Tag: M.W=150-200

Zaouak, Amira published the artcileDegradation mechanism of losartan in aqueous solutions under the effect of gamma radiation, Product Details of C8H13ClN2O, the publication is Radiation Physics and Chemistry (2021), 109435, database is CAplus.

In this paper, the impact of gamma radiation on one of emerging pharmaceutical pollutant was investigated. Deriving from sartan class, losartan, one of the most consumed antihypertensive drug was irradiated at doses of 0.5-4 kGy in aqueous solutions The removal of COD (COD) and total organic carbon (TOC) during the irradiation process reflects that the mineralization efficiency increases with increasing radiation dose. During the mineralization process some aromatic intermediates such as 4-[2-(1H-1,2,3,4-tetrazol-5-yl) phenyl] phenol, 2-butyl-4-chloro-5-(hydroxymethyl) imidazole-1-ol, 2,4prime-dihydroxybiphenyl, tetrazole, 1,2,4 benzentriol, 1,4-hydroxyquinone and quinone were identified by LC/MS. These results show that degradation process starts with cleavage of the starting mol. by hydroxyl radicals, which are generated by the radiolysis of water. Based on these observations, a mechanistic schema of losartan was proposed. At the end, losartan kinetic study was performed indicating a pseudo first order degradation process.

Radiation Physics and Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C14H10O4, Product Details of C8H13ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wysokowski, Marcin published the artcileIonic liquid-assisted synthesis of chitin-ethylene glycol hydrogels as electrolyte membranes for sustainable electrochemical capacitors, Related Products of imidazoles-derivatives, the publication is Scientific Reports (2022), 12(1), 8861, database is CAplus and MEDLINE.

A novel chitin-ethylene glycol hybrid gel was prepared as a hydrogel electrolyte for elec. double-layer capacitors (EDLCs) using 1-butyl-3-methylimidazolium acetate [Bmim][Ac] as a chitin solvent. Examination of the morphol. and topog. of the chitin-EG membrane showed a homogeneous and smooth surface, while the thickness of the membrane obtained was 27μm. The electrochem. performance of the chitin-EG hydrogel electrolyte was investigated by cyclic voltammetry and galvanostatic charge/discharge measurements. The specific capacitance value of the EDLC with chitin-EG hydrogel electrolyte was found to be 109 F g^-1 in a potential range from 0 to 0.8 V. The tested hydrogel material was electrochem. stable and did not decompose even after 10,000 GCD cycles. Addnl., the EDLC test cell with chitin-EG hydrogel as electrolyte exhibited superior capacitance retention after 10,000 charge/discharge cycles compared with a com. glass fiber membrane.

Scientific Reports published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C6H4ClNO2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Eom, Young Woo published the artcileCytotoxicity of substituted benzimidazolyl curcumin mimics against multi-drug resistance cancer cell, Quality Control of 7467-35-8, the publication is Bulletin of the Korean Chemical Society (2013), 34(4), 1272-1274, database is CAplus.

Recently, we discovered that introduction of benzimidazole groups to the feruloyl scaffold through aldol condensation greatly improved the cytotoxicity of synthetic curcumin mimics against various cancer cells. Because the benzimidazole mols. exhibit a variety of biol. properties such as anticancer, antiviral, and anti-hypertensive activity, we can expect their novel cytotoxic properties come from benzimidazolyl groups attached to the feruloyl structure. Our goal was to evaluate the cytotoxicity of novel curcumin mimics with structurally diverse benzimidazol moieties against multidrug resistance (MDR) cancer cells. A novel curcumin mimics library has been synthesized with the purpose of discovering novel anticancer drug candidates that inhibit a proliferation both MDR cancer cells and non-MDR cancer cells at the same time. We confirmed that our novel curcumin mimics inhibit the growth of MDR cancer cells more strongly than our previous inhouse curcumin mimic libraries and curcumin; among the tested derivatives, 13b, 14b, and 14h are the strongest candidates inhibiting multidrug resistance cancer cells.

Bulletin of the Korean Chemical Society published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Quality Control of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Baca, Kalin R. published the artcilePhase Equilibria and Diffusivities of HFC-32 and HFC-125 in Ionic Liquids for the Separation of R-410A, Synthetic Route of 79917-90-1, the publication is ACS Sustainable Chemistry & Engineering (2022), 10(2), 816-830, database is CAplus.

Current legislation calling for the phase out of hydrofluorocarbon (HFC) refrigerants is driving a global market shift that has prompted industry and research institutions to investigate new refrigerant mixtures and sustainable separation techniques for recycling refrigerants. The recent American Innovation and Manufacturing (AIM) Act of 2020 requires an 85% phase down of HFC production over the next 15 years. To achieve this goal, azeotropic refrigerant mixtures, such as R-410A composed of 50 wt % HFC-32 (difluoromethane, CH₂F₂) and 50 wt % HFC-125 (pentafluoroethane, CHF₂CF₃), will have to be separated to recycle the lower global warming HFC-32 component. The present work investigates the solubility of HFC-32 and HFC-125 in six ionic liquids (ILs) with halogen anions for the purpose of developing the thermophys. property data required for designing extractive distillation recycling processes and understanding the choice of cation and anion type. A gravimetric microbalance was used to collect isothermal vapor-liquid equilibrium data for each of the ILs at 298.15 K and pressures from 0.05 to 1.0 MPa. The Peng-Robinson equation of state was used to model the solubility of the HFCs in the ILs. The solubility of HFC-32 in the ILs showed small differences, while the solubility of HFC-125 had significant variations with respect to the anion type and the cation alkyl chain length. Fick’s law was applied to calculate diffusion coefficients for each HFC/IL system. HFC-32 has a greater diffusivity than HFC-125 based on the smaller mol. size. The 1-n-hexyl-3-methylimidazolium chloride and the trihexyl(tetradecyl)phosphonium chloride ILs have the highest HFC-125/HFC-32 selectivity at 298.15 K. Based on both the mass uptake and selectivity ratio, these two ILs are potential entrainers for the separation of R-410A using extractive distillation

ACS Sustainable Chemistry & Engineering published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Synthetic Route of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sieron, Leslaw published the artcileTrityl losartan, Synthetic Route of 79047-41-9, the publication is Acta Crystallographica, Section C: Crystal Structure Communications (2004), C60(11), o821-o823, database is CAplus and MEDLINE.

The title compound (systematic name: {2-butyl-4-chloro-1-[2′-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-yl}methanol), C₄₁H₃₇ClN₆O, crystallizes in the centrosym. space group P1̅ with two independent mols. in the asym. unit. Crystallog. data are given. These mols. differ significantly only in the relative orientations of the rings in the biphenylyltetrazole moieties. One of the mols. shows disorder for three C atoms in the Bu group. H bonds link the mols. in an infinite chain along the a axis.

Acta Crystallographica, Section C: Crystal Structure Communications published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C14H26O2, Synthetic Route of 79047-41-9.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Furukawa, Yoshiyasu published the artcileNonpeptide angiotensin II receptor antagonists. Synthetic studies on imidazoleacetic acid derivatives, Quality Control of 79047-41-9, the publication is Takeda Kenkyushoho (1991), 56-74, database is CAplus.

An improved synthetic route using 4-hydroxymethyl-2-phenylimidazole was developed for the synthesis of diuretic and angiotensin II-inhibitory CV-2198 (I, R = R¹ = H) (II). This route achieved a facile synthesis of 2-alkyl-1-benzyl-4-chloroimidazole-5-acetic acids. Study of structure-activity relationships on the 10 compounds indicated that Bu, pentyl, and hexyl groups were favorable as the 2-alkyl groups and substitution by a Cl or NO₂ group at the o-position of the benzyl moiety increased the activity. Thus, I (R = Bu, R¹ = Cl) (CV-2947) and I (R = Bu, R¹ = NO₂) (CV-2961) had angiotensin II-inhibitory activity 100-fold stronger than that of II.

Takeda Kenkyushoho published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, Quality Control of 79047-41-9.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sekhar Pattanaik, Sudhansu published the artcileInvestigation of the inter-ionic interactions of an imidazolium-based ionic liquid with the aqueous solutions of tripotassium citrate and trisodium citrate through volumetric, acoustic and FTIR routes, Computed Properties of 79917-90-1, the publication is Journal of Molecular Liquids (2022), 118644, database is CAplus.

Volumetric, acoustic and spectroscopic characteristics of an imidazolium-based ionic liquid, 1-Butyl-3-methylimidazolium chloride ([bmim][Cl]) in water and aqueous solutions of tri-potassium citrate, K₃Cit, and tri-sodium citrate, Na₃Cit were studied at five different temperatures T = (298.15 K, 303.15 K, 308.15 K, 313.15Kand 318.15 K) and atm. pressure (0.1Mpa). The apparent molar volume,VΦ, and apparent molar compressibility, KΦ, S were computed from the exptl. data of densities and ultrasonic speeds. The derived properties such as standard partial molar volume, V⁰Φ , partial molar compressibilities, K⁰Φ,S, limiting apparent molar expansivity, E⁰Φ, and their corresponding transfer volumes, Δ_trV⁰Φ, transfer compressibilities, ΔtrK⁰Φ,S, of [bmim][Cl] from water to aqueous potassium/sodium citrate solutions were also determined The transfer properties have been used to discuss the solute-solvent interactions that exist in the solutions The pos. value of Hepler’s constant indicates that the IL has structure-making ability in the studied solutions In addition, FTIR spectroscopy was executed on the systems. Based on these data, the predominant mol. interactions occurring between [bmim][Cl] and water and in between [bmim][Cl] and K₃Cit/Na₃Cit were found to be hydrogen bonds.

Journal of Molecular Liquids published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C10H16Br3N, Computed Properties of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Popov, I. I. published the artcileStudy of unsaturated azole derivatives. VII. Novel syntheses of 2-vinylbenzimidazoles, Name: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1978), 1104-7, database is CAplus.

Vinylbenzimidazole I (R = H, R¹ = H, Me; R = Me, MeO, NO₂, R¹ = Me) were obtained in 50-90% yields in 3 steps from II (R = H, NO₂) by cyclocondensation with ClCH₂CO₂H or from III (R = H, Me, MeO, R¹ = Me, R² = CH₂OH) by chlorination with SOCl₂ to give III (R = CH₂Cl) which were treated with Ph₃P to give 62-94% triphenylphosphonium chloride which were condensed with CH₂O via a Wittig reaction.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Name: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Popov, I. I. published the artcileStudy of unsaturated azole derivatives. VII. Novel syntheses of 2-vinylbenzimidazoles, Synthetic Route of 7467-35-8, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1978), 1104-7, database is CAplus.

Vinylbenzimidazole I (R = H, R¹ = H, Me; R = Me, MeO, NO₂, R¹ = Me) were obtained in 50-90% yields in 3 steps from II (R = H, NO₂) by cyclocondensation with ClCH₂CO₂H or from III (R = H, Me, MeO, R¹ = Me, R² = CH₂OH) by chlorination with SOCl₂ to give III (R = CH₂Cl) which were treated with Ph₃P to give 62-94% triphenylphosphonium chloride which were condensed with CH₂O via a Wittig reaction.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Synthetic Route of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kerche, Eduardo Fischer published the artcileThe influence of ionic liquid concentration on microcrystalline cellulose modification, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Carbohydrate Polymer Technologies and Applications (2022), 100211, database is CAplus.

Ethanolic ionic liquid (IL) solutions, containing different 1-n-butyl-3-methylimidazolium chloride (C₄MImCl) concentrations were used to modify the surface of com. microcrystalline cellulose (MCC). The chosen ratios were: 4, 8, 16, and 32 weight% of IL, in relation to the MCC mass. These treatments with IL did not affect the MCC morphol. FTIR anal. showed the characteristic bands of C₄MImCl when the IL concentration was higher than 4 weight%. XRD diffractograms show that the crystals may have been disrupted for IL concentrations above 4 weight%. ¹H NMR confirmed the formation of strong hydrogen bonds between C₄MImCl and MCC, especially for MCC treated with 4 weight% of IL. The functionalization using IL, regardless of the content, showed two DTG peaks, without altering the MCC Arrhenius’ parameters and degradation mechanisms. 4 Weight% of C₄MImCl proved to be suitable for the MCC surface modification, improving thermal stability without detrimental effects on MCC morphol.

Carbohydrate Polymer Technologies and Applications published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem