Tag: M.W=300-350

Tulus, Semiha published the artcileSpectrophotometric determination of antazoline and its salts by using 1,1-diphenyl-2-picrylhydrazyl, Synthetic Route of 2508-72-7, the publication is Journal of Faculty of Pharmacy of Istanbul University (1975), 11(1), 38-43, database is CAplus.

A visible spectrophotometric determination of antazoline (I) [91-75-8] or its’ salts (I-HCl [2508-72-7], I-methanesulfonte [3131-32-6]) was given based on the diminishing violet color intensity of 1,1-diphenyl-2-picrylhydrazyl [1898-66-4] which reacted with some substances by hydrogen abstraction. The method was sensitive to 20-50 mcg doses.

Journal of Faculty of Pharmacy of Istanbul University published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C6H13NO2, Synthetic Route of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Qiu, Yingheng published the artcileDetermination of antazoline hydrochloride tablets by HPLC, Category: imidazoles-derivatives, the publication is Zhongguo Yaoye (2009), 18(1), 26-27, database is CAplus.

To establish an HPLC method for the determination of antazoline hydrochloride tablets. NUCLEODUR C₁₈ column was used, the mobile phase was 5 mmol/L sodium acetate (adjusted to pH 3.4 with glacial acetic acid)-triethylamine (100:0.2)-methanol (50:50), the flow rate was 1.0 mL/min, the wavelength of detection was 241 nm, and the column temperature was 35°. The good linearity was obtained over the range of 20.22-202.2 μg/mL. The average recovery rate was 99.83% (RSD = 0.53%; n = 6). The method is accurate and sensitive with better reproducibility. It can be suitable for controlling the quality of antazoline hydrochloride tablets.

Zhongguo Yaoye published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Dutt, Manesh Chandra published the artcileGas chromatographic identification of common drugs by their multiple peaks and those of their trimethylsilyl derivatives, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Journal of Chromatography (1982), 248(1), 115-24, database is CAplus.

The extent to which common drugs produce multiple peaks in gas chromatog. on an OV-17 column at an injection port temperature of 300° and temperature programming from 120 to 270° or at an isothermal temperature of 300° was studied. Of the 116 drugs tested, 46 produced >1 peak either as the parent compound or as the trimethylsilyl derivative Retention times provide a useful means of identification.

Journal of Chromatography published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sun, Xinqi published the artcileDetermination of residual solvents in antazoline hydrochloride, Formula: C17H20ClN3, the publication is Henan Daxue Xuebao, Ziran Kexueban (2009), 39(1), 25-28, database is CAplus.

Capillary gas chromatog. was used to determine residual solventsin antazoline hydrochloride. The linear equation of ethanol is Y = 0.04627 +0.65369X, r = 0.99816 (n = 8), and the range of linearity is 50.35-718.9 g/L and average recovery rate is 98.32% with RSD of 6.79%. The linear equation of toluene is Y = 0.01928 +1.64319X, r = 0.99372 (n = 8), and the range of linearity is 11.6-162.4 g/L and average recovery rate is 98.17% with RSD of 1.5%. The linear equation of DMF is Y = 0.02531 +0.35654X, r = 0.99344 (n = 8), and the range of linearity is 9.8-137.2 g/L and average recovery rate is 98.99% with RSD of 2.34%. Capillary gas chromatog. can be used for determination of antazoline hydrochloride products.

Henan Daxue Xuebao, Ziran Kexueban published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C14H12N2S, Formula: C17H20ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ibrahim, S. A. published the artcileColorimetric method for the estimation of antazoline, Application of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Indian Journal of Pharmacy (1974), 36(3), 73-5, database is CAplus.

A sensitive colorimetric method was developed for the determination of antazoline-HCl (I) [2508-72-7] in the pure state and in pharmaceutical preparations It depends on estimating the color produced when I was treated with nitrite. Thus, a 20 ml aliquot of I solution (stock solution contains 0.5% I-HCl in water) was treated with 4 ml NaNO2 solution (7.5% in concentrated H2SO4) 5 min at room temperature, and the solution was diluted to 50 ml with 15% aqueous AcONa. Absorbance was read within 10 min at 416 nm against a reagent blank. Data were given on the estimation of I by this method in pharmaceutical formulations. No interference was produced by phenylephrine-HCl [61-76-7], ephedrine-HCl [50-98-6], naphazoline-HCl [550-99-2], chlorobutanol [57-15-8], benzalkonium chloride, or polyethylene glycol [25322-68-3].

Indian Journal of Pharmacy published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Application of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ke, Mi published the artcileSpatiotemporal profiling of cytosolic signalling complexes in living cells by selective proximity proteomics, SDS of cas: 901770-40-9, the publication is Nature Communications (2021), 12(1), 71, database is CAplus and MEDLINE.

Signaling complexes are often organized in a spatiotemporal manner and on a minute timescale. Proximity labeling based on engineered ascorbate peroxidase APEX2 pioneered in situ capture of spatiotemporal membrane protein complexes in living cells, but its application to cytosolic proteins remains limited due to the high labeling background. Here, we develop proximity labeling probes with increased labeling selectivity. These probes, in combination with label-free quant. proteomics, allow exploring cytosolic protein assemblies such as phosphotyrosine-mediated protein complexes formed in response to minute-scale EGF stimulation. As proof-of-concept, we systematically profile the spatiotemporal interactome of the EGFR signaling component STS1. For STS1 core complexes, our proximity proteomics approach shows comparable performance to affinity purification-mass spectrometry-based temporal interactome profiling, while also capturing addnl.-especially endosomally-located-protein complexes. In summary, we provide a generic approach for exploring the interactome of mobile cytosolic proteins in living cells at a temporal resolution of minutes.

Nature Communications published new progress about 901770-40-9. 901770-40-9 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Amide, name is N-(4-Hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C16H21N3O3S, SDS of cas: 901770-40-9.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kovar, Karl Artur published the artcileSilver perchlorate determination of halides and sulfates of nitrogen-containing bases, Name: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Deutsche Apotheker Zeitung (1982), 122(47), 2421-3, database is CAplus.

The halides and sulfates of N-containing bases (drugs) are determined by potentiometric titration with AgClO₄ in HOAc-Ac₂O mixtures The principles of the titrimetric method are discussed and various exptl. procedures for the determination are given. The relative standard deviations obtained by Hg(OAc)₂ and AgClO₄ methods are compared for salts of various N-containing bases. 0He advantages of this method over the (HgOAc)₂ method are discussed. The method can be used for the determination of drugs in tablets.

Deutsche Apotheker Zeitung published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Name: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sosnowski, Jerzy published the artcileMethod for obtaining sustained-release antazoline hydrochloride tablets, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Farmacja Polska (1985), 41(9), 524-9, database is CAplus.

Hydrophilic matrix tablets containing antazoline-HCl (I) [2508-72-7] were prepared by incorporation of hydroxpropyl Me cellulose  [9004-65-3]. Thus, double-layer tablets were obtained containing both the drug with an extended releasing rate (incorporated in the hydrophilic matrix) and the same drug with normal releasing rate. The release rate of I from these tablets was estimated by the half-exchange method.

Farmacja Polska published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C8H11BO2, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sosnowski, Jerzy published the artcilePreparation of prolonged-release tablets with antazoline hydrochloride by the mixed granulate method and double-layer tablets, Synthetic Route of 2508-72-7, the publication is Farmacja Polska (1986), 42(11), 611-15, database is CAplus.

One of the granulates used and one of the layers in the resulting tablets contained a hydrophobic matrix comprising poly(vinyl chloride). Two doses of the active substance were used as well as various excipients and various proportions of distribution of the active substance between the particular granulates or layers. The rate of in vitro release of antazoline-HCl from these tablets was estimated by the half-exchange method into artificial gastric and intestinal juices.

Farmacja Polska published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C7H8BClO2, Synthetic Route of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sosnowski, Jerzy published the artcileElaboration of a preparation method of matrix tablets containing antazoline hydrochloride, HPLC of Formula: 2508-72-7, the publication is Farmacja Polska (1986), 42(8), 409-11, database is CAplus.

The matrix comprised poly(vinyl chloride), Et cellulose or Eudragit RL PM. Antazoline-HCl (I) was incorporated in the matrix by wet granulation. A solution of 10% Et cellulose in anhydrous EtOH, aqueous 4% solution of gelatin or 96% EtOH were used as binders. The in vitro release rate of I from these tablets was estimated by the half-exchange method.

Farmacja Polska published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C18H23OP, HPLC of Formula: 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem