Tag: M.W=0-100

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288-32-4, name is 1H-Imidazole, This compound has unique chemical properties. The synthetic route is as follows., Formula: C3H4N2

Reference Example 7-1 N,N-Dimethyl-1H-imidazole-1-sulfonamide [Show Image] Imidazole (5.00 g, 73.6 mmol) was dissolved in toluene (80 ml), and thereto were added triethylamine (9.52 ml, 68.4 mmol) and dimethylsulfamoyl chloride (6.77 ml, 63.3 mmol), and the mixture was stirred at room temperature for 8 hours. The precipitates were removed by filtration, and the filtrate was concentrated under reduced pressure. The resulting residue was subjected to azeotropic distillation with hexane to give the title compound (10.9 g, 98 %). 1H NMR (CDCl3, 400 MHz) delta 7.87 (s, 1H), 7.23 (d, 1H, J = 1.4 Hz), 7.11 (d, 1H, J = 1.4 Hz), 2.82 (s, 6H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 288-32-4.

Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; EP1647546; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 288-32-4, These common heterocyclic compound, 288-32-4, name is 1H-Imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

0.680 g (10 mmol) of imidazole was weighed and 1.240 g (10 mmol) of p-fluorobenzaldehyde and 1.380 g (10 mmol) of anhydrous potassium carbonate were weighed and dissolved in 25 mL of N, N-dimethylformamide, Thermometer, stirring device 50mL four-necked flask.60 C for 20h, cooled to room temperature, poured into 100mL ice water, a yellow solid precipitated, suction filtered, recrystallized from ethanol, dried at 50 C for 8h under vacuum to give 4-imidazolyl benzaldehyde

The synthetic route of 288-32-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Qilu University of Technology; Xu Ting; Duan Hongdong; Bu Juan; (12 pag.)CN107043353; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 693-98-1, name is 2-Methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Product Details of 693-98-1

General procedure: To a stirred solution of aryl halide (1.2mmol) and [Pd(pp3S4)(dba)] (1mol %) in isopropanol (2.5ml) was added nitrogen/oxygen nucleophile (1mmol) followed by Cs2CO3 (2mol %) in the atmosphere of air. The mixture was heated to 80C and the progress of the reaction was monitored by TLC. After completion, the solvent was evaporated through rotavapour and the crude mixture was washed with dichloromethane-H2O and the organic phase was separated and dried over Na2SO4. The dichloromethane was evaporated followed by flash column purification on silica gel of the crude to obtain the pure products. The products were characterized using 1H, 13C NMR spectroscopy and GC-MS spectroscopy. The characterization data were in good agreement with those described in the literature.

The synthetic route of 693-98-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Majumder, Arpi; Gupta, Ragini; Mandal, Mrinmay; Babu, Madhu; Chakraborty, Debashis; Journal of Organometallic Chemistry; vol. 781; (2015); p. 23 – 34;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

1072-62-4, name is 2-Ethyl-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2-Ethyl-1H-imidazole

To a stirred slurry of9.95 g (0.125 mole) copper oxide in 100 mL 2% aqueous acetic acid at 95 0C was added 25.24 g (0.263 mole) 2-ethylimidazole. The mixture was brought to a boil and maintained under reflux for several hours. The resulting slurry was filtered and the solids washed with water and dried at 105 0C to give a brown powder. The product (23.92 g, 75% yield) gave a unique X-ray diffraction pattern and was confirmed to have the composition of copper 2- ethylimidazolate, by elemental analysis. Some unreacted copper oxide was present in the product.

The synthetic route of 1072-62-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; U.S. BORAX INC.; WO2007/87434; (2007); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 1072-63-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1072-63-5, name is 1-Vinyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Comprising the steps of: 0.840 g of alpha-mercaptomethyltrimethoxysilane prepared in Example 6 and 1.176 g of 1-Vinylimidazole were placed in a round bottom flask wrapped in aluminum box paper. Then, 8 mL of tetrahydrofuran was added, and after mixing uniformly, 0.076 g of benzoin dimethyl ether was added, the mixture was uniformly stirred, the aluminum box paper was removed, and irradiated at room temperature for 30 minutes under a UV lamp having a power of 20 W and a wavelength of 365 nm. After the completion of the reaction, the solvent was distilled off under reduced pressure, and the degree of vacuum was 5 to 6 mmHg, which was precipitated three times in n-hexane, and dried under vacuum at 40 C to a constant weight to obtain alpha-(1-ethylimidazolyl)mercaptomethyltrimethoxysilane, purity 96%, yield 96%. The infrared spectrum of the product alpha-(1-ethylimidazolyl)mercaptomethyltrimethoxysilane obtained in this example is shown in Fig. 19, and the nuclear magnetic resonance spectrum is shown in Fig. 20. 19 and 20, the product obtained in this example was alpha-(1-ethylimidazolyl)mercaptomethyltrimethoxysilane

The synthetic route of 1-Vinyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shandong University; Bei Yiling; Gao Yanhong; Zhu Qingzeng; Feng Shengyu; (24 pag.)CN109053794; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57090-88-7, name is 1H-Imidazole-4-carbonitrile belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 1H-Imidazole-4-carbonitrile

Example 1A Ethyl (4-cyano-1H-imidazol-1-yl)acetate 3.3 g (35.3 mmol) of 1H-imidazole-4-carbonitrile [Matthews et al., J. Org. Chem. 1986, 51, 3228-3231] are initially charged in 13.2 ml (11.5 g, 35.3 mmol) of 21percent strength sodium ethoxide solution in ethanol, and 4.3 ml (6.5 g, 38.9 mmol) of ethyl bromoacetate are added. The reaction mixture is stirred at RT for 16 h. For work-up, the precipitated solid is filtered off, the filter residue is washed with ethanol and the filtrate is concentrated under reduced pressure. Diisopropyl ether is added to the residue, the mixture is filtered again, the filtrate is once more concentrated on a rotary evaporator and the residue is dried under reduced pressure. Yield: 3.8 g (60percent of theory) LC-MS (Method 1): Rt=1.17 min; MS (ESIpos): m/z=180 [M+H]+; 1H-NMR (400 MHz, DMSO-d6): delta=8.12 (s, 1H), 7.88 (s, 1H), 5.06 (s, 2H), 4.18 (q, 2H), 1.22 (t, 3H).

The synthetic route of 57090-88-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2009/269420; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 3034-50-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3034-50-2 as follows.

A. 1-Trityl-4-carboxaldehyde-1H-imidazole (cas No.33016-47-6) According to procedure outlined in J. Med. Chem. 2002, 45(1), 177, to imidazole-4-carboxaldehyde (15.0 g, 156.2 mmol) in DMF (300 mL) is added triethylamine (43.8 ml, 312 mmol) followed by trityl chloride (44.4 g, 159.0 mmol). The reaction mixture is stirred at ambient temperature for 18 h before the solvent is removed in vacuo. The resulting solid is dissolved in dichloromethane and washed with sodium bicarbonate and water. The organic phase is concentrated in vacuo to give the desired material as a solid.

According to the analysis of related databases, 3034-50-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Ksander, Gary Michael; Meredith, Erik; Monovich, Lauren G.; Papillon, Julien; Firooznia, Fariborz; Hu, Qi-Ying; US2007/49616; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 930-62-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 930-62-1 as follows.

1. Preparation of 1-(2,4-dichlorophenyl)-2-(4-methylimidazol-2-yl)ethan-1-one. A solution of 2,4-dichlorobenzoyl chloride (7.24 M) in dichloromethane (25 ml) was added dropwise over 20 minutes to a stirred solution of 2,4-dimethylimidazole (0.80 M) in dichloromethane (75 ml) and N,N-diisopropylethylamine (Huenig’s base) (34 ml). The reaction mixture was cooled during the addition using a water bath. The reaction mixture was then heated to reflux for 5 hours. The reaction can turn a darker color. The product was stripped of solvent under reduced pressure, and the resulting solid was dried in vacuo for one hour. To the dry solid (described above) was added a solution (2:1 v/v, 120 ml) of gla. acetic acid and aq. con. HCl. The mixture was then stirred at reflux for ca. 90 min. The acetic acid was removed via rotary evaporator. Upon cooling, distilled water (200 ml) and toluene (100 ml) were added to the solid residue, which was vigorously stirred for 30 min. The solids were filtered, rinsed with 50 ml distilled water, and discarded. The filtrate was transferred to a separatory funnel. After the organic layer was discarded, the aqueous layer was washed with toluene (2¡Á100 ml). The aqueous layer was transferred to a large beaker (2 L) and diluted with isopropyl ether (50 ml). The stirred mixture was basified (pH 7-8) by careful addition of sodium bicarbonate which leads to the formation of a sticky white solid. Dichloromethane (200 ml) was added and stirring continued for 10 min. The organic layer was separated and the aqueous layer was again extracted with dichloromethane (100 ml). The organic layers were combined and washed with sat. aq. NaHCO3 (100 ml), distilled water (100 ml), brine (100 ml), dried with Na2SO4, filtered, concentrated, and dried in vacuo giving 1-(2,4-dichlorophenyl)-2-(4-methylimidazol-2-yl)ethan-1-one in 46% yield.

According to the analysis of related databases, 930-62-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bennett, Christina N.; Hankenson, Kurt D.; Harrison, Stephen D.; Longo, Kenneth A.; MacDougald, Ormond A.; Wagman, Allan S.; US2005/54663; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

3034-50-2, Adding a certain compound to certain chemical reactions, such as: 3034-50-2, name is Imidazole-4-carbaldehyde, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3034-50-2.

Reference Example 11 To 4 (5) -formylimidazole (2 g, 20.8 mmol) were added D Ac (30 mL) and triethylamine (3.5 mL, 25.0 mmol, 1.2 equivalents), and then trityl chloride (4.06 g, 14.6 mmol, 0.7 equivalents) was added thereto at room temperature. The mixture was stirred at room temperature for 24 hr, and to the reaction mixture was added water (60 mL) at room temperature, and the mixture was stirred at room temperature for 2 hr. The crystals werecollected by filtration, washed with water, and vacuum-dried(50C) to a constant amount to give a crude compound (4.6 g) . To the crude compound (0.2 g) was added methanol (1 mL) , and the. mixture was stirred at room temperature for 2 hr. The crystals were collected by filtration, was washed withmethanol (0.2 mL) , and vacuum-dried (50C) to a constant amount to give l-trityl-4-formyl-lH-imidazole (0.14 g) . yield 65%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Imidazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KAWABATA, Yoichi; SAWAI, Yasuhiro; KANNO, Kazuaki; SAWADA, Naotaka; WO2012/173280; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

7098-07-9, name is 1-Ethyl-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 7098-07-9

(1) in the equipped with a stirrer,thermometer,Calcium chloride drying tube and dropping funnel500 ml four-necked flask6.10 g (0.05 mol) of 1,3-propanesultone and150 mL of ethyl acetate was added and the mixture was stirred1,3-propane sultone dissolved,The flask was heated in an oil bath equipped with methyl silicone oil70 ¡ã C,Slowly drop dissolved(0.065 mol) of N-ethylimidazole50 mL of ethyl acetate was added dropwise(Dropwise addition time: 30 min)Insulation reaction 2h,Pressure filtration,The residue was washed with ethyl acetate,Vacuum drying,To give 1- (3-sulfopropyl) -3-ethylimidazolium salt (EIm-PS)10.20 g,The yield was 93.6percent.

Statistics shows that 7098-07-9 is playing an increasingly important role. we look forward to future research findings about 1-Ethyl-1H-imidazole.

Reference:
Patent; Guangxi Kemao Forest Chemical Co., Ltd.; Jiangxi Jinan Forest Products Industrial Co., Ltd.; Guangdong Komo Co., Ltd.; Weng, Liang; Xu, Sheyang; Chen, Jiuji; (16 pag.)CN104926664; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem