M.W=400-500 Archives - Page 11 of 14 - Imidazoles-derivatives

Introduction of a new synthetic route about 1402838-08-7

According to the analysis of related databases, 1402838-08-7, the application of this compound in the production field has become more and more popular.

Application of 1402838-08-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1402838-08-7 as follows.

2-(1-Trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (696 mg, 1.68 mmol, 1 eq),Compound ((5-(2-(Dimethoxyphosphoryl)acetyl)-6-fluorobenzofuran-2-yl)methyl) tert-butyl carbonate (0207-51) (772Mg, 1.85 mmol, 1.1 eq) andCesium carbonate (1090 mg, 3.36 mmol, 2 eq)Mixed in isopropanol (10 ml),The mixture was stirred at room temperature for 16 hours.After the reaction is completed, quench with water and filter to obtain the product ((6-Fluoro-5-(3-(2-(1-trityl-1H-imidazol-5-yl)phenyl)acryloyl)benzene. tert-Butyl furan-2-yl)methyl)carbonate (930 mg, crude) is a yellow solid

According to the analysis of related databases, 1402838-08-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Research on new synthetic routes about 96797-15-8

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 96797-15-8, A common heterocyclic compound, 96797-15-8, name is 4-Iodo-1-trityl-1H-imidazole, molecular formula is C22H17IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 4-Iodo-1-trityl-1H-imidazole (5, 2 g, 4.58 mmol), (5-chloro-2-methoxyphenyl)boronic acid(0.852 g, 4.58 mmol), K3PO4 (2.9 g, 13.7 mmol), Pd(PPh3)4 (0.74 g, 0.64 mmol) were added todry dimethylformamide (30 mL). The reaction mixture was stirred at 100 C under inert atmosphere,until the starting material disappeared in TLC. The reaction mixture was distilled in vacuo, and ethylacetate (100 mL) was added to the mixture. The organic extract was washed twice with saturatedaqueous NaCl (20 mL), and the organic extract was dried over Na2SO4. After solvent was removedunder vacuum, the product was purified as a white solid by silica gel column chromatography, 1.2 g,yield 63%.

Reference:
Article; Wen, Hui; Liu, Yuke; Wang, Shufang; Wang, Ting; Zhang, Gang; Chen, Xiaoguang; Li, Yan; Cui, Huaqing; Lai, Fangfang; Sheng, Li; Molecules; vol. 24; 11; (2019);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Research on new synthetic routes about 176721-01-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 176721-01-0, name is (2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanol, A new synthetic method of this compound is introduced below., Safety of (2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanol

The compound of formula IV (50 g, 0.11 mol) was added to 1,4-dioxane (750 mL).Add MnO2 (100g,1.15mol),Warming up to reflux,Reaction for 3h,The reaction is complete,Hot filtered,The filtrate is concentrated and dried.Obtained a crude white solid,Add methanol (350mL) at room temperature (25 C) for 1-2h,filter,Vacuum drying to give a white solid compound of formula V (45 g).Yield: 90.0%.

Reference:
Patent; Shanghai Tianci International Pharmaceutical Co., Ltd.; Chi Wangzhou; Sha Fei; (11 pag.)CN109912508; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New downstream synthetic route of 96797-15-8

Electric Literature of 96797-15-8, A common heterocyclic compound, 96797-15-8, name is 4-Iodo-1-trityl-1H-imidazole, molecular formula is C22H17IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1S,2R) and (1R,2S)-2-(4-chlorophenyl)-1′-(1-trityl-1H-imidazol-4-yl)spiro[cyclopropane-1,3′-indolin]-2′-one 4-Iodo-1-trityl-1H-imidazole (210 mg, 0.48 mmol) was added to a suspension of racemic (1S,2R)-2-(4-chlorophenyl)spiro[cyclopropane-1,3′-indolin]-2′-one (107 mg, 0.4 mmol) in acetonitrile (2 mL) under a nitrogen atmosphere. A steady stream of nitrogen was bubbled through the suspension as it was heated to 40 C. over 15 minutes. Potassium carbonate (110 mg, 0.8 mmol), copper (I) iodide (12 mg, 15 mol %), and N,N-dimethylethylenediamine (0.12 mmol, 30 mol %) were added and the reaction mixture was heated to 80 C. and kept for 21 hours under nitrogen atmosphere. The mixture was cooled to room temperature, filtered and concentrated to give the title product. The residue was purified by flash column chromatography (gradient elution, 5-10% ethyl acetate in petroleum ether) to give racemic trans-2-(4-chlorophenyl)-1′-(1H-imidazol-4-trityl)spiro[cyclopropane-1,3′-indolin]-2′-one (157 mg, 68%). LC/MS m/e calcd. for C38H28ClN3O: 577, observed (M+H)+: 578.2 MS calcd. for C38H28ClN3O 578, obsd. (ESI+) [(M+H)+] 579.3.

Reference:
Patent; Chen, Li; Feng, Lichun; He, Yun; Huang, Mengwei; Yun, Hongying; US2011/144106; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 96797-15-8

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 96797-15-8, name is 4-Iodo-1-trityl-1H-imidazole, A new synthetic method of this compound is introduced below., SDS of cas: 96797-15-8

4-Iodo-1-trityl-1H-imidazole (5, 2 g, 4.58 mmol), (5-chloro-2-methoxyphenyl)boronic acid(0.852 g, 4.58 mmol), K3PO4 (2.9 g, 13.7 mmol), Pd(PPh3)4 (0.74 g, 0.64 mmol) were added todry dimethylformamide (30 mL). The reaction mixture was stirred at 100 C under inert atmosphere,until the starting material disappeared in TLC. The reaction mixture was distilled in vacuo, and ethylacetate (100 mL) was added to the mixture. The organic extract was washed twice with saturatedaqueous NaCl (20 mL), and the organic extract was dried over Na2SO4. After solvent was removedunder vacuum, the product was purified as a white solid by silica gel column chromatography, 1.2 g,yield 63%. 1H-NMR (400 MHz, CDCl3): = 7.51-7.32 (m, 12H, H-phenyl, H-imidazolyl), 7.15-7.04 (m,8H, H-phenyl, H-imidazolyl), 6.94 (d, J = 8.1 Hz, 1H, H-phenyl), 3.99 (s, 3H, CH3). HRMS (ESI): m/z[M + H]+ calculated for C29H25N2O: 417.19614; found: 417.19647.

Continuously updated synthesis method about 96797-15-8

The synthetic route of 4-Iodo-1-trityl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Related Products of 96797-15-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 96797-15-8, name is 4-Iodo-1-trityl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step 40.a. (R,S) 4-(Hydroxy-(1-trityl-1H-imidazol-4-yl)-methyl)-benzonitrile A solution of 1-trityl-4-iodoimidazole (3.53g, 8.10mmol) in CH2Cl2 (35ml) was cooled to about -3C under N2 and 3M EtMgBr in Et2O was added dropwise while maintaining reaction temperature at below about 0C. The solution was stirred for about one hour at about 0C and then 4-cyanobenzaldehyde (1.18g, 9.00mmol) was added in one portion and the reaction was allowed to warm to room temperature for about 1 hour.. The reaction mixture was then again cooled to about 0C and 5% HCl (30ml) was added.. The reaction mixture was stirred about 15 min. and then extracted with CH2Cl2 (2x25ml).. The combined CH2Cl2 layers were washed with saturated NaHCO3, dried over Na2SO4, filtered, and then concentrated under reduced pressure.. The residue was triturated with EtOAc (25ml) and the product filtered off (2.92g, 82%).. Mass spec. 442.3 MH+, NMR (300MHZ, DMSO-d6, 30C) 7.7-7.8 (2H, d), 7.5-7.6 (2H, d), 7.3-7.5 (9H, m), 7.25-7.3 (1H, s), 7.0-7.15 (6H, m), 6.75-6.8 (1H, s), 5.9-6.90 (1H, m), 5.6-5.7 (1H, m).

The synthetic route of 4-Iodo-1-trityl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SOCIETE DE CONSEILS DE RECHERCHES ET D’APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.); EP1382607; (2004); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Share a compound : 1402838-08-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1402838-08-7, its application will become more common.

Some common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, molecular formula is C29H22N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: imidazoles-derivatives

A slurry of tert-butyl 2?-oxospiro[8-azabicyclo[3 .2.1 ]octane-3, I ?-cyclobutanej-8-carhoxylate (2.65 g, 9.98 .mmol), 2-[ 1.-(triphenylmethyl)- IH-imidazol-4-yl.]benzaldehyde (4.55 g,11.0 mmol) and Ca(OH)2 (1.48 g, 20.0 mmol) in EtOH (33 mL) was stirred for 24 h at 80 C.The reaction was cooled to room temperature and insoluble material was removed by filtration. The filtrate was concentrated. The residue was purified by a silica gel column eluting withDCM/methanoj. (90:10) to afford 5.60 g (85%) tertbutyl E)-2?-oxo-3?(2-(1-trity1-1Wirnidazo1.-4-yl)benzylidene)-8-azaspiro[bicyclo{3 .2.1 ]octane-3, 1 ?-cyclobutane]-S-carboxylate as a pale yellow solid. LCM.S (ESI) m/z 662.3 [M+F1]4.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1402838-08-7, its application will become more common.

Reference:
Patent; GENENTECH, INC.; PEI, Zhonghua; PASTOR, Richard; GAZZARD, Lewis; PARR, Brendan; LIU, Wendy; MENDONCA, Rohan; WU, Guosheng; YUEN, Po-Wai; (183 pag.)WO2019/5559; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Introduction of a new synthetic route about 96797-15-8

The synthetic route of 4-Iodo-1-trityl-1H-imidazole has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 96797-15-8, name is 4-Iodo-1-trityl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 96797-15-8

Under nitrogen protection,Tetrakistriphenylphosphine palladium (2.0 g, 1.7 mmol, 0.074 eq), 4-iodo-1-trityl-1H-imidazole (0102-1) (10.0 g, 23.0 mmol, 1.0 eq),2-aldehyde phenylboronic acid (0103-1) (4.1 g, 27.5 mmol, 1.2 equiv) andTripotassium phosphate (12.0 g, 46 mmol, 2.0 equiv)Add to a mixture of 180 ml of dimethylformamide and water (5:1),Heat to 90C and react for 6 hours.Cool to room temperatureAfter suction filtration through Celite, the resulting filtrate was diluted with ethyl acetate to 1000 ml, washed with saturated brine three times, dried over anhydrous sodium sulfate, concentrated under reduced pressure, and purified by silica gel column chromatography (eluent: petroleum ether: ethyl acetate. Ester = 8:1 and petroleum ether: dichloromethane = 2:1),2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (5.2 g, yield: 54%) was obtained as a white solid.

The synthetic route of 4-Iodo-1-trityl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Introduction of a new synthetic route about 96797-15-8

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 96797-15-8, name is 4-Iodo-1-trityl-1H-imidazole, A new synthetic method of this compound is introduced below., Computed Properties of C22H17IN2

Compound 1 (2.2 g, 5.0mmol), o-formylphenylboronic acid(1.2 g, 7.5mmol), K3PO4 (3.2 g, 15mmol), Pd (PPh3)4 (0.6 g, 1.0mmol) is dissolved in DMF/H20 (30mL/6mL). The system is replaced with nitrogen and warmed at 90C, the reaction is stirred overnight. The reaction solution is diluted with ethyl acetate (50mL), wash with saturated brine (25mL X 3), dry over anhydrous sodium sulfate, and dry under reduced pressure. Crude column chromatography (PE: EA = 5:1), and then obtained brown solid compound 2 (810 mg, 39%).

Reference:
Patent; Lunan Pharmaceutical Group Co., Ltd.; Zhang Guimin; Guan Yongxia; Li Xin; (15 pag.)CN107556315; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Continuously updated synthesis method about 1402838-08-7

The synthetic route of 2-(1-Trityl-4-imidazolyl)benzaldehyde has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-(1-Trityl-4-imidazolyl)benzaldehyde

Will (2-(2-phenylbenzofuran-5-yl)-2-oxoEthyl) dimethyl phosphate (0207-79) (254 mg, 0.738 mmol, 1.0 equiv),2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (305 mg, 0.738 mmol, 1.0 equiv) andCesium carbonate (480 mg, 1.476 mmol, 2.0 equiv)The isopropanol solution (10 ml) was stirred overnight at room temperature.After the reaction is completed, quench with water, dichlorineMethane extraction, the organic phase is washed with saturated brine,It was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a yellow oil.The resulting yellow oil was purified by column chromatography on silica gel (eluent: ethyl acetate/petroleum ether = 1/2) to give the target product 1-(2-phenylbenzene)(Furan-5-yl)-3-(2-(1-trityl-1H-imidazol-4-yl)phenyl)propan-2-en-1-one (306 mg, Yield:65.7%) is a yellow oil.

The synthetic route of 2-(1-Trityl-4-imidazolyl)benzaldehyde has been constantly updated, and we look forward to future research findings.