Tag: M.W=300-350

Constanti, A. published the artcileAntagonism by some antihistamines of the amino acid-evoked responses recorded from the lobster muscle fiber and the frog spinal cord, Quality Control of 2508-72-7, the publication is British Journal of Pharmacology (1976), 58(4), 583-92, database is CAplus and MEDLINE.

On lobster muscle in vitro, histamine [51-45-6] H1 receptor blockers, e.g. antazoline-HCl (I-HCl) [2508-72-7] (40μM-1mM) reversibly antagonized responses to both-applied glutamate [56-86-0] (0.1mM), aspartate [56-84-8] (1 or 2 mM), or quisqualic acid [52809-07-1] (1-6μM), but not GABA [56-12-2] (40μM). Histamine (â‰?mM) had no effect on this preparation The H1 antagonists produced a small increase in muscle hyperpolarization; procaine [59-46-1] (1mM) decreased membrane conductance but did not affect responses to GABA or glutamate. The H2 antagonist burimamide (II) [34970-69-9] blocked glutamate and GABA-evoked responses on the lobster muscle without affecting resting potential or conductance. In the frog spinal cord, bath-applied histamine produced ventral root depolarizations and dorsal root hyperpolarizations which were reduced by tetrodotoxin but not by I or II; II reversibly antagonized responses to both glutamate and GABA on tetrodotoxin-treated cords whereas I was ineffective. Antihistamines may act as nonspecific amino acid antagonists by interacting at the level of the receptor-coupled ionophores.

British Journal of Pharmacology published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Quality Control of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kassem, A. A. published the artcilePhysicochemical stability and bioavailability of antazoline hydrochloride suppositories, Quality Control of 2508-72-7, the publication is Bulletin of the Faculty of Pharmacy (Cairo University) (1977), 14(2), 239-49, database is CAplus.

Antazoline-HCl (I) [2508-72-7] suppositories formulated in 1:1 Witepsol H15 [18348884-L]-Witepsol E75 [18348884-L] base remained stable for 1 yr, while compositions in carbowax [25322-68-3] and cocoa butter preparations showed discoloration, crystallization, and other deterioration indications during storage. Bioavailability of I was good from Witepsol and cocoa butter formulations. I was rapidly absorbed from the rectum as indicated by protection of guinea pigs against injected histamine.

Bulletin of the Faculty of Pharmacy (Cairo University) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Quality Control of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kassem, A. A. published the artcileFormulation and stabilization of antazoline hydrochloride nasal drops, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Bulletin of the Faculty of Pharmacy (Cairo University) (1978), 15(2), 161-76, database is CAplus.

The influence of storage and various stabilizers on the degradation of antazoline-HCl (I) [2508-72-7] nasal drops was investigated. The degradation reaction of I was 1st order with half life of 162.8 days. Addition of stabilizers increased the stability of the drug. A mixture of 20% propylene glycol [57-55-6] with 0.1% w/v Na metabisulfite was relatively better than other stabilizers tested and the half life of the drug is protracted to 1995 days.

Bulletin of the Faculty of Pharmacy (Cairo University) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Issa, I. M. published the artcilePolarographic estimation of antazoline hydrochloride, Computed Properties of 2508-72-7, the publication is Pharmazie (1978), 33(8), 513-15, database is CAplus and MEDLINE.

Antazoline-HCl (I-HCl) [2508-72-7] was estimated polarog. at a dropping Hg electrode in KCl-HCl supporting electrolyte (pH 3.2). Two waves were produced with E_1/2 values of -1.35 V and -1.65 V. As revealed from the study of the effect of Hg column height, pH of the medium, and concentration of the depolarizer, the polarog. reduction of the antazolinium cation was preceded by a catalytic H-wave. The diffusion-controlled nature of the electrode process allowed I determination at â‰?.0 × 10^-4 M. The procedure is simple, accurate, and sensitive and could be used in the presence of tablet additives.

Pharmazie published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Computed Properties of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Isojima, Yasushi published the artcileCkIε/δ-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock, Category: imidazoles-derivatives, the publication is Proceedings of the National Academy of Sciences of the United States of America (2009), 106(37), 15744-15749, S15744/1-S15744/74, database is CAplus and MEDLINE.

A striking feature of the circadian clock is its flexible yet robust response to various environmental conditions. To analyze the biochem. processes underlying this flexible-yet-robust characteristic, we examined the effects of 1260 pharmacol. active compounds in mouse and human clock cell lines. Compounds that markedly (>10 s.d.) lengthened the period in both cell lines, also lengthened it in-central clock tissues and peripheral clock cells. Most compounds inhibited casein kinase Iε (CKIε) or CKIδ phosphorylation of the PER2 protein. Manipulation of CKIε/δ-dependent phosphorylation by these compounds lengthened the period of the mammalian clock from circadian (24 h) to circabidian (48 h), revealing its high sensitivity to chem. perturbation. The degradation rate of PER2, which is regulated by CKIε/δ-dependent phosphorylation, was temperature-insensitive in living clock cells, yet sensitive to chem. perturbations. This temperature-insensitivity was preserved in the CKIε/δ-dependent phosphorylation of a synthetic peptide in vitro. Thus, CKIε/δ-dependent phosphorylation is likely a temperature-insensitive period-determining process in the mammalian circadian clock.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Marrero-Ponce, Yovani published the artcileAtom, atom-type, and total nonstochastic and stochastic quadratic fingerprints: a promising approach for modeling of antibacterial activity, HPLC of Formula: 2508-72-7, the publication is Bioorganic & Medicinal Chemistry (2005), 13(8), 2881-2899, database is CAplus and MEDLINE.

The Topol. Mol. Computer Design (TOMOCOMD-CARDD) approach has been introduced for the classification and design of antimicrobial agents using computer-aided mol. design. For this propose, atom, atom-type, and total quadratic indexes have been generalized to codify chem. structure information. In this sense, stochastic quadratic indexes have been introduced for the description of the mol. structure. These stochastic fingerprints are based on a simple model for the intramol. movement of all valence-bond electrons. In this work, a complete data set containing 1006 antimicrobial agents is collected and presented. Two structure-based antibacterial activity classification models have been generated. The models (including nonstochastic and stochastic indexes) classify correctly more than 90% of 1525 compounds in training sets. These models permit the correct classification of 92.28% and 89.31% of 505 compounds in an external test sets. The approach, also, satisfactorily compares with respect to nine of the most useful models for antimicrobial selection reported to date. Finally, a virtual screening of 87 new compounds reported in the anti-infective field with antibacterial activities is developed showing the ability of the models to identify new leads as antibacterial.

Bioorganic & Medicinal Chemistry published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, HPLC of Formula: 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kurosu, Michio published the artcileSmall-molecule microarrays: Development of novel linkers and an efficient detection method for bound proteins, Product Details of C16H21N3O3S, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(13), 3392-3395, database is CAplus and MEDLINE.

Novel isocyanate and diazoketone linkers possessing polyoxypropylenediamine as a spacer for small-mol. microarray are developed. White light interferometry is introduced to detect bound proteins on the glass slides without using chem. modified proteins.

Bioorganic & Medicinal Chemistry Letters published new progress about 901770-40-9. 901770-40-9 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Amide, name is N-(4-Hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C16H21N3O3S, Product Details of C16H21N3O3S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Pawlaczyk, Jan published the artcileMineral contamination of drugs. I. Application of spectrography and atomic absorption spectrometry to the analysis of metal ion traces, SDS of cas: 2508-72-7, the publication is Acta Poloniae Pharmaceutica (1979), 36(1), 59-62, database is CAplus and MEDLINE.

Ca, Ag, Cu, Al, Bi, Ni, Fe, Mg, Pb, and Zn ions were the most abundant contaminants in phenylbutazone [50-33-9], Na aminosalicylate [133-10-8], carbromal [77-65-6], methylphenobarbital [115-38-8], chlorpromazine-HCl [69-09-0], Et aminobenzoate [94-09-7], nitrofurantoin [67-20-9], glutethimide [77-21-4], antazoline-HCl [2508-72-7], barbital [57-44-3], phenytoin [630-93-3], and bromisoval [496-67-3] preparations In some cases, the levels of the contaminants were determined by at. absorption spectrometry upon mineralization or extraction with HCl.

Acta Poloniae Pharmaceutica published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, SDS of cas: 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Galea, Charlene published the artcileMethod development for impurity profiling in SFC: The selection of a dissimilar set of stationary phases, Related Products of imidazoles-derivatives, the publication is Journal of Pharmaceutical and Biomedical Analysis (2015), 333-343, database is CAplus and MEDLINE.

Supercritical fluid chromatog. (SFC) is drawing considerable interest as separation technique in the pharmaceutical industry. The technique is already well established in chiral separations both anal. and on a preparative scale. The use of SFC as a technique for drug impurity profiling is examined here. To define starting conditions in method development for drug impurity profiling, a set of dissimilar stationary phases is screened in parallel. The possibility to select a set of dissimilar columns using the retention factors (k-values) for a set of 64 drugs measured on 27 columns in SFC was examined Experiments were carried out at a back-pressure of 150 bar and 25 °C with a mobile phase consisting of CO₂ and methanol with 0.1% isopropylamine (5-40% over 10 min) at a flow rate of 3 mL/min. These k-values were then used to calculate correlation coefficients on the one hand and to perform a principal component anal. on the other. The Kennard and Stone algorithm, besides dendrograms and correlation-coefficient color maps were used to select a set of 6 dissimilar stationary phases. The stationary phase characterization results from this study were compared to those from previous studies found in the literature. Retention mechanisms for compounds possessing different properties were also evaluated. The dissimilarity of the selected subset of 6 stationary phases was validated using mixtures of compounds with similar properties and structures, as one can expect in a drug impurity profile.

Journal of Pharmaceutical and Biomedical Analysis published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Muscat Galea, Charlene published the artcileInvestigation of the effect of mobile phase composition on selectivity using a solvent-triangle based approach in achiral SFC, Application In Synthesis of 2508-72-7, the publication is Journal of Pharmaceutical and Biomedical Analysis (2017), 247-257, database is CAplus and MEDLINE.

Defining a method development methodol. for achiral drug impurity profiling in SFC requires a number of steps. Initially, diverse stationary phases are characterized and a small number of orthogonal or dissimilar phases are selected for further method development. In this paper, we focus on a next step which is the investigation of the modifier composition on chromatog. selectivity. A solvent-triangle based approach is used in which blends of organic solvents, mainly ethanol (EtOH), propanol (PrOH), acetonitrile (ACN) and THF mixed with methanol (MeOH) are tested as modifiers on six dissimilar stationary phases. The tested modifier blends were composed to have equal eluotropic strengths as calculated on bare silica. The modifier leads to minor changes in terms of elution order, retention and mixture resolution However, varying only the modifier composition on a given stationary phase does not lead to the creation of dissimilar systems. Therefore the modifier composition is an optimization parameter, with the stationary phase being the factor determining most the selectivity of a given mixture in achiral SFC.

Journal of Pharmaceutical and Biomedical Analysis published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Application In Synthesis of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem