Tag: M.W=0-100

Some common heterocyclic compound, 288-32-4, name is 1H-Imidazole, molecular formula is C3H4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 288-32-4

EXAMPLE 2 Manufacturing of 1-[4-(4-phenylbutylamino)phenyl]imidazole STR22 9.5 g of imidazole were dissolved in 100 ml of DMF, and the resultant solution was further added with 6.1 g of 60% NaH while cooling it with ice. The solution was then stirred for 30 min. and further for 1 hour at room temperature. Then, the solution was added with 20.0 g of 4-chloronitrobenzene and then stirred for 2 hours at a temperature of from 80 to 85 C. The solution reacted was poured into ice water, and the crystals precipitated was filtered and then dried to obtain 22.5 g of 4-(imidazole-1-yl)nitrobenzene.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 288-32-4, its application will become more common.

Reference:
Patent; Nippon Soda Co., Ltd.; US5965743; (1999); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

288-32-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 288-32-4 as follows.

To imidazole (0.41 g, 6.0 mmol) in CH2CI2 was added bromoacetonitrile (0.21 g, 2.0 mmol), and the reaction was refluxed for 30 minutes. The mixture was cooled to room temperature and filtered, and the filtrate was concentrated to give the desired product.

According to the analysis of related databases, 1H-Imidazole, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AUTOIMMUNE PHARMA LLC; BENISON, Jeffrey; (157 pag.)WO2018/152405; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7098-07-9 as follows. 7098-07-9

General procedure: To a vigorously stirred solution of imidazole derivatives (23.39mmol) in dry toluene (10mL) at room temperature was added the solution of chloromethyl-salicylaldehydes 2a, b (19.50mmol) in dry toluene (10mL), drop-wise, under nitrogen atmosphere. The resulting solution was further stirred at 60¡ãC for 24h. The product separated out was washed twice with toluene (2¡Á5mL) and several times with ether (5¡Á10mL), to remove the unreacted materials, and dried under vacuum to give pale yellow solid which used for the following preparations without further purification. Samples of the products were nevertheless isolated and fully characterized, as described below.

According to the analysis of related databases, 7098-07-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Elshaarawy, Reda F.M.; Janiak, Christoph; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 31 – 42;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

288-32-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 288-32-4 name is 1H-Imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of N-H heterocycle (1 mmol) and aryl halide (2 mmol) in toluene were added catalyst (0.07 g, 0.016 mmol) and K2CO3 (276 g, 2 mmol) and the mixture stirred at 110 C for the specified time. The progress of the reaction was monitored by TLC. The reaction mixture allowed cooling to room temperature and ethyl acetate (25 mL) was added and the mixture stirred for 15 min to ensure product removal from catalyst. Then the catalyst was filtered, washed with ethyl acetate (2 9 25 mL). The organic layer was evaporated under vacuum on a rotary evaporator and the crude product was obtained. Further purification was achieved by column chromatography using ethyl acetate/n-hexane gradient. Structural assignments of the products are based on their 1H NMR and melting point.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Imidazole, and friends who are interested can also refer to it.

Reference:
Article; Hosseinzadeh, Rahman; Aghili, Nora; Tajbakhsh, Mahmood; Catalysis Letters; vol. 146; 1; (2016); p. 193 – 203;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

10111-08-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10111-08-7 as follows.

General procedure: A typical procedure involves, in a round-bottom flask equipped with a refluxcondenser, in which a mixture of 4-hydroxycoumarin (2 mmol), arylaldehyde(1 mmol), PIL catalyst (10 mol%) and 5 mL of ethanol was stirred at 80 C.The reaction was monitored by TLC. After completion of the reaction, a solidproduct is obtained which is filtered and recrystallized with ethanol(Scheme 2).

According to the analysis of related databases, Imidazole-2-carboxaldehyde, the application of this compound in the production field has become more and more popular.

Reference:
Article; Patil, Sandip K.; Awale, Deepak V.; Vadiyar, Madagonda M.; Patil, Suryakant A.; Bhise, Sagar C.; Kolekar, Sanjay S.; Research on Chemical Intermediates; vol. 43; 10; (2017); p. 5365 – 5376;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem