Tag: M.W=300-350

Roberts, Fiona published the artcileThe kinetics of competitive antagonists on guinea-pig ileum, Quality Control of 2508-72-7, the publication is British Journal of Pharmacology (1976), 58(1), 57-70, database is CAplus and MEDLINE.

The kinetics of the antagonistic action of mepyramine maleate [59-33-6], atropine sulfate [55-48-1], lachesine [1164-38-1], benziloyltropine methyliodide [21735-94-4], pentyltriethyl ammonium iodide [21735-95-5], and antazoline-HCl [2508-72-7] on guinea pig isolated ileum were not consistent with the predictions of the interaction-limited model described by W. D. M. Paton (1961). The apparent dissociation rate constant calculated from the decrease in occupancy on washout was not independent of the concentration of antagonist; the dissociation rate constant of a ‘slow’ antagonist calculated from the change in occupancy when a ‘fast’ antagonist was superimposed varied with the concentration of fast antagonist; if the concentration of slow antagonist was increased when the fast antagonist was superimposed so that the equilibrium occupancy of the ‘slow’ was the same as before, a transitional phase was observed

British Journal of Pharmacology published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Quality Control of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Tulus, Rasim published the artcileSpectrophotometric determination of antihistamine drugs containing o-(benzensulfonamido)-p-benzoquinone, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Journal of Faculty of Pharmacy of Istanbul University (1975), 11(2), 117-28, database is CAplus.

The treatment of a methanolic solution of some antihistamine amines, obtained from their hydrochloride, methanesulfonate, and maleate, with a methanolic solution of o-(benzenesulfonamido)-p-benzoquinone (I) [34238-55-6] afforded a red color, which was used in the spectrophotometric determination of these antihistamines.

Journal of Faculty of Pharmacy of Istanbul University published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C24H20Ge, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Khristova, M. published the artcileDetermination of naphazoline hydrochloride in the presence of antazoline hydrochloride, Application of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Farmatsiya (Sofia, Bulgaria) (1980), 30(6), 18-20, database is CAplus.

Naphazoline-HCl (I-HCl) [550-99-2] was determined in the presence of antazoline-HCl [2508-72-7] by mixing with H₂CO-H₂SO₄, extracting the colored product with CHCl₃ to remove the interference of SO₄^2-, and measuring the absorbance at 665 nm. Absorbance was linear with concentration for 20-100 μg/mL, and the error was 4.8%.

Farmatsiya (Sofia, Bulgaria) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Application of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Amer, M. M. published the artcileModified nitroprusside colorimetric determination of antazoline salts in some pharmaceutical preparation, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Pharmazie (1974), 29(5), 354-5, database is CAplus and MEDLINE.

The nitroprusside method of Slack and Mader (1957) was improved by using 80 mg H3BO3 in place of NaHCO3 (to alter pH) and adding 4 ml EtOH to give a red color instead of the violet, measurable at 540 nm, the color being maximum at 1 min and stable for 12 hr. The method is superior to that of BP 1968 and USP XV, since ephedrine and 19 other substances tested did not interfere with the reaction but naphazoline, Zn2+, and phentolamine did,. Recovery by this method ranged between 100.6.+-.0.23% to 102.3.+-.1.2%. Determinations were made against a standard curve for 0.1-1. mg of the corresponding antazoline salt.

Pharmazie published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

San Andres, M. P. published the artcileDetermination of antihistamines based on the formation of mixed aggregates with surfactants, Related Products of imidazoles-derivatives, the publication is Analyst (Cambridge, United Kingdom) (1998), 123(5), 1079-1084, database is CAplus.

The determination of antihistamines based on the measurement of the critical micelle concentration (CMC) of mixed sodium dodecyl sulfate (SDS)-antihistamine aggregates is proposed. The dye Coomassie Brilliant Blue G (CBBG) was used as a photometric probe (610 nm) for the rapid determination of CMCs. The micellar properties of the drugs permitted the determination of diphenhydramine, antazoline, tripelennamine, diphenylpyraline, and clemizole at the μM level, with detection limits from 0.1 to 0.7 μM. The proposed method surpasses in sensitivity the existing routine photometric methods used in the drug quality control and has detection limits similar to fluorimetric methods. The relative standard deviation for 6 μM diphenhydramine was 3.7%. The method was applied to the determination of these drugs in pharmaceutical preparations (solutions, capsules, creams, pills) which were analyzed directly after dissolution in distilled water.

Analyst (Cambridge, United Kingdom) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Thoma, K. published the artcileColloid association of antihistamines. Part 1. Relation between chemical structure and critical micelle formation concentration, Quality Control of 2508-72-7, the publication is Pharmaceutica Acta Helvetiae (1976), 51(3), 50-8, database is CAplus and MEDLINE.

