwise redox recognition reaction through dual-signals. A smartphone portable online detection platform for Ag⁺ and FA using Bluetooth for the color changes under visible light was not realized, and the results are consistent with the fluorescence sensing assay results. Moreover, a chitosan non-woven fabric coated with ZIF-90-Rhn@Cy-N on its surface was considered to evaluate its efficient capturing and removing effects on Ag⁺ and FA in a stepwise actual procedure in water.

Category: imidazoles-derivatives, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Synthetic Route of 10111-08-7.

Eckhardt, Andre K. research published 《 Spectroscopic evidence for 1,2-diiminoethane – a key intermediate in imidazole synthesis》, the research content is summarized as follows. Simple imines and diimines are common building blocks in organic synthesis, but the compound class is spectroscopically not well characterized. Herein we report the formation of the simplest diimine, namely 1,2-diiminoethane, as well as spectroscopic characterization by cryogenic matrix isolation IR and UV/Vis spectroscopy. Three conformers of 1,2-diiminoethane form after UV irradiation of 1,2-diazidoethane by N₂ extrusion at 3 K in solid argon and can be photochem. interconverted. In a matrix isolation pyrolysis experiment at 600°C with 1,2-diazidoethane as the starting material we observe hydrogen cyanide and formaldimine as the main decomposition products. All exptl. findings are supported by deuterium labeling experiments and B3LYP/6-311++G(2d,2p) calculations Irradiation of 1,2-diazidoethane in aqueous solution leads to the formation of imidazoles as indicated by NMR spectroscopy and GC-MS anal. Our results underline the key role of diimines as building blocks in N-heterocyclic chem.

10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Synthetic Route of 10111-08-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. HPLC of Formula: 1739-84-0.

Eftaiha, Ala′a F.;Qaroush, Abdussalam K.;Hasan, Areej K.;Helal, Wissam;Al-Qaisi, Feda′a M. research published 《 CO₂ fixation into cyclic carbonates catalyzed by single-site aprotic organocatalysts》, the research content is summarized as follows. CO₂ fixation is a prominent research theme that attracts the attention of scientists, stakeholders and governmental entities with the aim of ultimately bringing com. products to the market. Herein, a series of mono-, bi-functional and polymeric imidazolium-based catalysts were synthesized and utilized for the production of cyclic carbonates (CCs) using epoxides and 1 bar of CO₂ under mild reaction conditions. In addition, three onium salts, namely, ammonium, phosphonium, and pyridinium, were synthesized and characterized using ¹H/¹³C NMR (NMR) and attenuated total reflectance-Fourier transform IR (ATR-FTIR) spectroscopies, together with thermal gravimetric anal. (TGA), high-resolution mass spectrometry (HRMS) and elemental anal. (EA). All the investigated organocatalysts showed almost quant. CC conversions, which were isolated from the crude reaction and identified spectroscopically. D. functional theory (DFT) calculations revealed that the aforementioned onium salts followed the same detailed mechanism for the cycloaddition reaction, which started with the electrostatic interaction of the onium centers with the oxygen atom of the epoxide. Even in the case of the imidazolium nucleus, the acidic C₂ proton played a marginal role in the epoxide activation than in the ring-opening step.

1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., HPLC of Formula: 1739-84-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Quality Control of 1739-84-0.

Chen, Pinghua;Li, Songyuan;Tang, Xiaoqiu;Zheng, Huitao;Shi, Jinwen;Wen, Linyuan;Xu, Yong;Fominski, Vyacheslav;Jiang, Hualin research published 《 Photo-inactive ZIF-8 is applied to significantly enhance the photocatalytic water reduction by forming a built-in electric field with g-C₃N₄ and the mechanism analysis》, the research content is summarized as follows. It has been found in this study that the combination of ZIF-8 and g-C₃N₄ turns the photo-inactive ZIF-8 into ”active” and significantly enhances the photocatalytic performance for H₂ production The exptl. results such as contact p.d. (CPD) and photodeposition anal. suggest that a built-in elec. field exists at the interface of g-C₃N₄ and ZIF-8, and the direction is from ZIF-8 to g-C₃N₄. Furthermore, the theor. calculation of charge d. difference and work functions uncover the potential forming mechanism of the built-in elec. field. The mechanism anal. exhibits that the built-in elec. field is conducive to promote the directional transfer of photo-induced electrons from g-C₃N₄ to ZIF-8, which significantly boosts the catalytic ability. Hence, the construction of a built-in elec. field is considered to be an effective strategy to synthesize robust photocatalysts, and the strategy can be extended to prepare a range of advanced catalysts needing directional charge transfer.

1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., Quality Control of 1739-84-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Reference of 10111-08-7.

Chen, Qiufang;Deng, Bin;Luo, Qing;Song, Guanbin research published 《 Deep tumor-penetrated nanosystem eliminates cancer stem cell for highly efficient liver cancer therapy》, the research content is summarized as follows. Cancer stem cells (CSCs), which are resistant to the traditional therapies, have been considered to account for the development, metastasis, and relapse of various malignant tumors, and therefore, must be eliminated to cure cancer. However, they can reside in deep tumor regions away from the blood vessels, and are typically inaccessible owing to the low delivery efficiency and limited tumor penetrating ability of drug carriers. To overcome these problems, we designed a tumor-penetrating peptide (tLyP-1)-conjugated ZIF-90 nanosystem loaded with doxorubicin (DOX) and N-[N-(3,5-difluorophenacetyl)-1-alanyl]-S-phenylglycine t-Bu ester (DAPT) to penetrate and eradicate differentiated cancer cells and CSCs simultaneously. The nanosystem exhibited beneficial biocompatibility, enhanced tissue penetration, high blood circulation stability, and pH-responsive drug release for favoring cancer therapy. It was found that the nanosystem could kill both cancer cells and CSCs in vitro. The in vivo results demonstrated that the ZIF-90 nanosystem can effectively accumulate in tumor tissues after long blood circulation and flexibly permeate throughout the tumor tissues. In the HCCLM3 xenograft model, the ZIF-90 nanosystem presented high-efficiency tumor suppression and drastically eradicated the CSCs in the tumor tissues with low systemic toxicity. Overall, the deep tumor-penetrating nanosystem exhibits outstanding potential for improving curative effect.

Reference of 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Name: 1,2-Dimethyl-1H-imidazole.

Chen, Xiao-Lu;Li, Xiang-Yu;Li, Shuai-Shuai;Bai, Xue;Li, Tao;Goud, Erukala Yadaiah;Zhong, Chong-Min;Zuo, Ya-Jie research published 《 Ion-Functionalized Silver(I) Carboxylates: Synthesis and Application in Ru-Catalyzed Olefin Metathesis Reaction》, the research content is summarized as follows. The Grubbs-Hoveyda catalysts have a wide range of applications in catalyzed formation of the carbon-carbon double bonds. In this study, several imidazolium- functionalized or pyridinium-functionalized silver carboxylates have been prepared, and their reaction with Grubbs-Hoveyda 2^nd generation (G-H 2^nd) catalyst leads a new type of processes. Activity and selectivity of the catalysts have been preliminarily evaluated using cross olefin metathesis reactions.

Name: 1,2-Dimethyl-1H-imidazole, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Name: 1H-Imidazole-2-carbaldehyde.

Chen, Xi-Xi;Hou, Mei-Jia;Mao, Guo-Jiang;Wang, Wen-Xin;Xu, Fen;Li, Yongfei;Li, Chun-Yan research published 《 ATP-responsive near-infrared fluorescence MOF nanoprobe for the controlled release of anticancer drug》, the research content is summarized as follows. A near-IR (NIR) fluorescence nanoprobe named RhI-DOX@ZIF-90 has been synthesized by wrapping the guest mol. (RhI and DOX) into ZIF-90 framework. The nanoprobe itself is non-fluorescent and the drug (DOX) is inactive. Upon the addition of ATP, the structure of RhI-DOX@ZIF-90 is degraded. The fluorescence of RhI is recovered and DOX is released. The nanoprobe can detect ATP with high sensitivity and selectivity. There is good linear relationship between the nanoprobe and ATP concentration from 0.25 to 10 mM and the detection limit is 0.10 mM. The nanoprobe has the ability to monitor the change of ATP level in living cells and DOX is released inducing apoptosis of cancer cells. RhI-DOX@ZIF-90 is capable of targeting mitochondria, which provides a basis for improving the efficiency of drug delivery by mitochondrial administration. In particular, the nanoprobe is preferentially accumulated in the tumor sites and detect ATP in tumor mice by fluorescence imaging using near-IR fluorescence. At the same time, DOX can be released accurately in tumor sites and have good anti-tumor efficiency. So, this nanoprobe is a reliable tool to realize early diagnosis of cancer and improve effect of anticancer drug.

Name: 1H-Imidazole-2-carbaldehyde, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Electric Literature of 10111-08-7.

Chen, Yupeng;Zhu, Zhongpeng;Jiang, Xiangyu;Jiang, Lei research published 《 Construction of Free-Standing MOF Sheets through Electrochemical Printing on Superhydrophobic Substrates》, the research content is summarized as follows. Metal-organic framework (MOF) membranes have significant application prospects in different fields, such as separation, detection, anticorrosion and energy capture and conversion and so on. However, the difficulty of constructing free-standing MOF membranes has hindered their applications. Here, the authors propose a facile strategy to fabricate free-standing MOF sheets with easy-peeling and easy-transfer properties through electrochem. printing on superhydrophobic micropillar-structured substrates. During the electrochem. printing process, electrophoretic deposition will occur along the solid/liquid/gas triphase interface on these substrates. First, the effects of the electrophoretic deposition conditions, such as deposition time and current, on the thickness-controlled growth on superhydrophobic substrates are explored. Then, the influences of the geometric parameters, such as diameter and distance, and wettability of the micropillars on constructing free-standing MOF sheets are systematically studied. Also, the MOF sheets exhibit the properties of capillarity-assisted peeling from superhydrophobic substrates and spreading-assisted transfer to superhydrophilic substrates, followed by the demonstration of the generality. Therefore, it is a facile method to prepare free-standing MOF sheets with easy-peeling and easy-transfer properties taking advantage of electrochem. printing on superhydrophobic substrates, giving impetus to the improvement of the productivity and the corresponding applications in various fields.

10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Electric Literature of 10111-08-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Application In Synthesis of 3034-50-2.

Chen, Zi-Ye;Long, Zi-Hao;Wang, Xue-Zhi;Zhou, Jie-Yi;Wang, Xu-Sheng;Zhou, Xiao-Ping;Li, Dan research published 《 Cobalt-Based Metal-Organic Cages for Visible-Light-Driven Water Oxidation》, the research content is summarized as follows. Water oxidation to mol. oxygen is indispensable but a challenge for splitting H₂O. In this work, a series of Co-based metal-organic cages (MOCs) for photoinduced water oxidation were prepared MOC-1 with both bis(μ-oxo) bridged dicobalt and Co-O (O from H₂O) displays catalytic activity with an initial oxygen evolution rate of 80.4 mmol/g/h and a TOF of 7.49 x 10^-3 s^-1 in 10 min. In contrast, MOC-2 containing only Co-O (O from H₂O) in the structure results in a lower oxygen evolution rate (40.8 mmol/g/h, 4.78 x 10^-3 s^-1), while the amount of oxygen evolved from the solution of MOC-4 without both active sites is undetectable. Isotope experiments with or without H₂¹⁸O as the reactant successfully demonstrate that the mol. oxygen was produced from water oxidation Photophys. and electrochem. studies reveal that photoinduced water oxidation initializes via electron transfer from the excited [Ru(bpy)₃]²⁺* to Na₂S₂O₈, and then, the cobalt active sites further donate electrons to the oxidized [Ru(bpy)₃]³⁺ to drive water oxidation This proof-of-concept study indicates that MOCs can work as potential efficient catalysts for photoinduced water oxidation

Application In Synthesis of 3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, 3034-50-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. HPLC of Formula: 3034-50-2.

Chiaramonte, Niccolo;Gabellini, Alessio;Angeli, Andrea;Bartolucci, Gianluca;Braconi, Laura;Dei, Silvia;Teodori, Elisabetta;Supuran, Claudiu T.;Romanelli, Maria Novella research published 《 New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators》, the research content is summarized as follows. A series of histamine (HST)-related compounds was synthesized and tested for their activating properties on five physiol. relevant human carbonic anhydrase (hCA) isoforms (I, II, Va, VII and XIII). The imidazole ring of HST was replaced with various 5-membered heterocycles and the length of the aliphatic chain was varied. For the most interesting compounds, some modifications on the terminal amino group were also performed. The most sensitive isoform to activation was hCA I (K_A values in the low micromolar range), but surprisingly none of the new compounds displayed activity on hCA II. Some derivatives displayed an interesting selectivity for activating hCA I over hCA II, Va, VII and XIII.

3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, HPLC of Formula: 3034-50-2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem