Tag: M.W=200-250

Zaprutko, Lucjusz published the artcileRegioselective nitro group substitution. Synthesis of isomeric 4-amino-5-nitro- and 5-amino-4-nitroimidazoles, Computed Properties of 18874-52-7, the main research area is nitroimidazole cyclic amine regioselective nitro group substitution; imidazolamine nitro preparation.

On the basis of the reactions between 4,5-dinitroimidazoles (1-methyl-, 1,2-dimethyl-, and 1-ethoxycarbonylmethyl-4,5-dinitroimidazole) and cyclic amines (morpholine, piperidine, or pyrrolidine) under mild conditions (THF or EtOH solution), the order of nitro group substitution was discovered. The influence of the solvent, steric effects, and the possibility of hydrogen bond formation on the reaction direction was discussed. Also, the mechanism of formation of a diamino substitution product and an interesting isomerization process were presented.

Heterocycles published new progress about Amines, nitro Role: SPN (Synthetic Preparation), PREP (Preparation). 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Computed Properties of 18874-52-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Llona-Minguez, Sabin published the artcileVinylic MIDA Boronates: New Building Blocks for the Synthesis of Aza-Heterocycles, Related Products of imidazoles-derivatives, the main research area is haloarene MIDA boronate palladium catalyst Suzuki Miyaura coupling reaction; nitro vinylarene preparation Cadogan Sundberg reductive cyclization; aza heterocycle preparation; MIDA; aminophosphonate; boronate; cyclization; heterocycles; nitrene.

A two-step synthesis of structurally diverse pyrrole-containing bicyclic systems was reported. ortho-Nitro-haloarenes coupled with vinylic N-methyliminodiacetic acid (MIDA) boronates generated ortho-vinyl-nitroarenes, which underwent a ‘metal-free’ nitrene insertion, resulted in a new pyrrole ring. The Synthetic approach has a wide substrate tolerance and it was applicable in the preparation of more complex ‘drug-like’ mols. An ortho-nitro-allylarenes furnished a cyclic β-aminophosphonate motif.

Chemistry – A European Journal published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Related Products of imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Xu, Yan-Hong published the artcileSelf-assembly of zinc polymers based on a flexible linear ligand at different pH values: Syntheses, structures and fluorescent properties, Application of 4-((1H-Imidazol-1-yl)methyl)benzoic acid, the main research area is zinc imidazolylmethylbenzonitrile imidazolylmethylbenzoate terephthalate complex polymer preparation structure fluorescence; crystal structure zinc imidazolylmethylbenzonitrile imidazolylmethylbenzoate terephthalate complex polymer.

Five novel coordination polymers, [Zn(imbz)2]n (1), {[Zn(imbz)2]·H2O}n (2), [Zn(imbz)(μ2-OH)]n (3), [Zn3(imbt)2(p-bdc)3]n (4), [Zn4(μ3-OH)2(imbt)2(p-bdc)3]n (5), (imbt = 4′-(imidazol-1-ylmethyl)benzonitrile, imbz- = 4′-(imidazol-1-ylmethyl)benzoate and p-bdc = terephthalate) were hydrothermally prepared through systematically changing the pH values of reaction mixture, and structurally characterized by elemental anal., IR spectroscopy and single-crystal x-ray crystallog. Compounds 1 and 2 exhibit similar 2-dimensional (4,4) grid structures, whereas compound 2 contains a right-handed helix along b-axis. Compound 3 has a distorted diamond framework which was constructed via imbz- ligands and μ2-OH groups linking metal atoms. Compound 4 shows a 2-dimensional 6-connected network with trinuclear zinc clusters as secondary building units (SBUs), whereas 5 shows a distorted α-Po with tetranuclear zinc clusters as SBUs, in which p-bdc ligands act as bridges. Also, compounds 1-5 all exhibit strong blue photoluminescence in the solid state at room temperature

Solid State Sciences published new progress about Crystal structure. 94084-75-0 belongs to class imidazoles-derivatives, name is 4-((1H-Imidazol-1-yl)methyl)benzoic acid, and the molecular formula is C11H10N2O2, Application of 4-((1H-Imidazol-1-yl)methyl)benzoic acid.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Boncel, Slawomir published the artcileMichael-type addition of azoles of broad-scale acidity to methyl acrylate, Application of 5-Bromo-2-methyl-4-nitroimidazole, the main research area is Michael addition azole methyl acrylate; 1,2,4-triazole derivatives; Michael-type addition; imidazole derivatives; methyl acrylate; pyrazole derivatives.

An optimization of Michael-type addition of azole derivatives of broad-scale acidity – ranging from 5.20 to 15.00 pKa units – namely 4-nitropyrazole, 3,5-dimethyl-4-nitropyrazole, 4(5)-nitroimidazole, 4,5-diphenylimidazole, 4,5-dicyanoimidazole, 2-methyl-4(5)-nitroimidazole, 5(4)-bromo-2-methyl-4(5)-nitroimidazole and 3-nitro-1,2,4-triazole to Me acrylate as an acceptor was carried out. The optimization process involved the use of an appropriate basic catalyst (DBU, DIPEA, NaOH, NaH, TEDA), a donor/base/acceptor ratio and the reaction temperature The reactions were performed in DMF as solvent. Target Michael adducts I (R1 = R2 = R4 = H, Me, R3 = NO2, X = N, Y = Z = C; R1 = H, R2 = none, R 3 = R 4 = Ph, X = Z = C, Y = N; R1 = none, R2 = NO2, R3 = none, R4 = Z, Y = C) were obtained in medium to excellent yields. Importantly, for imidazole and 1,2,4-triazole derivatives, no corresponding regioisomers were obtained.

Beilstein Journal of Organic Chemistry published new progress about Michael reaction. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Application of 5-Bromo-2-methyl-4-nitroimidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem