Tag: M.W=100-200

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Medicinal Chemistry called Nα-Imidazolylalkyl and Pyridylalkyl Derivatives of Histaprodifen: Synthesis and in Vitro Evaluation of Highly Potent Histamine H1-Receptor Agonists, Author is Menghin, Sonja; Pertz, Heinz H.; Kramer, Kai; Seifert, Roland; Schunack, Walter; Elz, Sigurd, which mentions a compound: 3724-19-4, SMILESS is OC(=O)CCC1=CC=CN=C1, Molecular C8H9NO2, Recommanded Product: 3724-19-4.

A novel series of Nα-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen [i.e., 2-[2-(3,3-diphenylpropyl)imidazol-4-yl]ethanamine] was synthesized and evaluated as histamine H1-receptor agonists. The title compounds displayed partial agonism at contractile H1-receptors of guinea pig ileum and were at least equipotent with histamine. Agonist effects of the new derivatives were susceptible to blockade by the H1-receptor antagonist mepyramine (2-100 nM). In the imidazole series, suprahistaprodifen [i.e., 2-(3,3-diphenylpropyl)-N-[2-(1H-imidazol-4-yl)ethyl]-1H-Imidazole-4-ethanamine trihydrogen oxalate or [2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethyl]-[2-(1H-imidazol-4-yl)ethyl]amine, Nα-2-[(1H-imidazol-4-yl)ethyl]histaprodifen] showed the highest H1-receptor agonist potency ever reported in the literature (pEC50 8.26, efficacy Emax 96%). Elongation of the alkyl spacer from Et to Bu decreased activity from 3630% (Et substituent; suprahistaprodifen ) to 163% (Bu substituent) of histamine potency. The exchange of the terminal imidazole nucleus for a pyridine ring resulted in compounds with comparably high potency. A decrease in agonist potency and efficacy was observed when the attachment of the alkyl spacer was consecutively changed from the ortho to the meta and the para position, resp., of the pyridine ring. The pyridine series that contained a Bu chain possessed the highest potency and affinity. Nα-[4-(2-pyridyl)butyl]histaprodifen emerged as a strong partial agonist, being almost equipotent with suprahistaprodifen (pEC50 8.16, Emax 89%). Suprahistaprodifen and Nα-[4-(2-pyridyl)butyl]histaprodifen also showed potent partial agonism at contractile H1 receptors in guinea pig aorta and potently activated H1-receptor-mediated endothelium-dependent relaxation in the rat aorta. The compounds thus prepared displayed low to moderate affinity at H2, H3, and M3 receptors in functional models of guinea pig. Collectively, Nα-imidazolylalkyl- and Nα-pyridylalkyl-substituted histaprodifen derivatives represent a novel class of potent H1-receptor agonists. These compounds may be useful to define the (patho)physiol. role of the H1-receptor and refine mol. models of H1-receptor activation.

This compound(3-Pyridinepropionic acid)Recommanded Product: 3724-19-4 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Recommanded Product: 3724-19-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about A novel peptide-based encoding system for “”one-bead one-compound”” peptidomimetic and small molecule combinatorial libraries. Author is Liu, Ruiwu; Marik, Jan; Lam, Kit S..

The “”one-bead one-compound”” (OBOC) combinatorial library method is highly efficient, especially when used with well-established on-bead binding or functional assays. Literally, millions of compounds can be screened concurrently within 1 to 2 days. However, structure determination of peptidomimetic and small mol. compounds on one single bead is not trivial. A novel, highly efficient, and robust peptide-based encoding system has been developed for OBOC peptidomimetic and small mol. combinatorial libraries. In this system, topol. segregated bifunctional beads, which are made by a simple biphasic solvent strategy, are employed for the preparation and screening of an OBOC combinatorial peptidomimetic and small mol. libraries. Testing mols. are on the outer layer, and the coding tags in the interior of the bead do not interfere with screening. The coding tag is a peptide containing a large number of unnatural α-amino acids derived from different building blocks used for generating the peptidomimetic or small mol. By coupling common building blocks simultaneously to the scaffold of the testing compound and to the side chains of the α-amino acids on the coding peptide, extra synthetic steps are eliminated and the amount of undesirable side products is minimized. Pos. bead decoding is easy and straightforward as there is no need for cleavage and retrieval of the coding tag, and pos. beads can be sequenced directly with Edman degradation The authors demonstrate the efficiency and simplicity of their peptidyl encoding system by generating an encoded 158 400-member model peptidomimetic library and screening it for ligands that bind to streptavidin. Potent and novel ligands with clear motifs have been identified.

This compound(3-Pyridinepropionic acid)Recommanded Product: 3724-19-4 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Biomimetic hydroxylation of saturated carbons with artificial cytochrome P-450 enzymes-liberating chemistry from the tyranny of functional groups.HPLC of Formula: 3724-19-4.

Five mimics of cytochrome P 450 have been prepared and examined as catalysts for the specific hydroxylation of steroids. Reactions occur dictated by the geometries of the complexes, overcoming the intrinsic reactivity of a carbon-carbon double bond and of a secondary carbinol group. In some cases as many as 3000 catalytic turnovers are observed

《Biomimetic hydroxylation of saturated carbons with artificial cytochrome P-450 enzymes-liberating chemistry from the tyranny of functional groups》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Pyridinepropionic acid)HPLC of Formula: 3724-19-4.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-Pyridinepropionic acid(SMILESS: OC(=O)CCC1=CC=CN=C1,cas:3724-19-4) is researched.Quality Control of Tricyclohexylphosphonium tetrafluoroborate. The article 《Slow-Binding Human Serine Racemase Inhibitors from High-Throughput Screening of Combinatorial Libraries》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:3724-19-4).

One-bead one-compound combinatorial chem. together with a high-throughput screen based on fluorescently labeled enzyme allowed the identification of slow binding inhibitors of human serine racemase (hSR). A peptide library of topog. segregated encoded resin beads was synthesized, and several hSR-binding compounds were isolated, identified, and resynthesized for further kinetic study. Of these, several showed inhibitory effects with moderate potency (high micromolar KIs) toward hSR. A clear structural motif was identified consisting of 3-phenylpropionic acid and histidine moieties. Importantly, the inhibitors identified showed no structural similarities to the natural substrate, L-serine. Detailed kinetic analyses of the properties of selected inhibitors show that the screening protocol used here selectively identifies slow binding inhibitors. They provide a pharmacophore for the future isolation of more potent ligands that may prove useful in probing and understanding the biol. role of hSR.

《Slow-Binding Human Serine Racemase Inhibitors from High-Throughput Screening of Combinatorial Libraries》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Pyridinepropionic acid)Safety of 3-Pyridinepropionic acid.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Mukaiyama reagent as an efficient activating agent for anchoring carboxylic acids to hydroxymethylated resins, published in 2008-07-31, which mentions a compound: 3724-19-4, Name is 3-Pyridinepropionic acid, Molecular C8H9NO2, Related Products of 3724-19-4.

An efficient methodol. based on the use of Mukaiyama reagent as an activating agent for the immobilization of diverse carboxylic acids to hydroxymethylated resins through an ester linkage i s reported. The reaction efficiency was high for aromatic and aliphatic acids, including synthetic and biol. promising penicillin derivatives

《Mukaiyama reagent as an efficient activating agent for anchoring carboxylic acids to hydroxymethylated resins》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Pyridinepropionic acid)Related Products of 3724-19-4.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3724-19-4, is researched, Molecular C8H9NO2, about Cupric chelates of pyridinic acids. I. Monoacids, the main research direction is pyridine acid copper complex; copper pyridine acid.HPLC of Formula: 3724-19-4.

The pyridine monoacids (x-Q-(CH2)nCO2H), where x is the position of the substituent chain (2, 3 or 4 with respect to the heterocyclic N) and n = 0, 1, or 2, in aqueous solutions formed complexes with Cu2+ at Cu2+/complexing agent ratios of 1:1 and 1:2, except the 2-pyridinepropionic acid which did not give the 1:2 complex. The 2-pyridinemethanoic acid (or picolic acid, 2-QCO2H) was the only one to give, in alk. medium, a hydroxy complex: [Cu(2-QCO2)(OH2)]-. The acidity constants of the complexing agent mols. were measured by potentiometry and uv spectrophotometry. The formation constants of the complexes of the acids in positions 2 and 3 were calculated by potentiometry, polarog., and spectrometry. The stability of the complexes depend much more on the length and on the spatial configuration of the chelated rings than on the acidity of the complexing agent mols.

《Cupric chelates of pyridinic acids. I. Monoacids》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Pyridinepropionic acid)HPLC of Formula: 3724-19-4.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Edwards, Jacob T.; Merchant, Rohan R.; McClymont, Kyle S.; Knouse, Kyle W.; Qin, Tian; Malins, Lara R.; Vokits, Benjamin; Shaw, Scott A.; Bao, Deng-Hui; Wei, Fu-Liang; Zhou, Ting; Eastgate, Martin D.; Baran, Phil S. researched the compound: 3-Pyridinepropionic acid( cas:3724-19-4 ).Quality Control of 3-Pyridinepropionic acid.They published the article 《Decarboxylative alkenylation》 about this compound( cas:3724-19-4 ) in Nature (London, United Kingdom). Keywords: decarboxylative alkenylation. We’ll tell you more about this compound (cas:3724-19-4).

Olefin chem., through pericyclic reactions, polymerizations, oxidations, or reductions, has an essential role in the manipulation of organic matter. Despite its importance, olefin synthesis still relies largely on chem. introduced more than three decades ago, with metathesis being the most recent addition Here we describe a simple method of accessing olefins with any substitution pattern or geometry from one of the most ubiquitous and variegated building blocks of chem.: alkyl carboxylic acids. The activating principles used in amide-bond synthesis can therefore be used, with nickel- or iron-based catalysis, to extract carbon dioxide from a carboxylic acid and economically replace it with an organozinc-derived olefin on a molar scale. We prepare more than 60 olefins across a range of substrate classes, and the ability to simplify retrosynthetic anal. is exemplified with the preparation of 16 different natural products across 10 different families.

This compound(3-Pyridinepropionic acid)Quality Control of 3-Pyridinepropionic acid was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (6-Chloropyridin-2-yl)methanamine, is researched, Molecular C6H7ClN2, CAS is 188637-75-4, about Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group, the main research direction is morpholine aspartate HIV protease inhibitor preparation; HIV; MK-8718; inhibitor; protease.Name: (6-Chloropyridin-2-yl)methanamine.

A novel HIV protease inhibitor was designed using a morpholine core as the aspartate binding group. Anal. of the crystal structure of the initial lead bound to HIV protease enabled optimization of enzyme potency and antiviral activity. This afforded a series of potent orally bioavailable inhibitors of which MK-8718 was identified as a compound with a favorable overall profile.

This compound((6-Chloropyridin-2-yl)methanamine)Name: (6-Chloropyridin-2-yl)methanamine was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about The 3-(3-pyridine)propionyl anchor group for protease-catalyzed resolutions: p-toluenesulfinamide and sterically hindered secondary alcohols.Electric Literature of C8H9NO2.

Compared to an acetyl acyl group, the 3-(3-pyridine)propionyl group increases substrate binding to many proteases and substrate solubility in water, thereby increasing the rates of protease-catalyzed reactions. For example, proteases reacted up to six hundred-fold faster with the 3-(3-pyridine)propionyl ester of 1-phenylethanol than with the corresponding acetate ester. In addition, the 3-(3-pyridine)propionyl group enables a simple, mild acid extraction to sep. the remaining starting material and product. To demonstrate the synthetic usefulness of this strategy, we resolved multi-gram quantities of (R)- and (S)-p-toluenesulfinamide with α-chymotrypsin and gram quantities of (R)- and (S)-2,2-dimethylcyclopentanol with subtilisin Carlsberg. The 3-(3-pyridyl)propionyl group was better for these resolutions than the corresponding acetate or dihydrocinnamate because it decreased the reaction time due to increased reactivity, decreased the reaction volume due to increased substrate solubility and enabled purification without chromatog. Mol. modeling suggests the enantioselectivity of α-chymotrypsin toward (R)-p-toluenesulfinamide is high (E = 52) because of a favorable hydrophobic interaction between the p-tolyl group of the fast-reacting (R)-enantiomer and leaving group pocket. The enantioselectivity of subtilisin Carlsberg toward (S)-2,2-dimethylcyclopentanol is high (E = 43) because the large substituent (the 2,2-di-Me quaternary carbon) of the slow-reacting (R)-enantiomer cannot fit in the S1′ leaving group pocket.

This compound(3-Pyridinepropionic acid)Electric Literature of C8H9NO2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3724-19-4, is researched, SMILESS is OC(=O)CCC1=CC=CN=C1, Molecular C8H9NO2Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Structure-Based Discovery of Glycolipids for CD1d-Mediated NKT Cell Activation: Tuning the Adjuvant versus Immunosuppression Activity, Author is Fujio, Masakazu; Wu, Douglass; Garcia-Navarro, Raquel; Ho, David D.; Tsuji, Moriya; Wong, Chi-Huey, the main research direction is glycolipid derivative preparation structure immunostimulant CD1d NKT cell activation.SDS of cas: 3724-19-4.

Introduction of an aromatic group into the fatty acyl chain of α-GalCer modulates the activity and selectivity of IFN-γ/IL-4 secretion through CD1d-mediated activation of NKT cells. Compounds (I, II, and III) are more potent than α-Galcer and biased for IFN-γ than for IL-4. These new glycolipids may find use as adjuvants or as antimetastatic agents.

This compound(3-Pyridinepropionic acid)SDS of cas: 3724-19-4 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem