Tag: M.W=150-200

Laviron, Etienne published the artcile< Polarographic and physicochemical study of pyridine derivatives and heterocyclic bases. III. Nitro, carbonyl, and halogen-containing derivatives of imidazole>, Quality Control of 1003-21-0, the main research area is .

Exptl. data from polarographic ultraviolet and spectrophotometric measurements showed that the 4 (or 5)-NO2 (or Br) derivative of imidazole exists almost totally as I (R =NO2 or Br) in solution

Bulletin de la Societe Chimique de France published new progress about Ionization. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Quality Control of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Taylor, Steven J.; Abeywardane, Asitha; Liang, Shuang; Muegge, Ingo; Padyana, Anil K.; Xiong, Zhaoming; Hill-Drzewi, Melissa; Farmer, Bennett; Li, Xiang; Collins, Brandon; Li, John Xiang; Heim-Riether, Alexander; Proudfoot, John; Zhang, Qiang; Goldberg, Daniel; Zuvela-Jelaska, Ljiljana; Zaher, Hani; Li, Jun; Farrow, Neil A. published the artcile< Fragment-Based Discovery of Indole Inhibitors of Matrix Metalloproteinase-13 [Erratum to document cited in CA155:648013]>, Formula: C4H5BrN2, the main research area is erratum indole derivative structure MMP 13 inhibitor arthritis.

The PDB accession codes of MMP-13 in complex with 1, 10, and 15 are 5BOT, 5BOY, and 5BPA, resp.

Journal of Medicinal Chemistry published new progress about Antiarthritics. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Formula: C4H5BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sadeghzadeh, Seyed Mohsen; Zhiani, Rahele published the artcile< Synthesis of pyridopyrimidinones by N-heterocyclic carbene palladium(II) supported on KCC-1 in aqueous solution>, Application of C4H5BrN2, the main research area is silica supported imidazolyl diiodopyridinepalladium nanocatalyst preparation; pyridopyrimidine preparation chemoselective; aminopyridine acrylate one pot palladium nanocatalyst.

New N,N’-substituted imidazolium salts supported on KCC-1 and their corresponding diiodopyridinepalladium (II) complexes (KCC-1/Pd-NHC-Py) was developed for synthesis of pyridopyrimidinones such as I [R = H, 7-F, 9-Me, etc.; R1 = Me, Bn] from 2-aminopyridines and Baylis-Hillman adducts in excellent yields with remarkable chemoselectivity. This morphol. ultimately led to higher catalytic activity for the KCC-1-supported nanoparticles. The KCC-1/Pd-NHC-Py NPs were thoroughly characterized by using TEM, FESEM, TGA, and BET.

Journal of Organometallic Chemistry published new progress about Aminopyridines Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Application of C4H5BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Geraschenko, Oleksandr V.; Solomin, Vitalii V.; Vashchenko, Bohdan V.; Khodakivskyi, Pavlo; Tolmachev, Andrey A.; Grygorenko, Oleksandr O. published the artcile< Synthesis and chemical transformations of diazolyl α,α-difluoroacetates>, HPLC of Formula: 1003-21-0, the main research area is hetaryl difluoroacetate preparation chem transformation; glyoxylate hetaryl deoxofluorination.

Optimized protocols for the synthesis of diazolyl α,α-difluoroacetates RC(F)2C(O)OEt (R = 1-methyl-1H-imidazol-2-yl, 1,3-thiazol-2-yl, 1-methyl-1H-1,3-benzodiazol-2-yl, etc.) via deoxofluorination of the corresponding glyoxylates RC(O)C(O)OEt with Morph-DAST are described. The method allowed the preparation of the title fluoridated building blocks in 73-96% yield on up to 15 g scale. Utility of the hetaryl α,α-difluoroacetates was demonstrated by the synthesis of advanced building blocks for medicinal chem., i.e. carboxylic acids RC(F)2C(O)OH/RC(F)2C(O)OH.HCl, amides RC(F)2C(O)NH2, nitriles RC(F)2CN, and alcs. RC(F)2CH2OH.

Journal of Fluorine Chemistry published new progress about Aromatic amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, HPLC of Formula: 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ibrahim, Mansur; Malik, Imran; Mansour, Waseem; Sharif, Muhammad; Fettouhi, Mohammed; El Ali, Bassam published the artcile< Efficient N-heterocyclic carbene palladium(II) catalysts for carbonylative Suzuki-Miyaura coupling reactions leading to aryl ketones and diketones>, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole, the main research area is palladium heterocyclic carbene pyridine complex catalyst preparation; aryl ketone diketone preparation; iodide aryl boronic acid palladium catalyst carbonylative Suzuki Miyaura.

New N, N’substituted imidazolium salts and their corresponding diiodopyridinepalladium(II) complexes I [R = CN, OMe] were successfully synthesized and characterized. Reactions of palladium iodide with the newly synthesized N, N’-substituted imidazolium iodides in pyridine afforded the corresponding new palladium-N-heterocyclic carbene pyridine complexes I in high yields. The new palladium(II) complex I [R = OMe] was characterized by single crystal X-ray diffraction anal. The Pd(II) ion was bonded to the nitrogen atom of the pyridine, the carbon atom of the NHC carbene ligand and two trans iodides resulting in distorted square planar geometry. The carbonylative Suzuki-Miyaura coupling reaction of aryl iodides with aryl boronic acids afforded aryl ketones II [R1 = H, CN, C(O)Me, OMe; R2 = H, OMe, COOH, etc.] and diketones III [R3 = H, CN, OMe] using palladium-N-heterocyclic carbene pyridine complexes.

Journal of Organometallic Chemistry published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chen, Hu; Lei, Min; Hu, Lihong published the artcile< Synthesis of 1-aryl indoles via coupling reaction of indoles and aryl halides catalyzed by CuI/metformin>, Product Details of C4H5BrN2, the main research area is aryl indole preparation; Ullmann coupling indole aryl halide copper metformin catalyst.

Ullmann-type C-N coupling reaction has been developed for the synthesis of 1-aryl indole derivatives by indoles and aryl halides in the presence of CuI/metformin (CuI/Met) in DMF. This method is very easy, rapid, and high yielding reaction for the synthesis of 1-aryl indoles. In particular, the metformin, which is used as ligand, is inexpensive and nontoxic that is considered to be relatively environmentally benign.

Tetrahedron published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Product Details of C4H5BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zhang, Patricia; Le, Chi “Chip”; MacMillan, David W. C. published the artcile< Silyl Radical Activation of Alkyl Halides in Metallaphotoredox Catalysis: A Unique Pathway for Cross-Electrophile Coupling>, Application In Synthesis of 1003-21-0, the main research area is alkyl halide coupling reaction aryl bromide metallaphotoredox catalyst tristrimethylsilylsilane.

A strategy for cross-electrophile coupling has been developed via the merger of photoredox and transition metal catalysis. In this report, we demonstrate the use of com. available tris(trimethylsilyl)silane with metallaphotoredox catalysis to efficiently couple alkyl bromides with aryl or heteroaryl bromides in excellent yields. We hypothesize that a photocatalytically generated silyl radical species can perform halogen-atom abstraction to activate alkyl halides as nucleophilic cross-coupling partners. This protocol allows the use of mild yet robust conditions to construct Csp3-Csp2 bonds generically via a unique cross-coupling pathway.

Journal of the American Chemical Society published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Application In Synthesis of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tanis, Virginia M.; Venkatesan, Hariharan; Cummings, Maxwell D.; Albers, Michael; Kent Barbay, J.; Herman, Krystal; Kummer, David A.; Milligan, Cynthia; Nelen, Marina I.; Nishimura, Rachel; Schlueter, Thomas; Scott, Brian; Spurlino, John; Wolin, Ronald; Woods, Craig; Xue, Xiaohua; Edwards, James P.; Fourie, Anne M.; Leonard, Kristi published the artcile< 3-Substituted Quinolines as RORγt Inverse Agonists>, Quality Control of 1003-21-0, the main research area is quinoline derivative preparation ROR gamma t inverse agonist SAR; IL-17; Inverse agonist; RORγt; Retinoic acid-related orphan nuclear receptor gamma t; Th17.

We have previously reported the syntheses of a series of 3,6-disubstituted quinolines as modulators of the retinoic acid receptor-related orphan receptor gamma t (RORγt). These mols. are potent binders but are high mol. weight and they exhibited poor solubility at pH 2 and pH 7. This manuscript details our efforts at improving phys. chem. properties for this series of compounds by increasing the diversity at the 3-position (i.e. introducing heteroatoms and lowering the mol. weight). These efforts have led to mols. which are potent binders with improved solubility

Bioorganic & Medicinal Chemistry Letters published new progress about Drug design. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Quality Control of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ling, Irene; Sobolev, Alexandre N.; Dalgarno, Scott J. published the artcile< Inclusion complexes of imidazolium carboxylate-metal species in the water-soluble sulfonated calix[4]arene system>, Computed Properties of 700370-07-6, the main research area is preparation imidazolium carboxylate metal water sulfonated calixarene inclusion complex; crystal structure imidazolium carboxylate metal sulfonated calixarene inclusion complex.

Two multi-component crystal structures comprising a carboxylic acid-functionalized imidazolium zwitterion, a p-sulfonatocalix[4]arene anion and aquated metal ion (Na+ or Y3+) with or without an auxiliary component (the 3-methoxyphenyl-triphenylphosphonium cation) are reported. The carboxylic acid-functionalized imidazolium ion binds either as a monodentate or a bidentate ligand depending on the nature of the metal ions, and a bi-layer arrangement prevails in the extended structure regardless of the type of metal ion employed or presence/lack of auxiliary component.

Journal of Coordination Chemistry published new progress about Crystal structure. 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, Computed Properties of 700370-07-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Lei; Duan, Lele; Stewart, Beverly; Pu, Maoping; Liu, Jianhui; Privalov, Timofei; Sun, Licheng published the artcile< Toward Controlling Water Oxidation Catalysis: Tunable Activity of Ruthenium Complexes with Axial Imidazole/DMSO Ligands>, Formula: C4H5BrN2, the main research area is controlling water oxidation catalysis tunable activity; ruthenium complex axial imidazole DMSO ligand.

Using the combinations of imidazole and DMSO (DMSO) as axial ligands and 2,2′-bipyridine-6,6′-dicarboxylate (bda) as the equatorial ligand, we have synthesized six novel ruthenium complexes with noticeably different activity as water oxidation catalysts (WOCs). In four Cs sym. RuII(κ3-bda)(DMSO)L2 complexes L = imidazole (1), N-methylimidazole (2), 5-methylimidazole (3), and 5-bromo-N-methylimidazole (4). Addnl., in two C2v sym. RuII(κ4-bda)L2 complexes L = 5-nitroimidazole (5) and 5-bromo-N-methylimidazole (6), i.e., fully equivalent axial imidazoles. A detailed characterization of all complexes and the mechanistic investigation of the catalytic water oxidation have been carried out with a number of exptl. techniques, i.e., kinetics, electrochem. and high resolution mass spectrometry (HR-MS), and d. functional theory (DFT) calculations We have observed the in situ formation of a RuII-complex with the accessible seventh coordination position. The measured catalytic activities and kinetics of complex 1-6 revealed details about an important structure-activity relation: the connection between the nature of axial ligands in the combination and either the increase or decrease of the catalytic activity. In particular, an axial DMSO group substantially increases the turnover frequency of WOCs reported in the article, with the ruthenium-complex having one axial 5-bromo-N-methyl-imidazole and one axial DMSO (4), we have obtained a high initial turnover frequency of ∼180 s-1. DFT modeling of the binuclear reaction pathway of the O-O bond formation in catalytic water oxidation further corroborated the concept of the mechanistic significance of the axial ligands and rationalized the exptl. observed difference in the activity of complexes with imidazole/DMSO and imidazole/imidazole combinations of axial ligands.

Journal of the American Chemical Society published new progress about Bond angle. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Formula: C4H5BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem