M.W=400-450 Archives - Page 32 of 35 - Imidazoles-derivatives

Koller, Sebastian team published research in Helvetica Chimica Acta in 2021 | 250285-32-6

Application of C27H37ClN2, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., 250285-32-6.

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Application of C27H37ClN2.

Koller, Sebastian;Klein, Philippe;Reinhardt, Katja;Ochmann, Lukas;Seitz, Antonia;Jandl, Christian;Pothig, Alexander;Hintermann, Lukas research published 《 New Access Routes to Privileged and Chiral Ligands for Transition-Metal Catalyzed Hydrogen Autotransfer (Borrowing Hydrogen), Dehydrogenative Condensation, and Alkene Isomerization Reactions》, the research content is summarized as follows. A group of transition-metal catalyzed hydrogen moving reactions, encompassing hydrogen autotransfer (HAT; also called borrowing hydrogen, BH), dehydrogenative condensation (DHC) and alkene isomerization, displays high atom economy and relies on widely available starting materials. Such reactions have considerable potential for clean reaction design and application in sustainable synthesis. With the aim to develop and study synthetic applications of the title reactions, authors have set up synthetic access routes to a toolbox of structurally varied ligands for and pincer complexes of some transition metals (cobalt, ruthenium, iridium) that are well established for the title reactions. Ligand target structures, for which often improved syntheses have been found, encompass 6,6′-dihydroxy-2,2′-bipyridine, 2(3-hydroxyphenyl)pyridines (as backbones for PCN pincers), 2(6-methylpyridine-2-yl)pyridines (as backbones for PNN pincers) and 2(3-tolyl)pyridines (as backbones for PCN pincers). To support research towards asym. versions of the title reactions, they have prepared asym. modified versions of well-established catalysts, including chiral, enantiopure versions of Milstein’s PNN-ruthenium pincer, Kempe’s triazinyl-diaminophosphanyl PNP-iridium- or -cobalt pincers, Huang’s PCN-iridium pincers, and Grotjahn’s alkene zipper complex. The strategy applied to ‘chiral switching’ relied on replacing sym. dialkylphosphine donor-groups by dimenthylphosphine or aryl(menthyl)phosphine donor units. The resulting ligands or complexes have been structurally characterized, and the catalytic potential of the catalysts has been established in exploratory model reactions (transfer hydrogenation; diol to lactone dehydrogenative condensation; alkene isomerization). Several model reactions have been designed which will allow to study asym. catalytic hydrogen moving reactions.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Konstandaras, Nicholas team published research in Organic & Biomolecular Chemistry in 2020 | 250285-32-6

HPLC of Formula: 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. HPLC of Formula: 250285-32-6.

Konstandaras, Nicholas;Dunn, Michelle H.;Luis, Ena T.;Cole, Marcus L.;Harper, Jason B. research published 《 The pK_a values of N-arylimidazolinium salts, their higher homologues, and formamidinium salts in dimethyl sulfoxide》, the research content is summarized as follows. A series of imidazolinium salts, their six-, seven- and eight-membered homologues, and the related formamidinium salts were prepared, and their pK_a values were determined in DMSO at 25°C using the bracketing indicator method. The effect of each type of structural variation on the acidity of each salt was considered, particularly noting the importance of ring size and the effect of the steric and electronic nature of the N-aryl substituents. The effect of a cyclic structure was also probed through comparing the cyclic systems with the corresponding formamidinium salts, noting the importance of conformational flexibility in the latter cases. Along with allowing choice of appropriate bases for deprotonation of these species, it is anticipated that the data presented will aid in the understanding of the nucleophilicity, and potentially catalytic efficacy, of the corresponding carbenes.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jiang, Binyang team published research on Chinese Journal of Chemistry in 2022 | 250285-32-6

Computed Properties of 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Computed Properties of 250285-32-6.

Jiang, Binyang;Shi, Shi-Liang research published 《 Pd-Catalyzed Cross-Coupling of Alkylzirconocenes and Aryl Chlorides》, the research content is summarized as follows. The first Pd-catalyzed aryl-alkyl cross-coupling of alkylzirconocenes and aryl halides was reported. A com. available N-heterocyclic carbene (IPr) as the ligand for palladium catalyst was critical to enable the challenging process. This mild protocol does not require base additives and tolerated a broad scope of both coupling partners bearing various functional groups and heterocycles. Moreover, both terminal and internal alkenes were applicable, and the latter underwent “chain walking”, giving the terminal coupling product exclusively. Preliminary mechanistic studies revealed a precatalyst activation pathway and inhibited β-H elimination due to steric bulk of NHC ligand.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jiang, Kunming team published research on Journal of the American Chemical Society in 2020 | 250285-32-6

Related Products of 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Jiang, Kunming;Han, Shantao;Ma, Mingyu;Zhang, Lu;Zhao, Yucheng;Chen, Mao research published 《 Photoorganocatalyzed Reversible-Deactivation Alternating Copolymerization of Chlorotrifluoroethylene and Vinyl Ethers under Ambient Conditions: Facile Access to Main-Chain Fluorinated Copolymers》, the research content is summarized as follows. Fluoropolymers have found broad applications for many decades. Considerable efforts have focused on expanding ac-cesses toward main-chain fluorinated polymers. In contrast to previous polymerizations of gaseous fluoroethylenes con-ducted at elevated temperatures and with high-pressure metallic vessels, we here report the development of a photoor-ganocatalyzed reversible-deactivation radical alternating copolymerization of chlorotrifluoroethylene (CTFE) and vinyl ethers (VEs) at room temperature and ambient pressure by exposing to LED light irradiation This method enables the synthesis of various fluorinated alternating copolymers with low ETH and high chain-end fidelity, allowing iterative switch of the copolymerization between “ON” and “OFF” states, the preparation of fluorinated block alternating copolymers, as well as post-synthetic modifications.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jiang, Nan team published research on ChemCatChem in 2021 | 250285-32-6

Name: 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Jiang, Nan;Mei, Yuling;Yang, Yu;Dong, Youxian;Ding, Zekun;Zhang, Jianbo research published 《 A General Strategy for the Stereoselective Synthesis of Pyrrole-Fused Chiral Skeletons: [3+2] Cycloaddition with 2-Nitro-2,3-Unsaturated Glycosides》, the research content is summarized as follows. In this study, a two-step methodol. was developed for the synthesis of chiral pyrroles from 2-nitroglycals via Ferrier rearrangement and Barton-Zard reaction under mild conditions without transition metal catalysts. The Ferrier rearrangement reaction of 2-nitro-glycals and a series of O-nucleophiles proceeded smoothly in the presence of N-heterocyclic carbene (NHC) catalyst and K₂CO₃ which allowed the highly stereoselective synthesis of the diverse 2-nitro-2,3-unsaturated glycosides in excellent yields. Subsequently, the rearrangement products were conveniently transformed into the desired chiral pyrroles by [3+2] cycloaddition (Barton-Zard reaction) with isocyanoacetate in the presence of Cs₂CO₃. One-pot strategy was also successfully demonstrated for the gram-scale synthesis of one chiral pyrrole. This is the first report of stereoselective conversion from 2-nitroglycals to chiral pyrrole.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jo, Minyoung team published research on Dalton Transactions in 2020 | 250285-32-6

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Jo, Minyoung;Li, Jingbai;Dragulescu-Andrasi, Alina;Rogachev, Andrey Yu.;Shatruk, Michael research published 《 Incorporation of coinage metal-NHC complexes into heptaphosphide clusters》, the research content is summarized as follows. Cu(I) and Au(I) ions, capped with an N-heterocyclic carbene (NHC), react with (TMS)₃P₇ (TMS = trimethylsilyl) to afford an η⁴-coordinated anion [NHC^DippCu-P₇(TMS)]^– and a neutral trinuclear complex (NHC^DippAu)₃P₇. Protecting the P₇ cage with the TMS groups is instrumental in controlling these reactions.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Johnson, Chloe team published research on ChemCatChem in 2021 | 250285-32-6

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Johnson, Chloe;Dabral, Saumya;Rudolf, Peter;Licht, Ulrike;Hashmi, A. Stephen K.;Schaub, Thomas research published 《 Liquid-liquid-phase Synthesis of exo-Vinylene Carbonates from Primary Propargylic Alcohols: Catalyst Design and Recycling》, the research content is summarized as follows. A straight-forward approach to sep. catalyst from the exo-vinylene carbonate (EVC) products of the carboxylative cyclisation of primary propargylic alcs. has been developed. The liquid-liquid phase synthesis utilizes lipophilic silver(I) carboxylate salts and N,N-dioctyl modified phosphine (FatPhos) ligands to enhance catalyst solubility in non-polar solvents. Following simple liquid-liquid phase separation, EVCs relevant as monomers for poly(urethane) and poly(carbonate) synthesis were isolated in the non-miscible polar phase in good yields. In situ reaction monitoring by ReactIR gave insights into the reaction kinetics and informed the conditions used to afford good EVC selectivity. Under optimized conditions, silver leaching into the product phase was very minor as confirmed by ICP-MS. Furthermore, a protocol for catalyst recycling by liquid-liquid separation was demonstrated, with modest loss of catalytic activity over 3 runs.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jonsson, Helgi Freyr team published research on Dalton Transactions in 2021 | 250285-32-6

Application In Synthesis of 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Jonsson, Helgi Freyr;Fiksdahl, Anne;Harvie, Andrew J. research published 《 Rapid and mild synthesis of Au-NHC complexes in a simple two-phase flow reactor》, the research content is summarized as follows. We describe a simple two-phase flow reactor which allows for the rapid synthesis of several Au(I)-NHC complexes in high yields (>88%), under mild conditions, and with minimal workup. Translation of the standard weak base method to a two-phase flow reaction prevents the common problem of decomposition to Au(0). The reaction can be scaled up more than ten-fold without loss in conversion efficiency. An optional second stage allows for direct synthesis of Au(III)-NHC complexes, without isolation of the Au(I)-NHC intermediate, with a two-step isolated yield of 82%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jenkins, Aireal D. team published research on Journal of Organic Chemistry in 2020 | 250285-32-6

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Computed Properties of 250285-32-6.

Jenkins, Aireal D.;Robo, Michael T.;Zimmerman, Paul M.;Montgomery, John research published 《 Nickel-Catalyzed Three-Component Cycloadditions of Enoates, Alkynes, and Aldehydes》, the research content is summarized as follows. A method for the three-component cycloaddition of aldehydes R¹CHO (R¹ = Ph, i-Pr), enoates PhOC(O)C(R²)=CHR³ (R² = H, Me; R³ = H, Me, Ph), and alkynes R⁴CCR⁵ (R⁴ = Me, n-Pr, (CH₂)₃OTBS, (CH₂)₂C(O)₂Me; R⁵ = Ph, n-Pr) has been developed. Building upon previous work by this group in which stoichiometrically generated metallacycles undergo alkylation, a catalytic, alkylative [3+2] cycloaddn was reported. From simple starting materials, structurally complex cyclopentenones I may be rapidly assembled. Computational investigation of the mechanism (ωB97X-D3/cc-pVTZ // ωB97X/6-31G(d)) identified three energetically feasible pathways. Based on the relative rates of ketene formation compared to isomerization to a 7-membered metallacycle, the most likely mechanism has been determined to occur “ketene-first”, with carbocyclization prior to aldol addition Deuterium labeling studies suggest that formation of the 7-membered metallacycle becomes possible when an α-substituted enoate is used. This observed change in selectivity is due to the increased difficulty of phenoxide elimination with the inclusion of addnl. steric bulk of the α-substituent. The net transformation results in a [3+2] cycloaddition accompanied by an alkylation of the enoate substituent.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jia, Jie team published research on Organic Letters in 2022 | 250285-32-6

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Jia, Jie;Yuan, Fushan;Zhang, Zihao;Song, Xuejiao;Hu, Fangdong;Xia, Ying research published 《 Copper-Catalyzed Ring-Opening Defluoroborylation of gem-Difluorinated Cyclobutenes: A General Route to Bifunctional 1,3-Dienes and Their Applications》, the research content is summarized as follows. The exploration of the reactivity of gem-difluorinated small-size rings has continuously drawn attention in recent years but is limited to three-membered carbocycles. Herein, the authors report a Cu-catalyzed reaction of gem-fluorinated cyclobutenes with bis(pinacolato)diboron (B₂pin₂). A sequence of defluoroborylation and ring opening process produces B,F-bifunctional 1,3-dienes in a stereoselective manner. The transformation together with the efficient downstream coupling of the boronate and the fluoride moiety collectively constitutes a modular route to highly functionalized and stereocontrolled 1,3-dienes.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem