Tag: M.W=200-250

Teulade, J. C. published the artcileNew aspects of the nitration of some imidazo[1,2-a]pyridines. CNDO/2 calculations from x-ray structures, Recommanded Product: Ethyl 6-chloroimidazo[1,2-a]pyridine-2-carboxylate, the main research area is nitration regiochem imidazopyridine derivative; crystal structure imidazopyridine derivative; mol structure imidazopyridine derivative; MO imidazopyridine derivative.

The reactivity of the imidazo[1,2-a]pyridine system was examined CNDO/2 calculations based on x-ray structure determinations of 5-ethoxyimidazo[1,2-a]pyridine, Et 8-methylimidazo[1,2-a]pyridine-2-carboxylate, and Et 6-methyl-3-nitroimidazo[1,2-a]pyridine-2-carboxylate are compared with exptl. results of the nitration of variously substituted imidazo[1,2-a]pyridines, and are found compatible with the individual reactivities.

Australian Journal of Chemistry published new progress about Bond order. 67625-38-1 belongs to class imidazoles-derivatives, name is Ethyl 6-chloroimidazo[1,2-a]pyridine-2-carboxylate, and the molecular formula is C10H9ClN2O2, Recommanded Product: Ethyl 6-chloroimidazo[1,2-a]pyridine-2-carboxylate.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Meshcheryakova, S. A. published the artcileSynthesis of new thietanylpyrimidine and thietanylimidazole derivatives, Synthetic Route of 18874-52-7, the main research area is pyrimidine chloromethylthiirane alkylation rearrangement; chloromethylthiirane imidazole alkylation rearrangement; thietane pyrimidine preparation; imidazole thietane preparation.

New thietanyl-substituted derivatives of pyrimidine-2,4(1H,3H)-dione and imidazole were synthesized. The alkylation of 6-methylpyrimidine-2,4(1H,3H)-diones with 2-(chloromethyl)thiirane in water involved N(1) of the pyrimidine ring and afforded 6-methyl-1-(thietan-3-yl)pyrimidine-2,4(1H,3H)-diones. Under analogous conditions, 6-aminopyrimidine-2,4(1H,3H)-dione gave 6-(thietan-3-ylamino)pyrimidine-2,4(1H,3H)-dione. Unsym. substituted 2-methyl-4(5)-nitro- and 5(4)-bromo-2-methyl-4(5)-nitro-1H-imidazoles reacted with 2-(chloromethyl)thiirane to produce mixtures of isomeric 2-methyl-4(5)-nitro-1-(thietan-3-yl)-1H-imidazoles and 5(4)-bromo-2-methyl-4(5)-nitro-1-(thietan-3-yl)-1H-imidazoles.

Russian Journal of Organic Chemistry published new progress about Alkylation. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Synthetic Route of 18874-52-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Foldesi, Tamas published the artcileEfficient synthesis of a new compound family, 9-aryl-5H-imidazo[2,1-d][1,2,5]triazepin-6(7H)-ones, SDS of cas: 62457-94-7, the main research area is imidazole aroyl alkylation hydrolysis protection acid ring closure; triazepinone aryl imidazo preparation.

Representatives of a new compound family, 9-aryl-5H-imidazo[2,1-d][1,2,5]triazepin-6(7H)-ones I (Ar = Ph, 4-FC6H4, 4-ClC6H4, 3-ClC6H4, 4-MeOC6H4, 3-CF3C6H4, 4-NO2C6H4, 2-thienyl) have been synthesized. As structural analogs of biol. active 1-aryl-2,3-benzodiazepine-4-ones, these compounds are potential drug candidates in the diseases of the central nervous system. An efficient five-step synthesis starting from imidazole is described here for the preparation of the target compounds Shorter routes have also been studied, however, these attempts failed.

Tetrahedron published new progress about Alkylation. 62457-94-7 belongs to class imidazoles-derivatives, name is (4-Chlorophenyl)(1H-imidazol-2-yl)methanone, and the molecular formula is C10H7ClN2O, SDS of cas: 62457-94-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Demirayak, Seref published the artcileSynthesis of some 6,8-diarylimidazo[1,2-a]pyrazine derivatives by using either reflux or microwave irradiation method and investigation of their anticancer activities, Product Details of C10H7ClN2O, the main research area is diarylimidazopyrazine anticancer agent structure activity relationship human cancer leukemia; microwave irradiation alkylation heterocyclization diarylimidazopyrazine pyrazine derivative preparation.

The preparation of 6,8-diarylimidazo[1,2-a]pyrazines, e.g. I, via the reaction of 1-(2-aryl-2-oxoethyl)-2-aryloylimidazole derivatives, e.g. II, with ammonium acetate in acetic acid utilizing a new method, is reported. Anticancer activities of the compounds obtained were evaluated and the activity values were reported.

Journal of Heterocyclic Chemistry published new progress about Alkylation. 62457-94-7 belongs to class imidazoles-derivatives, name is (4-Chlorophenyl)(1H-imidazol-2-yl)methanone, and the molecular formula is C10H7ClN2O, Product Details of C10H7ClN2O.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sobiak, Stanislaw published the artcileTetrabutylammonium bromide as a catalyst for reaction of 5(4)-bromo-2-methyl-4(5)-nitroimidazole with phenacyl bromides, Category: imidazoles-derivatives, the main research area is tetrabutylammonium bromide catalyst alkylation bromomethylnitroimidazole; bromomethylnitroimidazole sonication alkylation phenacyl bromide; nitroimiazole bromo alkylation phenacyl bromide; imidazole bromomethylnitro alkylation phenacyl bromide.

Reactions of 5(4)-bromo-2-methyl-4(5)-nitroimidazole with phenacyl bromides BrCH2COC6H4X-4 (X = H, F, Cl, Br, iodo), tetrabutylammonium bromide and sodium bicarbonate under sonication conditions gave mixtures of 4-bromo-5-nitroimidazoles I and 5-bromo-4-nitroimidazoles II in excellent yields of over 85% and, surprisingly, with I/II isomer ratios of 2:1.

Acta Poloniae Pharmaceutica published new progress about Alkylation. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Category: imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rao, A. K. S. Bhujanga published the artcileA new high-yielding method for the preparation of 2-alkyl- and 1,2-dialkyl-4-nitro-5-bromoimidazoles, Synthetic Route of 18874-52-7, the main research area is alkylnitroimidazole bromination; bromoimidazole alkylnitro; alkylbromonitroimidazole; imidazole alkylnitro bromination.

A new brominating system Br2-DMF-KHCO3 is described for the preparation of the title compounds I (R = H, Et, CH2CH2CN, CH2CH2COMe, CH2CH2CO2Et, CH2CH2CO2H, CH2CO2Et, CH2Ph, CH2C6H4Cl-4, CH2CH2SO2Et, cyclopropylmethyl; R1 = Me, Et). The mild conditions of the reaction allow bromination to be carried out in the presence of acid and base sensitive functionalities in nearly quant. yields.

Journal of Organic Chemistry published new progress about Bromination. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Synthetic Route of 18874-52-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ikemoto, Tomomi published the artcileReactions with N-chlorosuccinimide of various 5-methylimidazo[1,2-a]pyridine derivatives with an electron-withdrawing group substituted at the 3-position, Formula: C8H7BrN2, the main research area is methylimidazopyridine preparation reaction chlorosuccinimide; pyridine methylimidazo preparation reaction chlorosuccinimide; imidazopyridine methyl preparation reaction chlorosuccinimide; chlorination mechanism methylimidazopyridine.

Chlorination reactions using N-chlorosuccinimide (NCS) was investigated for various 5-methylimidazo[1,2-a]pyridine derivatives, e.g. I (R = Cl, Br, NO2, CHO, CO2Et), with an electron-withdrawing group substituted at the 3-position. These reactions showed different results. Thus, reacting I (R = Cl) with NCS gave chloromethyl derivatives II (R1 = CH2Cl, CHCl2), whereas reacting I (R = Br) with NCS gave imidazopyridinium salts III (R2 = Br, Cl; X = Br, Cl). A proposed reaction mechanism for these transformations involved 3-halogenoimidazo[1,2-a]pyridium compounds as reaction intermediates.

Heterocycles published new progress about Chlorination. 5857-47-6 belongs to class imidazoles-derivatives, name is 3-Bromo-5-methylimidazo[1,2-a]pyridine, and the molecular formula is C8H7BrN2, Formula: C8H7BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dumanovic, D. published the artcileSimultaneous determination of N-substituted and N-substituted nitroazoles, and criteria for their identification. III. Chromatographic separation and polarographic determination of halonitroimidazoles, Name: 5-Bromo-2-methyl-4-nitroimidazole, the main research area is halonitroimidazole mixture polarog chromatog; chromatog thin layer halonitroimidazole; nitroimidazole halo polarog determination; imidazole halo nitro determination.

Halonitroimidazoles with the NO2 group in the same position are separated for identification by thin-layer chromatog. on unactivated silica gel HF254 in an atm. saturated with the vapor of 1 of 5 developers, the plate then being sprayed with 15% SnCl2 solution in aqueous HCl, dried, sprayed with p-dimethylaminobenzaldehyde solution, and redried. All 4-nitro derivatives give a yellow color and 4(5)- and 5-nitro compounds are yellow-red. Polarog. determination of halonitroimidazoles may be used in all synthetic processes where the azoles were prepared by nitration of haloimidazoles. A sample of the reaction mixture containing ≤10-3M polarog.-active compound and a suitable buffer is polarographed in the presence and absence of 2 ml 10-3M standard solution of the imidazole being determined and the amount imidazole is directly calculated from the observed wave heights. For halonitroimidazoles obtained from 5(4)-halo-4(5)-nitroimidazoles by substitution of the imino H, and when only one N-substituted derivative is present in the reaction mixture, simultaneous polarog. determination of both compounds is possible only in alk. medium. For mixtures on which simultaneous polarog. determination is impossible a sample of the reaction mixture containing 3 × 10-3-10-2M of all polarog.-active compounds is chromatog. separated and the bands are removed, dissolved in water, and then polarographed.

Talanta published new progress about Chromatography. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Name: 5-Bromo-2-methyl-4-nitroimidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Yamada, Junji published the artcileParticipation of peroxisomal β-oxidation system in the chain-shortening of a xenobiotic acyl compound, SDS of cas: 94084-75-0, the main research area is drug metabolism liver beta oxidation; peroxisome function drug metabolism.

A model drug, (E)-3-[4-(1-imidazolylmethyl)phenyl]-2-propenoic acid  [82571-53-7], was metabolized to 4-(1-imidazolylmethyl)benzoic acid  [94084-75-0] by isolated hepatocytes of rats and this metabolism was enhanced by pretreatment of rats with clofibrate. With liver homogenates, the formation of the CoA-ester [94666-06-5] of this drug and its subsequent chain-shortening were demonstrated. Acyl-CoA synthetase  [9013-18-7], CoA  [85-61-0], ATP  [56-65-5], and NAD  [53-84-9] were required for this metabolic sequence; CN- did not inhibit the reaction. These results indicate that peroxisomes are capable of shortening the acyl side-chains of drugs by the β-oxidation, giving an addnl. suggestion on the functions of peroxisomes.

Biochemical and Biophysical Research Communications published new progress about Alkyl groups. 94084-75-0 belongs to class imidazoles-derivatives, name is 4-((1H-Imidazol-1-yl)methyl)benzoic acid, and the molecular formula is C11H10N2O2, SDS of cas: 94084-75-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kim, Moon H. published the artcileThe design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors, Product Details of C10H7ClN2O, the main research area is indolinone derivative preparation antitumor receptor tyrosine kinase inhibitor pharmacokinetic.

Variously substituted indolin-2-ones were synthesized and evaluated for activity against KDR, Flt-1, FGFR-1 and PDGFR. Extension at the 5-position of the oxindole ring with Et piperidine (I) proved to be the most beneficial for attaining both biochem. and cellular potencies. Further optimization of I to balance biochem. and cellular potencies with favorable ADME/ PK properties led to the identification of II, a compound with a clean CYP profile, acceptable pharmacokinetic and toxicity profiles, and robust efficacy in multiple xenograft tumor models.

Bioorganic & Medicinal Chemistry Letters published new progress about Angiogenesis. 62457-94-7 belongs to class imidazoles-derivatives, name is (4-Chlorophenyl)(1H-imidazol-2-yl)methanone, and the molecular formula is C10H7ClN2O, Product Details of C10H7ClN2O.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem