Tag: M.W=400-500

Electric Literature of 1402838-08-7,Some common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, molecular formula is C29H22N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (200 mg, 0.483 mmol, 1.0 equiv),Compound (2-(Diphenyl[b,d]furan-2-yl)-2-oxoethyl)phosphoric acid dimethyl ester (0604-96) (170 mg, 0.53 mmol, 1.1 eq) andCesium carbonate (315 mg, 0.966 mmol, 2.0 equiv)Mixed in isopropyl alcohol (30 ml),The reaction was stirred at room temperature overnight. After the reaction is over, add water andSolids precipitated, filtered and the cake was dried to give the product 1-(diphenyl[b,d]furan-2-yl)-3-(2-(1-trityl-1H-)Imidazol-4-yl)phenyl)prop-2-en-1-one (300 mg, crude).

The synthetic route of 1402838-08-7 has been constantly updated, and we look forward to future research findings.

Application of 96797-15-8, These common heterocyclic compound, 96797-15-8, name is 4-Iodo-1-trityl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[275] To an ice-salt bath cooling solution of 4-iodo-1-trityl-1H-imidazole (2.5 g, 5.7 mmol) in dichloromethane (DCM) (30 mL) was added ethylmagnesium bromide (2.5 mL, 7.5 mmol, 3.0 M solution in diethyl ether) slowly. The resulted mixture was stirred at roomtemperature for lh, then added chlorotributyltin (2.6 g, 8.0 mmol). The resulted mixture was stirred at room temperature for 2h, then added saturated ammonium chloride solution (50 mL), the mixture was extracted with dichloromethane (100 mLx2). The combined organic phase was washed with brine (25 mL), dried over sodium sulfate, filtered and concentrated. The residue was recrystallization with a mixed solvent (petroleum ether: ethyl acetate= 6:1) toafford 4-(tributylstannyl)-1-trityl-1H-imidazole (2.6 g, yield: 76%) as a white solid.[276] m/z: [M+H] 601

Statistics shows that 4-Iodo-1-trityl-1H-imidazole is playing an increasingly important role. we look forward to future research findings about 96797-15-8.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 96797-15-8, name is 4-Iodo-1-trityl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C22H17IN2

Step 11C 62ATo a solution of 4-iodo-trityl-imidazole (6.77 g, 15.5 mmol) in DCM (100 ml_) was added EtMgBr (3.0M in Et2O, 4.96 mL, 14.9 mmol) slowly at -200C, stirred at – 200C for 30 min. A solution of 1C (2.8 g, 13.5 mol) in DCM (20 mL) was added very slowly. The mixture was stirred at RT for 1 h, quenched with saturated NH4CI, diluted with DCM. The DCM layer was washed with brine, dried and concentrated. Flash chromatography (EtOAc/Hexanes, 1 :2 then 10:1 ) afforded 62A (5.0 g, 72%).

The synthetic route of 96797-15-8 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 139481-44-0, name is Methyl 1-((2′-cyano-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate, A new synthetic method of this compound is introduced below., Formula: C25H21N3O3

Starting material (Compound 2A) 20 g, placed in a reaction flask, adding ethanol 200ml, 5 g of triethylamine, 37 g of 50% aqueous hydroxylamine solution, the reaction 24h, cooling crystallization to give a white solid 13.6 g (63.0%). At the end of the reaction the reaction mixture by HPLC lactam impurity was mainly (Compound. 6A): the product was 7.15%: 92.84% (i.e. a ratio of an impurity with the product: 12.9),

The synthetic route of 139481-44-0 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-(1-Trityl-4-imidazolyl)benzaldehyde

To a three-necked flask was added 2- (1-trityl-1H-imidazole-4-) benzaldehyde (400 mg, 0.97 mmol)Acetyl-1-deuterated cyclohexane (122 mg, 0.97 mmol)And anhydrous tetrahydrofuran (5 ml)Under nitrogen protection,A solution of sodium ethoxide (85 mg, 1.25 mmol) in ethanol was added at room temperature,Stir at room temperature for 3 h, spin dry solvent,Saturated ammonium chloride (10 ml) was added, Extracted with ethyl acetate, the combined organic layers were dried over anhydrous sodium sulfate, the solvent was dried,Acetic acid (1 ml) and ethanol (5 ml) were added,Was stirred at 90 3h, cooled to room temperature,The organic layer was combined and dried over anhydrous sodium sulfate. The solvent was concentrated and purified by column chromatography on silica gel to give compound 23 (210 mg, yield: 77%), and the residue was extracted with ethyl acetate.

The synthetic route of 2-(1-Trityl-4-imidazolyl)benzaldehyde has been constantly updated, and we look forward to future research findings.

Related Products of 1402838-08-7,Some common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, molecular formula is C29H22N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (1.4 g, 3.37 mmol, 1.0 equiv),Compound (2-(3-Fluoro-4-nitrophenyl)-2-oxoethyl)phosphoric acid dimethyl ester (0702-102) (1.36 g, 4.38 mmol, 1.3 equivalents) andCesium carbonate (2.2 g, 6.74 mmol, 2.0 eq.)Mixed in isopropyl alcohol (30 ml),The reaction was stirred at room temperature overnight.After the reaction was completed, quenched with water and extracted with dichloromethane. The organic phase was dried over anhydrous sodium sulfate, concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol=100/1-50/ 1) Purification,The product (Z)-1-(3-fluoro-4-nitrophenyl)-3-(2-(1-trityl-1H-imidazol-4-yl)phenyl)prop-2-ene is obtained 1-ketone (1.8 g, yield: 92%).

The synthetic route of 1402838-08-7 has been constantly updated, and we look forward to future research findings.

Electric Literature of 1402838-08-7,Some common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, molecular formula is C29H22N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-(2-(Dimethoxyphosphoryl)acetyl)-1H-carbazole-1-carboxylic acid tert-butyl ester (0304-105) (375 mg, 1.0 mmol, 1.4 equiv),2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (300 mg, 0.73 mmol, 1.0 equiv) andCesium carbonate (900 mg, 2.8 mmol, 3.8 eq.)Added to 60 ml of isopropanol,The reaction was stirred at room temperature overnight, concentrated under reduced pressure, ethyl acetate and water were added,The layers were separated, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the product as a yellow solid 5-(3-(2-(1-triphenylmethyl-1H-imidazole-4-(phenyl)acryloyl)-1H-carbazole-1-carboxyl

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(1-Trityl-4-imidazolyl)benzaldehyde, its application will become more common.

Synthetic Route of 147403-65-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 147403-65-4 name is Methyl 2-ethoxy-1-((2′-(N-hydroxycarbamimidoyl)-[1,1′-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 19Methyl 2-ethoxy- 1 -((2′-(5-oxo-4,5-dihydro- 1 ,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)- 1 H- benzo[c ]imidazole-7-carboxylate of formula laFirst, active carbon (0.1 g) and then a solution of diphosgene (0.15 g, 0.75 mmol) in THE (1 ml) were added to a mixture of methyl 2-ethoxy- 1 -((2′-((hydroxyamino)iminomethyl)- biphenyl-4-yl)methyl)-l H-benzo[(i]imidazole-7-carboxylate (of formula Va; 0.44 g, 1 mmol), THF (10 ml) and triethylamine (0.5 g, 5 mmol) and the mixture was stirred in a closed pressure flask at the room temperature for 1 hour. Then, the temperature was increased to 100 C and the mixture was stirred at this temperature for 4 hours. After cooling down, water (20 ml) was added under stirring and, after stirring for 30 minutes, the active carbon was aspirated through kieselguhr. The filtration cake was washed with 5 % ammonia (5 ml). The filtrate was then acidified with acetic acid and the resulting mixture was extracted with ethyl acetate (2 x 25 ml). After washing with water (5 5 ml) the extract was dried and after evaporation 0.4 g of a product was obtained, which contained 66.3 % of the compound of formula la according to HPLC. Centrifugal chromatography (Cyclograph from Analtech, plate thickness 2 mm, dichloromethane-methanol 20 : 1 to 10 : 1 system) and subsequent crystallization from ethyl acetate yielded 0.25 g (53.1 %) of a product, which contained 99.8 % of the compound of formula la according to HPLC.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-ethoxy-1-((2′-(N-hydroxycarbamimidoyl)-[1,1′-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate, and friends who are interested can also refer to it.

Electric Literature of 147403-65-4,Some common heterocyclic compound, 147403-65-4, name is Methyl 2-ethoxy-1-((2′-(N-hydroxycarbamimidoyl)-[1,1′-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate, molecular formula is C25H24N4O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound (3A) 9.5 g, placed in a reaction flask was added dichloromethane 100ml, 5ml of triethylamine was added dropwise 2.5 g of methyl chloroformate, the reaction at room temperature for 2 hours.Water was added to 60ml, stirring layers were separated dichloromethane layer was separated, and the aqueous layer extracted with dichloromethane, dichloromethane layers were combined, dried over anhydrous sodium sulfate, filtered, and concentrated to give the crude product was purified by solid 8.2, yield 79 %.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-ethoxy-1-((2′-(N-hydroxycarbamimidoyl)-[1,1′-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate, its application will become more common.

Reference:
Patent; Shanghai Institute of pharmaceutical industry; Wang, Xiaomei; Sui, Qiang; Tang, Chao; Ouyang, Qunxiang; Shi, Huilin; Liu, Shuai; (18 pag.)CN103664920; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 1402838-08-7,Some common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, molecular formula is C29H22N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of tert-butyl 5-oxo-2-azaspiro[3.4]octane-2-carboxylate (2 g, 8.89 minol), 2-[ 1 -(triphenylmethyl)- I. H-iniidazol-4-y1]benzaldehyde (5.53 g, 13.34 mmol) and Ca(OH)2 (1.64g. 22.13 mniol) in EtOH (250 mL) was stirred for 6 hat 80C. The solids were filtered out. The solids were filtered out. The solvent was concentrated under vacuum. The residue was purified by silica gel column eluting with EtOAc /PE (1:2). This resulted in 5.24 g (95%) of tert-butyl (6E)-5-oxo-6-([2-[ 1 -(triphenyl.methyl)-1 H-imidazoi-4-yljphenyljmethylidene)-2-azaspiro[3.4]octane-2-carboxylate as a light yellow solid. LCMS (ESI)mJz = 622.8 [.M+Hr.

The synthetic route of 1402838-08-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GENENTECH, INC.; PEI, Zhonghua; PASTOR, Richard; GAZZARD, Lewis; PARR, Brendan; LIU, Wendy; MENDONCA, Rohan; WU, Guosheng; YUEN, Po-Wai; (183 pag.)WO2019/5559; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem