Tag: M.W=0-100

Synthetic Route of 7098-07-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7098-07-9, name is 1-Ethyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of Zn(CH3COO)22H2O (0.1705 g, 0.8 mmol), NH4VO3(0.1404 g, 0.8 mmol), eIM (0.3 mL), and H2O (8 mL) was heated at about 120 ¡ãC for 72 h. After the mixture was cooled to room temperature, yellow crystals were isolated from the mixture.Yield: 76percent (based on NH4VO3); Anal. Calcd. for C30H48Zn2N12V4O12(percent): C, 32.63; H, 4.35; N, 15.23. Found: C, 32.76; H, 4.41; N, 15.21.

The synthetic route of 1-Ethyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Niu, Yan-Hong; Yang, Song; Li, Ji-Kun; Xu, Yan-Qing; Hu, Chang-Wen; Chinese Chemical Letters; vol. 27; 5; (2016); p. 649 – 654;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 288-32-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 288-32-4, name is 1H-Imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Under nitrogen, imidazole was dissolved in anhydrous THF, and an appropriate amount of acetic anhydride was dropped slowly into the solution; then reaction was carried out for about half an hour accompanied by exothermic phenomena. After the reaction was completed, the solvent was removed by vacuum reduced pressure concentration to generate a solid product. Then, the obtained solid was rinsed with n-hexane and filtered to provide compound 11 as white solid, with yield of about 98percent.

The synthetic route of 1H-Imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eternal Chemical Co., Ltd.; Cheng, Pi-Jen; Chou, Meng-Yen; Lee, Chuan Zong; Wu, Chung-Jen; US2013/172569; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 693-98-1,Some common heterocyclic compound, 693-98-1, name is 2-Methyl-1H-imidazole, molecular formula is C4H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To the reaction vessel containing benzimidazole or imidazole (1mmol), alkyl halide (1mmol), 50% NaOH (0.5mL) and anionic surfactant sodium dodecyl sulfate (5mol%) was added and the reaction mixture was vigorously stirred at room temperature or 60C. After the completion of reaction (TLC) followed by standard workup using ethyl acetate as extracting solvent the crude product was purified over silica-gel (60-120 mesh) using ethyl acetate-hexane (3:7) as eluent to afford pure products. Identities of the products were judged by the comparison of melting point, IR data, 1H NMR, 13C NMR and HRMS analyses.

The synthetic route of 693-98-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chakraborty, Ankita; Debnath, Sudipto; Ghosh, Tanmoy; Maiti, Dilip K.; Majumdar, Swapan; Tetrahedron; vol. 74; 40; (2018); p. 5932 – 5941;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 1739-84-0, name is 1,2-Dimethyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1739-84-0, SDS of cas: 1739-84-0

General procedure: Quaternization of 1,2-dimethylimidazole withalkyl halides was performed in acetonitrile (50% solution)at the boiling point of the solvent and an equimolarratio of the starting reagents for 48 h. The solvent was then removed, and lithium bis(trifluoromethylsulfonyl)imide (10% excess) in water (30% solution) was added to the solid residue, and the reaction mixture was stirred for 30 min. The desired product precipitated from water into the lower liquid phase. The upper aqueous layer was decanted, methylene chloride (equal volume) was added to the lower layer, and the resulting solution was washed again with distilled water till negative reaction to Cl- with AgNO3. The ionic liquids were dried by azeotropic distillation of absolute methylene chloride, then the traces of the organic solvent were removed in vacuum by heating (3 h at 100C).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2-Dimethyl-1H-imidazole, and friends who are interested can also refer to it.

Reference:
Article; Krasovskiy; Chernikova; Glukhov; Kapustin; Koroteev; Russian Journal of Physical Chemistry; vol. 92; 12; (2018); p. 2379 – 2385; Zh. Fiz. Khim.; vol. 92; 12; (2018); p. 1851 – 1858,8;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 288-32-4, The chemical industry reduces the impact on the environment during synthesis 288-32-4, name is 1H-Imidazole, I believe this compound will play a more active role in future production and life.

General procedure: In a flame-driedvessel, equipped with a magnetic stirrer, under argon atmosphere,were added 0.3 mL of anhydrous acetonitrile, the nucleophile (imidazoleor benzimidazole – 0.75 mmol, 1.5 eq.), the electrophile(alkyl or aryl iodide – 0.5 mmol, 1 eq.), the base (1 mmol, 2 eq.),and the copper catalyst (0.05 mmol – 10% loading). The reactionvessel was heated to 80 C and left under stirring for 24 h. Thereaction mixture was then allowed to cool to room temperature,diluted with dichloromethane (5 mL) and filtered through celite. The celitepad was further washed with dichloromethane(2 x 5 mL). The combined organic phases were washed with water(2 x 5 mL) and brine (2 x 5 mL). The organic solvents were thenremoved in vacuo to yield the crude product, which was purifiedby flash column chromatography on silica gel using a gradient mixtureof ethyl acetate/petroleum ether as eluent. The 1H and 13CNMR spectral data for all N-arylatedimidazoles and benzimidazolesare in full agreement with those reported to literature [57-61].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Milenkovi?, Milica R.; Papastavrou, Argyro T.; Radanovi?, Du?anka; Pevec, Andrej; Jagli?i?, Zvonko; Zlatar, Matija; Gruden, Maja; Vougioukalakis, Georgios C.; Turel, Iztok; An?elkovi?, Katarina; ?obelji?, Bo?idar; Polyhedron; vol. 165; (2019); p. 22 – 30;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 3034-50-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3034-50-2, name is Imidazole-4-carbaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a stirring solution of 1H-imidazole-4-carbaldehyde (2.00 g, 20.81 mmol) in THF (20 mL) was added DMAP (0.64 g, 5.20 mmol) and TEA (5.80 ml, 41.60 mmol) followed by Boc-anhydride (5.80 mL, 24.98 mmol) and the resulting reaction mixture was stirred as ambient temperature for 18 h. The reaction mixture was concentrated to dryness under reduced pressure and diluted with water (50 mL). The solid precipitate was filtered and dried under vacuum to obtain Intermediate 130A (2.50 g, 49.00%) as a pale yellow solid. 1H NMR (400 MHz, DMSO-d6) G ppm 1.59 (s, 9 H), 8.37-8.39 ( d, J = 5.40 Hz, 2 H), 9.80 (s., 1 H). LCMS (Method-O): retention time 1.00 min, [M-56] 141.2.

The synthetic route of Imidazole-4-carbaldehyde has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; YADAV, Navnath Dnyanoba; BHIDE, Rajeev S.; BORA, Rajesh Onkardas; GUNAGA, Prashantha; PANDA, Manoranjan; PRIESTLEY, Eldon Scott; RICHTER, Jeremy; (444 pag.)WO2018/222795; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

288-32-4, name is 1H-Imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 1H-Imidazole

Synthesis of 1-benzylimidazole 9 illustrated by step (a) of FIG. 3. (0085) According to the selected experimental protocol, 44 g of imidazole (0.65 mol.), 100 g of benzyl chloride (0.78 mol.), and 60 g of KOH (1.07 mol.) in 700 ml of THF are placed in a 1-liter balloon flask. The reaction mixture is brought to reflux for 120 h, then cooled at ambient temperature. The organic phase is filtered and the solvent is evaporated under reduced pressure. The obtained solid product is dissolved in 500 ml of CH2Cl2, then washed with water (3¡Á100 ml). The organic phase is dried on Na2SO4, filtered, then evaporated under reduced pressure. The collected solid is recristallized in toluene to yield 67 g of desired product.

The synthetic route of 288-32-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Peugeot Citroen Automobiles SA; CNRS (Centre National de la Recherche Scientifique); Glipa, Xavier; Ameduri, Bruno; Delon, Louis; Jones, Deborah; Roziere, Jacques; Frutsaert, Guillaume; US8859160; (2014); B2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 693-98-1, name is 2-Methyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 693-98-1, Quality Control of 2-Methyl-1H-imidazole

10 mmol of 2-methyl-1H-imidazole was added to a suspensionof potassium carbonate (10 mmol) in acetonitrile (10 mL), and then stirred for 15 min at r.t. 10 mmol of1-(chloromethyl)benzene was added to the reaction mixture and the mixture was heated to 70C and kept for 72 h. After completion of the reaction, the solvent was removed and the residue was dissolved in EtOAc (20 mL), washed with H2O(2¡Á10 mL) and concentrated under reduced pressure. The residue was purified by silica gel chromatography (eluent: CHCl3)to afford the desired product. Yield 38%; yellow oil; UV-Vis (chloroform, lambda, nm): 290; IR spectrum (KBr, nu, cm-1): 2939,1712, 1508, 1434, 1365, 1272, 1118, 983, 721; 1H NMR (250.13 MHz, CDCl3) delta: 7.43-7.32 (m, 5H), 7.17-7.14 (m, 2H), 6.99(d, J = 1.3 Hz, 1H), 6.84 (d, J = 1.2 Hz, 1H), 5.11 (s, 2H), 2.27 (s, 3H); 13C NMR (62.9 MHz, CDCl3) delta: 144.3, 138.0, 129.3,128.1, 127.5, 127.1, 120.9, 49.2, 13.4.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Bouchouit; Bouraiou; Bouacida; Belfaitah; Merazig; Journal of Structural Chemistry; vol. 57; 4; (2016); p. 835 – 839; Zh. Strukt. Kim.; vol. 57; 4; (2016); p. 873 – 876,4;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 1072-63-5,Some common heterocyclic compound, 1072-63-5, name is 1-Vinyl-1H-imidazole, molecular formula is C5H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Allyl chloride (0.10 mol, 7.652 g) was added dropwise over a periodof 30 min to a round-bottomed flask containing 1-benzylimidazole(0.05 mol, 7.910 g) in 20mLAcN under continuous stirring. The mixturewas then stirred for about 1 h and subsequently refluxed at 70 C for24 h till a light brown liquid forms. Excess reactants and solvent wereremoved by rotary evaporation. The crude product was then diluted inan appropriate volume of water and washed three times with 15 mLethyl acetate in a separating funnel. Finally, excess water was removedby rotary evaporation and dried under vacuum at 60 C overnight

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Vinyl-1H-imidazole, its application will become more common.

Reference:
Article; Sidek, Nadiah; A. Manan, Ninie S.; Mohamad, Sharifah; Journal of Molecular Liquids; vol. 240; (2017); p. 794 – 802;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 10111-08-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10111-08-7 name is Imidazole-2-carboxaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of acetophenone 7 (0.56g, 3.0mmol) and imidazole-4-carbaldehyde (0.29g, 3.0mmol) in ethanol (25mL) was added 10% sodium hydrate aqueous (5mL), the mixture was stirred for 24h at room temperature [17]. The solution was acidified with 1N HCl and filtered, and the filter cake was recrystallized from ethanol got 8 as white power (0.60g). Yield: 87.4%;

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Imidazole-2-carboxaldehyde, and friends who are interested can also refer to it.

Reference:
Article; Zhang, Ling; Ge, Yu; Wang, Qing Ming; Zhou, Cheng-He; Bioorganic Chemistry; vol. 88; (2019);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem