Tag: M.W=0-100

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 822-55-9, Name is 4-(Hydroxymethyl)imidazole, SMILES is OCC1=CNC=N1, belongs to imidazoles-derivatives compound. In a document, author is Olender, Dorota, introduce the new discover, Computed Properties of C4H6N2O.

Anti-Candida Activity of 4-Morpholino-5-Nitro- and 4,5-Dinitro-Imidazole Derivatives

The activities of some 4-morpholino-5-nitro- and 4,5-dinitro-imidazole derivatives with respect to several Candida species were evaluated. It is established that 4,5-dinitroimidazole derivatives constitute an important group of compounds possessing antifungal activity against Candida species. Some analogs showed moderate antifungal ability in vitro, especially in relation well-known antifungals such as flucytosine (5FC). The best results of antifungal action were obtained for 1-(3-bromo-2-hydroxypropyl)-2-methyl-4,5-dinitroimidazole (3c), 1-(3-bromo-2-oxopropyl)-2-methyl-4,5-dinitroimidazole (4c) and 2-methyl-1-phenacyl-4,5-dinitroimidazole (2b). The latter compound proved to be effective against Candida sake S-1 (in contrast to inactive 5FC).

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 822-55-9 is helpful to your research. Computed Properties of C4H6N2O.

Chemistry is an experimental science, Computed Properties of C5H6N2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1072-63-5, Name is 1-Vinyl-1H-imidazole, molecular formula is C5H6N2, belongs to imidazoles-derivatives compound. In a document, author is Zhu, Yingzhong.

A Series of Imidazole Derivatives: Synthesis, Two-Photon Absorption, and Application for Bioimaging

A new series of D-pi-A type imidazole derivatives have been synthesized and characterized. Two corresponding imidazolium salts (iodine and hexafluorophosphate) were prepared from the imidazole compound. Their electron-withdrawing ability can be largely tunable by salt formation reaction or ion exchange. UV-vis absorption and single-photon fluorescence spectra have been systematically investigated in different solvents. The two-photon cross sections (delta(2PA)) of the imidazole derivatives are measured by two-photon excited fluorescence (2PEF) method. Compared with those of T-1 (107 GM) and T-3 (96GM), T-2 (imidazolium iodine salt) has a large two-photon absorption (2PA) cross section value of 276 GM. Furthermore, the cytotoxicity and applications in bioimaging for the imidazole derivatives were carried out. The results showed that T-1 can be used as a lysosomal tracker with high stability and water solubility within pHs of 4-6, while T-2 and T-3 can be used as probes for cell cytoplasm.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1072-63-5, in my other articles. Computed Properties of C5H6N2.

Related Products of 288-32-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 288-32-4, Name is 1H-Imidazole, SMILES is C1=NC=CN1, belongs to imidazoles-derivatives compound. In a article, author is Khaled, K. F., introduce new discover of the category.

Electrochemical and molecular dynamics simulation studies on the corrosion inhibition of aluminum in molar hydrochloric acid using some imidazole derivatives

The corrosion inhibition and adsorption characteristics of three selected imidazole derivatives namely, 2-amino-4,5-imidazoledicarbonitril (AID), 5-amino-4-imidazolecarboxamide (AIC) and imidazole (IM) on aluminum in 1.0 M HCl was investigated at 25 A degrees C. Measurements were carried out under various experimental conditions using chemical (weight loss), and electrochemical (Tafel polarization and impedance) methods. Molecular dynamics (MD) method and density functional theory were also applied here for theoretical study. Results obtained showed that inhibition efficiency of these compounds increases with increase in their concentrations due to the formation of a surface film on the aluminum surface. Adsorption energy as well as hydrogen bond length calculations showed that AID was the best corrosion inhibitor among the tested imidazole derivatives. Polarization measurements reveal that the selected imidazole derivatives function mainly as cathodic-type inhibitors. Physisorption, followed by chemisorption was proposed as the mechanism for the inhibition process. Adsorption via H-bond formation was also considered here. Results obtained from theoretical study were found to confirm experimental findings.

Related Products of 288-32-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 288-32-4.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 1072-62-4, Name is 2-Ethyl-1H-imidazole, molecular formula is C5H8N2, belongs to imidazoles-derivatives compound. In a document, author is Lauro, Figueroa-Valverde, introduce the new discover, Product Details of 1072-62-4.

Design and synthesis of some imidazole derivatives: theoretical evaluation of interaction with a coronavirus (HCoV-NL63)

Some compounds have been developed for the treatment of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) using different protocols; however, some methods use different reagents which are dangerous and require special conditions. the objective of this investigation was to synthesize some imidazole derivatives from 2-methyl-5-nitroimidazole using some reactions such as etherification, reduction, and a hydroxy-keto derivative formation. In addition, the theoretical activity of imidazole derivatives (compounds 2, 3 and 5-8) was evaluated in a docking model using hydroxylchloroquine and favipiravir as controls. The results showed that 1) compounds 3 and 5 have a higher affinity by 5ewp protein surface compared with hydroxylchloroquine, favipiravir, 2 and 6-8. In conclusion, compounds 3 and 5 could inhibit the biological activity of coronavirus.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 1072-62-4. Product Details of 1072-62-4.

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 288-32-4, Name is 1H-Imidazole, SMILES is C1=NC=CN1, in an article , author is Malhotra, Vineet, once mentioned of 288-32-4, Product Details of 288-32-4.

Substituted imidazole derivatives as novel cardiovascular agents

A series of novel substituted imidazole derivatives were synthesized and have been screened in vivo for their hypotensive and acute toxicity activities. Out of seventeen compounds eight compounds (2b, 2c, 3b, 3c, 3f, 4a, 4b and 4c) have shown good hypotensive & bradycardiac responses. Compounds 3b, 3c, 3f & 4c have shown better activity than reference drug clonidine. All the compounds have shown ALD50>1000mg/kg with maximum in 2e & 4c (>1200mg/kg). (C) 2010 Elsevier Ltd. All rights reserved.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 288-32-4, you can contact me at any time and look forward to more communication. Product Details of 288-32-4.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 822-55-9, Name is 4-(Hydroxymethyl)imidazole, formurla is C4H6N2O. In a document, author is Navas, JM, introducing its new discovery. SDS of cas: 822-55-9.

Induction of CYPIA by the N-imidazole derivative, 1-benzylimidazole

Xenobiotics can induce cytochrome P4501A (CYP1A) by ligand binding to the aryl hydrocarbon receptor (AhR). Typical AhR ligands are polycyclic aromatic compounds with planar molecular conformation. The present work investigated the ability of the N-imidazole derivative, 1-benzylimidazole (BIM), to induce CYP1A in rainbow trout hepatocytes. Benzylimidazole increased hepatocellular CYP1A catalytic activity (determined as 7-ethoxyresorufin-O-deethylase [EROD] activity) and CYP1A mRNA in a concentration-dependent way. Computational studies on the molecular structure of BIM indicated that the energetically most stable BIM conformer has the imidazole ring and the phenyl ring in different planes, i.e., does not take a planar conformation. This property of BIM does not agree with the structural requirements of a typical AhR ligand. In line with this observation, we found that the AhR antagonist, alpha-naphthoflavone (alphaNF), was not able to inhibit BIM induction of EROD activity and CYP1A mRNA, although it inhibited the induction of CYP1A by the prototypic AhR ligand, alpha-naphthoflavone (betaNF). The results suggest that transcriptional activation of CYP1A by the N-imidazole derivative, BIM, is not mediated through direct ligand binding to the AhR.

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Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 288-32-4, Name is 1H-Imidazole, SMILES is C1=NC=CN1, in an article , author is Aydogan, Goezde, once mentioned of 288-32-4, Safety of 1H-Imidazole.

Mutagenic activities of ten imidazole derivatives in Salmonella typhimurium

Ten imidazole derivatives were tested for mutagenicity in Salmonella typhimurium strains TA98 and TA100 both in the absence and presence of metabolic activation by the microsomal fraction S9 mix. In a general manner, derivatives tested exhibited a greater mutagenic activity in the TA100 strain comparing to the responses in TA 98. In the standard plate incorporation assay, 8 of these substances (80%) were found to be mutagenic for at least one of the two strains in the presence or absence of metabolic activation. Two compounds showed positive results in TA98 and 6 compounds were also mutagenic in TA100 without S9. In the presence of S9 mix, all of the 10 substances were non-mutagenic in TA98, whereas 4 compounds were positive in TA100. The results suggested the mutagenic potentials of the imidazole derivatives particularly inducing the reversion of base-pair substitutions. According to the structure-activity relationships phenyl groups in position 2 with different substituents can confer the mutagenic activity of the tested compounds. Methyl groups in different positions of these phenyl substituents can cause different types of mutations. This mutagenic effect is observed more clearly when the phenyl group is inhibited with a nitro group.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 288-32-4, you can contact me at any time and look forward to more communication. Safety of 1H-Imidazole.

Reference of 1072-62-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 1072-62-4, Name is 2-Ethyl-1H-imidazole, SMILES is CCC1=NC=CN1, belongs to imidazoles-derivatives compound. In a article, author is MAURICE, M, introduce new discover of the category.

EFFECTS OF IMIDAZOLE DERIVATIVES ON CYTOCHROMES-P450 FROM HUMAN HEPATOCYTES IN PRIMARY CULTURE

The expression of several forms of cytochrome P450 including P450 1A2, 2D6, 2E1 and 3A was investigated in human hepatocytes maintained in primary culture for 96 h in the absence or presence of 50-mu-M of various imidazole derivatives. These included ketoconazole, clotrimazole, miconazole, fluconazole, secnidazole and metronidazole. In addition, the typical inducers rifampicin and beta-naphthoflavone were used for comparison. Western and Northern blot analysis of microsomes and RNA prepared from these cultures as well as de novo synthesis experiments revealed that, among the imidazole derivatives tested, only clotrimazole was a strong rifampicin-like inducer of P450 3A. The expression of the other forms of P450 tested was not affected by the treatments. Analysis of the inhibition of 13 monoxygenase activities, including ethoxyresorufin and phenacetin O-deethylases, coumarin 7-alpha-, lauric acid 11- and 12-, mephenytoin 4-, debrisoquin 4-, and aniline hydroxylases, benzphetamine, aminopyrine, mephenytoin and erythromycin demethylases, and cyclosporin oxidase (representative of 10 different forms of P450 in human liver microsomes) revealed that ketoconazole was a strong and selective in vitro inhibitor of P450 3A (cyclosporin oxidase) with a K(i) < 1-mu-M. Clotrimazole and miconazole were also strong inhibitors of P450 3A-mediated activities in contrast to the other imidazole derivatives. Reference of 1072-62-4, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1072-62-4.

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 822-55-9, Name is 4-(Hydroxymethyl)imidazole. In a document, author is GRECH, E, introducing its new discovery. Safety of 4-(Hydroxymethyl)imidazole.

COUPLING OF NU(NH…N) VIBRATIONS WITH THE GAMMA(NH…N) OVERTONE IN SOLID IMIDAZOLE DERIVATIVES

The IR spectra of a number of imidazole derivatives were studied in the solid state at room and liquid nitrogen temperatures. The bands ascribed to stretching and out-of-plane deformation vibrations of NH groups involved in strong NH…N hydrogen bonds were analysed. The energy of this bond reflected in the position of the nu(NH…N) band changes over a broad range so that it was possible to investigate band shaping due to the overlap with the overtone band of the gamma(NH…N) mode. The correlation between the gamma(NH…N) and nu(NH…) frequencies shows that the gamma(NH…N) value for strong NH…N bridges only slightly depends on nu(NH…N).

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 822-55-9 help many people in the next few years. Safety of 4-(Hydroxymethyl)imidazole.

In an article, author is Singh, Ambrish, once mentioned the application of 616-47-7, Name is 1-Methyl-1H-imidazole, molecular formula is C4H6N2, molecular weight is 82.1, MDL number is MFCD00005292, category is imidazoles-derivatives. Now introduce a scientific discovery about this category, Computed Properties of C4H6N2.

Electrochemical, surface and quantum chemical studies of novel imidazole derivatives as corrosion inhibitors for J55 steel in sweet corrosive environment

The corrosion inhibition performance of three novel imidazole derivatives namely 2-(4-methoxyphenyl)4,5-diphenyl-imidazole (M-1), 4,5-diphenyl-2-(p-tolyl)-imidazole (M-2) and 2-(4-nitrophenyl)-4,5-diphenyl-imidazole (M-3) for J55 steel in CO2 saturated brine solution was studied by weight loss method, electrochemical impedance spectroscopy (EIS), potentiodynamic polarization, scanning electrochemical microscopy (SECM), contact angle, scanning electron microscope (SEM), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS) and quantum chemical calculation. M-1 exhibited the best inhibition efficiency of 93% at 400 mg/L concentration. The adsorption of the imidazole derivatives obeyed the Langmuir adsorption isotherm. Contact angle measurement reveals the hydrophobic nature of J55 steel in presence of inhibitors. Quantum chemical calculation well supports the experimental results. (C) 2017 Elsevier B.V. All rights reserved.

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