Surface tensions were determined for 17 antihistamines in 0.5% aqueous solutions, and critical micelle concentrations ranging from 0.012 mole/l. (medrylamine maleate [60407-52-5]) to 0.185 mole/l. (Thenfadil [91-79-2]) were determined for all of these compounds and also for chlorphenamine-HCl [56343-98-7] in 0.9% saline. Cryoscopic, spectrophotometric, tensiometric, potentiometric, and conductometric methods were used to determine the critical micelle concentrations, and the results and ease of use were compared. The unsubstituted ethylenediamine, propylamine, and ethanolamine derivatives, Pyribenzamine [91-81-6], Avil [3269-83-8], and Benadryl [147-24-0], had similar critical micelle concentrations These concentrations decreased on phenyl group substitution in the order Me > Cl > Br.

Pharmaceutica Acta Helvetiae published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C10H15ClO3S, Quality Control of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Mazur, Elzbieta published the artcileEffect of histamine on tissue respiration of the cardiac muscle of rats treated with antihistaminics, Application of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Annales Universitatis Mariae Curie-Sklodowska, Sectio D: Medicina (1977), 273-80, database is CAplus and MEDLINE.

Incubation of rat myocardial slices with histamine-HCl (I-HCl) [23758-34-1] decreased O consumption by up to 67% after 45 min. Similar treatment of myocardial slices from rats pretreated with Diphergan [60-87-7] (30 mg/kg/day, i.p., for 7-10 days) resulted in only 43% inhibition at the end of 45 min. Pretreatment of rats with thenalidine calcium [67250-62-8] (25 mg/kg/day) or phenazoline-HCl [2508-72-7] (100 mg/kg/day) did not alter the effect of I on myocardial respiration.

Annales Universitatis Mariae Curie-Sklodowska, Sectio D: Medicina published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Application of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Biryol, Inci published the artcileStudy of antazoline hydrochloride by voltammetric method, Quality Control of 2508-72-7, the publication is FABAD Farmasotik Bilimler Dergisi (1976-2000) (1987), 12(2), 135-43, database is CAplus.

A study of electrochem. behavior of antazoline-HCl (I-HCl) in 0.2M H₂SO₄ by using Pt electrode showed that I can be quant. determined by a voltammetric method. The method was applied for I determination in tablets. The detection limit was 3.02-30.2 μg/mL. Recoveries were between 95.97 and 102.91% with relative standard deviation of 1.187%. Results were comparable with those obtained by the official British Pharmacopeia (1973) method.

FABAD Farmasotik Bilimler Dergisi (1976-2000) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Quality Control of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Gohil, Vishal M. published the artcileNutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis, HPLC of Formula: 2508-72-7, the publication is Nature Biotechnology (2010), 28(3), 249-255, database is CAplus and MEDLINE.

Most cells have the inherent capacity to shift their reliance on glycolysis relative to oxidative metabolism, and studies in model systems have shown that targeting such shifts may be useful in treating or preventing a variety of diseases ranging from cancer to ischemic injury. However, we currently have a limited number of mechanistically distinct classes of drugs that alter the relative activities of these two pathways. We screen for such compounds by scoring the ability of >3500 small mols. to selectively impair growth and viability of human fibroblasts in media containing either galactose or glucose as the sole sugar source. We identify several clin. used drugs never linked to energy metabolism, including the antiemetic meclizine, which attenuates mitochondrial respiration through a mechanism distinct from that of canonical inhibitors. We further show that meclizine pretreatment confers cardioprotection and neuroprotection against ischemia-reperfusion injury in murine models. Nutrient-sensitized screening may provide a useful framework for understanding gene function and drug action within the context of energy metabolism

Nature Biotechnology published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, HPLC of Formula: 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sambasivarao, K. published the artcileEffect of some antihistamines on the uterine response to estrogen in the rat, Synthetic Route of 2508-72-7, the publication is Indian Journal of Physiology and Pharmacology (1977), 21(3), 207-8, database is CAplus and MEDLINE.

Water imbibition by rat uterus induced by estradiol dipropionate (I dipropionate) [113-38-2] (10 μg/day for 5 days, i.p.) was not decreased by antihistamines, but was augmented by 1 of them, viz. antazoline-HCl [2508-72-7]. Thus, previously observed prolongation of the estrous cycle by antihistamines may not be due to blockade of uterine hyperemia or edema induced by estrogens.

Indian Journal of Physiology and Pharmacology published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Synthetic Route of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem