Tag: M.W=0-100

Electric Literature of 822-55-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 822-55-9, Name is 4-(Hydroxymethyl)imidazole, SMILES is OCC1=CNC=N1, belongs to imidazoles-derivatives compound. In a article, author is Navas, JM, introduce new discover of the category.

Induction of cytochrome P4501A (CYPIA) by clotrimazole, a non-planar aromatic compound. Computational studies on structural features of clotrimazole and related imidazole derivatives

The classical pathway for induction of cytochrome P4501A (CYP1A) by xenobiotics is ligand binding to the aryl hydrocarbon receptor (AhR). High-affinity AhR ligands are planar polyaromatic molecules such as the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The present work investigated the ability of the imidazole derivative, clotrimazole [ 1-(2′ chlorotrityl)imidazole, CLO], to induce CYP1A in cultured rainbow trout (Oncorhynchus mykiss) hepatocytes at the catalytic activity (determined as 7-ethoxyresorufin-O-deethylase, EROD) and at the transcriptional level. CLO resulted in a significant increase of hepatocyte EROD activity and CYP1A mRNA at a concentration of 1.56 muM. Computational studies on the molecular structure of CLO show that CLO is unlikely to take a planar conformation. Further indications that CLO does not behave like a planar AhR ligand come from the experimental observation that co-incubation of trout hepatocytes with CLO and the AhR antagonist, alpha-naphthoflavone (alpha-NF), did not result in an inhibition of CLO induction of CYP1A mRNA, whereas alpha-NF was able to inhibit CYP1A induction by the prototpyic, planar AhR ligand, beta-naphthoflavone. The experimental findings on CLO agree with previous results obtained for another non-planar imidazole derivative, 1-benzylimidazole (B1M). Further, computational studies showed that the non-planar imidazoles, BIM and CLO, are highly similar with respect to some electrostatic properties, namely the dipole moment and the molecular electrostatic potential (MEP). Overall our experimental and computational studies suggest that transcriptional activation of CYP1A by the imidazole derivatives CLO and BIM is mediated by a mechanism different to that of prototypic CYP1A inducers such as the planar AhR-ligands. (C) 2004 Elsevier Inc. All rights reserved.

Electric Literature of 822-55-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 822-55-9.

Electric Literature of 1072-63-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 1072-63-5, Name is 1-Vinyl-1H-imidazole, SMILES is C=CN1C=CN=C1, belongs to imidazoles-derivatives compound. In a article, author is EL-Sharief, Marwa A. M. Sh, introduce new discover of the category.

Synthesis and Evaluation of Antibacterial and Antifungal Activities of 1,3-Disubstituted-4-thioxoimidazolidin-2-one Derivatives

1,3-Disubstituted-4-thioxoimidazolidin-2-one derivatives with various substituents at N(1 )and N-3 were synthesized with high yields and excellent purity by the reaction of various N-arylcyanothioformamide derivatives with isocyanate derivatives. The activity of these products as antibacterial and antifungal agents was studied to through some light on structural activity relationship. Some of synthesized compounds showed significant antibacterial and antifungal activities. Most of the imidazole derivatives possess significant antifungal activity aginst S. cerevisiae (MIC 1-10 mu g mL(-1)). As comparision with ketoconazole, most of the imidazole derivatives showed activity ranging from 50 % less activity to fourfold activity.

Electric Literature of 1072-63-5, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 1072-63-5 is helpful to your research.

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 822-55-9, Name is 4-(Hydroxymethyl)imidazole, molecular formula is C4H6N2O, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Yue, Yuanyuan, once mentioned the new application about 822-55-9, Recommanded Product: 4-(Hydroxymethyl)imidazole.

Synthesis of imidazole derivatives and the spectral characterization of the binding properties towards human serum albumin

Small molecular drugs that can combine with target proteins specifically, and then block relative signal pathway, finally obtain the purpose of treatment. For this reason, the synthesis of novel imidazole derivatives was described and this study explored the details of imidazole derivatives binding to human serum albumin (HSA). The data of steady-state and time-resolved fluorescence showed that the conjugation of imidazole derivatives with HSA yielded quenching by a static mechanism. Meanwhile, the number of binding sites, the binding constants, and the thermodynamic parameters were also measured; the raw data indicated that imidazole derivatives could spontaneously bind with HSA through hydrophobic interactions and hydrogen bonds which agreed well with the results from the molecular modeling study. Competitive binding experiments confirmed the location of binding. Furthermore, alteration of the secondary structure of HSA in the presence of the imidazole derivatives was tested. (C) 2015 Elsevier B.V. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 822-55-9. The above is the message from the blog manager. Recommanded Product: 4-(Hydroxymethyl)imidazole.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 1072-62-4, Name is 2-Ethyl-1H-imidazole, SMILES is CCC1=NC=CN1, in an article , author is Jayachandran, JP, once mentioned of 1072-62-4, Product Details of 1072-62-4.

N-alkylation of 2,4,5-triphenyl imidazole derivatives using a new phase transfer reagent under PTC conditions

The phase transfer catalyzed N-alkylation of 2,4,5-triphenyl imidazole derivatives using a new phase transfer reagent namely, 2-benzilidine-N,N,N,N’,N’,N’-hexaethyl propane-1,3-diammonium dibromide have been described. The structures of all the 14 compounds have been established by spectroscopic means.

Interested yet? Read on for other articles about 1072-62-4, you can contact me at any time and look forward to more communication. Product Details of 1072-62-4.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Product Details of 693-98-1, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 693-98-1, Name is 2-Methyl-1H-imidazole, molecular formula is C4H6N2. In an article, author is STUPNISEKLISAC, E,once mentioned of 693-98-1.

IMIDAZOLE DERIVATIVES AS CORROSION-INHIBITORS FOR ZINC IN HYDROCHLORIC-ACID

The efficiency of various imidazole derivatives as zinc corrosion inhibitors in hydrochloric acid (HCl) was investigated using electrochemical and gravimetric methods. A difference in efficiency (z) was observed with the introduction of different substituents into a imidazole skeleton. It was established that substituents which increased the electron density at the reaction center improved the corrosion inhibiting properties of the heterocyclic compound. A linear correlation between reaction kinetic data and the sum of the polar substituent constants was obtained.

If you¡¯re interested in learning more about 693-98-1. The above is the message from the blog manager. Product Details of 693-98-1.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1072-62-4, Name is 2-Ethyl-1H-imidazole, molecular formula is C5H8N2. In an article, author is Ruan, Yi-tong,once mentioned of 1072-62-4, COA of Formula: C5H8N2.

Preparation of Imidazole Derivatives via Bisfunctionalization of Alkynes Catalyzed by Ruthenium Carbonyl

A one-step, oxidative bisfunctionalization of alkynes to generate cis-enediol diacetates catalyzed by ruthenium carbonyl (triruthenium dodecacarbonyl) is presented. The reaction was performed using the alkyne, (diacetoxyiodo) benzene, Ru-3(CO)(12) as the catalyst, and toluene as the solvent at 100 degrees C to give the cis-enediol diacetates in up to 82% yields. This method overcomes the shortcomings of existing methods, such as tedious reaction steps, substrate limitations, and the use of toxic reagents. Furthermore, the reaction of module cis-enediol diacetates with ammonium carbonate [(NH4)(2)CO3] in an alcohol solvent gave imidazole derivatives in 37-84% yields, thus providing a simple and mild new method for the synthesis of imidazole compounds.

Interested yet? Keep reading other articles of 1072-62-4, you can contact me at any time and look forward to more communication. COA of Formula: C5H8N2.

Synthetic Route of 616-47-7, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 616-47-7, Name is 1-Methyl-1H-imidazole, SMILES is CN1C=CN=C1, belongs to imidazoles-derivatives compound. In a article, author is Mariappan, G., introduce new discover of the category.

Design, synthesis and neuropharmacological activity of dihydro imidazole derivatives

A new series of dihydro imidazole derivatives have been synthesized and characterized by UV-Vis, IR, H-1 NMR and mass spectroscopy. The synthesized compounds have been screened for neuro pharmacological activities. All the compounds are effective; amongst them compound 8 shows more prominent anticonvulsant and CNS depressant property. The standard drug diazepam at 25 mg / kg i.p. has been used for comparison. The results are statistically treated for their significance at p<0.05 and p<0.01 level. Synthetic Route of 616-47-7, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 616-47-7 is helpful to your research.

822-55-9, Name is 4-(Hydroxymethyl)imidazole, molecular formula is C4H6N2O, Recommanded Product: 4-(Hydroxymethyl)imidazole, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Macchiarulo, A, once mentioned the new application about 822-55-9.

1,4-benzothiazine and 1,4-benzoxazine imidazole derivatives with antifungal activity: A docking study

We have recently described the synthesis and antifungal activity of a series of 1,4-benzothiazine and 1,4-benzoxazine imidazole derivatives that mainly showed in vivo activity against a murine experimental model of candidiasis but that very often lacked in vitro activity. Here, we report a docking study of a representative set of our molecules in a 3D model of CYP51 of Candida albicans (CA-CYP51). The model was constructed on the basis of the sequence homology relationship with the recently reported crystal structure of the CYP51 of Mycobacterium tuberculosis (MT-CYP51). (C) 2002 Elsevier Science Ltd. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 822-55-9 help many people in the next few years. Recommanded Product: 4-(Hydroxymethyl)imidazole.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1072-63-5, name is 1-Vinyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1072-63-5

A 100-mL round-bottom flask, equipped with reflux condenser and magnetic stirrer was flame dried while flushed with nitrogen. Anhydrous tetrahydrofuran (THF) 50 ml_ was added into the flask via syringe. THF solution of 0.5M 9-borabicyclo[3.3.1]nonane (9-BBN) (0.02 mole) was added, followed by 0.021 mole of freshly distilled 1 -vinyl imidazole. The reaction mixture was refluxed for 5 hours. The reaction mixture was gradually cooled to room temperature and 25 ml_ of 3M odium hydroxide solution was added. Later 25 ml_ of 30% hydrogen peroxide was added dropwise into the flask and the mixture was stirred for 5 hours to complete oxidation. The reaction mixture was extracted with 20-mL portions of ethyl ether, and the combined extracts dried with anhydrous magnesium sulfate. Distillation under reduced pressure gave 83% of 1.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1072-63-5.

Reference:
Patent; MIMOS BERHAD; AHMAD, Mohd Rais; WO2010/33014; (2010); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57090-88-7, name is 1H-Imidazole-4-carbonitrile belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 57090-88-7

A 22-L, four-neck, round-bottom flask equipped with a mechanical stirrer, a temperature probe, and an addition funnel with a nitrogen inlet was charged with IH- imidazole-4-carbonitrile (830 g, 8.91 mol, as prepared in the previous step), potassium carbonate (2.47 kg, 17.8 mol), and acetone (6.0 L). Agitation was initiated and the mixture was cooled to 10 0C with an ice bath. SEMCl (1.50 kg, 9.00 mol) was added through the addition funnel over 210 min to maintain the internal temperature below 15 0C. The reaction was then allowed to warm to ambient temperature and stirred at ambient temperature overnight (20 h). The reaction mixture was then cooled in an ice bath to 10 0C and quenched by the slow addition of water (8.0 L) over 30 min to maintain the internal temperature below 30 ¡ãC. The resulting mixture was transferred to a 22-L separatory funnel and extracted with ethyl acetate (2 x 7.0 L). The combined organics were concentrated under reduced pressure at 35 0C to give the crude product as a dark brown oil, EPO which was purified through a plug of silica gel (16.5 x 20 cm, 2.4 kg silica gel) using 2:1 heptane/ethyl acetate (15 L) as eluent. The fractions containing the product were combined and concentrated under reduced pressure at 35 0C to afford a mixture of the title compounds as a light brown oil [1785 g, 90percent). The 1H NMR spectrum was consistent with the assigned structure and indicated the presence of a 64:36 ratio of regioisomers.

The synthetic route of 57090-88-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2006/47277; (2006); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem