Tag: M.W=50-100

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Product Details of C5H8N2.

Wang, Jian;Li, Yuao;Chen, Xiguang;Wei, Ning;Tong, Jing research published 《 Excess properties and activation properties for viscous flow of amino acid ionic liquids with H₂O binary mixtures》, the research content is summarized as follows. Amino acid ionic liquids (ILs) 1-butyl-2,3-dimethylimidazolium glycine ([C₄Dmim][Gly]), 1-butyl-2,3-dimethylimidazolium alanine ([C₄Dmim][Ala]) and 1-butyl-2,3-dimethylimidazolium threonine ([C₄Dmim][Thr]) were prepared Over the temperature from (288.15-318.15) K, the d., surface tension and viscosity for binary system mixtures of ILs with H₂O were measured, and excess thermodn. properties and activation properties for viscous flow of these binary system mixtures were systematically studied. Secondly, the variation trend between excess molar volume (VE)/excess molar surface Gibbs energy (gEs) and mole fraction for ILs + H₂O binary system mixtures was investigated. With the increase of mole fraction, the VE and gEs values of binary system mixtures increased firstly and then decreased, and they were pos. value, which may be due to the weak chem. interaction between ILs and H₂O in the mixture Furthermore, according to the thermodn. formula, the Gibbs energy of activation for viscous flow of the relative viscosity (ΔG^≠_r), activation entropy (ΔS^≠_r) and activation enthalpy (ΔH^≠_r) were calculated Over the entire concentration range, the ΔG^≠_r values for binary system mixtures of ILs with H2O were neg. value, and the result was in good agreement with relative viscosity (η_r).

Product Details of C5H8N2, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Product Details of C4H4N2O.

Wang, Minghui;Lin, Yuxin;Lu, Jianyang;Sun, Zhaowei;Deng, Ying;Wang, Lei;Yi, Yongxiang;Li, Jinlong;Yang, Jie;Li, Genxi research published 《 Visual naked-eye detection of SARS-CoV-2 RNA based on covalent organic framework capsules》, the research content is summarized as follows. The ongoing outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted that new diagnosis technologies are crucial for controlling the spread of the disease. Especially in the resources-limit region, conveniently operated methods such as “naked-eye” detection are urgently required that no instrument is needed. Herein, we have designed a novel and facile strategy to fabricate covalent organic framework (COF) capsules, which can be utilized to establish a new colorimetric assay for naked-eye detection of SARS-CoV-2 RNA. Specifically, we employ the digestible ZIF-90 as the sacrificial template to prepare the hollow COF capsules for horseradish peroxidase (HRP) encapsulation. The fabricated COF capsules can provide an appropriate microenvironment for the enzyme mols., which may improve the conformational freedom of enzymes, enhance the mass transfer, and endow the enzyme with high environmental resistance. With such design, the proposed assay exhibits outstanding anal. performance for the detection of SARS-CoV-2 RNA in the linear range from 5 pM to 50 nM with a detection limit of 0.28 pM which can go parallel to qTR-PCR anal. Our method also possesses excellent selectivity and reproducibility. Moreover, this method can also be served to analyze the clin. samples, and can successfully differentiate COVID-19 patients from healthy people, suggesting the promising potential in clin. diagnosis.

Product Details of C4H4N2O, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Recommanded Product: 1H-Imidazole-2-carbaldehyde.

Wang, Sheng;Gai, Yongkang;Sun, Lingyi;Lan, Xiaoli;Zeng, Dexing;Xiang, Guangya;Ma, Xiang research published 《 Synthesis and evaluation of novel 1,4,7-triazacyclononane derivatives as Cu²⁺ and Ga³⁺ chelators》, the research content is summarized as follows. Advances in chelator design are the cornerstone for the development of metals like copper and gallium based biomedical agents and radiopharmaceuticals. To develop optimal chelating ligands, the authors explored the synthesis and chelating properties of azaheterocycle pendant armed 1,4,7-triazacyclononane (TACN) dimethylcarboxylate derivatives and dimethylphosphonate derivatives In the complexation kinetics test, dicarboxylate pendant armed TACN derivatives 2,2′-(7-((1H-imidazol-2-yl)methyl)-1,4,7-triazonane-1,4-diyl)diacetic acid (NODA-Im), 2,2′-(7-((1-methyl-1H-imidazol-2-yl)methyl)-1,4,7-triazonane-1,4-diyl)diacetic acid (NODA-MeIm), and 2,2′-(7-(thiazol-2-ylmethyl)-1,4,7-triazonane-1,4-diyl)diacetic acid (NODA-Thia) exhibited fast complexation kinetics towards Cu (II) cations, which were comparable to the frequently explored ligand 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA). And the diphosphonate pendant armed TACN derivative ((7-(thiazol-2-ylmethyl)-1,4,7-triazonane-1,4-diyl)bis(methylene))bis(phosphonic acid) (NODP-Thia) bound with Ga (III) cations at a much faster rate than NOTA. D. functional theory studies confirmed that the better complexation kinetics and metal chelating efficiency of NODA-Im, NODA-MeIm, NODA-Thia, and NODP-Thia could be ascribed to the lower Gibbs energies of corresponding chelator-metal complexes than NOTA-metal complexes. The kinetic inertness of the Cu (II) complex with NODA-Im, NODA-MeIm, and NODA-Thia was also demonstrated by cyclic voltammetry studies. Subsequently radiolabeling experiment demonstrated that these metal chelators could efficiently labeled with ⁶⁴Cu or ⁶⁸Ga in good radiochem. purities. These preliminary findings support NODA-Im, NODA-MeIm, NODA-Thia, and NODP-Thia as promising leading chelating agents for the development of bifunctional Cu²⁺ and Ga³⁺ chelators in biomedical applications.

Recommanded Product: 1H-Imidazole-2-carbaldehyde, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Computed Properties of 3034-50-2.

Wang, Xue-Zhi;Sun, Meng-Ying;Huang, Zhijin;Xie, Mo;Huang, Ruishan;Lu, Huihui;Zhao, Zujin;Zhou, Xiao-Ping;Li, Dan research published 《 Turn-On Circularly Polarized Luminescence in Metal-Organic Frameworks》, the research content is summarized as follows. The fabrication of circularly polarized luminescence (CPL) active materials by self-assembly is still in its challenge. In this work, a family of homochiral metal-organic frameworks (MOFs) and metal-organic cages (MOCs) are constructed by solvothermal subcomponent self-assembly. These MOFs feature an eta topol. with trifold helical chains, while the MOCs adopt a cubic cage structure. The chiral ligands show two distinct types of conformations: “opened” and “closed” in MOFs and MOCs, resp. Although homochiral MOFs and MOCs show similar spectra of CD and photoluminescence with similar quantum yields and lifetimes, the MOFs yield clear CPL signals and the CPL of MOCs are silent. The turn-on CPL in MOFs achieved by tuning the conformation of ligands and controlling self-assembly provides a new approach for development of CPL-active MOF materials.

Computed Properties of 3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, 3034-50-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Application In Synthesis of 3034-50-2.

Wang, Yanyan;Xu, Fangzhou;Luo, Dexia;Guo, Shengxin;He, Feng;Dai, Ali;Song, Baoan;Wu, Jian research published 《 Synthesis of Anthranilic Diamide Derivatives Containing Moieties of Trifluoromethylpyridine and Hydrazone as Potential Anti-Viral Agents for Plants》, the research content is summarized as follows. A series of novel anthranilic diamide derivatives I (R = 4-Cl-2-Me, 4,6-di-F, 6-Me, etc.; Ar = thiophen-2-yl, 5-bromopyridin-2-yl, iso-Pr, etc.) containing moieties of trifluoromethylpyridine and hydrazone was synthesized and evaluated in vivo for their activities against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV). Few compounds had the curative activity over 65% against TMV at the concentration of 500 μg/mL, which were significantly higher than those of ningnanmycin (55.0%) and ribavirin (37.9%). Notably, the curative activity of compound I (R = 4-Cl-2-Me, Ar = 5-Me-thien-2-yl) was up to 79.5%, with the EC₅₀ value of 75.9 μg/mL, whereas the EC₅₀ value of ningnanmycin was 362.4 μg/mL and pot experiments also further demonstrated the significantly curative effect of the compound Meanwhile, few compounds displayed more protective activities on TMV than that of ningnanmycin. Moreover few, compounds showed inactivation activity similar to ningnanmycin at 500 μg/mL, and the EC₅₀ value of I (R = 4-Cl-2-Me, Ar = 2-CH₃C₆H₄) (41.5 μg/mL) was lower than ningnanmycin (50.0 μg/mL). The findings of TEM indicated that the synthesized compounds exhibited strong and significant binding affinity to TMV coat protein (CP) and could obstruct the self-assembly and increment of TMV particles. Microscale thermophoresis (MST) studies on TMV-CP and CMV CP revealed that some of the active compounds, particularly I (R = 4-Cl-2-Me, Ar = 5-Me-thien-2-yl) exhibited a strong binding capability to TMV-CP or CMV-CP.

Application In Synthesis of 3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, 3034-50-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Computed Properties of 10111-08-7.

Wang, Yifeng;Luo, Xi;Sun, Xiaolong;Hu, Jiahuan;Guo, Qing;Shen, Baoxing;Fu, Yongqian research published 《 Lactate dehydrogenase encapsulated in a metal-organic framework: A novel stable and reusable biocatalyst for the synthesis of D-phenyllactic acid》, the research content is summarized as follows. In this study, we synthesized a novel biocatalyst by encapsulating lactate dehydrogenase (LDH) in the metal-organic framework ZIF-90 by one-pot embedding. It showed strong biol. activity for efficient synthesis of -phenyllactic acid (-PLA). The morphol. and structure of LDH@ZIF-90 was systematically characterized by powder X-ray diffraction (XRD), SEM (SEM), Fourier transform IR (FT-IR) spectroscopy, confocal laser scanning microscopy (CLSM) and gas sorption. According to thermogravimetric anal. (TGA), the enzyme loading of the biocatalyst was 3%. The Michaelis-Menten constant (Km) and maximal reaction rate (Vmax) of LDH@ZIF-90 were similar to those of free LDH, which proved that ZIF-90 had good biocompatibility to encapsulate LDH. At the same time, LDH@ZIF-90 exhibited enhanced tolerance to temperature, pH and organic solvents, and its reusability was greatly improved with 68% of initial enzyme activity remaining after 7 rounds of recylcing. Overall, LDH encapsulated in ZIF-90 may be an economically competitive and environmentally friendly novel biocatalyst for the synthesis of -PLA.

Computed Properties of 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Electric Literature of 1739-84-0.

Wang, Yijie;Li, Aoshuang;Cheng, Chuanwei research published 《 Ultrathin Co(OH)₂ Nanosheets@Nitrogen-Doped Carbon Nanoflake Arrays as Efficient Air Cathodes for Rechargeable Zn-Air Batteries》, the research content is summarized as follows. Developing highly active, cost-effective, and durable bifunctional oxygen electrocatalysts is an important step for the advancement of rechargeable Zn-air batteries (ZABs). Herein, an efficient bifunctional oxygen electrocatalyst of ultrathin Co(OH)₂ nanosheets supported on nitrogen-doped carbon nanoflake arrays (named as Co(OH)₂@NC), is reported, which yields excellent bifunctional activity, i.e., a low overpotential of 285 mV to reach 10 mA cm-2 for oxygen evolution reaction (OER), a high half-wave potential (0.83 V) for oxygen reduction reaction (ORR), and a low potential gap (ΔE) of 0.69 V. The excellent bifunctional catalytic performance can be ascribed to the concerted efforts of cobalt hydroxide toward OER and nitrogen-doped carbon for ORR. The Co(OH)₂@NC nanoflake arrays is further used as binder-free air cathodes for rechargeable Zn-air batteries, exhibiting a high specific capacity of 798.3 mAh gZn-1, improved stability (a working life of >70 h at 5 mA cm-2), as well as a reduced long-term charging voltage, which outperforms the counterparts of NC nanoflake arrays and Pt/C-based air cathodes. One step further, the Co(OH)₂@NC nanoflake arrays on carbon cloth are directly used as binder-free air cathodes for flexible, solid-state ZABs, showing excellent performance under deformation as well.

1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., Electric Literature of 1739-84-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Product Details of C4H4N2O.

Wang, Ying;Li, Hai-Zhen;Li, Min-Yu;Wang, Fei;Zhang, Jian research published 《 Facile method on the fast synthesis of hybrid zeolitic imidazolate frameworks》, the research content is summarized as follows. Hybrid zeolitic imidazolate frameworks (HZIFs) have become promising porous materials like ZIF-8 and ZIF-67. Presented here is one facile method for the rapid and scalable synthesis of HZIFs. According to this method, HZIFs can be easily synthesized at ambient pressure, low temperature (50°), in very short time (30 min) and on a large scale (ca. 4 g) through heating mixture of reactants in DMF solvent. The samples exhibited similar surface areas but higher catalytically activity than former ones. In addition, the -CHO functional HZIF-1 can also be obtained under similar condition. These results will lay a solid foundation for further application of these promising materials.

Product Details of C4H4N2O, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Recommanded Product: Imidazole-4-carbaldehyde.

Wang, Yu-Ting;An, Lian-Cai;Zhang, Yun-Qin;Zhang, Xin-Kun;Gao, Zhu-Feng;Zhang, Ying-Hui research published 《 Improving iodine adsorption performance of porous organic polymers by rational decoration with nitrogen heterocycle》, the research content is summarized as follows. Four kinds of porous aminal-linked organic polymers (PAOPs) were synthesized via one-step condensation between cheap melamine and resp. aldehydes decorated with different nitrogen heterocycle, to evaluate the influence of nitrogen heterocycle on the adsorption performance of target polymer toward iodine. Though having the smallest surface area of 209.9 m²/g, PAOP-4 decorated with pyridine group exhibits an adsorption capacity of 108 wt% (iodine/adsorbent weight%), surpassing other three PAOPs with Brunauer-Emmett-Teller area varying from 305.8 to 533.0 m²/g. Based on Raman spectral analyses, the characteristic band of I₃^– and I₅^– was used to evaluate the electronic interaction between iodine and the nitrogen heterocycle, giving an order of pyridine > tetrazole > pyrazole > imidazole. This manifests the vital role of chem. interaction playing in the iodine adsorption by PAOP-4, which is much helpful for designing high-performance organic adsorbent toward iodine.

3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, Recommanded Product: Imidazole-4-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Name: Imidazole-4-carbaldehyde.

Whitely, Chelsi;Li, Yangmei research published 《 One-pot high-throughput synthesis of N3-substituted 5-arylidene-2-thiohydantoin amides and acids》, the research content is summarized as follows. A one-pot high-throughput solid-phase method for the synthesis of N3-substituted 5-arylidene-2-thiohydantoin amide and acid has been developed. A tandem ring-closure and ring-open pathway is proposed as the mechanism of forming the two products.

3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, Name: Imidazole-4-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem