Tag: M.W=100-150

Ono, Takeshi published the artcileThe synthesis of ophidin, Name: (2-Methyl-1H-imidazol-4-yl)methanol, the publication is Hoppe-Seyler’s Zeitschrift fuer Physiologische Chemie (1956), 77-81, database is CAplus.

cf. f. Biochem. (Tokyo) 36, 265(1942). Ophidin (I), a dipeptide from snake muscle, was proven by synthesis to be 2-methyl-Nα – (β-alanyl)-L-histidine (II). D-fructose, AcH, NH₃, and CuCO₃ gave the Cu salt of 2-methyl-4-(hydroxymethyl)imidazole, which was freed from Cu by H₂S and isolated in 60% yield as the picrate, m. 187-90°, giving an HCl salt (III), m. 138-40°. III and SOCl₂ gave 2-methyl-4-(chloromethyl)imidazole, m. 125°, condensed with AcNHCH(CO₂Et), to give Et α-acetamido-α-carbethoxy-β-[4-(2-methylimidazolyl)]propionate (IV), m. 120°, in 50% yield. IV refluxed with concentrated HCl gave DL-2-methylhistidine (V) (isolated as the Hg salt and freed with H₂S), m. 231°; di-HCl salt (VI), m. 247°; dipicrate, m. 165°. V gave pos. ninhydrin and diazo reactions. The Ac derivative of V was resolved with acylase I to give L-2-methylhistidine (VII), m. 235°, [α]¹⁵_D -25.00° (1% aqueous solution). VI and β-phthalimido-propionyl chloride gave 50% phthalimide of DL-II, decompose 240°, which with N₂H₄ gave DL-II, m. 249°, in 72% yield. By similar reactions VII gave II, m. 246-8°, [α]¹²_D 36.6° (1% aqueous solution); picrolonate, m. 232° (undepressed by I picrolonate).

Hoppe-Seyler’s Zeitschrift fuer Physiologische Chemie published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Name: (2-Methyl-1H-imidazol-4-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kurdziel, K. published the artcileCoordination properties of 4(5)-hydroxymethylimidazole and 4(5)-hydroxymethyl-5(4)-methylimidazole towards cobalt(II) ions, Safety of (2-Methyl-1H-imidazol-4-yl)methanol, the publication is Journal of Coordination Chemistry (2007), 60(8), 877-889, database is CAplus.

Two new complexes of imidazole alcs., 4-hydroxymethylimidazole (4-CH₂OHim) and 4-hydroxymethyl-5-methylimidazole (4-CH₂OH-5-CH₃i.m.), with Co(II), [CoL₂(H₂O)₂](NO₃)₂ were obtained. These compounds were characterized through single x-ray diffraction studies, spectroscopic (IR, far-IR, UV-visible-NIR) and magnetic measurements. The hydroxymethylimidazole ligands are bidentate, coordinating the heterocyclic ring through pyridine-like N atoms and the O atom of the hydroxymethyl group (chromophore CoN₂O₄). The Co(II) coordination polyhedra are distorted octahedrons, with the equatorial plane defined by the 4-CH₂OHim (or 4-CH2OH-5-CH₃i.m.) bidentate ligands and two H₂O mols. occupying axial (trans) positions. Formation of successive Co(II) complexes with 4-CH₂OH-5-CH₃i.m. in aqueous solution was followed quant. by potentiometry.

Journal of Coordination Chemistry published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Safety of (2-Methyl-1H-imidazol-4-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Amodio, Emanuele published the artcileEffectiveness of mRNA COVID-19 Vaccines in Adolescents Over 6 Months., SDS of cas: 274-78-2, the main research area is .

BACKGROUND AND OBJECTIVES: On June 4, 2021, Italy launched the COVID-19 vaccination of adolescents to pace down the COVID-19 spread. Although clinical trials have evaluated mRNA vaccine effectiveness in adolescents, there is limited literature on its real-world effectiveness. Accordingly, this study aimed to estimate the effectiveness of mRNA COVID-19 vaccines against SARS-CoV-2 infection and mild or severe COVID-19 in a cohort of Sicilian adolescents within a six-month observation period. METHODS: A retrospective cohort study was conducted with adolescents aged 12-18, residents of Sicily, that were followed from July 15 to December 31, 2021. SARS-CoV-2 infections, mild and severe COVID-19, and COVID-19-related intubation or deaths during the study period were compared between subjects vaccinated with two doses of mRNA vaccines and unvaccinated individuals. The Cox regression analysis, adjusted for age and sex, was performed to compare the two groups. RESULTS: Overall, the study included a total at-risk population of 274,782 adolescents with 61.4% (168,633) of them having completed the vaccination cycle by the end of the study. Unvaccinated subjects had higher incidence rates of SARS-CoV-2 (1,043 x 10,000 vs. 158.7 x 10,000 subjects), mild COVID-19 (27.7 x 10,000 vs. 1.8 x 10,000 subjects) and severe COVID-19 (1.41 x 10,000 vs. 0 subjects) compared to the vaccinated population. The estimated adjusted vaccine effectiveness against SARS-CoV-2 infection was 71.2%, reaching 92.1% and 97.9% against mild and severe COVID-19, respectively. CONCLUSIONS: This study provides rigorous evidence of the mRNA COVID-19 vaccines effectiveness in protecting adolescents from both SARS-CoV-2 infection, and mild or severe COVID-19.

Pediatrics published new progress in MEDLINE about 274-78-2, 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, SDS of cas: 274-78-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wu, Qiongyou published the artcileSynthesis and characterization of potential photolabeling probes for studying the antiviral mechanisms of EICAR, Recommanded Product: 5-Amino-1-methyl-1H-imidazole-4-carboxamide, the main research area is diazoniumribofuranosylimidazole azidoribofuranosylimidazole carboxamide nucleoside preparation azidolysis nucleophilic substitution photolysis.

The designed photo-labeling probes: 5-diazonium-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide (I) and 5-azido-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide (II) were synthesized via a short and convenient synthetic route, namely by diazotizing AICAR and subsequently performing substitution with NaN3. Although I was not stable even at low temperatures, II showed a rapid and clean photochem. reaction, which suggests that it may be a valuable tool for use in photo-labeling studies.

Heterocycles published new progress about Azidation. 21343-04-4 belongs to class imidazoles-derivatives, name is 5-Amino-1-methyl-1H-imidazole-4-carboxamide, and the molecular formula is C5H8N4O, Recommanded Product: 5-Amino-1-methyl-1H-imidazole-4-carboxamide.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Milchev, Boyan published the artcileDiet of Barn Owl Tyto alba in central South Bulgaria as influenced by landscape structure, Category: imidazoles-derivatives, the main research area is diet Barn Owl landscape feeding ecol central South Bulgaria.

This study of the diet of Barn Owl Tyto alba analyzed pellets containing 18,810 prey specimens. Small mammals (98.2% by number, 97.5% by biomass) dominated, while birds, reptiles, amphibians, and insects constituted a negligible portion of the diet (1.8% by number, 2.5% by biomass). Voles (Microtus spp.) were the most numerous prey (35.3 ± 14.4%, range 14.6%-67.1%) in 9 localities (69.2%, n = 13 individually studied localities) and dominated the biomass in all diets (51.4 ± 14.1%, range 27.4%-78.2%). The lesser white-toothed shrew (Crocidura suaveolens) (20.8 ± 7.6%, range 7.3%-32.8%) was the most frequent prey in the other 4 localities (30.8%). The breeding localities with more similar proportions of habitats in their hunting territories had significantly higher diet overlaps (r = 0.336, P < 0.01). The amount of wetlands and the indexes of habitat heterogeneity and topog. relief among the landscape characteristics of the hunting territories significantly influenced diet composition according to redundancy anal. Larger areas of wetlands correlated with higher predation on wetland mammal species, as well as the European pine vole (Microtus subterraneus) and white-toothed shrews, and thus with broader food niche breadth. Turkish Journal of Zoology published new progress about Amphibia. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Category: imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ranganathan, Darshan published the artcileRepetitive imidazole synthesis using an immobilized imidazole template, HPLC of Formula: 21343-04-4, the main research area is imidazole repetitive synthesis template; ATP imidazole cycle model.

A model is presented for the chem. simulation of the ATP-imidazole cycle programmed to continuous production of the daughter imidazoles from the immobilized parent imidazole template. 6-Chloropurine was treated with chloromethylated polystyrene and hydrolysis of the product followed by alkylation with PhCOCH2Br afforded polymer-bound hypoxanthine I (R = CH2COPh, R1 = chloromethylated polystyrene). Treating I (R = CH2COPh, R1 = chloromethylated polystyrene) with PhCH2NH2 and p-MeC6H4SO3H produced the expected daughter mol., 1-benzyl-5-phenylimidazole (II) in 30% yield and the polymer-bound 5-aminoimidazole-4-carboxamide III, which, in turn, was transformed to the template hypoxanthine I (R = H) by treatment with MeSO3H followed by HCONH2. To prove the concept of the continuous generation of the daughter mol., the regenerated parent template was processed through a second cycle using the same protocol when the expected daughter product II was obtained in 14% yield. Polymer-bound adenine when subjected to a similar protocol failed to yield any daughter mol. Endeavors to prepare polymer-linked 4-oxoquinazoline and anthranilic acid are also reported.

Journal of Organic Chemistry published new progress about imidazole repetitive synthesis template; ATP imidazole cycle model. 21343-04-4 belongs to class imidazoles-derivatives, name is 5-Amino-1-methyl-1H-imidazole-4-carboxamide, and the molecular formula is C5H8N4O, HPLC of Formula: 21343-04-4.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Clark, Jim published the artcileHeterocyclic studies. XVI. Imidazo and diimidazopyrimidines, Quality Control of 274-78-2, the main research area is imidazopyrimidines; diimidazopyrimidines; pyrimidines imidazo.

Condensation of 2,4-dichloro-6-methyl-5-nitropyrimidine (I, X = Cl) with Cl(CH2)2NH2 gave the tetrahydrodiimidazopyrimidine (II). A hydrated derivative (III) of II was prepared by POCl3 treatment of either the 2,4-bis[(2-hydroxyethyl)amino]pyrimidine (I, X = NH(CH2)2OH), the dihydroimidazo[1,2-a]pyrimidine [IV, R1 = Me, R2 = NH(CH2)2OH] or the dihydroimidazo[1,2-a]pyrimidine (V). 4,6-Dichloro-2-methyl-5-nitropyrimidine (VI, X = Cl) and Cl(CH2)2NH2 gave the bis[(2-chloroethyl)amino]-pyrimidine (VI, X = NH(CH2)2Cl), which cyclized in two steps to the dihydroimidazo[1,2-c]pyrimidine [IV, R1 = NH(CH2)2Cl, R2 = Me] and then the quaternary tricyclic compound (VII).

Journal of the Chemical Society [Section] C: Organic published new progress about Cyclization. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Quality Control of 274-78-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Armarego, W. L. F. published the artcileTriazaindenes (diazaindolizines). The site of protonation, Application of Imidazo[1,2-c]pyrimidine, the main research area is .

The syntheses of 1,3a,4-, 1,3a,5-, 1,3a,6-, and 1,3a,7-triazaindenes and their 2,3-dihydro derivatives are described. Ionization and uv spectra measurements indicate that in each case protonation occurs on N-1. Evidence is given that 1,2,3a- and 2-methyl-1,3,3a-triazaindene cations are also protonated on N-1, but 1,2,7a-triazaindene cation is protonated on N-2.

Journal of the Chemical Society published new progress about Protonation. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Application of Imidazo[1,2-c]pyrimidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem