Tag: M.W=300-350

Sambasivarao, K. published the artcileEffect of some antihistaminic drugs on the estrous cycle of rats, COA of Formula: C17H20ClN3, the publication is Indian Journal of Physiology and Pharmacology (1977), 21(2), 156-8, database is CAplus and MEDLINE.

The effect of some antihistaminic drugs namely antazoline-HCl [2508-72-7], diphenhydramine-HCl [147-24-0] and mepyramine maleate [59-33-6] has been investigated on the estrous cycle in albino rats. On daily i.p. administrationfor 6 days, all 3 drugs (10 mg/kg) significantly prolonged the duration of the estrous cycle. The duration of subsequent cycles returned to near normal.

Indian Journal of Physiology and Pharmacology published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, COA of Formula: C17H20ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Dessouky, Y. M. published the artcileDetermination of some pharmaceutical amines by sodium dioctyl sulfosuccinate, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Bulletin of the Faculty of Pharmacy (Cairo University) (1979), 16(1), 67-74, database is CAplus.

The conditions of diphasic titration of amines, based on ion-pair formation, were modified and applied to the determination of 7 pharmaceutical amines, e.g., aminopyrine (I) [58-15-1] and promethazine-HCl [58-33-3]. Acetate buffer of pH 0.91 or 0.65 and dimethylyellow screened with methylene blue as indicator were used. The stoichiometry (1:1) of the reaction between Na dioctyl sulfosuccinate [577-11-7] and the amines was determined; this made it unnecessary the need for the side-by-side titration of an authentic sample of the amine. Amounts as low as 0.30 mg could be determined by the modified procedure as against 10 mg by the unmodified procedure. The results obtained with the modified procedure are compared with those of British pharmacopeia(1973) and European pharmacopeia(1971) methods.

Bulletin of the Faculty of Pharmacy (Cairo University) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Beleslin, D. B. published the artcileAnalysis of the gross behavioral changes induced by tetraethylammonium and a comparison with other substances affecting the autonomic and central nervous system after intraventricular injections to conscious cats, Application In Synthesis of 2508-72-7, the publication is Neuropharmacology (1974), 13(12), 1171-7, database is CAplus and MEDLINE.

Tetraethylammonium chloride (TEA) [56-34-8] (0.2-3.0 mg, intraventricularly) caused emotional behavior, autonomic changes, motor phenomena, and convulsions in cats. Other drugs which affect the autonomic or central nervous system did not block the effects of TEA. Of the drugs tested for behavioral effects, 7 caused behavioral changes similar to TEA, 2 caused autonomic and motor phenomena followed by sedation and sleep, and 2 caused depressant behavior. The emotional behavior caused by TEA appears to involve central muscarinic cholinoceptive sites, while the autonomic changes, motor phenomena, and convulsions appeared to result from direct actions on the nerve cells.

Neuropharmacology published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Application In Synthesis of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sane, R. T. published the artcileExtractive spectrophotometric determination of antazoline hydrochloride, maphazoline nitrate, xylometazoline hydrochloride and tetrahydrozoline hydrochloride, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Indian Drugs (1979), 16(10), 239-41, database is CAplus.

A direct spectrophotometric method for the quant. determination of antazoline-HCl (I) [2508-72-7], naphazoline nitrate [5144-52-5], xylometazoline-HCl [1218-35-5], and tetrahydrozoline-HCl [522-48-5] is described. The method is based on the formation of colored complexes between these compounds and bromocresol green, bromophenol blue, bromothymol blue, and methyl orange. The complexes formed can be extracted in chloroform.

Indian Drugs published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

El Alaoui, Abdessamad published the artcileShiga toxin-mediated retrograde delivery of a topoisomerase I inhibitor prodrug, Safety of N-(4-Hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Angewandte Chemie, International Edition (2007), 46(34), 6469-6472, database is CAplus and MEDLINE.

A retrograde strategy: An innovative cancer-cell delivery concept exploits the naturally evolved characteristics of the Shiga toxin B-subunit (STxB) for the intracellular activation of a newly synthesized prodrug at the level of the biosynthetic/secretory pathway. Retrograde prodrug targeting allows its slow release, which should sustain the presence of the active principle in dividing tumor cells.

Angewandte Chemie, International Edition published new progress about 901770-40-9. 901770-40-9 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Amide, name is N-(4-Hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C16H21N3O3S, Safety of N-(4-Hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kralova, Jana published the artcileThe effects of H₁-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity, SDS of cas: 2508-72-7, the publication is International Immunopharmacology (2009), 9(7-8), 990-995, database is CAplus and MEDLINE.

H₁-antihistamines are known to be important modulators of inflammatory response. However, the information about the influence of these drugs on reactive nitrogen species generation is still controversial. The main aim of the present study was to investigate the effects of selected H₁-antihistamines on nitric oxide production by lipopolysaccharide-stimulated murine macrophages RAW 264.7, measured as changes in inducible nitric oxide synthase (iNOS) protein expression in cell lysates by Western blotting and nitrite formation in cell supernatants using the Griess reaction. In pharmacol. non-toxic concentrations, H₁-antihistamines significantly inhibited nitrite accumulation that was not caused by the scavenging ability of drugs against nitric oxide, measured amperometrically. The degree of inhibition of nitrite accumulation pos. correlated with the degree of tested lipophilicity, measured by reversed-phase thin layer chromatog. Furthermore, H₁-antihistamines differentially modulated the iNOS protein expression. In conclusion, as was shown in this study, the modulation of nitric oxide production could be caused by the downregulation of iNOS protein expression and/or the iNOS protein activity.

International Immunopharmacology published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, SDS of cas: 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Dutt, Manesh Chandra published the artcileUse of ninhydrin as a spray reagent for the detection of some basic drugs on thin-layer chromatograms, HPLC of Formula: 2508-72-7, the publication is Journal of Chromatography (1980), 195(1), 133-8, database is CAplus.

In a study aimed at exploring the potential of ninhydrin [485-47-2] to produce colored spots on thin-layer chromatog. plates, a wide variety of colors, on a white background, were produced by 52 of the 56 bases studied. In most instances different colors were produced at each of the selected temperatures (80, 120, and 160°), e.g., with amphetamine sulfate [60-13-9] the colors produced were pink-violet, grey-brown, and red-brown, resp. The response of the compounds to this method varied from 20 μg at room temperature to 1 μg at 160°.

Journal of Chromatography published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, HPLC of Formula: 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Dutt, Manesh Chandra published the artcileIdentification of basic drugs by the thin-layer chromatographic profiles of their ninhydrin complexes, Synthetic Route of 2508-72-7, the publication is Journal of Chromatography (1981), 206(2), 267-77, database is CAplus.

Fifty-two common basic drugs produce various colors when spotted with ninhydrin [485-47-2] on plastic thin-layer plates and heated. When the plate is then developed in a suitable solvent each of the colored spots separates into a variety of addnl. colored spots and patches, the number of which depends on the temperature of heating. The relative intensity and spatial arrangement form a profile that is highly characteristic of the compounds The formation of such profiles was investigated at 100 and 160°C.

Journal of Chromatography published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Synthetic Route of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhang, Ling-chun published the artcileDetermination of antazoline hydrochloride in rat plasma by HPLC and its application to pharmacokinetic study, Application of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Zhongguo Yiyuan Yaoxue Zazhi (2014), 34(17), 1456-1459, database is CAplus.

A HPLC method for the determination of antazoline hydrochloride in rat plasma was established and the pharmacokinetics of antazoline hydrochloride in rats were studied. A sensitive and specific HPLC method was developed and validated using phenacetin as the internal standard (IS). The analyte and the IS were extracted from rat by Et acetate under the basic condition. The analytes were separated by a C₁₈ column and detected with a variable wavelength UV-detector. The mobile phase consisted of methanol-5 mmol L^-1 tetra-Bu ammonium bromide (40:60) and the flow rate was 1.0ml·min^-1. Standard calibration graph for antazoline hydrochloride was linear over a curve range of 50-4 000 ng·ml^-1 (R=0.999 3) and the lower limit of quantification was 50 ng·ml^-1 using a plasma sample of 100 μl. The intra-and inter-day precision values were less than 13.3% relative standard deviation (RSD). The intra-day and inter-day assay precision was in the range of ±15% and the accuracy in the range of 89.9%-110.6%. The extraction recoveries were on the average of 80% for antazoline hydrochloride and 75%for IS. After i. g. administration of antazoline hydrochloride, the major pharmacokinetic parameters were as follows: AUC_0-t=(5.15±0.39) mg·h·L^-1, AUC_t-∞=(5.37±0.26) mg·h·L^-1, t_1/2=(3.91±0.88) h, CL=(1.86±0.09) L·kg^-1·h^-1, V=(8.07±2.51) L·kg^-1, C_max=(3.35±0.21) mg·L^-1, t_max=(0.75±0.36) h. This method was successfully applied to pharmacokinetic studies of antazoline hydrochloride after ig administration to SD rats.

Zhongguo Yiyuan Yaoxue Zazhi published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C11H12O4, Application of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sanghavi, N. M. published the artcileColorimetric determination of insoluble phosphomolybdic acid complexes of antihistamines, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Indian Drugs (1980), 18(1), 25-8, database is CAplus.

Antihistamines viz. antazoeine-HCl [2508-72-7], dimenhydrinate [523-87-5], cyclizine-HCl [303-25-3], chlorcyclizine-HCl [14362-31-3] and diphenhydramine-HCl [147-24-0] are precipitated with phosphomolybdic acid; hydrazine hydrate quant. reduces the insoluble complexes to molybdenum blue which is measured colorimetrically. A linear relationship exists between the absorbance of the reaction product and the concentration of the drug present. Recovery from spiked tablet samples is 99.0-100.3%.

Indian Drugs published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem