Tag: M.W=150-200

Kummer, David A.; Cummings, Maxwell D.; Abad, Marta; Barbay, Joseph; Castro, Glenda; Wolin, Ronald; Kreutter, Kevin D.; Maharoof, Umar; Milligan, Cynthia; Nishimura, Rachel; Pierce, Joan; Schalk-Hihi, Celine; Spurlino, John; Urbanski, Maud; Venkatesan, Hariharan; Wang, Aihua; Woods, Craig; Xue, Xiaohua; Edwards, James P.; Fourie, Anne M.; Leonard, Kristi published the artcile< Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt>, Computed Properties of 1003-21-0, the main research area is quinoline tertiary alc preparation RORgammat antagonist inverse agonist; Agonist; IL-17; Inverse agonist; Neutral antagonist; RORγt; Retinoic acid-related orphan nuclear receptor gamma t; Th17.

A high-throughput screen of the ligand binding domain of the nuclear receptor retinoic acid-related orphan receptor gamma t (RORγt) employing a thermal shift assay yielded a quinoline tertiary alc. hit. Optimization of the 2-, 3- and 4-positions of the quinoline core using structure-activity relationships and structure-based drug design methods led to the discovery of a series of modulators with improved RORγt inhibitory potency and inverse agonism properties.

Bioorganic & Medicinal Chemistry Letters published new progress about Drug design (structure-based). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Computed Properties of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Marshall, Checkers R.; Dvorak, Josh P.; Twight, Liam P.; Chen, Lan; Kadota, Kentaro; Andreeva, Anastasia B.; Overland, Alexandra E.; Ericson, Thomas; Cozzolino, Anthony F.; Brozek, Carl K. published the artcile< Size-Dependent Properties of Solution-Processable Conductive MOF Nanocrystals>, Computed Properties of 1003-21-0, the main research area is conductive iron triazolate MOF nanocrystal size property.

The diverse optical, magnetic, and electronic behaviors of most colloidal semiconductor nanocrystals emerge from materials with limited structural and elemental compositions Conductive metal-organic frameworks (MOFs) possess rich compositions with complex architectures but remain unexplored as nanocrystals, hindering their incorporation into scalable devices. Here, we report the controllable synthesis of conductive MOF nanoparticles based on Fe(1,2,3-triazolate)2. Sizes can be tuned to as small as 5.5 nm, ensuring indefinite colloidal stability. These solution-processable MOFs can be analyzed by solution-state spectroscopy and electrochem. and cast into conductive thin films with excellent uniformity. This unprecedented anal. of MOF materials reveals a strong size dependence in optical and electronic behaviors sensitive to the intrinsic porosity and guest-host interactions of MOFs. These results provide a radical departure from typical MOF characterization, enabling insights into phys. properties otherwise impossible with bulk analogs while offering a roadmap for the future of MOF nanoparticle synthesis and device fabrication.

Journal of the American Chemical Society published new progress about Absorptivity. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Computed Properties of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Taylor, Steven J.; Abeywardane, Asitha; Liang, Shuang; Muegge, Ingo; Padyana, Anil K.; Xiong, Zhaoming; Hill-Drzewi, Melissa; Farmer, Bennett; Li, Xiang; Collins, Brandon; Li, John Xiang; Heim-Riether, Alexander; Proudfoot, John; Zhang, Qiang; Goldberg, Daniel; Zuvela-Jelaska, Ljiljana; Zaher, Hani; Li, Jun; Farrow, Neil A. published the artcile< Fragment-Based Discovery of Indole Inhibitors of Matrix Metalloproteinase-13>, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole, the main research area is indole derivative structure MMP 13 inhibitor arthritis.

Matrix metalloproteases (MMPs) play an important role in cartilage homeostasis under both normal and inflamed disease states and, thus, have become attractive targets for the treatment of arthritic diseases. Herein, we describe the identification of a potent, selective MMP-13 inhibitor, developed using fragment-based structure-guided lead identification and optimization techniques. Virtual screening methods identified a novel, indole-based MMP-13 inhibitor that bound into the S1′ pocket of the protein exhibiting a novel interaction pattern hitherto not observed in MMP-13 inhibitors. X-ray crystallog. structures were used to guide the elaboration of the fragment, ultimately leading to a potent inhibitor that was >100-fold selective over nine other MMP isoforms tested.

Journal of Medicinal Chemistry published new progress about Antiarthritics. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Akopyan, A. V.; Eseva, E. A.; Polikarpova, P. D.; Baigil’diev, T. M.; Rodin, I. A.; Anishnov, A. V. published the artcile< Catalytic Activity of Polyfunctional Ionic Liquids in Oxidation of Model Sulfur Organic Compounds>, Computed Properties of 700370-07-6, the main research area is imidazolium molybdate ionic liquid oxidative desulfurization catalyst.

Ionic liquids based on 1-methylimidazole were synthesized. The liquids contain Bronsted acid centers in the cation and a transition metal atom in the anion. The polyfunctional ionic liquids synthesized in the study are effective catalysts for the oxidative desulfurization process. The conditions are found for reaching the 100% conversion of Me Ph sulfide under mild conditions in the presence of the catalysts, ionic liquids [ionic liquid: 3-(carboxymethyl)-1-methyl-1H-imidazol-3-ium molybdate with S:Mo molar ratio = 24:1, 2 h, 40°C, H2O2:S molar ratio = 12:1].

Russian Journal of Applied Chemistry published new progress about Anion exchange (with molybdate, tungstate and vanadate). 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, Computed Properties of 700370-07-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kusama, Hitoshi; Arakawa, Hironori; Sugihara, Hideki published the artcile< Density functional study of imidazole-iodine interaction and its implication in dye-sensitized solar cell>, SDS of cas: 1003-21-0, the main research area is imidazole iodine interaction dye sensitized solar cell; charge transfer complex imidazole iodine density functional theory.

The monomer and charge-transfer complexes of 14 different imidazole derivatives with diiodine were studied by a d. functional theory (DFT) method. DFT calculations revealed that the σ* orbital of iodine interacts with the nitrogen lone pair of imidazoles at position 3. The influence of these imidazoles addition on the performance of a bis(tetrabutylammonium)cis-bis(thiocyanato)bis(2,2′-bipyridine-4-carboxylic acid, 4′-carboxylate)ruthenium(II) (N719) dye-sensitized nanocrystalline TiO2 solar cell with an I-/I3- redox electrolyte in acetonitrile was also studied. All of the imidazole derivatives enhanced the open-circuit photovoltage (Voc). The resulting Voc values of solar cell were compared to computational calculations on the interaction between imidazoles and I2 by a DFT method. Optimized geometries, frequency analyses, and interaction energies suggest that the V oc value is higher, the more the imidazole complexes with I2.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about Bond angle. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, SDS of cas: 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Yan, Kui; Bai, Zhengwu; Huang, Shaohua published the artcile< NMR signal separation of ionic liquids by poly(sodium-p-styrenesulfonate)-assisted chromatographic NMR spectroscopy>, Application of C6H9ClN2O2, the main research area is ionic liquid polysodium styrenesulfonate chromatog NMR spectroscopy.

Diffusion-ordered NMR spectroscopy (DOSY), dubbed chromatog. NMR spectroscopy, can be used to simultaneously distinguish and identify the structures of components in a mixture according to their different diffusion coefficients In order to improve the resolution of DOSY on the diffusion dimension, a lot of matrixes have been developed to expand the application of this technique in mixture anal. However, there is no matrix to detect the mixture of ionic liquids (ILs). Herein, we introduced a new matrix, poly(sodium-p-styrenesulfonate) (PSSNa), which can be used to fully sep. the signals of a mixture of different ILs. The mixture of three imidazolium ILs of 1-butyl-3-methylimidazolium bromide, 1-allyl-3-vinylimidazolium bromide and 1-carboxymethyl-3-methylimidazolium chloride could be fully distinguished by virtue of their different interactions with PSSNa. We also investigated the influences of PSSNa amount, IL concentration and solution pH value on the signal resolution of mixtures This work provides a scientific reference for the anal. of the other IL analytes.

Magnetic Resonance Letters published new progress about Chromatography. 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, Application of C6H9ClN2O2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Iddon, Brian; Lim, Bee Lan published the artcile< Metalation and metal-halogen exchange reactions of imidazoles>, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole, the main research area is lithiation sulfuration ethoxymethylimidazole; imidazole lithiation sulfuration.

Imidazoles I (R = SPh, R1 = H, R2 = H, MeS) underwent lithiation and sulfuration to give thioimidazoles. E.g., I (R = SPh, R1 = R2 = H) was treated with BuLi in THF at -78° followed by addition of (PhS)2 to give I (R = R2 = SPh, R1 = H) quant. Similar treatment of I (R-R2 = Br) gave 67% I (R = SPh, R1 = R2 = Br).

Journal of the Chemical Society, Chemical Communications published new progress about Sulfuration. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

El Borai, M.; Moustafa, A. H.; Anwar, M.; Ghattas, A. G. published the artcile< Synthesis of new formyl halo N-methylimidazole derivatives>, Category: imidazoles-derivatives, the main research area is imidazole formylbromomethyl; methylimidazole formylation bromination.

Title compounds [I, R, R1, R2 = CHO, Br, H (II), Br, CHO, H; H, Br, CHO; CHO, H, Br; CHO, Br, Br] were prepared E. g., formylation of I (R = Br, R1 = R2 = H) followed by bromination gave II.

Croatica Chemica Acta published new progress about 1003-21-0. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Category: imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mardaneh, Jalal; Beyzaei, Hamid; Hashemi, Seyed Hadi; Ghasemi, Behzad; Rahdar, Abbas published the artcile< Comparative evaluation of the inhibitory potential of synthetic N-heterocycles, Cu/Fe3O4@SiO2 nanocomposites and some natural products against non-resistant and antibiotic-resistant Acinetobacter baumannii>, Application In Synthesis of 30086-64-7, the main research area is Acinetobacter Trachyspermum thiazole iron oxide silicon dioxide nanocomposite antibacterial.

Acinetobacter baumannii is a common infectious agent in hospitals. New antimicrobial agents are identified and prepared to combat these bacterial pathogens. In this context, the blocking potentials of a series of synthesized N-heterocyclic compounds, Cu/Fe3O4@SiO2 nanocomposites, glycine, poly-L-lysine, nisin and hydroalcoholic extracts of Trachyspermum ammi, Curcuma longa and green tea catechins were evaluated against non-resistant and multidrug-resistant strains of A. baumannii. Solutions of heterocyclic derivatives and hydroalcoholic extracts of Trachyspermum ammi, Curcuma longa and green tea catechins were prepared at initial concentration of 10240μg ml-1 in 10% DMSO. Other compounds were dissolved in water at the same concentrations Their in vitro inhibitory activity was assessed by determination of IZD, MIC and MBC values. Glycine, poly-L-lysine, nisin, Curcuma longa and green tea catechins extracts, and thiazoles 3a, 3d and 3f were ineffective at their initial concentrations Heterocyclic derivatives 7a-f, 3c, 3e and 3h, Cu/Fe3O4@SiO2 nanocomposites and Trachyspermum ammi extract could block the growth of bacterial strains with IZDs (7.40-15.51 mm), MICs (32-1024μg ml-1) and MBCs (128-2048μg ml-1). Among synthetic chems. and natural products, the best antimicrobial effects were recorded with (E)-2-(5-acetyl-4-methylthiazol-2-yl)-2-(thiazolidin-2-ylidene)acetonitrile (7b) and the extract of Trachyspermum ammi. It is imperative that their toxic and histopathol. effects were assessed in future researches. It is predicted that the essential oil of Trachyspermum ammi will improve its antibacterial activities.

Pharmaceutical Sciences (Tabriz, Islamic Republic of Iran) published new progress about Acinetobacter baumannii. 30086-64-7 belongs to class imidazoles-derivatives, and the molecular formula is C7H12N2S, Application In Synthesis of 30086-64-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Okazaki, Shogo; Noguchi-Yachide, Tomomi; Sakai, Taki; Ishikawa, Minoru; Makishima, Makoto; Hashimoto, Yuichi; Yamaguchi, Takao published the artcile< Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activity>, Reference of 401567-00-8, the main research area is phenoxyphenyloxadiazolylethylacetamide acetyl CoA carboxylase ACC2 inhibitor PPAR agonist; Acetyl-CoA carboxylase; Multi-target drug; Peroxisome proliferator-activated receptor.

Acetyl-Co-A carboxylases (ACCs) catalyze a critical step in de novo lipogenesis, and are considered as promising targets for treatment of obesity, dyslipidemia and type 2 diabetes mellitus. On the other hand, peroxisome proliferator-activated receptors (PPARs) are well-established therapeutic targets for these metabolic syndrome-related diseases. Therefore, the authors considered that dual modulators of ACC and PPARs would be promising candidates as therapeutic agents. Here, the authors designed a series of acetamides based on the mol. similarity between ACC inhibitors and PPAR agonists. Screening of the synthesized compounds identified N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel ACC2 inhibitors with PPARα/PPARδ dual agonistic activity. Structure-activity relationship studies and further structural elaboration afforded compounds with distinct activity profiles. The findings should be helpful for the discovery of candidate agents with an appropriate balance of ACC-inhibitory and PPAR-activating activities for therapeutic lipid control.

Bioorganic & Medicinal Chemistry published new progress about Homo sapiens. 401567-00-8 belongs to class imidazoles-derivatives, and the molecular formula is C8H4ClN3, Reference of 401567-00-8.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem