Tag: M.W=300-350

Kassem, A. A. published the artcileProlonged release antazoline hydrochloride tablets. Part II. Using repeated granulation technique, Product Details of C17H20ClN3, the publication is Bulletin of the Faculty of Pharmacy (Cairo University) (1976), 14(1), 187-205, database is CAplus.

Repeated granulation of antazoline-HCl (I) [2508-72-7] with 5% and 10% Et cellulose [9004-57-3] and shellac solutions, followed by release-time study of the drug from its tablets, showed no increase in the release proportional to the concentration of the former binder. However, with shellac the increase in the release time was proportional to the concentration increase. In both cases, the release of I was relatively more rapid in gastric fluid than in that observed in intestinal fluid. The effects of number of granulations and surface area of the tablet on drug release were also studied. Shellac was more effective than Et cellulose in reducing the release of the drug.

Bulletin of the Faculty of Pharmacy (Cairo University) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Product Details of C17H20ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kassem, A. A. published the artcileProlonged release antazoline hydrochloride tablets. Part 1. Using insoluble substances, Category: imidazoles-derivatives, the publication is Bulletin of the Faculty of Pharmacy (Cairo University) (1976), 14(1), 85-99, database is CAplus.

Addition of Mg stearate [557-04-0] and hydrogenated castor oil to antazoline-HCl (I) [2508-72-7] tablets made with Et cellulose [9004-57-3], prolonged the drug release. The tablets containing 15% and 20% Mg stearate released I more slowly in the gastric fluid than in the intestinal fluid, the release being more pronounced with the latter. Hydrogenated castor oil (10-20%) was perferred since it caused a gradual and uniform drug release both in gastric and intestinal fluids. Of the various retarding materials studied, hydrogenated castor oil caused the least erosion of I tablets, followed by Mg stearate.

Bulletin of the Faculty of Pharmacy (Cairo University) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Motawi, A. published the artcileAccelerated stability studies of amaranth solution in presence of some drugs and excipients, Product Details of C17H20ClN3, the publication is Scientia Pharmaceutica (1980), 48(4), 377-84, database is CAplus.

Accelerated stability studies of amaranth (FD & C Red No 2) [915-67-3] solution in the presence of some excipients commonly used in pharmaceutical formulations, namely, lactose [63-42-3], mannitol [69-65-8], syrup, gelatin, Tween 80 [9005-65-6], polyethylene glycol (PEG 6000, 4000 and 1500) [25322-68-3] and some drugs, namely, ascorbic acid [50-81-7], chlorpheniramine maleate [113-92-8], antazoline-HCl [2508-72-7], chlorpromazine-HCl [69-09-0] and diphenhydramine-HCl [147-24-0], were carried out at 60°. The dye solution itself was very stable. Lactose and mannitol did not produce marked effects on dye stability. Syrup and gelatin caused fading of the dye solution Complete discoloration of the dye solutions resulted in the presence of Tween 80, PEG 6000, 4000, and 1500 after storage of 12-48 h. Diphenhydramine-HCl, antazoline-HCl and chlorpheniramine maleate did not affect the stability of the dye. On the other hand, ascorbic acid caused fading of the dye solution within few hours. Chlorpromazine-HCl gave a faint pinkish violet colloidal solution when mixed with the dye solution

Scientia Pharmaceutica published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Product Details of C17H20ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ayad, E. M. published the artcileSelective and indicator antazoline lactose agar medium (ALA-medium), Formula: C17H20ClN3, the publication is Egyptian Journal of Pharmaceutical Sciences (1974), 15(4), 489-94, database is CAplus.

Antazoline-HCl was incorporated into a solid agar medium in order to study the isolation and identification of certain gram-neg. bacteria from stool samples. The medium for isolation of gram-neg. bacteria from gram-pos. bacteria contained 0.625 mg/ml of antazoline-HCl (called ALA-medium A), while the medium for isolating non-lactose fermenting gram-neg. bacteria contained 0.7 mg/ml of antazoline-HCl (called ALA-medium B). A comparison was made of the inhibitory action on different microorganisms of various antazoline-HCl concentrations and MacConkey’s agar and SS agar. Non-lactose fermenters were successfully isolated from stool samples before and after enrichment in selenite broth.

Egyptian Journal of Pharmaceutical Sciences published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Formula: C17H20ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Dindar, Cigdem K. published the artcileThe Development of Spectrophotometric and Validated Stability- Indicating RP-HPLC Methods for Simultaneous Determination of Ephedrine HCL, Naphazoline HCL, Antazoline HCL, and Chlorobutanol in Pharmaceutical Pomade Form, Synthetic Route of 2508-72-7, the publication is Combinatorial Chemistry & High Throughput Screening (2020), 23(10), 1090-1099, database is CAplus and MEDLINE.

Allergic rhinitis, acute nasal congestion and sinusitis are one of the most common health problems and have a major effect on the quality of life. Several medications are used to improve the symptoms of such diseases in humans. Pharmaceutical pomade form containing Ephedrine (EPD) HCl, Naphazoline (NPZ) HCl, Antazoline (ANT) HCl, and Chlorobutanol (CLO) is one of them. Objective: For these reasons, this study includes the development of spectrophotometric and chromatog. methods for the determination of EPD HCl, NPZ HCl, ANT HCl, and CLO active agents in the pharmaceutical pomade. Method: In the spectrophotometric method, third-order derivative of the amplitudes at 218 nm n=5 and the first-order derivative of the amplitudes 254 nm n=13 was selected for the determination of EPD, ANT, resp. while NPZ was determined by the second derivative at 234 nm and n=21. Colorimetric detection was applied for assay anal. of CLO at 540 nm. Furthermore, a reverse phase high performance liquid chromatog. (RP- HPLC) method has been developed and optimized by using Agilent Zorbax Eclipse XDB C18 (75 mm x 3.0 mm, 3.5μm) column. The column temperature was 40°C, binary gradient elution was used and the mobile phase consisted of 15 mM phosphate buffer in distilled water (pH 3.0) and methanol, and the flow rate was 0.6 mL min^-1 and the UV detector was detected at 210 nm. The linear operating range was obtained as 11.97-70, 0.59-3, 2.79-30, and 2.92-200μg mL^-1 for EPD HCl, NPZ HCl, ANT HCl, and CLO resp. The LOD values were found to be 3.95, 0.19, 0.92 and 0.96μg mL^-1 for EPD HCl, NPZ HCl, ANT HCl, and CLO in the spectrophotometric method, resp. The linear ranges in the RP-HPLC method were 8.2-24.36μg mL^-1, 0.083 – 0.75μg/mL, 2.01-7.5μg mL^-1 and 2.89-24.4μg mL^-1 for EPD HCl, NPZ HCl, ANT HCl, and CLO, resp. The LOD values in the validation studies were 2.7, 0.025, 0.66 and 0.86μg mL^-1 for EPD HCl, NPZ HCl, ANT HCl, and CLO in RP-HPLC method resp. Conclusion: The results of the spectrophotometric and chromatog. methods were compared and no differences were found between the two methods.

Combinatorial Chemistry & High Throughput Screening published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Synthetic Route of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Dingjan, H. A. published the artcileColor tests for the identification of alkaloids (and related compounds). A literature review and a study of color changes in relation to time, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Pharmaceutisch Weekblad (1980), 115(14), 445-67, database is CAplus.

The color tests with concentrated H₂SO₄ Erdmann’s, Froehde’s, Mandelin’s and Marquis’ reagent applied to a large number of alkaloids (and related compounds) are given together with those found in the literature. Special attention is given to color changes in relation to time.

Pharmaceutisch Weekblad published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Li, Xiaotian published the artcileDetermination of antazoline hydrochloride in Beagle dog plasma by HPLC-UV and its application to pharmacokinetics, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2013), 97-101, database is CAplus and MEDLINE.

In order to evaluate the pharmacokinetics characteristic of antazoline hydrochloride in Beagle dogs, a sensitive and specific HPLC method was developed and validated using phenacetin as the internal standard (IS). The analyte and the IS were extracted from dog plasma by Et acetate under the basic condition. The analyte was separated by a C₁₈ column and detected with a variable wavelength UV-detector. The mobile phase consisted of methanol-5 mmol L^-1 tetra-Bu ammonium bromide (45:55, volume/volume) containing 0.5% glacial acetic acid in a flow rate of 1.0 mL min^-1. Standard calibration graph for antazoline was linear over a curve range of 20-1600 ng mL^-1 (R > 0.99) and the lower limit of quantification was 20 ng mL^-1 using a plasma sample of 500 μL. The intra- and inter-day precision values were less than 14.3% relative standard deviation (RSD). The intra-day assay accuracy was in the range of 98.1-100.6% and the inter-day assay accuracy in the range of 99.2-101.1%. The extraction recoveries were on the average of 88.4% for antazoline and 76.8% for IS. Plasma samples were stable at least for 1 mo at -20 °C. This method was successfully applied to pharmacokinetics study of antazoline after i.v. administration to Beagle dogs.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wang, Rui published the artcileDetermination of antazoline hydrochloride in rat plasma and excreta by reversed-phase ion-pair chromatography and its application to pharmacokinetics, COA of Formula: C17H20ClN3, the publication is Biomedical Chromatography (2013), 27(12), 1595-1602, database is CAplus and MEDLINE.

A reversed-phase ion pair chromatog. method with liquid-liquid extraction anal. method was developed and validated for the determination of antazoline hydrochloride in plasma and excreta of rat. The aim of our study was to characterize the preclin. pharmacokinetics and excretion profiles of antazoline hydrochloride in rats after i.v. injection at the dose of 10 mg/kg. Plasma and excreta samples were extracted with Et acetate, and phenacetin was used as the internal standard The result showed that the method is suitable for the quantification of antazoline hydrochloride in plasma and excreta samples. Anal. of accuracy (90.89-112.33%), imprecision (<7.1%) and recovery (>82.5%) showed adequate values. After a single i.v. administration at 10 mg/kg to rats, plasma concentration profile showed a relative fast elimination proceeding with a terminal elimination half-life of 3.53 h. Approx. 61.8 and 14.2% of the administered dose were recovered in urine and bile after 72 and 24 h post-dosing resp.; 5.9% of the administered dose was recovered in feces after 72 h post-dosing. The above results show that the major elimination route is urinary excretion. Copyright © 2013 John Wiley & Sons, Ltd.

Biomedical Chromatography published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C18H34N4O5S, COA of Formula: C17H20ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Van Gyseghem, E. published the artcileDetermining orthogonal and similar chromatographic systems from the injection of mixtures in liquid chromatography-diode array detection and the interpretation of correlation coefficients color maps, Product Details of C17H20ClN3, the publication is Journal of Chromatography A (2004), 1026(1-2), 117-128, database is CAplus and MEDLINE.

Generic orthogonal chromatog. systems might be helpful tools as potential starting points in the development of methods to sep. impurities and the active substance in drugs with unknown impurity profiles. The orthogonality of 38 chromatog. systems was evaluated from weighted-average-linkage dendrograms and color maps, both based on the correlation coefficients between the retention factors on the different systems. On each chromatog. system, 68 drug substances were injected as mixtures of three or four components to increase the throughput. The (overlapping) peaks were identified and resolved with a peak purity algorithm, orthogonal projection approach (OPA). The visualization techniques applied allowed a simple evaluation of orthogonal and (groups of) similar systems.

Journal of Chromatography A published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C7H16Cl2Si, Product Details of C17H20ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Van Santvliet, L. published the artcilePhysicochemical properties, NMR spectroscopy and tolerance of inclusion complexes of antazoline and tetracaine with hydroxypropyl-β-cyclodextrin, Related Products of imidazoles-derivatives, the publication is International Journal of Pharmaceutics (1998), 171(2), 147-156, database is CAplus.

To improve the tolerance of antazoline and tetracaine ophthalmic solutions, inclusion complexes of the free bases of both drugs with hydroxypropyl-β-cyclodextrin (HP-β-CD) were prepared The physicochem. properties of the drug:HP-β-CD solutions were determined and the inclusion complexes were characterized by ¹H and ¹³C NMR spectroscopy. The apparent complex constants were calculated from the phase-solubility diagram and were estimated at 403 M^-1 and 1308 M^-1 for the antazoline:HP-β-CD complex and tetracaine:HP-β-CD complex, resp. NMR anal. showed that in the 1:1 complexes the total antazoline fraction was present as an inclusion complex, whereas tetracaine was only partly included in spite of a similar phase solubility diagram. NMR spectroscopy also revealed the site of interaction of the drugs with the HP-β-CD mol. A solution acceptability test was carried out on volunteers. A relationship between the surface tension of the solutions and the tolerance was observed

International Journal of Pharmaceutics published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C10H10O2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem