Tag: M.W=250-300

Katsifis, Andrew published the artcileSynthesis of [123I]N’,N’-dimethyl-6-methyl-(4′-iodophenyl)imidazo[1,2-a]pyridin e-3-acetamide for the study of Peripheral Benzodiazepine Receptors using SPECT, Name: 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, the main research area is iodine 123 iodozolpidem preparation SPECT peripheral benzodiazepine receptor.

The [123I] labeled imidazo[1,2-a]pyridine [123I]iodozolpidem was found to exhibit preferential activity towards peripheral rather than central benzodiazepine receptors in vivo and was synthesized for the potential study of the peripheral benzodiazepine receptors (PBR) using SPECT. [123I]Iodozolpidem was prepared from the corresponding tri-Bu tin precursor by iododestannylation with Na[123I] in the presence of peracetic acid or chloramine-T. Purification by semipreparative C-18 RP HPLC gave the product in radiochem. yields of 60-85%. The product was obtained in > 97% chem. and radiochem. purity with a specific activity > 80 GBq/μmol.

Journal of Labelled Compounds & Radiopharmaceuticals published new progress about Radiodiagnosis. 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Name: 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zhuang, Zhi-Ping published the artcileStructure-Activity Relationship of Imidazo[1,2-a]pyridines as Ligands for Detecting β-Amyloid Plaques in the Brain, SDS of cas: 1023-01-4, the main research area is imidazopyridine iodo preparation beta amyloid aggregate ligand; iodine 125 labeled dimethylaminophenyliodoimidazopyridine preparation imaging agent Alzheimer disease; anti Alzheimer agent iodine labeled imidazopyridine preparation biodistribution.

A series of novel β-amyloid (Aβ) aggregate-specific ligands, e.g., 2-(4′-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine (I; IMPY), and its related derivatives were prepared An in vitro binding study with preformed Aβ aggregates showed that I and its bromo derivative competed with binding of 2-(4′-dimethylaminophenyl)-6-iodobenzothiazole, [125I]7(TZDM), a known ligand for Aβ aggregates, with high binding affinities (Ki = 15 and 10 nM, resp.). In vitro autoradiog. of brain sections of a transgenic mouse (Tg2576) with [125I]-I displayed high selective binding to amyloid-like structures, comparable to that observed by staining with thioflavin-S visualized under fluorescence. In vivo biodistribution after an i.v. injection of [125I]-I in normal mice showed a high initial brain uptake and fast washout, indicating a low background activity associated with this iodinated ligand. Taken together, the data suggests that [123I]-I may be useful for imaging Aβ aggregates in patients with Alzheimer’s disease.

Journal of Medicinal Chemistry published new progress about Alzheimer disease. 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, SDS of cas: 1023-01-4.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tufail, Fatima published the artcileCatalyst-Free, Glycerol-Assisted Facile Approach to Imidazole-Fused Nitrogen-Bridgehead Heterocycles, COA of Formula: C14H11BrN2, the main research area is imidazopyridine imidazopyrimidine imidazopyrazine preparation regioselective green chem; phenacyl bromide aminopyridine aminopyrimidine aminopyrazine coupling glycerol solvent.

A completely regioselective, environmentally benign strategy for the facile synthesis of biol. important imidazole-fused nitrogen-bridgehead heterocycles has been developed using glycerol/water 4:1 as a green promoting media. The methodol. involves the simple coupling of 2-halocarbonyl compounds with 2-aminopyridines, 2-aminopyrimidine, 2-aminopyrazine to obtain a variety of 2-aryl substituted imidazo-pyridines, imidazo-pyrimidines and imidazo-pyrazines containing bridgehead nitrogen. This protocol eliminates the use of toxic catalysts and volatile organic solvents – two key principles in the development of a green chem. process. Other significant highlights include mild reaction conditions, operational simplicity, short reaction times, easy workup and purification process, high yields and potential for scale-up.

ChemistrySelect published new progress about Coupling reaction. 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, COA of Formula: C14H11BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Yang, Daoshan published the artcileCatalyst-Free Regioselective C-3 Thiocyanation of Imidazopyridines, Recommanded Product: 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, the main research area is regioselective thiocyanation imidazopyridine.

A direct and straightforward approach for highly regioselective thiocyanation of imidazoheterocycles through sp2 C-H functionalization has been realized at room temperature Various C-3 thiocyanated imidazopyridines are formed in moderate to good yield. The present method exhibits a mild and selective access to a variety of imidazopyridine derivatives of pharmacol. interest.

Journal of Organic Chemistry published new progress about Crystal structure. 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Recommanded Product: 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Yang, Daoshan published the artcileCatalyst-Free Regioselective C-3 Nitrosation of Imidazopyridines with tert-Butyl Nitrite under Neutral Conditions, SDS of cas: 1023-01-4, the main research area is regioselective nitrosation imidazopyridine.

We have successfully developed a novel and efficient catalyst-free method for the synthesis of 3-nitroso-substituted imidazopyridines from readily available imidazo[1,2-a]pyridines and tert-Bu nitrite in good to excellent yields. Importantly, the use of transition-metal catalysts, stoichiometric amounts of acids, and toxic or potentially dangerous oxidants is avoided. This easy and practical method complements nitrosation reactions by expanding the scope and practicality, and should attract much attention in synthetic and pharmaceutical chem.

Synthesis published new progress about Crystal structure. 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, SDS of cas: 1023-01-4.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sundberg, Richard J. published the artcilePreparation of 2-aryl- and 2-(aryloxymethyl)imidazo[1,2-a]pyridines and related compounds, Related Products of imidazoles-derivatives, the main research area is aminopyridine phenacyl bromide cyclocondensation; aminopyrimidine phenacyl bromide cyclocondensation; aminothiazole phenacyl bromide cyclocondensation; imidazopyridine aryl bromide cyclocondensation; imidazolthiazole aryl bromide cyclocondensation; imidazopyrimidine aryl bromide cyclocondensation.

A series of arylimidazopyridines I (R = H, R1 = H, 6-Me, 7-Me, 6-NO2, 6-Cl, 6-iodo, 6-OMe, 6-SEt, 6-SPr; R2 = Br, NO2) were prepared by the cyclocondensation of 2-aminopyridines with 4-R2C6H4COCH2Br (II). I (R = H, R1 = 6-NHAc, 6-SOEt, 6-SO2Et, 6-cyano- 6-CHO, R2 = NHAc, NHSO2Me, NHSO2Ph, cyano, CHO, CO2Me, CONH2, CSNH2; R = Br, cyano, CHO, R1 = H, R2 = Me, Br, NO2) were also prepared Imidazolthiazoles III and imidazopyrimidines IV (R2 = NO2, NHAc, iodo, cyano, CHO) were prepared by the reactions of 2-aminothiazoles and 2-aminopyrimidine resp. with II (R2 = Br, NO2, iodo). Various other heterocyclic compounds, e.g., 4-R3CH2OC6H4CHO (R3 = 1-methylimidezol-2-yl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 4-thiazolyl, etc.), were prepared by condensation reactions.

Journal of Heterocyclic Chemistry published new progress about Cyclocondensation reaction. 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Related Products of imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kandimalla, Satheeshkumar Reddy published the artcileMetal-free C-N bond formations: one-pot synthesis of pyrido[2′,1′:2,3]imidazo[4,5-c]cinnolines, benzo[4′,5′]thiazolo- and thiazolo[2′,3′:2,3]imidazo[4,5-c]cinnolines, COA of Formula: C14H11BrN2, the main research area is imidazo heterocyclic cinnoline preparation regioselective; hydrazine imidazopyridinyl preparation oxidative arylation; imidazopyridine aryl diisopropyl azodicarboxylate hydrazination.

An efficient one-pot synthesis of novel pyrido[2′,1′:2,3]imidazo[4,5-c]cinnoline derivatives I (R1 = H, 10-CH3, 11-CH3, etc.; R2 = H, 3-Br, 3-OMe, etc.) has been achieved with moderate to good yields, with two C-N bond formations through C-H functionalization of 2-arylimidazo[1,2-a]pyridines II (R3 = H, 7-CH3, 8-CH3, etc.; R4 = H, 4-Br, 2,4-Cl2, etc.). The reaction proceeds via C-3 regioselective hydrazination with diisopropyl azodicarboxylate followed by oxidative N-arylation mediated by phenyliodine(III) diacetate (PIDA) in trifluoroacetic acid by means of C-H functionalization to produce pyrido[2′,1′:2,3]imidazo[4,5-c]cinnolines I. Other imidazoheterocycles such as 2-arylbenzo[d]imidazo[2,1-b]thiazoles and 6-arylimidazo[2,1-b]thiazoles, e.g., III, underwent similar transformations giving the corresponding cinnolines, e.g., IV, under transition metal-free and mild conditions.

RSC Advances published new progress about Addition reaction (hydrazination). 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, COA of Formula: C14H11BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bodke, Yadav D. published the artcileSynthesis and biological evaluation of imidazo pyridine derivatives containing morpholine nucleus, Related Products of imidazoles-derivatives, the main research area is phenylimidazopyridine morpholinylmethyl preparation antioxidant antifungal antibacterial.

A series of substituted 3-(morpholin-4-ylmethyl)-2-phenylimidazo[1,2-a]pyridine derivatives I (R1 = H, Br, CH3; R2 = H, OCH2C6H5; R3 = Cl, Br, NO2, CN; R4 = H, Cl) were synthesized. The title compounds I were synthesized by the Mannich reaction of imidazo[1,2-a]pyridines derivatives II, morpholine and formaldehyde with catalytic amount of acetic acid at reflux temperature The synthesized compounds I were screened for the antimicrobial and antioxidant activities. From antimicrobial activity results it was found that compounds I (R1 = Br; R2 = H; R3 = Br, CN; R4 = H) displayed very good antibacterial against Staphylococcus aureus and the compound I (R1 = Br; R2 = H; R3 = Br; R4 = H) showed very good antifungal activity against Pseudomonas aeruginosa. Compounds I (R1 = H, CH3; R2 = H, OCH2C6H5; R3 = Cl, CN; R4 = H, Cl) showed promising free radical scavenging activity.

Heterocyclic Letters published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Related Products of imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kumar, G. Santosh published the artcileA copper-catalyzed multi-component reaction accessing fused imidazo-heterocycles via C-H functionalization, Formula: C14H11BrN2, the main research area is pyridone acetophenone copper triflate catalyst microwave irradiation; phenylimidazopyridine preparation multicomponent reaction green chem; thiazole acetophenone copper triflate catalyst microwave irradiation; phenylimidazothiazole preparation multicomponent reaction green chem.

An efficient synthesis of fused imidazo-heterocycles was described using Cu(OTf)2 in [bmim]BF4 by the multi-component reaction of pyridin-2(1H)-one or thiazol/benzo[d]thiazol-2(3H)-ones with O-tosylhydroxyl amine and acetophenones under microwave irradiation The method was very rapid and the product formation occurred via a C-H functionalization/tandem addition-cyclization process. The ionic liquid containing copper triflate was recovered and reused four times.

RSC Advances published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Formula: C14H11BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kotla, Siva K. Reddy published the artcileRhodium(III)-catalyzed double C-H activation: a straightforward approach to fused imidazo[1,2-a]pyridines from internal alkynes, Safety of 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, the main research area is polycyclic imidazopyridine preparation; rhodium catalyst oxidative coupling imidazopyridine internal alkyne.

The Rh(III)-catalyzed oxidative coupling of 2-arylimidazopyridines with internal alkynes via double C-H activation has been described. This approach provides straightforward access to highly functionalized polycyclic imidazopyridines in good to excellent yields. E.g., in presence of [Cp*RhCl2]2, Cu(OAc)2, and Cs2CO3, oxidative coupling of 2-arylimidazo[1,2-a]pyridine (I) with PhCCPh gave 85% 5,6-diphenylnaphtho[1′,2′:4,5]imidazo[1,2-a]pyridine (II).

Tetrahedron Letters published new progress about Alkynes, internal Role: RCT (Reactant), RACT (Reactant or Reagent). 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Safety of 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem