Tag: M.W=250-300

Prakash, Sekar published the artcileRhenium(I)-Catalyzed ortho-C-H Addition to Bicyclic Alkenes, Application of 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Chemistry – An Asian Journal (2018), 13(13), 1664-1668, database is CAplus and MEDLINE.

Hydroarylation of bicyclic alkenes was developed using a low-valent Re^I-catalyzed, directing group-assisted C-H bond activation strategy. The addition of sodium acetate significantly improves the reaction efficiency; moreover, bicyclic alkenes such as 7-oxa and aza benzonorbornadienes worked efficiently under this reaction condition. Preliminary mechanistic studies suggest that, after the alkene insertion, the rhenacycle preferentially undergoes protonolysis rather than reductive elimination.

Chemistry – An Asian Journal published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Application of 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Secci, Daniela published the artcileConventional and microwave-assisted synthesis of benzimidazole derivatives and their in vitro inhibition of human cyclooxygenase, Synthetic Route of 2622-67-5, the publication is Journal of Heterocyclic Chemistry (2012), 49(5), 1187-1195, database is CAplus.

1,2-Diaryl- and 2-aryl-1H-benzimidazoles were synthesized using both microwave irradiation and conventional heating methods. Usually higher yields and reaction time reduction were obtained with the former method. All compounds were assayed for their in vitro ability to inhibit human cyclooxygenases, and most of them showed an encouraging inhibitory activity and isoform selectivity in the micromolar range.

Journal of Heterocyclic Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C16H10O5, Synthetic Route of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Nardi, Monica published the artcileThe Highly Efficient Synthesis of 1,2-Disubstituted Benzimidazoles Using Microwave Irradiation, HPLC of Formula: 2622-67-5, the publication is Molecules (2022), 27(5), 1751, database is CAplus and MEDLINE.

The benzimidazole ring of the heterocyclic pharmacophores is one of the most widespread and studied systems in nature. The benzimidazole derivative synthesis study is a crucial point for the development of a clin. available benzimidazole-based drug. Here, authors report a simple microwave assisted method for the synthesis of 1,2-disubstituted benzimidazoles. The combination of the molar ratio of N-phenyl-o-phenylenediamine:benzaldehyde (1:1) using microwave irradiation and only 1% mol of Er(OTf)₃ provides an efficient and environmental mild access to a diversity of benzimidazoles under solvent-free conditions. The proposed method allows for the obtainment of the desired products in a short time and with very high selectivity.

Molecules published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, HPLC of Formula: 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Baars, Hannah published the artcileTransition-Metal-Free Synthesis of Benzimidazoles Mediated by KOH/DMSO, SDS of cas: 2622-67-5, the publication is Organic Letters (2014), 16(2), 536-539, database is CAplus and MEDLINE.

Benzimidazoles are prepared by intramol. N-arylations of amidines mediated by potassium hydroxide in DMSO at 120 °C. In this manner, diversely substituted products have been obtained in moderate to very good yields. E.g., in presence of KOH in DMSO, intramol. N-arylation of amidine (I) gave 73% benzimidazole derivative (II).

Organic Letters published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, SDS of cas: 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Saha, Prasenjit published the artcileCobalt-catalyzed intramolecular C-N and C-O cross-coupling reactions: synthesis of benzimidazoles and benzoxazoles, Name: 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Organic & Biomolecular Chemistry (2010), 8(24), 5692-5699, database is CAplus and MEDLINE.

Cobalt(II)-complex catalyzes efficiently the intramol. C-N and C-O cross-couplings of Z-N’-(2-halophenyl)-N-phenylamidines, e.g. I, and N-(2-bromophenyl)benzamides, e.g. II, to afford the corresponding substituted benzimidazoles and benzoxazoles, e.g. III [X = NPh, O], in the presence of K₂CO₃ at moderate temperature The protocol is general, air stable and affords the products selectively in moderate to high yield.

Organic & Biomolecular Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Name: 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wang, Ting-Hsuan published the artcileNickel-Catalyzed Heteroarenes Cross Coupling via Tandem C-H/C-O Activation, Synthetic Route of 2622-67-5, the publication is ACS Catalysis (2018), 8(12), 11368-11376, database is CAplus.

Inert aryl Me ethers as coupling components via C-O activation have been established with a Ni catalyst for C-H activation of heteroarene. The key to simultaneous C-H/C-O bond activation is the use of sterically demanding o-tolylMgBr. The protocol is effective for a wide scope of substrates including naphthyl Me ethers, anisoles, and a variety of other heteroarene derivatives Detailed mechanistic studies indicated that the C-O cleavage is assisted via synergistic effect of nickel and Grignard reagent in this C-H/C-O reaction, which is supported by DFT calculation At this stage, single-electron transfer can be ruled out as a main operative process for this tandem strategy.

ACS Catalysis published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C8H4FNO3, Synthetic Route of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sharma, Rohit published the artcileMetal-Free Ionic-Liquid-Mediated Synthesis of Benzimidazoles and Quinazolin-4(3H)-ones from Benzylamines, Product Details of C19H14N2, the publication is Asian Journal of Organic Chemistry (2017), 6(10), 1370-1374, database is CAplus.

An expedient metal-free synthetic protocol for the construction of benzimidazoles I (R = C₆H₅, 4-FC₆H₄, 3-ClC₆H₄, etc.; X = H, C₆H₅) has been developed from o-phenylenediamine and benzylamine, using an imidazolium-based ionic liquid as the reaction medium. The reactions proceed by oxidation of benzylamine derivatives to their corresponding imines, followed by intramol. cyclization, to yield benzimidazoles. Advantages of this method include: an environmentally friendly metal-free process, recyclable reaction media, high yields, short reaction times, and the applicability for the synthesis of quinazolin-4(3H)-ones III (R = C₆H₄, 4-ClC₆H₄, 3-BrC₆H₄, etc.). An NMR spectroscopy study provided further insight into the reaction.

Asian Journal of Organic Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C5H12O2, Product Details of C19H14N2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Gaber, Abd El-Aal M. published the artcileThermal fragmentation and rearrangement of N-arylbenzamidoxime and O-phenylsulfonyloxime derivatives, Category: imidazoles-derivatives, the publication is Journal of Analytical and Applied Pyrolysis (2008), 82(1), 110-116, database is CAplus.

Thermal fragmentation of N-arylbenzamide oximes I, II (Ar = Ph, p-tolyl) under nitrogen gives rise to benzanilide and 2-phenylbenzoxazole as the major products, in addition to benzonitrile, arylamines, phenols, benzoic acid, o- and p-aminophenols and benzimidazole derivatives In the presence of naphthalene as radical scavenger, I gave α- and β-naphthols beside the previous products. Also, heating N-arylbenzamide O-phenylsulfonyloximes III under reflux in boiling tetralin lead to the formation of benzonitrile, arylamines, diphenylamine, benzenesulfonic acid, di-Ph sulfone, 1-hydroxytetralin, α-tetralone, and 1,1′-bitetralyl as the major products. Analogous results are obtained on heating III in the presence of isoquinoline as a radical trap which formed 1-phenylisoquinoline. The isolated products have been interpreted in terms of a free radical mechanism involving the homolysis of N-O and/or C-N bonds.

Journal of Analytical and Applied Pyrolysis published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem