Tag: M.W=150-200

Grob, Jonathan E.; Nunez, Jill; Dechantsreiter, Michael A.; Hamann, Lawrence G. published the artcile< One-pot reductive amination and Suzuki-Miyaura cross-coupling of formyl aryl and heteroaryl MIDA boronates in array format>, Related Products of 1003-21-0, the main research area is arylmethylpyrrolidinylmethanol amine derivative preparation; aryl MIDA boronate preparation aryl halide amination Suzuki reaction; boronic acid MIDA.

Formyl-substituted aryl and heteroaryl MIDA boronates were prepared by a DMSO-free method and used in the first reported one-pot reductive amination-Suzuki-Miyaura cross-coupling sequence. This sequence was then carried out in parallel array format, using microwave-assisted in situ release cross-coupling of MIDA boronates to generate a library with diversity along two axes, affording rapid and convenient access to an array of druglike mols.

Journal of Organic Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Related Products of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ford, Jodi L; Browning, Christopher R published the artcile< Effects of exposure to violence with a weapon during adolescence on adult hypertension.>, HPLC of Formula: 1003-21-0, the main research area is Adverse childhood experiences; Exposure to violence; Hypertension; Victimization; Witnessed violence.

OBJECTIVES: To examine the longitudinal associations between exposure to violence with a weapon during the past year among adolescents and hypertension during adulthood, including the extent to which adult cardiovascular risk factors mediated the association. METHODS: Secondary analysis of the National Longitudinal Study of Adolescent Health, 1994-2008. The sample included 3555 male and 4416 female participants who were aged 11-17 years at wave 1 (1994-1995). Participants were categorized as hypertensive if they had a mean systolic blood pressure of 140 mm Hg or higher or a mean diastolic pressure of 90 mm Hg or higher at wave 4 (2008). Witnessed violence with a weapon was defined as having seen a shooting or stabbing during the year before wave 1, whereas victim of violence with a weapon was defined as having been shot, cut, or stabbed or had a gun or knife drawn on them during the year before wave 1. Potential mediators of adult cardiovascular risk (wave 4) included body mass index, daily smoking, alcohol abuse, and depression. RESULTS: Males who witnessed violence and females who were victims of violence in the year before wave 1 had an increased odds of hypertension at wave 4 compared with their unexposed peers (adjusted odds ratio, 1.45; 95% confidence interval, 1.003-2.10 and adjusted odds ratio, 1.72; 95% confidence interval, 1.04-2.84, respectively). The hypothesized adult cardiovascular risk mediators did not significantly attenuate the associations for either the male or female samples. CONCLUSIONS: Interventions addressing prior violence exposure are needed to promote adult cardiovascular health.

Annals of epidemiology published new progress about 1003-21-0. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, HPLC of Formula: 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Alonso, Nerea; Munoz, Juan de M.; Egle, Brecht; Vrijdag, Johannes L.; De Borggraeve, Wim M.; de la Hoz, Antonio; Diaz-Ortiz, Angel; Alcazar, Jesus published the artcile< First example of a continuous-flow carbonylation reaction using aryl formates as CO precursors>, COA of Formula: C4H5BrN2, the main research area is haloarene aryl formate carbonylation flow chem.

The first continuous flow carbonylation reaction using aryl formates as CO precursor is reported. The reaction is practical, scalable and high yielding. The use of a flow protocol safely allows expanding the scope to activated chlorides, nitrogen heterocycles and to the selective introduction of an ester group in dihalo-derivatives Further selective reduction of the ester formed to an aldehyde in flow is also described.

Journal of Flow Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, COA of Formula: C4H5BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Moraes, Carolina V.; Demetrio da Silva, Vinicius; Castegnaro, Marcus V.; Morais, Jonder; Schrekker, Henri S.; Amico, Sandro C. published the artcile< Lightweight Composites through Imidazolium Ionic Liquid Enhanced Aramid-Epoxy Resin Interactions>, Product Details of C6H9ClN2O2, the main research area is lightweight composite imidazolium ionic liquid aramid epoxy resin.

Poly(p-phenylene terephthalamide) (PPTA) is mostly used as a low-d. polymeric fiber with high specific stiffness and strength, and thermal and chem. stability. The fiber is used as a reinforcement in composite materials in the aerospace and automobile industries, as well as in ballistic and stab-resistant articles. However, its use in composite materials is hampered by its low interfacial affinity with polymeric matrixes due to its smooth and inert surface. To overcome such low interfacial interaction, various treatments have been applied to modify the aramid surface. However, it is still challenging to identify an industrially feasible process that does not neg. impact mech. properties of the aramid fibers. The objective of this study was to investigate different ionic liquids (ILs) with suitable chem. structures as alternative compatibilizers for aramid fibers with epoxy resin. Kevlar fibers were submitted to ethanolic solutions of imidazolium IL (1-n-butyl-3-methylimidazolium chloride, 1-carboxymethyl-3-methylimidazolium chloride, 1-triethyleneglycol monomethyl ether-3-methylimidazolium methanesulfonate, or 1-n-butyl-3-methylimidazolium methanesulfonate) and then analyzed by IR spectroscopy, thermogravimetry, SEM, and XPS. Fiber tensile tests, pull-out tests, and contact angle measurements were used to characterize the fiber and its interface with the epoxy resin. Treatment with all IL, except 1-carboxymethyl-3-methylimidazolium chloride, enhanced the wettability and adhesion of the fibers without imparing mech. properties. Epoxy resin-based composites were produced using com. fabrics before and after 1-triethyleneglycol monomethyl ether-3-methylimidazolium methanesulfonate treatment and characterized via tensile and short-beam tests. The composite produced with treated fabrics presented slightly higher tensile strength, modulus, and interfacial shear strength, which can be of interest to the composite sector.

ACS Applied Polymer Materials published new progress about Adhesion, physical, interfacial. 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, Product Details of C6H9ClN2O2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Fonseca, E.; Demetrio da Silva, V.; Klitzke, J. S.; Schrekker, H. S.; Amico, S. C. published the artcile< Imidazolium ionic liquids as fracture toughening agents in DGEBA-TETA epoxy resin>, Formula: C6H9ClN2O2, the main research area is epoxy resin imidazolium ionic liquid mech thermal property.

Although epoxy resins are used in a broad variety of applications due to their good mech. and thermal properties, their low fracture toughness is a limitation, exhibiting brittle behavior. This study explored the potential use of imidazolium ionic liquids (IL) as toughening agents for epoxy resin based on diglycidyl ether of bisphenol A (DGEBA) with triethylenetetramine (TETA) as curing agent. Fracture toughness was evaluated for DGEBA-TETA epoxy resins with eleven imidazolium IL and the best results were found for the IL with the chloride anion and the shortest N-alkyl side chain, C4MImCl. The use of 1.0 phr of C4MImCl lead to the reduction of the crosslink d. of the post-cured resin, resulting in the increase of 25.5% in stress intensity factor and 8.2% in tensile strength with no significant loss in other mech. properties.

Polymer Testing published new progress about Bending strength. 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, Formula: C6H9ClN2O2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Gibson, Christoph; Schnatbaum, Karsten; Pfeifer, Jochen R.; Locardi, Elsa; Paschke, Matthias; Reimer, Ulf; Richter, Uwe; Scharn, Dirk; Faussner, Alexander; Tradler, Thomas published the artcile< Novel Small Molecule Bradykinin B2 Receptor Antagonists>, Reference of 1003-21-0, the main research area is small mol bradykinin B2 receptor antagonist preparation structure.

Blockade of the bradykinin B2 receptor provides therapeutic benefit in hereditary angioedema (HAE) and potentially in many other diseases. Herein, we describe the development of highly potent B2 receptor antagonists with a mol. weight of approx. 500 g/mol. First, known quinoline-based B2 receptor antagonists were stripped down to their shared core motif 53, which turned out to be the min. pharmacophore. Targeted modifications of 53 resulted in the highly water-soluble lead compound 8a. Extensive exploration of its structure-activity relationship resulted in a series of highly potent B2 receptor antagonists, featuring a hydrogen bond accepting functionality, which presumably interacts with the side chain of Asn-107 of the B2 receptor. Optimization of the microsomal stability and cytochrome P 450 inhibition eventually led to the discovery of the highly potent and orally available B2 receptor antagonist 52e (JSM10292), which showed the best overall properties.

Journal of Medicinal Chemistry published new progress about Angioedema. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Reference of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Manasieva, Leda Ivanova; Maria, Battisti Umberto; Prandi, Adolfo; Brasili, Livio; Franchini, Silvia published the artcile< Synthesis of Heteroaryl ortho-Phenoxyethylamines via Suzuki Cross-Coupling: Easy Access to New Potential Scaffolds in Medicinal Chemistry>, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole, the main research area is heteroaryl ortho phenoxyethylamine preparation Suzuki cross coupling.

Heteroaryl ortho-phenoxyethylamines have been extensively employed in medicinal chem. as privileged scaffolds for the design of highly potent and selective ligands. Herein an efficient, fast, and general method for the synthesis of heteroaryl phenoxyethylamines via Suzuki cross-coupling is reported. This approach offers the opportunity to obtain a large variety of biaryls incorporating five-membered (thiophene, furan, thiazole, pyrazole, imidazole) or six-membered (pyridine, pyrimidine) heteroaromatic rings for appropriate libraries of ligands. All the compounds presented here have never been synthesized before and a full structural characterization is given.

Synthesis published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation) (phenoxyethylamines). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ohba, Masashi; Mukaihira, Takafumi; Fujii, Tozo published the artcile< Synthesis of 5-arylthio-3-methyl-L-histidine, a model for the starfish alkaloid imbricatine>, Electric Literature of 1003-21-0, the main research area is histidine arylthiomethyl; imbricatine model synthesis.

Syntheses of 3-methyl-5-phenylthio-L-histidine (I, R = Ph) and 3-methyl-5-(1-naphthyl)thio-L-histidine ( R = 1-naphthyl), selected as models for the asteroid alkaloid imbricatine (II), have now become feasible through a 10-step route starting from 4(5)-bromoimidazole. The key steps involve replacement of the 4-bromo group by an arylthio group in the aldehyde III and construction of the L-alanine moiety in the chlorides IV by the “”bis-lactim ether”” method.

Heterocycles published new progress about 1003-21-0. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Electric Literature of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ansideri, Francesco; Macedo, Joana T.; Eitel, Michael; El-Gokha, Ahmed; Zinad, Dhafer S.; Scarpellini, Camilla; Kudolo, Mark; Schollmeyer, Dieter; Boeckler, Frank M.; Blaum, Baerbel S.; Laufer, Stefan A.; Koch, Pierre published the artcile< Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3>, Category: imidazoles-derivatives, the main research area is pyridinylimidazole preparation JNK3 inhibitor p38alpha MAP kinase.

Starting from known p38α mitogen-activated protein kinase (MAPK) inhibitors, a series of inhibitors of the c-Jun N-terminal kinase (JNK) 3 was obtained. Altering the substitution pattern of the pyridinylimidazole scaffold proved to be effective in shifting the inhibitory activity from the original target p38α MAPK to the closely related JNK3. In particular, a significant improvement for JNK3 selectivity could be achieved by addressing the hydrophobic region I with a small Me group. Furthermore, addnl. structural modifications permitted to explore structure-activity relationships. The most potent inhibitor 4-(4-methyl-2-(methylthio)-1H-imidazol-5-yl)-N-(4-morpholinophenyl)pyridin-2-amine showed an IC50 value for the JNK3 in the low triple digit nanomolar range and its binding mode was confirmed by x-ray crystallog.

ACS Omega published new progress about Bioactive lead compounds. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Category: imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kerche, Eduardo Fischer; da Silva, Vinicius Demetrio; da Silveira Jankee, Gabriela; Schrekker, Henri Stephan; de Avila Delucis, Rafael; Irulappasamy, Siva; Amico, Sandro Campos published the artcile< Aramid pulp treated with imidazolium ionic liquids as a filler in rigid polyurethane bio-foams>, Reference of 700370-07-6, the main research area is aramid pulp imidazolium ionic liquid filler polyurethane biofoam.

This article reports an aramid pulp (AP) treated with two ionic liquids (IL), namely 1-n-butyl-3-methylimidazolium chloride (C4.Cl) and 1-carboxymethyl-3-methylimidazolium chloride (HO2C), and its use as a filler in reinforced rigid polyurethane foams (RPUF). The RPUF were incorporated with the treated AP at three weight fractions (c.a. 0.1, 0.5, and 1.0 wt%) and were produced by the free rising method. The results showed that the studied IL promoted a better interaction between the AP and the RPUF system, which increased the overall reactivity, imparting a higher cell anisotropy. This also yielded a pos. effect in mech. properties and thermal stability of the RPUF. Compared to the neat RPUF, outstanding increases of approx. 50 and 20% were achieved in compressive modulus and strength, resp. In all, the use of IL promoted increased compatibility between matrix and reinforcement, especially that HO2C IL.

Journal of Applied Polymer Science published new progress about Anisotropy. 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, Reference of 700370-07-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem