Tag: M.W=150-200

Danovich, D. K.; Turchaninov, V. K. published the artcile< Basicity of azoles. 2. Relationship with the energy of nonbonding electrons and reorganization energy of the π- and σ-electronic systems of the base upon ionization and protonation>, COA of Formula: C4H5BrN2, the main research area is azole ionization potential proton affinity; electron reorganization azole basicity.

Linear relationships between proton affinity (AM1) and ionization potential (Green’s function AM1 quantum-chem. method) were observed for series of imidazoles and pyrazoles and explained with a thermodn. cycle which took explicit account of the differences in electronic reorganization (relaxation) energy of the π- and σ-electronic systems of the azole cation and cation radical relative to the neutral mol.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about Azoles Role: PRP (Properties). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, COA of Formula: C4H5BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rheault, Tara R.; Donaldson, Kelly H.; Cheung, Mui published the artcile< Convenient synthesis of heteroaryl-linked benzimidazoles via microwave-assisted boronate ester formation>, Quality Control of 1003-21-0, the main research area is halobenzimidazole pinacolatoboron boration microwave; benzimidazolylboronate preparation Suzuki Miyaura cross coupling; benzimidazole heteroaryl preparation.

N-Substituted 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazoles were conveniently accessed via microwave-assisted synthesis. Subsequent Suzuki-Miyaura cross-coupling with heteroaryl halides proceeded to give a wide variety of heteroarylbenzimidazoles.

Tetrahedron Letters published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Quality Control of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Begtrup, Mikael; Larsen, Peter published the artcile< Alkylation, acylation, and silyation of azoles>, Formula: C4H5BrN2, the main research area is azole alkylation solvent effect; acylation azole anion; silylation azole anion; methylation benzylation azole anion.

Performing alkylation, acylation, and silylation reactions in sep. deprotonation and nucleophilic displacement steps allows for better control of reaction conditions and facilitates problem handling in these processes. In the alkylation of azoles, the alkylating agents and solvents possess individual reaction capabilities which seem to be approx. additive. Monoalkylation occurs if the sum of the normalized reaction potentials is equal or larger than the pKa value of the azole. Dialkylation is avoided by keeping the sum of the normalized reaction potentials below the pKa value of the alkylazole. The applicability of these principles is demonstrated by the development of effective procedures for the methylation, benzylation, acetylation, methoxycarbonylation, and trimethylsilylation of azoles.

Acta Chemica Scandinavica published new progress about Acylation. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Formula: C4H5BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

De Bie, D. A.; Van Der Plas, H. C.; Geurtsen, G. published the artcile< Didehydrohetarenes. XX. Reactions of 4- and 5-haloimidazoles with lithium piperidide in piperidine>, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole, the main research area is halo imidazole lithium piperidide reaction.

On treatment of 5-halo-1-methyl-imidazole with lithium piperidide in piperidine, an addition-elimination reaction giving 1-methyl-5-piperidinoimidazole, transhalogenation giving 4-halo-1-methylimidazole and a meta substitution yielding the 1-methyl-2-piperidinoimidazole, were observed. No indication for the occurrence of a 4,5-didehydro-1-methylimidazole was obtained.

Recueil des Travaux Chimiques des Pays-Bas published new progress about 1003-21-0. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Khalil-Moghaddam, Shiva; Shahvelayati, Ashraf Sadat; Aliahmadi, Atousa published the artcile< Synthesis and antioxidant properties of two new derivatives of indeno-benzofuran>, Safety of 1-carboxymethyl-3-methylimidazolium chloride, the main research area is pyrogallol ninhydrin adduct preparation green chem antioxidant.

Ninhydrin reacts with poly-phenols in different ratios to produce tetracyclic adducts. Here, pyrogallol was used as a polyphenol compound In the company of acidic ionic liquid (AIL), there was a selective reaction between the ortho-site of polyphenol and the ninhydrin’s carbonyl group. Mono-adduct (1:1) and bis-adduct (2:1) were prepared using 1-(carboxymethyl)-3-methyl-1H-imidazolium chloride (mcmimCl) as a solvent and catalyst. Moreover, the antioxidant activity of these adducts was investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical assay and butylated hydroxytoluene (BHT) was considered to be standard The results indicated that mono-adduct showed the strongest antioxidant activity (IC50 = 5.289μg/mL).

Journal of Chemical Health Risks published new progress about Antioxidants. 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, Safety of 1-carboxymethyl-3-methylimidazolium chloride.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Zhen; Zhang, Yali; Pinkas, Daniel M.; Fox, Alice E.; Luo, Jinfeng; Huang, Huocong; Cui, Shengyang; Xiang, Qiuping; Xu, Tingting; Xun, Qiuju; Zhu, Dongsheng; Tu, Zhengchao; Ren, Xiaomei; Brekken, Rolf A.; Bullock, Alex N.; Liang, Guang; Ding, Ke; Lu, Xiaoyun published the artcile< Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2>, Safety of 5-Bromo-1-methyl-1H-imidazole, the main research area is design synthesis heterocycloalkynylbenzimide dual inhibitor Discoidin domain receptor; antiinflammatory drug discovery human pharmacokinetic mol modeling.

Discoidin-domain receptors 1 and 2 (DDR1 and DDR2) are new potential targets for anti-inflammatory-drug discovery. A series of heterocycloalkynylbenzimides were designed and optimized to coinhibit DDR1 and DDR2. One of the most promising compounds, I, tightly bound to DDR1 and DDR2 proteins with Kd values of 7.9 and 8.0 nM; potently inhibited the kinases with IC50 values of 9.4 and 20.4 nM, resp.; and was significantly less potent for a panel of 403 wild-type kinases at 1.0 μM. DDR1- and DDR2-kinase inhibition by I was validated by Western-blotting anal. in primary human lung fibroblasts. The compound also dose-dependently inhibited lipopolysaccharide (LPS)-induced interleukin 6 (IL-6) release in vitro and exhibited promising in vivo anti-inflammatory effects in an LPS-induced-acute-lung-injury (ALI) mouse model. Compound I may serve as a lead compound for new anti-inflammatory drug discovery.

Journal of Medicinal Chemistry published new progress about Acute toxicity. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Safety of 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem