Tag: M.W=250-300

Bhutia, Zigmee T. published the artcileIodine Promoted Efficient Synthesis of 2-Arylimidazo[1,2-a]pyridines in Aqueous Media: A Comparative Study between Micellar Catalysis and an “”On-Water”” Platform, Name: 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, the main research area is aryl methyl ketone aminopyridine iodine micellar catalyst cyclization green; imidazopyridine preparation.

In a new and environmentally sustainable approach, a series of 2-arylimidazo[1,2-a]pyridine derivatives were synthesized in aqueous media in the presence of iodine as a catalyst. The reaction proceeded by condensation of various aryl Me ketones with 2-aminopyridines to afford 2-arylimidazo[1,2-a]pyridines in good overall yields. Although several of the reactions were efficiently performed “”on water””, the addition of a surfactant, namely, sodium dodecyl sulfate , was found effective in terms of substrate scope and yield enhancement. Both methods were successfully used for the gram-scale synthesis of a marketed drug, zolimidine. The simple exptl. setup, water as “”green”” media, and inexpensive catalyst are some of the merits of this protocol.

ACS Omega published new progress about Aminopyridines Role: RCT (Reactant), RACT (Reactant or Reagent). 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Name: 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dabiri, Yasamin published the artcileImidazopyridines as Potent KDM5 Demethylase Inhibitors Promoting Reprogramming Efficiency of Human iPSCs, Product Details of C14H11BrN2, the main research area is induced pluripotent stem cell reprogramming efficiency imidazopyridine KDM5 demethylation; Biochemistry; Biological Sciences; Molecular Biology.

Pioneering human induced pluripotent stem cell (iPSC)-based pre-clin. studies have raised safety concerns and pinpointed the need for safer and more efficient approaches to generate and maintain patient-specific iPSCs. One approach is searching for compounds that influence pluripotent stem cell reprogramming using functional screens of known drugs. Our high-throughput screening of drug-like hits showed that imidazopyridines-analogs of zolpidem, a sedative-hypnotic drug-are able to improve reprogramming efficiency and facilitate reprogramming of resistant human primary fibroblasts. The lead compound (O4I3) showed a remarkable OCT4 induction, which at least in part is due to the inhibition of H3K4 demethylase (KDM5, also known as JARID1). Experiments demonstrated that KDM5A, but not its homolog KDM5B, serves as a reprogramming barrier by interfering with the enrichment of H3K4Me3 at the OCT4 promoter. Thus our results introduce a new class of KDM5 chem. inhibitors and provide further insight into the pluripotency-related properties of KDM5 family members.

iScience published new progress about Cadherin CDH1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Product Details of C14H11BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem