Tag: M.W=0-100

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1072-63-5, name is 1-Vinyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C5H6N2

1-vinyl imidazole (5.18 g, 55 mmol) and 1,6-dibromohexane (2.79 g, 22 mmol) were dissolved in methanol (50 mL) in a round-bottom flask fitted with a condenser and N2 bubbler. Subsequently, the mixture was stirred at 80 C for 48 h under a nitrogen atmosphere. After then, the reaction mixture was precipitated from diethyl ether (150 mL), and recrystallized twice from diethyl ether. The products were dried under vacuum for 24 h at R.T. [C6VIm]Br was obtained as white solid. Yield: 71%. [C6VIm]Br: 1H-NMR (D2O, 400 MHz, ppm):7.57 (1H, s); 7.37 (1H, s); 6.93 (1H, m); 5.60 (1H, d); 5.22 (1H, d); 4.04 (2H, t); 1.70 (2H, s); 1.17 (2H, s).1H-NMR (DMSO, 400 MHz, ppm): 9.66 (1H, s); 8.24 (1H, t); 7.99 (1H, t); 7.33 (1H, m); 5.99 (1H, m);5.43 (1H, m); 4.22 (2H, t); 1.83 (2H, d); 1.31 (2H, s). 13C-NMR (DMSO, 100 MHz, ppm): 135.36,128.88, 123.31, 119.23, 109.04, 49.02, 28.80, 24.77. ESI-MS (m/z): calcd. for C16H24N4Br2: 432.2,found: 432.2. Elemental analysis (%): Calculated: C, 44.46; H, 5.60; N, 12.96; Br, 36.98. Found: C,42.94; H, 5.36; N, 12.50; Br, 39.20. M.P.: 219 C.

The synthetic route of 1072-63-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Jing; Liu, Jingjiang; Zuo, Yong; Wang, Rongmin; Xiong, Yubing; Molecules; vol. 20; 9; (2015); p. 17378 – 17392;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 930-62-1,Some common heterocyclic compound, 930-62-1, name is 2,4-Dimethylimidazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound TX63822: Compound 11 (0.2 mmol) and 2,4-Dimethyl-lH- imidazole (19.2 mg, 0.2 mmol) were taken up in toluene (1 mL), and the mixture was stirred at room temperature for 65 h, no reaction happened. Additional 2,4-Dimethyl- lH-imidazole (76.8 mg, 0.8 mmol) and toluene (2 mL) was added, and the mixture was stirred at room temperature for 3h. The reaction mixture was quenched with H20 (10 mL) and extracted with CH2C12 (2×5 mL). The combined organic phase was filtered through a Na2S04 plug, then directly loaded on a silica gel column and purified by column chromatography (silica gel, twice, 0-65 % EtOAc in Hexanes then 0-60% EtOAc in Hexanes) to give the compound TX63822 as a white solid (22.2 mg, 22%). 1H NMR (500 MHz, CDC13) delta 8.02 (s, 1H), 7.22 (s, 1H), 6.03 (s, 1H), 3.25- 3.30 (m, 1H), 3.06 (d, 1H, J = 4.5 Hz), 2.56 (s, 3H), 2.42-2.51 (m, 1H), 2.19 (s, 3H), 1.95-2.16 (m, 3H), 1.83-1.93 (m, 2H), 1.58-1.77 (m, 4H), 1.15-1.45 (m, 6H), 1.44 (s, 3H), 1.30 (s, 3H), 1.24 (d, 3H, J = 6.5 Hz), 1.06 (s, 3H), 1.04 (s, 3H), 0.95 (s, 3H); m/z 556 (M+l).

The synthetic route of 930-62-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; REATA PHARMACEUTICALS, INC.; ANDERSON, Eric; JIANG, Xin; VISNICK, Melean; BENDER, Christoper, F.; LIU, Xiaofeng; WO2012/125488; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 288-32-4, name is 1H-Imidazole, molecular formula is C3H4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 1H-Imidazole

(a) A solution of alpha-bromo-4-toluonitrile (86.6 g) in dichloromethane (1000 mL) is mixed with imidazole (68.0 g). The mixture is stirred at ambient temperature for 15 hours and then diluted with water (1000 mL). Any undissolved solid is removed by filtration and the separated organic solution is then repeatedly washed with water (5*200 mL) to remove excess imidazole, and then dried (MgSO4). The crude product obtained upon evaporation of the solvent can be purified by trituration with cold diethyl ether (200 mL) to obtain 4-(1-imidazolylmethyl)-benzonitrile, m.p. 99-101; HCl salt, m.p. 142-144.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 288-32-4, its application will become more common.

Reference:
Patent; Ciba-Geigy Corporation; US4749713; (1988); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 10111-08-7, name is Imidazole-2-carboxaldehyde, molecular formula is C4H4N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C4H4N2O

To a solution of compound 1 H-imidazole-2-carbaldehyde (5g, 52.08 mmol) in MeOH (50 mL) was added sodium borohydride (3.93g, 104.16 mmol) portion-wise, at 5 00, and the reaction mixture was allowed to stir at RT for 3h. The reaction mixture was quenched with brine (25 mL) and concentrated in vacuo. The crude compound was purified by silica gel column chromatography eluting with 10% MeOH/CHCI3) to obtain (1H-imidazol-2-yl)-methanol as a pale yellow solid (4g, 78%).R:0.1 (10% MeOH/CHCI3).1H NMR (400MHz, CD3OD): O 6.97 (5, 2H), 4.61 (5, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 10111-08-7, its application will become more common.

Reference:
Patent; INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE); ASHWORTH, Alan; LORD, Christopher, James; ELLIOTT, Richard, James, Rowland; NICULESCU-DUVAZ, Dan; PORTER, Roderick, Alan; AQIL, Rehan; BOFFEY, Raymond, John; BAYFORD, Melanie, Jayne; FIRTH-CLARK, Stuart; HOPKINS, Anna; JARVIS, Ashley, Nicholas; PERRIOR, Trevor, Robert; SKONE, Philip, Alan; KEY, Rebekah, Elisabeth; WO2015/36759; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1072-63-5, name is 1-Vinyl-1H-imidazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C5H6N2

With reference to FIG. 4, 0.14 mmloe of 1-vinylimidazole, being the imidazolium liquid monomer, and 50 ml of toluene are mixed to obtain a mixture, followed by sequentially dropping 0.16 mmole of 2-bromoethanol into the mixture to trigger off an alkylation of the 1-vinylimidazole and the 2-bromoethanol. Then, a solution with two phase of layering is obtained after three days of reaction, wherein the lower layer of the solution is further isolated and repeatedly washed by toluene and ether, followed by being condensed and dried in vacuo for 1 hour, to obtain 1-(2-hydroxyl-ethyl)-3-vinylimidazolium bromide (also known as HEVIMB).

The synthetic route of 1072-63-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HORNG, Shiey-Shiun; US2013/274485; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

1072-62-4, name is 2-Ethyl-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C5H8N2

General procedure: To a solution of 1 (0.02 mmol) in H2O/MeCN (v/v=2/1, 4 mL) was added 1H-imidazole (1.0 mmol) and arylboronic acid (2 mmol)under O2 atmosphere. The mixture was stirred at 60 C for 24 h. After cooling to ambient temperature, the mixture was partitioned between water and CH2Cl2. The organic layer was separated, and the aqueous layer was extracted with CH2Cl2. The combined organic layers were washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by flash chromatography on silica gel.

The synthetic route of 1072-62-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xue, Jiang-Yan; Li, Jun-Chi; Li, Hong-Xi; Li, Hai-Yan; Lang, Jian-Ping; Tetrahedron; vol. 72; 44; (2016); p. 7014 – 7020;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 822-36-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 822-36-6, name is 4-Methyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows.

4-Fluoro-3-methoxybenzaldehyde (85 g, 0.55 mol), 4-methyl-1 /-/-imidazole (90.5 g,1.1 mol) and cesium carbonate (268.8 g, 0.82 mol) were combined in dimethylformamide (1.7 L) and stirred at 100 0C for 1 hour. The mixture was cooled to room temperature, filtered, and the filtrate was concentrated in vacuo. The residue was dissolved in water (2 L) and extracted with ethyl acetate (3 x 2 L). The combined organic layers were washed with water and brine, dried over sodium sulfate, and concentrated under reduced pressure. Chromatography on silica (Eluant: 2:1 petroleum ether: ethyl acetate) afforded a yellow solid, which was recrystallized from ethyl acetate (300 mL) to provide the title compound as a white solid. Yield: 17.8 g, 0.082 mol, 15%. 1H NMR (300 MHz, CDCI3) delta 2.31 (d, J=1.0 Hz, 3H), 3.97 (s, 3H), 7.01 (m, 1H), 7.45 (d, J=7.8 Hz, 1 H), 7.54-7.58 (m, 2H), 7.83 (d, J=1.3 Hz, 1 H), 10.01 (s, 1 H).

The chemical industry reduces the impact on the environment during synthesis 4-Methyl-1H-imidazole. I believe this compound will play a more active role in future production and life.

Reference:
Patent; PFIZER INC.; ALLEN, Martin, Patrick; AM ENDE, Christopher, William; BRODNEY, Michael, Aaron; DOUNAY, Amy, Beth; JOHNSON, Douglas, Scott; PETTERSSON, Martin, Youngjin; SCHWARZ, Jacob, Bradley; TRAN, Tuan, Phong; WO2010/100606; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7098-07-9, name is 1-Ethyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: imidazoles-derivatives

The reaction end point was monitored by adding 6.16 g (10 mmol) of M1 ‘, 0.96 g (10 mmol) of 1-ethyl tasteless, 50 mL of acetonitrile at room temperature for 48 h in a dry 100 mL three-necked flask. Washed with petroleum ether (100 mL x 3), the resulting viscous liquid was again Washed with ether (100 mL x 3) to give a yellow solid, Recrystallization from methylene chloride and drying in vacuo for 24 h afforded a pale yellow solid As the target compound (B2), 7.1 g, and the yield was 99percent.

The synthetic route of 7098-07-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Central China Normal University; Zhang Aidong; Zhang Tiejiang; Duan Jiang; Tu Haiyang; (22 pag.)CN107188869; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 288-32-4, name is 1H-Imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288-32-4, Computed Properties of C3H4N2

A mixture of KI (29.3 g,176.0 mmol) and I2 (22.4 g, 88.0 mmol) inwater (60 mL) was addedto a solution of 1H-imidazole (3.0 g, 44.1 mmol) in 2 M NaOH(10.6 g, 264.5 mmol). The mixture was stirred at 20 C for 3 h andthen neutralized with 6 M HCl (pH 7). The resulting solid wascollected by filtration, recrystallization from ethanol to give 2 as agrey solid (14.0 g, 99.0%). Mp 166e168 C. 1H NMR (300 MHz,DMSO-d6) d(ppm) 12.75 (br s, 1H), 7.8 (br s, 1H). MS (EI) m/z 320.8[MH].

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Imidazole, and friends who are interested can also refer to it.

Reference:
Article; Zou, Yi; Wang, Fang; Wang, Yan; Sun, Qirui; Hu, Yue; Li, Yuezhen; Liu, Wen; Guo, Wenjie; Huang, Zhangjian; Zhang, Yihua; Xu, Qiang; Lai, Yisheng; European Journal of Medicinal Chemistry; vol. 140; (2017); p. 293 – 304;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 1072-62-4, These common heterocyclic compound, 1072-62-4, name is 2-Ethyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 2-ethylimidazole (15.000 g; 156.03 mmol; 1.0 eq.) in dioxane (250 ml), and water (250 ml) was added at rt (in one portion) successively Na2CO3 (49.614 g; 468.10 mmol; 3.0 eq.), and iodine (87.126 g; 343.27 mmol; 2.2 eq.). The resulting brown heterogeneous reaction mixture was further stirred at rt, under nitrogen, for 24 h. AcOEt (500 ml) was then added followed by an aq. solution of sodium thiosulfate (45.0 g Na2S2O3 in 300 ml of water). The yellow organic layer was separated, and additionally washed with an aq. solution of sodium thiosulfate (30.0 g Na2S2O3 in 300 ml of water), and finally with brine (200 ml). The resulting yellow organic layer was then dried over anh. MgSO4, filtered, and concentrated to dryness under reduced pressure to give 2-ethyl-4,5-diiodo-1H-imidazole as a pale yellow solid which was further dried under HV (49.760 g; 92%). LC-MS: tR=0.55 min.; [M+H]+: 349.18 g/mol.

Statistics shows that 2-Ethyl-1H-imidazole is playing an increasingly important role. we look forward to future research findings about 1072-62-4.

Reference:
Patent; Aissaoui, Hamed; Boss, Christoph; Koberstein, Ralf; Siegrist, Romain; Sifferlen, Thierry; US2011/105514; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem