Tag: M.W=150-200

Asoh, Kohsuke; Kohchi, Masami; Hyoudoh, Ikumi; Ohtsuka, Tatsuo; Masubuchi, Miyako; Kawasaki, Kenichi; Ebiike, Hirosato; Shiratori, Yasuhiko; Fukami, Takaaki A.; Kondoh, Osamu; Tsukaguchi, Toshiyuki; Ishii, Nobuya; Aoki, Yuko; Shimma, Nobuo; Sakaitani, Masahiro published the artcile< Synthesis and structure-activity relationships of novel benzofuran farnesyltransferase inhibitors>, Name: 5-Bromo-1-methyl-1H-imidazole, the main research area is benzofuran imidazolyl preparation farnesyltransferase inhibitor.

A series of imidazolylbenzofuran-based farnesyltransferase inhibitors have been designed and synthesized as antitumor agents. Among them, I showed the most potent enzyme inhibitory activity (IC50 = 1.1 nM) and antitumor activity in human cancer xenografts in mice.

Bioorganic & Medicinal Chemistry Letters published new progress about Crystal structure. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Name: 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ambati, Srinivasa Rao; Patel, Jeevan Lal; Gudala, Satish; Chandrakar, Komal; Penta, Santhosh; Mahapatra, S. P.; Banerjee, Subhash published the artcile< Synthesis of novel coumarinyl-pyrido[2,3-d]pyrimidine-2,4-diones using task-specific magnetic ionic liquid, [AcMIm]FeCl4 as catalyst>, Application In Synthesis of 700370-07-6, the main research area is chloroacrolein coumarinyl heterocyclization uracil reusable ionic liquid catalyst; coumarinyl pyridopyrimidinedione preparation green chem.

An acid-functionalized magnetic ionic liquid, 1-carboxymethyl-3-methylimidazolium tetrachloroferrate, was utilized for the synthesis of a series of novel highly functionalized (coumarinyl)pyrido[2,3-d]pyrimidine-2,4-diones I (R1 = H,Br, Cl, MeO; R2 = H, Cl, Br; R3 = Me, cyclopropyl) by the reactions of various 3-chloro-3-(2-oxo-2H-chromen-3-yl)acrylaldehydes II with functionalized 6-aminouracils III. The central point of the present procedure was the use of task-specific acidic ionic liquid which acts as catalyst as well as reaction medium thus avoiding the use of organic solvent and/or protic acid catalyst. The other major advantages of the protocol were (i) shorter reaction time (1 h), (ii) easy work up procedure, (iii) excellent yields of products (91-94%) and (iv) recyclability of the catalyst. The compounds I were identified using FT-IR, 1H-NMR and 13C-NMR and mass spectroscopic studies.

Synthetic Communications published new progress about Coumarins Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, Application In Synthesis of 700370-07-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ognyanov, Vassil I.; Balan, Chenera; Bannon, Anthony W.; Bo, Yunxin; Dominguez, Celia; Fotsch, Christopher; Gore, Vijay K.; Klionsky, Lana; Ma, Vu V.; Qian, Yi-Xin; Tamir, Rami; Wang, Xianghong; Xi, Ning; Xu, Shimin; Zhu, Dawn; Gavva, Narender R.; Treanor, James J. S.; Norman, Mark H. published the artcile< Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles>, Recommanded Product: 2-Chloro-1H-benzo[d]imidazole-5-carbonitrile, the main research area is benzimidazole piperazinyl preparation transient receptor potential vanilloid antagonist antihyperalgesic.

The vanilloid receptor-1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel that is predominantly expressed by peripheral neurons sensing painful stimuli. TRPV1 antagonists produce antihyperalgesic effects in animal models of inflammatory and neuropathic pain. The synthesis and the structure-activity relationships of a series of 2-(4-pyridin-2-ylpiperazin-1-yl)-1H-benzo[d]imidazoles I [R1 = H, Me3SiCH2CH2OCH2, PhCH2; R2 = F, Cl, Br, F3C, Me, CN, Me3C, MeO2C, etc.; R3 = H, 4-(2-thiazolyl), 4-(4-pyridyl), 5-(4-F3CC6H4), etc.; R4 = H, Me; R5 = H, H2N, MeCHOH, H2C:CH, etc.; R6 = H, Cl, F3C, etc.] and analogs as novel TRPV1 antagonists have been described. I [R1 = H; R2 = F3C; R3 = 4-(3,4,5-F3C6H2); R4 = (R)-Me; R5 = HOCH2CHOH; R6 = Cl; (II)] was among the most potent analogs in this series. This compound was orally bioavailable in rats and was efficacious in blocking capsaicin-induced flinch in rats in a dose-dependent manner. II also reversed thermal hyperalgesia in a model of inflammatory pain, which was induced by complete Freund’s adjuvant (CFA).

Journal of Medicinal Chemistry published new progress about Analgesics. 401567-00-8 belongs to class imidazoles-derivatives, and the molecular formula is C8H4ClN3, Recommanded Product: 2-Chloro-1H-benzo[d]imidazole-5-carbonitrile.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ren, Yun-lai; Wang, Qian; Tian, Xin-zhe; Wang, Bin-yu; Wang, Pei published the artcile< Nitrogen dioxide-catalyzed oxidative bromination of benzenes and naphthalines with electron-donating substituents at room temperature>, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole, the main research area is aryl bromide preparation oxidative bromination arene nitrogen dioxide catalyst.

Oxidative bromination of benzenes and naphthalines with electron-donating substituents was investigated by using 8.2% nitrogen dioxide as the catalyst, the residual oxygen in the reaction tube as the oxidant, and mol. bromine as the brominating reagent at room temperature The used heavy metal waste-free catalyst can be easily removed from the products and scarcely stains the final products. But a small amount of byproduct from the nitration of the benzene ring was observed, which led to the consumption of nitrogen dioxide. The reaction is highly atom economic, and a majority of bromine atoms in bromine source were transferred to the bromination products. The bromination was controllable: mono- and di-bromination products were controllably obtained by changing the loading amount of the brominating reagent. Preliminary mechanistic investigation suggests that the bromination firstly undergoes the reaction between mol. bromine and aromatic ring to give aryl bromide and HBr, which is followed by oxygenation of the resulting bromine hydride to form the reactive bromine under the catalysis of the catalytic species.

Fenzi Cuihua published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chen, Shuai; Graceffa, Russell F.; Boezio, Alessandro A. published the artcile< Direct, Regioselective N-Alkylation of 1,3-Azoles>, COA of Formula: C4H5BrN2, the main research area is regioselective alkylation azole purine organomagnesium reagent.

Regioselective N-alkylation of 1,3-azoles is a valuable transformation. Organomagnesium reagents were discovered to be competent bases to affect regioselective alkylation of various 1,3-azoles. Counterintuitively, substitution selectively occurred at the more sterically hindered nitrogen atom. Numerous examples are provided, on varying 1,3-azole scaffolds, with yields ranging from 25 to 95%.

Organic Letters published new progress about Alkylation, regioselective. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, COA of Formula: C4H5BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Daghlavi, Amneh; Kowsari, Elaheh; Abdouss, Majid; Ghasemi, Mohammad Hadi; Asadi, Elham published the artcile< Catalytic synthesis of thiazolidines by the reaction of Nef-isocyanide reaction>, COA of Formula: C7H12N2S, the main research area is phosphoric acid graphene oxide catalyst preparation thiazolidine Nef isocyanide.

A practical and efficient method for the synthesis of thiazolidine derivatives via Nef-isocyanide three-component reaction using supported phosphoric acid on graphene oxide (GO-H2PO4) is described. A relatively simple method starting with cyclic and acyclic thiourea was employed. The catalyst was characterized using FTIR, SEM, energy-dispersive x-ray spectroscopy, and X-ray diffraction techniques. Using a combination of acetonitrile as solvent and GO-H2PO4 as a catalytic system, the best results were obtained. All products were characterized using m.p., FTIR, MASS, 1H NMR, and 13C NMR techniques. The use of com. available chems., reusability of the catalyst, high yields, decreased environmental hazards, with no need for the separation of stereoisomers, and, consequently, a reduced number of overall steps are the advantages of this approach that make it an appropriate choice at an increased scale.

Research on Chemical Intermediates published new progress about Imidazoles Role: SPN (Synthetic Preparation), PREP (Preparation). 30086-64-7 belongs to class imidazoles-derivatives, and the molecular formula is C7H12N2S, COA of Formula: C7H12N2S.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Beckmann, Udo; Sueslueyan, Diyana; Kunz, PeterC. published the artcile< Is the 1JPSe Coupling Constant a Reliable Probe for the Basicity of Phosphines? A 31P NMR Study>, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole, the main research area is coupling constant phosphine basicity probe.

The influence of different heteroaryl and functionalized aryl substituents on the electron-donating ability and basicity of the phosphorus atoms in heteroaryl phosphines and diphosphines has been determined by the use of the direct 1JPSe coupling constants of the corresponding selenides. The generality of the use of 31P-77Se spin-spin coupling constants as probe for the basicity of phosphines is discussed as well as the scope and limits of this concept.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Basicity (Broensted). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hernandez, Elisa; Santiago, Ruben; Belinchon, Alejandro; Maria Vaquerizo, Gema; Moya, Cristian; Navarro, Pablo; Palomar, Jose published the artcile< Universal and low energy-demanding platform to produce propylene carbonate from CO2 using hydrophilic ionic liquids>, Synthetic Route of 700370-07-6, the main research area is ionic liquid catalyst propylene carbonate carbon dioxide.

Ionic liquids (ILs) have been extensively proposed as efficient catalysts to promote CO2 cycloaddition reaction to epoxides for producing cyclic carbonates. Recently, liquid-liquid extraction with water as an enhancer approach to regenerate ILs and to purify the product was proposed, since it reduces energy consumption and enhances the neat catalytic activity of the IL due to hydroxyl groups of water. In this work, a comprehensive sample of homogeneous IL catalysts proposed in the literature is exptl. evaluated both in the catalytic step and in its separation by liquid-liquid extraction with water, to demonstrate the universality of the proposed reaction-separation proposal for hydrophilic ILs. Then the complete processes for CO2 conversion to propylene carbonate were modelled using Aspen Plus to compare the catalyst/product separation efficiency and the specific energy consumption using liquid-liquid extraction and distillation-based platforms. The energy consumption is significantly lower using liquid-liquid platform (1.1-1.3 kWh/kgPC) than distillation one (2.4-3.1 kWh/kgPC). It is concluded that hydrophilic ionic liquids, as those formed by [EtOHmim] cation and halide anions, are promising catalysts since they allow: (i) reducing the process energy consumption due to their high catalytic activity and (ii) full catalyst recovering, even at high catalyst loadings, by improving the water extractive properties for IL separation from PC.

Separation and Purification Technology published new progress about Cycloaddition reaction. 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, Synthetic Route of 700370-07-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Lizhi; Liu, Yang; Lu, Chanfang; Yang, Zhouping; Liu, Yaqing; Wang, Yanying; Rao, Hanbing; Zhang, Wei; Wang, Xianxiang published the artcile< Ultrasonic synthesis of nano-PrO1.8 as nanozyme for colorimetric determination of trans-resveratrol>, Recommanded Product: 1-carboxymethyl-3-methylimidazolium chloride, the main research area is trans resveratrol nanozyme colorimetric determination ultrasonic synthesis.

In this study, nano-PrO1.8 were synthesized successfully in ionic liquids (ILs) as template assisted ultrasonic irradiation method. Various precipitating agents and different types of ILs were investigated to determine their resp. effects on the morphol. of the end products. Using hydrazine hydrate as a precipitating agent and 1-carboxymethyl-3-methylimidazolium chloride as a template, spherical structure with an average diameter of 250 nm was obtained. It is worth noting that the prepared material exhibits high peroxidase-like activity and weak oxidase activity. Then, the catalytic oxidation capacity of the nano-PrO1.8 was evaluated by the peroxidase substrate 3,3′,5,5′-tetramethylbenzidine (TMB). The colorless of TMB can be converted into blue oxidized TMB (oxTMB) in the presence of nano-PrO1.8, but trans-resveratrol inhibited its peroxidase-like activity and weakened the blue color. Hence, we developed a sensitive, selective and simple colorimetric method for trans-resveratrol detection using nano-PrO1.8 as peroxidase-like enzyme. A linear relationship was found in the range of 0.30μM-16μM trans-resveratrol with the detection limit of 0.29μM. Satisfactory results were achieved when the method was submitted to the determination of trans-resveratrol in white wine samples.

Scientific Reports published new progress about Champagne. 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, Recommanded Product: 1-carboxymethyl-3-methylimidazolium chloride.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Holden, Kenneth G.; Mattson, Matthew N.; Cha, Kyung Hoi; Rapoport, Henry published the artcile< Synthesis of Chiral Pilocarpine Analogues via a C-8 Ketone Intermediate>, Name: 5-Bromo-1-methyl-1H-imidazole, the main research area is pilocarpine analog chiral synthesis; oxazolidinone analog pilocarpine stereoselective synthesis.

The synthesis of a chiral pilocarpine analog I in which the lactone ring is replaced by an oxazolidinone and the bridging methylene group is in the ketone oxidation state has been accomplished. The utility of this compound as a key intermediate for the preparation of more complex structures was demonstrated by its reduction to two alc. epimers and its reaction with a methylene ylide.

Journal of Organic Chemistry published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation) (imidazole-containing, oxazolidine analogs). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Name: 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem