Tag: M.W=0-100

Application of 1072-62-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 1072-62-4, Name is 2-Ethyl-1H-imidazole, SMILES is CCC1=NC=CN1, belongs to imidazoles-derivatives compound. In a article, author is Wang, Jinchang, introduce new discover of the category.

Electrochemical and Theoretical Study of Imidazole Derivative as Effective Corrosion Inhibitor for Aluminium

The corrosion inhibition performance of 2-styryl-1,8-dihydro-1,3,8-triaza-cyclopentaindene (IIZ) on Aluminium in 1M HCl was investigated by electrochemical impedance spectroscopy (EIS), Potentiodynamic polarization, scanning electron microscopy (SEM), atomic force microscopy (AFM), and quantum chemical techniques. Potentiodynamic polarization study confirmed that IIZ is mixed type inhibitor with cathodic predominance. SEM and AFM confirm the formation of an adsorption film on the aluminium surface. Quantum chemical study reveals that protonated IIZ interacts more than neutral IIZ. The theoretical data obtained are in agreement with experimental results.

Application of 1072-62-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 1072-62-4 is helpful to your research.

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 1072-63-5, Name is 1-Vinyl-1H-imidazole, molecular formula is C5H6N2. In an article, author is Olender, Dorota,once mentioned of 1072-63-5, Recommanded Product: 1072-63-5.

Anti-Candida Activity of 4-Morpholino-5-Nitro- and 4,5-Dinitro-Imidazole Derivatives

The activities of some 4-morpholino-5-nitro- and 4,5-dinitro-imidazole derivatives with respect to several Candida species were evaluated. It is established that 4,5-dinitroimidazole derivatives constitute an important group of compounds possessing antifungal activity against Candida species. Some analogs showed moderate antifungal ability in vitro, especially in relation well-known antifungals such as flucytosine (5FC). The best results of antifungal action were obtained for 1-(3-bromo-2-hydroxypropyl)-2-methyl-4,5-dinitroimidazole (3c), 1-(3-bromo-2-oxopropyl)-2-methyl-4,5-dinitroimidazole (4c) and 2-methyl-1-phenacyl-4,5-dinitroimidazole (2b). The latter compound proved to be effective against Candida sake S-1 (in contrast to inactive 5FC).

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Reference of 616-47-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 616-47-7, Name is 1-Methyl-1H-imidazole, SMILES is CN1C=CN=C1, belongs to imidazoles-derivatives compound. In a article, author is Wnuk, Malgorzata, introduce new discover of the category.

Prediction of antimicrobial activity of imidazole derivatives by artificial neural networks

The main goal of our study is the analysis of data obtained from molecular modeling for a series of imidazole derivatives that possess strong antifungal activity. The research was designed to use artificial neural network (ANN) analysis to determine quantitative relationships between the structural parameters and anti-Streptococcus pyogenes activity of a series of imidazole derivatives. ANN in association with quantitative structure-activity relationships (QSAR) represents a promising tool in the search for drug candidates among the practically unlimited number of possible derivatives. In this work, a series of 286 imidazole derivatives presented as cationic three-dimensional structures was used. The activity was expressed as a logarithm of the reciprocal of the minimal inhibitory concentrations, log 1/MIC. Multilayer perceptron ANN was used for predictions of antimicrobial potency of new imidazole derivatives on the basis of their structural descriptors. The obtained correlation coefficient equaled 0.9461 for the learning set, 0.9060 for the validation set and 0.8824 for the testing set of imidazole derivatives. Hence, satisfactory and practically useful predictions of anti-Streptococcus pyogenes activity for a series of imidazole derivatives was obtained, supporting the future successful interpretation of QSAR analysis for those compounds.

Reference of 616-47-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 616-47-7 is helpful to your research.

In an article, author is lauro, Figueroa-Valverde, once mentioned the application of 616-47-7, Name is 1-Methyl-1H-imidazole, molecular formula is C4H6N2, molecular weight is 82.1, MDL number is MFCD00005292, category is imidazoles-derivatives. Now introduce a scientific discovery about this category, Recommanded Product: 616-47-7.

Synthesis and biological activity of two oxireno-azecin-imidazole derivatives on perfusion pressure via guanylate cyclase inhibition

Some drugs have used in the treatment of heart failure; however, several of these drugs can produce secondary effects such as arrhythmia, hypotension and others. Therefore, the objective of this study was to synthesize two oxireno-azecin-imidazole derivatives (compounds 13 and 14) from two estradiol and estrone analogs through a series of reactions which involving; a) addition; b) acetylation; c) epoxidation; d) formation of two azecine derivatives; e) removal of silyl fragment of the azecines with hydrofluoric acid. Additionally, these compounds were confirmed by NMR spectroscopic data. Then, biological activity of the oxireno-diazepam-imidazole derivatives against perfusion pressure was evaluate in an isolated rat heart model, using the BAY-41-2272 (guanylate cyclase agonist), NS-2028 (guanylate cyclase inhibitor) and nifedipine (calcium channel antagonist) as controls. The results indicate that compounds 13 and 14 increased the perfusion pressure in the absence or presence of BAY-41-2272 and NS-2028; however, this effect was inhibited by nifedipine. These data indicate that compounds 13 and 14 could have a dual effect on perfusion pressure through guanylate cyclase inhibition and calcium channel type-L activation.

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Synthetic Route of 693-98-1, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 693-98-1, Name is 2-Methyl-1H-imidazole, SMILES is CC1=NC=CN1, belongs to imidazoles-derivatives compound. In a article, author is Adeyemi, Oluyomi Stephen, introduce new discover of the category.

Imidazole derivatives as antiparasitic agents and use of molecular modeling to investigate the structure-activity relationship

Toxoplasmosis is a common parasitic disease caused by Toxoplasma gondii. Limitations of available treatments motivate the search for better therapies for toxoplasmosis. In this study, we synthesized a series of new imidazole derivatives: bis-imidazoles (compounds 1-8), phenyl-substituted 1H-imidazoles (compounds 9-19), and thiopene-imidazoles (compounds 20-26). All these compounds were assessed for in vitro potential to restrict the growth of T. gondii. To explore the structure-activity relationships, molecular analyses and bioactivity prediction studies were performed using a standard molecular model. The in vitro results, in combination with the predictive model, revealed that the imidazole derivatives have excellent selectivity activity against T. gondii versus the host cells. Of the 26 compounds screened, five imidazole derivatives (compounds 10, 11, 18, 20, and 21) shared a specific structural moiety and exhibited significantly high selectivity (> 1176 to > 27,666) towards the parasite versus the host cells. These imidazole derivatives are potential candidates for further studies. We show evidence that supports the antiparasitic action of the imidazole derivatives. The findings are promising in that they reinforce the prospects of imidazole derivatives as alternative and effective antiparasitic therapy as well as providing evidence for a probable biological mechanism.

Synthetic Route of 693-98-1, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 693-98-1.

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Adiyala, Praveen Reddy, once mentioned the application of 1072-62-4, Name is 2-Ethyl-1H-imidazole, molecular formula is C5H8N2, molecular weight is 96.13, MDL number is MFCD00005192, category is imidazoles-derivatives. Now introduce a scientific discovery about this category, Category: imidazoles-derivatives.

Continuous-flow photo-induced decarboxylative annulative access to fused imidazole derivatives via a microreactor containing immobilized ruthenium

Visible-light-driven continuous-flow decarboxylative annulation was achieved and used along with a microreactor containing immobilized ruthenium catalyst to construct valuable fused imidazole derivatives with high yields under an open atmosphere. Notably, this chemistry included the use of l-proline and alpha-azidochalcone as precursors of an alpha-amino radical and 2H-azirine via photo-induced decarboxylation and denitrogenation, respectively, to give the annulated imidazole derivatives as a result of the formation of two new C-N bonds. Moreover the novel, environmentally benign and efficient continuous-flow protocol was further improved by carrying out the reaction in a polydimethylsiloxane (PDMS) microreactor with immobilized Ru3+ under fluorescent or white LED light, enabling excellent yields (70-94%) at a reaction time (2 min) significantly shorter than that (16 h) of the batch protocol.

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Crystallization Processes through Self-assembled Materials Dependent on the Substituents of Tetrapodal Adamantanes

Three tetrapodal tetraaryladamantanes bearing imidazole derivatives exhibit unique self-assembly and crystallization behaviors, including hollow spherical aggregation, a morphological change by fusion events, and phase transition into crystals. In crystals, the packing and arrangements of tetrapodal adamantanes are subject to the substituents of imidazole derivatives in the molecules.

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616-47-7, Name is 1-Methyl-1H-imidazole, molecular formula is C4H6N2, Name: 1-Methyl-1H-imidazole, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Gulevich, Anton V., once mentioned the new application about 616-47-7.

The first example of a diastereoselective thio-Ugi reaction: A new synthetic approach to chiral imidazole derivatives

The first example of a diastereoselective thio-Ugi reaction with chiral a-methylbenzylamine is described. The reaction results in formation of two diastereomers of thioamides, the major of which was isolated. We have found that under similar conditions stereochemical results of the thio-Ugi reaction are opposite to stereochemical results of the Ugi reaction. Several chiral thioamides were synthesized. The reaction of thioamides with ammonia results in substituted amidines, which can be cyclized to imidazole derivatives in aqueous HC1. The synthesis of chiral imidazole derivatives was elaborated. Using certain approaches, both isomers of a key synthon in the synthesis of SB203386 (an orally bioactive HIV-1 protease inhibitor) were prepared. The scope, limitations, and stereochemistry of the approach are discussed.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 616-47-7 help many people in the next few years. Name: 1-Methyl-1H-imidazole.

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 1072-62-4, Name is 2-Ethyl-1H-imidazole, SMILES is CCC1=NC=CN1, in an article , author is PEDERSEN, M, once mentioned of 1072-62-4, HPLC of Formula: C5H8N2.

FORMATION AND ANTIMYCOTIC EFFECT OF CYCLODEXTRIN INCLUSION COMPLEXES OF ECONAZOLE AND MICONAZOLE

The stability constants between beta-cyclodextrin (beta-CD) and the two antimycotic imidazole derivatives, miconazole and econazole were measured. Increased ionization of the imidazole derivatives decreased the size of the stability constants. The same phenomenon was observed for miconazole and hydroxypropyl-beta-cyclodextrin. In addition, the type of solubility diagram obtained was dependent on the degree of ionization of the imidazole derivatives. A type Bs solubility diagram was obtained for econazole and beta-CD in buffer solution, pH 7.1. An econazole beta-CD complex with a molar ratio of 1:1 was isolated. In a fluid medium the antimycotic effect of the econazole beta-CD complex against a strain of Candida albicans was superior to the effect of a physical mixture of the two compounds. A small inhibitory effect of beta-CD on the growth of the test organism was observed.

Interested yet? Read on for other articles about 1072-62-4, you can contact me at any time and look forward to more communication. HPLC of Formula: C5H8N2.

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , COA of Formula: C3H4N2, 288-32-4, Name is 1H-Imidazole, molecular formula is C3H4N2, belongs to imidazoles-derivatives compound. In a document, author is FLORIS, G, introduce the new discover.

PLATINUM(IV) COMPLEXES WITH PURINE OR PYRIMIDINE AND IMIDAZOLE DERIVATIVES

Pt(IV) mixed chloride complexes with purine or pyrimidine and imidazole derivatives have been prepared and characterized. The compounds have general formula [Pt(L1)(L2)Cl4], where L1 = purine (pur) or pyrimidine (pyr) and L2 = N-methylimidazole (N-MeIm), N-ethylimidazole (N-EtIm) or N-propylimidazole (N-PropIm), except for the complex [Pt(pur)(pyr)CI4]. The nitrogen bases act as monodentate ligands coordinated via nitrogen. The far i.r. and electronic reflectance spectra indicate a hexacoordinate geometry. The complexes competitively inhibit lentil amine oxidase, with highest inhibition for [Pt(pur)(N-EtIm)Cl4].

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 288-32-4. COA of Formula: C3H4N2.