Tag: M.W=350-400

Kayarohanam, Saminathan published the artcileA validated RP HPLC method for the estimation of esomeprazole sodium injection, Product Details of C17H18N3NaO3S, the publication is International Journal of Pharmacy (Hyderabad, India) (2014), 4(2), 183-188, database is CAplus.

Esomeprazole is chem. bis (5methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl) methyl]sulfinyl]- 1Hbenzimidazole-1-yl). It is a gastric proton-pump inhibitor (PPI) used in treatment of gastric-acid related diseases. A Simple, sensitive, selective and accurate reverse phase high performance liquid chromatog. (RP-HPLC) methods were developed, estimated and validated for the anal. of Esomeprazole sodium in bulk and injection forms. The chromatog. separation was performed by the using C8, column having 250 × 4.6mm 5μm. Using mobile phase containing Acetonitrile and phosphate buffer (58:42vol./volume) adjusted to PH 7.6 with phosphoric acid. The anal. was run at a flow rate of 1.5ml/min and injection volume was 20 μL. The detection was monitored at 280nm. The retention time of Esomeprazole was 2.93 min. The developed method was validated for precision, intermediate precision (ruggedness), linearity, specificity, accuracy, and stability. Recovery of Esomeprazole in formulations was found to be in the range of 99.08%, 100.86%, and 101.52% resp. And the correlation coefficient was 0.999. Hence, it was concluded that the developed method is suitable for routine anal. due to its less anal. time.

International Journal of Pharmacy (Hyderabad, India) published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Product Details of C17H18N3NaO3S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lipi, Farhana published the artcileDevelopment and validation of analytical method for determination of esomeprazole sodium by HPLC, Recommanded Product: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, the publication is International Research Journal of Pharmacy (2016), 7(5), 10-14, database is CAplus.

A very simple, accurate, specific, precise and rapid reverse phase high performance liquid chromatog. technique has been built up as well as validated to determine the Esomeprazole Sodium. The method is applicable for the quant. anal. of the drug substance. Chromatog. seperation was achieved on a Supelco 250-mm, 4.6-mm, and 5-μ m C-18 anal. column with a mixture of Buffer and Acetonitrile at a volume ratio of 55:45 (volume/volume) as mobile phase at a flow rate of 1.0 mL/min. The mol. eluted within a short runtime (within 7.0 min). The eluted compound was monitored at a detector wavelength of 302 nm and the column oven temperature was maintained at 25°C. The developed method was validated according to ICH guidelines. The high recovery and low relative standard deviation confirm the suitability of the method for detection of Esomeprazole Sodium. The repeatability and intermediate precision, expressed by the % RSD, were less than 2%. Accuracy (% recovery: 98.00-102.00%) was found to satisfactory. The method was validated by determining its accuracy, precision, system suitability, linearity and robustness. Validation studies reveal that the method is simple, specific, rapid, reproducible, precise and accurate, which is useful for the routine detection of Esomeprazole Sodium.

International Research Journal of Pharmacy published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Recommanded Product: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

De Milito, Angelo published the artcileProton Pump Inhibitors Induce Apoptosis of Human B-Cell Tumors through a Caspase-Independent Mechanism Involving Reactive Oxygen Species, Computed Properties of 161796-78-7, the publication is Cancer Research (2007), 67(11), 5408-5417, database is CAplus and MEDLINE.

Proton pumps like the vacuolar-type H⁺ ATPase (V-ATPase) are involved in the control of cellular pH in normal and tumor cells. Treatment with proton pump inhibitors (PPI) induces sensitization of cancer cells to chemotherapeutics via modifications of cellular pH gradients. It is also known that low pH is the most suitable condition for a full PPI activation. Here, we tested whether PPI treatment in unbuffered culture conditions could affect survival and proliferation of human B-cell tumors. First, we showed that PPI treatment increased the sensitivity to vinblastine of a pre-B acute lymphoblastic leukemia (ALL) cell line. PPI, per se, induced a dose-dependent inhibition of proliferation of tumor B cells, which was associated with a dose- and time-dependent apoptotic-like cytotoxicity in B-cell lines and leukemic cells from patients with pre-B ALL. The effect of PPI was mediated by a very early production of reactive oxygen species (ROS), that preceded alkalinization of lysosomal pH, lysosomal membrane permeabilization, and cytosol acidification, suggesting an early destabilization of the acidic vesicular compartment. Lysosomal alterations were followed by mitochondrial membrane depolarization, release of cytochrome c, chromatin condensation, and caspase activation. However, inhibition of caspase activity did not affect PPI-induced cell death, whereas specific inhibition of ROS by an antioxidant (N-acetylcysteine) significantly delayed cell death and protected both lysosomal and mitochondrial membranes. The proapoptotic activity of PPI was consistent with a clear inhibition of tumor growth following PPI treatment of B-cell lymphoma in severe combined immunodeficient mice. This study further supports the importance of acidity and pH gradients in tumor cell homeostasis and suggests new therapeutic approaches for human B-cell tumors based on PPI.

Cancer Research published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Computed Properties of 161796-78-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Baishya, Himankar published the artcileLyophilization cycle comparison and scale-up of esomeprazole sodium for injection between lab scale and scale-up batches vs FDM study, Quality Control of 161796-78-7, the publication is International Journal of Pharmaceutical Sciences and Research (2016), 7(11), 4407-4413, database is CAplus.

Lyophilization also known as freeze drying is a process in which water is removed from a product after it was frozen and placed under a vacuum, allowing the ice to change directly from solid to vapor without passing through a liquid phase. The process consists of three sep., unique, and interdependent processes; freezing, primary drying (sublimation), and secondary drying (desorption). Esomeprazole sodium for Injection 20 mg and 40 mg formulation was developed by optimized Lyophilization cycle. The objective of the research work was to compare the lyophilsation process cycle between Lab scale and scale up batches. The collapse temperature (Tc) for the product was identified using Freeze-drying microscope (FDM). During manufacturing the samples were exposed to above said collapse temperature to study the impact on product quality. Lab scale manufacturing was executed in Tofflon Lyophilizer 0.5 and scale-up batches were executed in Tofflon Lyophilizer 13. The Lyophilisation cycle and anal. results for both the batches were compared.

International Journal of Pharmaceutical Sciences and Research published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Quality Control of 161796-78-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liang, Shuang published the artcileHigh-performance chiral stationary phases based on chitosan derivatives with a branched-chain alkyl urea, Recommanded Product: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, the publication is Analytica Chimica Acta (2017), 183-193, database is CAplus and MEDLINE.

Two series of chitosan 3,6-bis(arylcarbamate)-2-(isobutylurea)s and corresponding coated-type chiral stationary phases (CSPs) were prepared from two kinds of chitosans with different mol. weights Most of the prepared CSPs demonstrated better enantioseparation performance than the homemade CSP of cellulose tris(3,5-dimethylphenylcarbamate). The CSPs of chitosan 3,6-bis(4-methylphenylcarbamate)-2-(isobutylurea) with higher mol. weight and chitosan 3,6-bis(3-chloro-4-methylphenylcarbamate)-2-(isobutylurea) with lower mol. weight possessed outstanding chiral recognition abilities which were at least as good as that of the commercialized CSP of Chiralcel OD-H towards the tested chiral analytes. Except for the two CSPs derived from chitosan 3,6-bis(4-methylphenylcarbamate)-2-(isobutylurea)s, the CSPs (the 1st class) with the chiral selectors of lower mol. weight provided better enantioseparations than the ones (the 2nd class) with the chiral selectors of higher mol. weight However, the chiral selectors of the 1st class CSPs showed higher swelling capacities in organic solvents than the ones of the 2nd class. All prepared CSPs could be analyzed with a wider range of mobile phases, in which some unusual organic solvents such as Et acetate, chloroform and THF etc. could be used as additives. According to separation performance and tolerance against organic solvents, the chitosan derivatives with branched-chain alkyl urea at 2-C of glucosamine residue were preferable to be used as chiral selectors for enantiomeric separation

Analytica Chimica Acta published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Recommanded Product: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Hui published the artcileChiral metalloporphyrin-catalyzed industrial synthesis of sodium esomeprazole, Recommanded Product: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, the publication is Zhongnan Daxue Xuebao, Ziran Kexueban (2015), 46(12), 4417-4421, database is CAplus.

Sodium esomeprazole is a kind of excellent proton pump inhibitor, used as an effective drug for peptic ulcer disease. A new industrialized synthetic technol. of sodium esomeprazole catalyzed by chiral metalloporphyrin was reported. The target product was approved by ¹H NMR, MS and polarimetry. The effect of reaction time, reaction temperature, and molar ratio of catalyst and solvent were investigated. The results show that sodium esomeprazole can be obtained with high yield from oxidation by oxygen in the NaOH solution and ufiprazole, synthesized by the addition reaction between 2-chloro-3,5-dimethyl-4-methoxypyridine hydrochloride and 5-methoxy-2-mercaptobenzimidazole in the combination of 20% NaOH and TBAB. Synthesis of esomeprazole sodium used by ufiprazole has the highest yield and enantioselectivity when reaction time is 3.0 h, the solvent is toluene, the reaction temperature is 80°C and the ratio of omeprazole sulfide and chiral metal porphyrin is 1: (3.7 × 10^-5). The total industrial yield is 60% and the enantioselectivity is 98.9%.

Zhongnan Daxue Xuebao, Ziran Kexueban published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Recommanded Product: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Dai, Yu-ting published the artcileMicroanalysis for flame atomic absorption spectroscopy in determination of high content sodium, Name: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, the publication is Fenxi Ceshi Jishu Yu Yiqi (2013), 19(1), 24-27, database is CAplus.

A new method using Flame Atomic Absorption Spectroscopy (FAAS) and Microanal. to determine high content sodium is developed. The developed method involves the choosing of suitable absorption line of sodium, the optimization of testing parameters and the evaluation of the linearity of the method. The linearity is 0-5 mg/L, the detection limit is 0.02 mg/L and the repeatability is 0.5% RSD. By comparing the measured sodium content with its truth value in some known organic and inorganic compounds, the absolute error is less than 0.3%, the relative error is less than 1%, and the recovery is 99.2%-100.6%.

Fenxi Ceshi Jishu Yu Yiqi published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Name: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Dai, Yu-ting published the artcileMicroanalysis for flame atomic absorption spectroscopy in determination of high content sodium, Name: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, the publication is Fenxi Ceshi Jishu Yu Yiqi (2013), 19(1), 24-27, database is CAplus.

A new method using Flame Atomic Absorption Spectroscopy (FAAS) and Microanal. to determine high content sodium is developed. The developed method involves the choosing of suitable absorption line of sodium, the optimization of testing parameters and the evaluation of the linearity of the method. The linearity is 0-5 mg/L, the detection limit is 0.02 mg/L and the repeatability is 0.5% RSD. By comparing the measured sodium content with its truth value in some known organic and inorganic compounds, the absolute error is less than 0.3%, the relative error is less than 1%, and the recovery is 99.2%-100.6%.

Fenxi Ceshi Jishu Yu Yiqi published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Name: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem