Tag: M.W=150-200

Liu, Yi; Zhou, Cuihan; Jiang, Meijing; Arndtsen, Bruce A. published the artcile< Versatile Palladium-Catalyzed Approach to Acyl Fluorides and Carbonylations by Combining Visible Light- and Ligand-Driven Operations>, Formula: C4H5BrN2, the main research area is acyl fluoride preparation; acyl halide carbon monoxide photochem carbonylation palladium catalyst.

The development of a general palladium-catalyzed carbonylative method to synthesize acyl fluorides RC(O)F (R = n-Bu, cyclohexyl, 4-methylphenyl, pyridin-3-yl, etc.) from aryl, heteroaryl, alkyl, and functionalized organic halides RX was described. Mechanistic anal. suggests that the reaction proceeds via the unique, synergistic combination of visible light photoexcitation of Pd(0) to induce oxidative addition with a ligand-favored reductive elimination. These together create a unidirectional catalytic cycle that is uninhibited by the classical effect of carbon monoxide coordination. Coupling the catalytic formation of acyl fluorides with their subsequent nucleophilic reactions has opened a method to perform carbonylation reactions with unprecedented breadth, including the assembly of highly functionalized carbonyl-containing products.

Journal of the American Chemical Society published new progress about Acid fluorides Role: SPN (Synthetic Preparation), PREP (Preparation). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Formula: C4H5BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sandfort, Frederik; Knecht, Tobias; Pinkert, Tobias; Daniliuc, Constantin G.; Glorius, Frank published the artcile< Site-Selective Thiolation of (Multi)halogenated Heteroarenes>, Quality Control of 1003-21-0, the main research area is heteroarene thiol site selective thiolation photochem iridium.

A general and simple strategy for the site-selective thiolation of various pharmaceutically relevant electron-rich heteroarenes with thiols is reported. This mild and reliable photocatalytic protocol enables C-S coupling at the most electron-rich position of the (multi)halogenated substrates, complementing established methodologies. Exptl. and computational studies suggest a radical chain mechanism with the key step being a homolytic aromatic substitution of the heteroaryl halide by an electrophilic thiyl radical, highlighting an underdeveloped reactivity mode.

Journal of the American Chemical Society published new progress about Free energy. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Quality Control of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Schareina, Thomas; Zapf, Alexander; Cotte, Alain; Gotta, Matthias; Beller, Matthias published the artcile< An Improved Protocol for Palladium-Catalyzed Alkoxycarbonylations of Aryl Chlorides with Alkyl Formates>, Category: imidazoles-derivatives, the main research area is aryl heteroaryl halide alkyl formate alkoxycarbonylation palladium catalysis.

The palladium-catalyzed alkoxycarbonylation of aryl and heteroaryl halides using Bu formate has been investigated. In the presence of palladium(II) acetate/n-butylbis(1-adamantyl)phosphine (L1), and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as base for the first time non-activated chloroarenes can be conveniently carbonylated in good yields.

Advanced Synthesis & Catalysis published new progress about Alkoxycarbonylation. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Category: imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lu, Dingkun; Qin, Menghan; Liu, Chang; Deng, Jingjing; Shi, Guoyue; Zhou, Tianshu published the artcile< Ionic liquid-functionalized magnetic metal-organic framework nanocomposites for efficient extraction and sensitive detection of fluoroquinolone antibiotics in environmental water>, Synthetic Route of 700370-07-6, the main research area is ionic liquid functionalized magnetic metal organic framework nanocomposite extractant; adsorption detection fluoroquinolone antibiotics environmental water; detection; fluoroquinolone antibiotic; ionic liquid-functionalized; magnetic metal−organic framework; nanocomposites.

Herein, the hydrophobic carboxyl-functionalized ionic liquid (IL-COOH) was encapsulated into the prepared Fe3O4@Zr-MOFs, and the novel water-stable IL-COOH/Fe3O4@Zr-MOF nanocomposites were first synthesized. The polydopamine-functionalized Fe3O4 was introduced to construct the core-shell structure via layer-by-layer modification, and the controlled growth of Zr-MOFs was achieved, which realized the adjustment of charged properties of nanocomposites and simplified the adsorption or extraction process. The IL-COOH/Fe3O4@Zr-MOFs were fully studied by IR, HNMR, XRD, N2 adsorption-desorption isotherms, TEM, EDS mapping, VSM, and so on. Then, they were employed for the selective adsorption and detection of fluoroquinolone antibiotics (FQs). The adsorption isotherms and kinetics demonstrated that the adsorption process followed a pseudo-second-order kinetic model and the Langmuir isotherm model. Among them, IL-COOH/Fe3O4@UiO-67-bpydc showed the best adsorption performance, and the maximum adsorption capacity of ofloxacin was 438.5 mg g-1. Coupled magnetic solid-phase extraction with HPLC-DAD, a convenient, sensitive, and efficient method for extraction and detection of FQs in environmental water, was developed based on IL-COOH/Fe3O4@UiO-67-bpydc. The recoveries of environmental water were ranging from 90.0 to 110.0%, and the detection limits were lower than 0.02μg L-1. The novel functionalized composites served as solid-phase adsorbents and liquid-phase extractants. This study also provided a promising strategy for designing and preparing multi-functionalized nanocomposites for the removal or detection of pollutants in environmental samples.

ACS Applied Materials & Interfaces published new progress about Adsorbents. 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, Synthetic Route of 700370-07-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Barbay, J. Kent; Cummings, Maxwell D.; Abad, Marta; Castro, Glenda; Kreutter, Kevin D.; Kummer, David A.; Maharoof, Umar; Milligan, Cynthia; Nishimura, Rachel; Pierce, Joan; Schalk-Hihi, Celine; Spurlino, John; Tanis, Virginia M.; Urbanski, Maud; Venkatesan, Hariharan; Wang, Aihua; Woods, Craig; Wolin, Ronald; Xue, Xiaohua; Edwards, James P.; Fourie, Anne M.; Leonard, Kristi published the artcile< 6-Substituted quinolines as RORγt inverse agonists>, HPLC of Formula: 1003-21-0, the main research area is quinoline preparation RORt inverse agonist structure activity relationship; IL-17; RORγt; Retinoic acid-related orphan nuclear receptor gamma t; Th17.

We identified 6-substituted quinolines as modulators of the retinoic acid receptor-related orphan receptor gamma t (RORγt). The synthesis of this class of RORγt modulators is reported, and optimization of the substituents at the quinoline 6-position that produced compounds with high affinity for the receptor is detailed. This effort identified mols. that act as potent, full inverse agonists in a RORγt-driven cell-based reporter assay. The X-ray crystal structures of two full inverse agonists, I and II, from this chem. series bound to the RORγt ligand binding domain are disclosed, and we highlight the interaction of a hydrogen-bond acceptor on the 6-position substituent of the inverse agonist with Glu379:NH as a conserved binding contact.

Bioorganic & Medicinal Chemistry Letters published new progress about Hydrogen bond. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, HPLC of Formula: 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kunz, Peter C.; Wetzel, Corinna; Bongartz, Melanie; Noffke, Anna Louisa; Spingler, Bernhard published the artcile< Novel multitopic diphos-type ligands>, Computed Properties of 1003-21-0, the main research area is chlorophosphinoethane substitution reaction imidazole thiazole derivative; imidazolyl thiazolyl diphoshine ligand rhodium complex preparation crystal structure; mol structure imidazole thiazole derivative diphosphine ligand rhodium complex; hydrophilicity partition coefficient imidazolyl thiazolyl diphoshine ligand.

Seven novel imidazole and thiazole derivatives of diphos-type ligands are prepared They are of the general structure R2P(CH2)2PR2, where R is imidazol-2-yl (1), 1-methylimidazol-2-yl (2), 1-methylbenzimidazol-2-yl (3), 1-methylimidazol-5-yl (4), 2-isopropylimidazol-4(5)-yl (5), thiazol-2-yl (6), benzothiazol-2-yl (7), thiazol-4-yl (8) or thiazol-5-yl (9). Syntheses involved direct metalation or halogen-metal exchange reactions. E.g., nBuLi reacted with 1-methylbenzimidazole in toluene at -78° and bis(dichlorophosphino)ethane was added and stirred overnight to give 80% yield of bis(di-1-methylbenzimidazol-2-ylphosphino)ethane. Their solubility, especially in aqueous solution, is strongly dependent on the nature of the substituents as is their partition coefficient log D. The crystal structures of compounds 2, 3, 7 and 9 as well as the structure of the Rh complex [(2)2Rh2Cl2]Cl2 (10) were determined

Journal of Organometallic Chemistry published new progress about Coordinative substitution reaction. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Computed Properties of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Xu, Jingyu; Jia, Hongge; Yang, Nan; Wang, Qingji; Yang, Guoxing; Zhang, Mingyu; Xu, Shuangping; Zang, Yu; Ma, Liqun; Jiang, Pengfei; Zhou, Hailiang; Wang, Honghan published the artcile< High efficiency gas permeability membranes from ethyl cellulose grafted with ionic liquids>, SDS of cas: 700370-07-6, the main research area is ethyl cellulose ionic liquid membrane elastic modulus gas permeability; ethyl cellulose; gas permeation properties; imidazole; liquid; membrane.

Et cellulose was grafted with ionic liquids in optimal yields (62.5-64.1%) and grafting degrees (5.93-7.90%) by the esterification of the hydroxyl groups in Et cellulose with the carboxyl groups in ionic liquids In IR spectra of the Et cellulose derivatives exhibited C = O bond stretching vibration peaks at 1760 or 1740 cm-1, confirming the formation of the ester groups and furnishing the evidence of the successful grafting of Et cellulose with ionic liquids The Et cellulose grafted with ionic liquids could be formed into membranes by using the casting solution method. The resulting membranes exhibited good membrane forming ability and mech. properties. The EC grafted with ionic liquids-based membranes demonstrated PCO2/PCH4 separation factors of up to 18.8, whereas the PCO2/PCH4 separation factor of 9.0 was obtained for pure EC membrane (both for CO2/CH4 mixture gas). The membranes also demonstrated an excellent gas permeability coefficient PCO2, up to 199 Barrer, which was higher than pure EC (PCO2 = 46.8 Barrer). Therefore, it can be concluded that the ionic liquids with imidazole groups are immensely useful for improving the gas separation performances of EC membranes.

Polymers (Basel, Switzerland) published new progress about Elongation, mechanical. 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, SDS of cas: 700370-07-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Guo, Pengfei; Zhang, Hao; Zhou, Jianguang; Gallou, Fabrice; Parmentier, Michael; Wang, Hui published the artcile< Micelle-Enabled Suzuki-Miyaura Cross-Coupling of Heteroaryl Boronate Esters>, Synthetic Route of 1003-21-0, the main research area is micelle catalyzed Suzuki heteroaryl boronic ester aryl heteroaryl halide; heterobiaryl synthesis.

We report a micellar protocol for Suzuki-Miyaura cross-coupling of heteroaryl boronic esters with aryl or heteroaryl halides. The micellar catalysis enables this coupling reaction to run under mild conditions, which avoids the decomposition of heteroaryl boronate esters and allows for high chemoselectivity for cross-coupling reaction with 6-chloropridine-2-boronic ester. The micellar protocol expands the scope of the cross-coupling reaction with challenging heteroaryl boronic esters and complements the existing cross-coupling methods for construction of heterobiaryl building blocks.

Journal of Organic Chemistry published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Synthetic Route of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Laviron, Etienne published the artcile< Polarographic and physicochemical studies of nitro, halo-, and carbonyl derivatives of imidazol>, Formula: C4H5BrN2, the main research area is .

The equilibrium between 2 forms of imidazole substituted in position 4 or 5 was investigated. In acidic solutions, the E1/2 values of 4-nitroimidazole (I) and 4-nitro-1-methylimidazole as well as their ultraviolet absorption spectra are identical, indicating that the form A of I predominates over B. The difference in E1/2 between I and 2-nitroimidazole is sufficient for analysis of their mixture The last of the 3 polarographic waves of 2,4,5-triiodoimidazole corresponds to the wave of 2-iodoimidazole, the iodine atom in position 2 being most difficultly reducible. The ratio of the concentrations of form A and B of 4-bromoimidazole is equal to the ratio of the ionization constants of 4-bromo-1-methylimidazole and 5-bromo-1-methylimidazole, viz., 35. Imidazole-4-carboxaldehyde in MeOH or EtOH formed a polarographically inactive hemiacetal.

Compt. Rend. published new progress about 1003-21-0. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Formula: C4H5BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Salvitti, Chiara; Pepi, Federico; Manago, Marta; Bortolami, Martina; Michenzi, Cinzia; Chiarotto, Isabella; Troiani, Anna; de Petris, Giulia published the artcile< Free N-heterocyclic carbenes from Bronsted acidic ionic liquids: Direct detection by electrospray ionization mass spectrometry>, Related Products of 700370-07-6, the main research area is methyl carboxymethylimidazolium chloride ionic liquid preparation zwitterion.

The occurrence of N-heterocyclic carbenes in imidazolium-based ionic liquids has long been discussed, but no spectroscopic evidence has been reported yet due to their transient nature. The insertion of an ionizable acid group into the cation scaffold of an ionic liquid which acts as a charge tag allows for the direct detection of free carbenes by mass spectrometry. Three different Broensted acidic ionic liquids were synthesized: 1-methyl-3-carboxymethylimidazolium chloride (MAICl), 1-methyl-3-carboxymethylimidazolium acetate (MAIAc) and the corresponding 2-(3-methyl-1H-imidazol-3-ium-1-yl)acetate zwitterion (MAI – H). The speciation of these compounds was then analyzed by electrospray ionization ion-trap mass spectrometry in the neg. ion mode. The C2-H deprotonation of the imidazolium cation leading to the formation of the corresponding carbene is highly affected by the basic properties of the counter-anion. In the case of MAICl and MAI – H ionic liquids, no charged species corresponding to the free N-heterocyclic carbene was detected. On the contrary, in the presence of a sufficiently basic anion, such as acetate of MAIAc ionic liquid, an intense signal related to the free carbenic species was observed without the addition of an external base. In situ formation of free N-heterocyclic carbenes from Broensted acidic ionic liquids was demonstrated, highlighting the crucial role of anion basicity in promoting the C2-H proton abstraction from imidazolium cations with a carboxylic side chain.

Rapid Communications in Mass Spectrometry published new progress about Collision-induced dissociation. 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, Related Products of 700370-07-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem