Tag: M.W=300-350

Yin, Zhiqiang published the artcileMulti-residue determination of 210 drugs in pork by ultra-high-performance liquid chromatography-tandem mass spectrometry, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Journal of Chromatography A (2016), 49-59, database is CAplus and MEDLINE.

This paper presents a multi-residue anal. method for 210 drugs in pork using ultra-high-performance liquid chromatog.-Q-Trap tandem mass spectrometry (UPLC-MS/MS) within 20 min via pos. ESI in scheduled multi-reaction monitoring (MRM) mode. The 210 drugs, belonging to 21 different chem. classes, included macrolides, sulfonamides, tetracyclines, β-lactams, β-agonists, aminoglycosides, antiviral drugs, glycosides, phenothiazine, protein anabolic hormones, non-steroidal anti-inflammatory drugs (NSAIDs), quinolones, antifungal drugs, corticosteroids, imidazoles, piperidines, piperazidines, insecticides, amides, alkaloids and others. A rapid and simple preparation method was applied to process the animal tissues, including solvent extraction with an acetonitrile/water mixture (80/20, volume/volume), defatting and clean-up processes. The recoveries ranged from 52% to 130% with relative standard deviations (RSDs) < 20% for spiked concentrations of 10, 50 and 250 μg/kg. More than 90% of the analytes achieved low limits of quantification (LOQs) < 10 μg/kg. The decision limit (CCα), detection capability (CCβ) values were in the range of 2-502 μg/kg and 4-505 μg/kg, resp. This method is significant for food safety monitoring and controlling veterinary drug use.

Journal of Chromatography A published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C14H12N2S, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sanghavi, N. M. published the artcileEstimation of antazoline hydrochloride in tablets of antazoline hydrochloride, Related Products of imidazoles-derivatives, the publication is Indian Journal of Pharmacy (1974), 36(6), 137-8, database is CAplus.

The method of estimation of antazoline-HCl [2508-72-7] in tablets was based on the formation of a stable yellow nitroso derivative with NaNO2 solution in the presence of dilute HCl which shows maximum absorption at 412 mμ. A graph of optical d. against concentration gave a straight line over a concentration range of 10 μg/ml to 50 μg/ml showing that the reaction was in compliance with Beer’s Law. Known amounts of antazoline-HCl were added to known amounts of previously analyzed samples of antazoline-HCl and analyzed again by the proposed method. The percentage recovery was 98.6. The proposed method was found to be satisfactory within a narrow range of ± 2%. It was also found that other antihistamines like chlorpheniramine [132-22-9], dimenhydrinate [523-87-5], diphenhydramine [58-73-1] did not interfere. Excipients like starch [9005-25-8], gum arabic [9000-01-5], magnesium stearate [557-04-0], etc. did not interfere while paracetamol [103-90-2], phenylephrine-HCl [61-76-7] interfered.

Indian Journal of Pharmacy published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Konieczna, Lucyna published the artcileChemometric exploration of the dependencies between molecular modeling descriptors and analytical chemistry data of antihistaminic drugs, Synthetic Route of 2508-72-7, the publication is Journal of AOAC International (2012), 95(3), 713-723, database is CAplus and MEDLINE.

The relationships between exptl. and computational descriptors of antihistamine drugs were studied using principal component anal. (PCA). Empirical data came from UV and IR spectroscopic measurements. Nonempirical data, such as structural mol. descriptors, and chromatog. data, were obtained from HyperChem software. Another objective was to test whether the parameters used as independent variables (nonempirical and empirical-spectroscopic) could lead to attaining classification similar to that developed on the basis of the chromatog. parameters. To arrive at the answer to the question, a matrix of 18 × 49 data, including HPLC and UV and IR spectroscopic data, together with mol. modeling studies, was evaluated by the PCA method. The obtained clusters of drugs were consistent with the drugs’ chem. structure classification. Moreover, the PCA method applied to the HPLC retention data and structural descriptors allowed for classification of the drugs according to their pharmacol. properties; hence it may potentially help limit the number of biol. assays in the search for new drugs.

Journal of AOAC International published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Synthetic Route of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Bertolasi, V. published the artcileCrystallographic and conformational studies on histamine H₁ receptor antagonists. III. Antazoline hydrochloride, Computed Properties of 2508-72-7, the publication is Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry (1982), B38(9), 2522-5, database is CAplus.

The title compound is monoclinic, space group I2/c, with a 25.819(5), b 5.917(3), c 21.549(4) Å, and β 104.30(3)°; d_c = 1.26 for Z = 8. The structure was refined to R = 0.041. The at. parameters, bond angles and distances are given. Comparison of the present and previous crystal-structure determinations seems to substantiate the idea that a distance of 6.00-6.40 Å between the amino N and the center of gravity of 1 unsaturated ring is the main requirement to be fulfilled for the mol. to display antihistaminic activity.

Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Computed Properties of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Marszall, Michal Piotr published the artcileReduction of silanophilic interactions in liquid chromatography with the use of ionic liquids, Synthetic Route of 2508-72-7, the publication is Analytica Chimica Acta (2005), 547(2), 172-178, database is CAplus.

A suppression of silanophilic interactions by the selected ionic liquids added to the mobile phase in thin-layer chromatog. (TLC) and HPLC is reported. Acetonitrile was used as the eluent, alone or with various concentrations of water and phosphoric buffer pH 3. Selectivity of the normal (NP) and the reversed (RP) stationary phase material was examined using proton-acceptor basic drugs analytes. The ionic liquids studied appeared to significantly affect analyte retention in NP-TLC, RP-TLC and RP-HPLC systems tested. Consequently, the increased separation selectivity was attained. Due to ionic liquid additives to eluent even analytes could be chromatographed, which were not eluted from the silica-based stationary phase materials with 100% of acetonitrile in the mobile phase. Addition of ionic liquid already in very small concentration (0.5%, volume/volume) could reduce the amount of acetonitrile used during the optimization of basic analytes separations in TLC and HPLC systems. Also, the influence of temperature on the separation of basic analytes was demonstrated and considered in practical HPLC method development.

Analytica Chimica Acta published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Synthetic Route of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Marszall, Michal Piotr published the artcileEvaluation of the silanol-suppressing potency of ionic liquids, Name: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Journal of Separation Science (2006), 29(8), 1138-1145, database is CAplus and MEDLINE.

Recently, increasing attention was paid to the use of ionic liquids for HPLC and capillary electrophoresis. The silanol-suppressing potency of ionic liquids was evaluated by HPLC using the two-retention site model proposed previously by Nahum and Horvath. The binding constant, K_A, in that approach was demonstrated to reliably reflect the ability of the ionic liquids to block the silanols of the silica support material of the stationary phase. The determinations were carried out for ionic liquids of the 1-alkyl-3-methylimidazolium group using basic drugs as the test analytes. Comparison of ionic liquids with standard mobile phase additives such as triethylamine showed the former to possess advantages as silanol suppressors in HPLC. The main advantage of the method is that it provides a simple and fast determination of the silanol complex stability, which allowed comparison of the suppressing efficiency of several ionic liquids

Journal of Separation Science published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Name: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ali, H. M. published the artcileIdentification of two in vitro metabolic products after liver microsomal incubation of antazoline, Quality Control of 2508-72-7, the publication is Journal of Chromatography (1981), 210(2), 350-5, database is CAplus and MEDLINE.

N-Benzylaniline [103-32-2] and p-benzylaminophenol [103-14-0] were identified as metabolic products of antazoline-HCl (I) [2508-72-7] following incubation of I with a rabbit liver microsomal fraction.

Journal of Chromatography published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Quality Control of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kracmar, J. published the artcileUltraviolet spectrophotometry in drug control. XX. Study on the effect of substitution and solvents in more recent medicinal substances with the chromophores of benzene rings in the molecules, Related Products of imidazoles-derivatives, the publication is Cesko-Slovenska Farmacie (1976), 25(7), 243-57, database is CAplus.

Thirty RPh, RC6H4-alkyl, RC6H4-halo, RC6H4O-alkyl, RC6H4OH, RC6H4N alkyl2, RC6H4NO2, RC6H4NH2NHaryl, and RC6H4Ch:N(N:N) drugs were characterized by the absorption bands E, K, B, and R, and vibration structures of the bands K and B. Absorption maximum at 235 nm were used for quant. determination of active substances in drugs. More specific long-wave absorption maximum were used for determination of substances having several absorption maximum Agreement with Beer’s law at the recommended absorption maximum was verified.

Cesko-Slovenska Farmacie published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kracmar, J. published the artcileUV spectrophotometry in drug analysis. Part 19. New drugs with substituted benzene chromophores, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Pharmazie (1976), 31(9), 614-17, database is CAplus.

Data are given on the uv-spectrophotometric properties of 14 drugs and related compounds containing substituted benzene chromophores. The substituents are alkyl, alkoxy, OH, NO2, NH2, and azomethine. Further, a study of solvent effects (alcs. and H2O, acidic and basic solutions) is reported.

Pharmazie published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Abdel-Halim, Lamia M. published the artcileComparative study between recent methods manipulating ratio spectra and classical methods based on two-wavelength selection for the determination of binary mixture of antazoline hydrochloride and tetryzoline hydrochloride, SDS of cas: 2508-72-7, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2016), 98-105, database is CAplus and MEDLINE.

A comparative study was developed between two classical spectrophotometric methods (dual wavelength method and Vierordt’s method) and two recent methods manipulating ratio spectra (ratio difference method and first derivative of ratio spectra method) for simultaneous determination of Antazoline hydrochloride (AN) and Tetryzoline hydrochloride (TZ) in their combined pharmaceutical formulation and in the presence of benzalkonium chloride as a preservative without preliminary separation The dual wavelength method depends on choosing two wavelengths for each drug in a way so that the difference in absorbance at those two wavelengths is zero for the other drug. While Vierordt’s method, is based upon measuring the absorbance and the absorptivity values of the two drugs at their λ_max (248.0 and 219.0 nm for AN and TZ, resp.), followed by substitution in the corresponding Vierordt’s equation. Recent methods manipulating ratio spectra depend on either measuring the difference in amplitudes of ratio spectra between 255.5 and 269.5 nm for AN and 220.0 and 273.0 nm for TZ in case of ratio difference method or computing first derivative of the ratio spectra for each drug then measuring the peak amplitude at 250.0 nm for AN and at 224.0 nm for TZ in case of first derivative of ratio spectrophotometry. The specificity of the developed methods was investigated by analyzing different laboratory prepared mixtures of the two drugs. All methods were applied successfully for the determination of the selected drugs in their combined dosage form proving that the classical spectrophotometric methods can still be used successfully in anal. of binary mixture using minimal data manipulation rather than recent methods which require relatively more steps. Furthermore, validation of the proposed methods was performed according to ICH guidelines; accuracy, precision and repeatability are found to be within the acceptable limits. Statistical studies showed that the methods can be competitively applied in quality control laboratories

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, SDS of cas: 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem