Tag: 300-400

Kinetics and mechanism of oxidation of Rabeprazole sodium by potassium permanganate in alkaline medium was written by Ramyashree, H.;Shastry, Vidyavati. And the article was included in International Journal of Current Research in Chemistry and Pharmaceutical Sciences in 2020.Application of 117976-90-6 The following contents are mentioned in the article:

The oxidation of Rabeprazole sodium by potassium permanganate has been studied by spectrophotometrically in the presence of alk. medium at 298 K at 525 nm. The oxidation kinetics was also studied by varying the ionic strength of the medium. The reaction was studied at different temperatures and products of oxidation were analyzed by LCMS. By the exptl. observations, rate law was derived and mechanism was suggested. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Application of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of 1-(2,6-diisopropylphenyl)-2-phenyl-1H-imidazole was written by Zhou, Lin-bo;Lu, Meng-meng;Xing, Lei;Chen, Guo-liang. And the article was included in Jingxi Huagong Zhongjianti in 2015.Recommanded Product: 914306-50-6 The following contents are mentioned in the article:

The target compound 1-(2,6-diisopropylphenyl)-2-phenyl-1H-imidazole was prepared in overall yield of 47.69% starting from 2,6-diisopropyl aniline via acylation by benzoyl chloride, chlorination by phosphorus oxychloride, nucleophilic substitution by aminoacetaldehyde di-Et acetal and cyclization by phosphate. The structure of target compound was characterized by ¹H NMR and ESI-MS. This study involved multiple reactions and reactants, such as 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6Recommanded Product: 914306-50-6).

1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 914306-50-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bis(arylimidazole) Iridium Picolinate Emitters and Preferential Dipole Orientation in Films was written by Huckaba, Aron J.;Senes, Alessia;Aghazada, Sadig;Babaei, Azin;Meskers, Stefan C. J.;Zimmermann, Iwan;Schouwink, Pascal;Gasilova, Natalia;Janssen, Rene A. J.;Bolink, Henk J.;Nazeeruddin, Mohammad Khaja. And the article was included in ACS Omega in 2018.Product Details of 914306-50-6 The following contents are mentioned in the article:

The straightforward synthesis and photophys. properties of a new series of heteroleptic iridium(III) bis(2-arylimidazole) picolinate complexes are reported. Each complex has been characterized by NMR, UV-vis, cyclic voltammetry, and photoluminescent angle dependency, and the emissive properties of each are described. The preferred orientation of transition dipoles in emitter/host thin films indicated more preferred orientation than homoleptic complex Ir(ppy)₃. This study involved multiple reactions and reactants, such as 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6Product Details of 914306-50-6).

1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Product Details of 914306-50-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effectiveness of ibrutinib as first-line therapy for chronic lymphocytic leukemia patients and indirect comparison with rituximab-bendamustine: Results of study on 486 cases outside clinical trials was written by Morabito, Fortunato;Tripepi, Giovanni;Del Poeta, Giovanni;Mauro, Francesca Romana;Reda, Gianluigi;Sportoletti, Paolo;Laurenti, Luca;Coscia, Marta;Herishanu, Yair;Bossio, Sabrina;Varettoni, Marzia;Murru, Roberta;Chiarenza, Annalisa;Visentin, Andrea;Condoluci, Adalgisa;Moia, Riccardo;Pietrasanta, Daniela;Loseto, Giacomo;Consoli, Ugo;Scortechini, Ilaria;Rossi, Francesca Maria;Zucchetto, Antonella;Al-Janazreh, Hamdi;Vigna, Ernesto;Martino, Enrica Antonia;Cassin, Ramona;D’Arrigo, Graziella;Galimberti, Sara;Rago, Angela;Angeletti, Ilaria;Biagi, Annalisa;Del Giudice, Ilaria;Bomben, Riccardo;Neri, Antonino;Fronza, Gilberto;Monti, Paola;Menichini, Paola;Olivieri, Jacopo;Cutrona, Giovanna;Rossi, Davide;Cuneo, Antonio;Di Raimondo, Francesco;Gaidano, Gianluca;Polliack, Aaron;Trentin, Livio;Foa, Robin;Ferrarini, Manlio;Gattei, Valter;Gentile, Massimo. And the article was included in American Journal of Hematology in 2021.SDS of cas: 16506-27-7 The following contents are mentioned in the article:

However, these biomarkers’ practical prognostic relevance in the era of new drugs remains an open issue. Results investigating the clin. impact of IB in the current clin. practice mainly focused so far on relapsedresistant (RR) patients. Here, we conducted a multicenter, retrospective study to ascertain the predictive and prognostic relevance of well-known biol. and clin. indicators in 165 patients treated with IB as first-line. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7SDS of cas: 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.SDS of cas: 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kinetics and mechanism of oxidation of Rabeprazole sodium by potassium permanganate in alkaline medium was written by Ramyashree, H.;Shastry, Vidyavati. And the article was included in International Journal of Current Research in Chemistry and Pharmaceutical Sciences in 2020.Application of 117976-90-6 The following contents are mentioned in the article:

The oxidation of Rabeprazole sodium by potassium permanganate has been studied by spectrophotometrically in the presence of alk. medium at 298 K at 525 nm. The oxidation kinetics was also studied by varying the ionic strength of the medium. The reaction was studied at different temperatures and products of oxidation were analyzed by LCMS. By the exptl. observations, rate law was derived and mechanism was suggested. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Application of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of 1-(2,6-diisopropylphenyl)-2-phenyl-1H-imidazole was written by Zhou, Lin-bo;Lu, Meng-meng;Xing, Lei;Chen, Guo-liang. And the article was included in Jingxi Huagong Zhongjianti in 2015.Recommanded Product: 914306-50-6 The following contents are mentioned in the article:

The target compound 1-(2,6-diisopropylphenyl)-2-phenyl-1H-imidazole was prepared in overall yield of 47.69% starting from 2,6-diisopropyl aniline via acylation by benzoyl chloride, chlorination by phosphorus oxychloride, nucleophilic substitution by aminoacetaldehyde di-Et acetal and cyclization by phosphate. The structure of target compound was characterized by ¹H NMR and ESI-MS. This study involved multiple reactions and reactants, such as 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6Recommanded Product: 914306-50-6).

1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 914306-50-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

How I treat and prevent venous thrombotic complications in patients with lymphoma was written by Schmidt, Robert A.;Lee, Agnes Y. Y.. And the article was included in Blood in 2022.Quality Control of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

Venous thromboembolism (VTE) is a common complication occurring in 5% to 10% of patients with lymphoma. As the complexity of lymphoma management has increased with novel therapies, so too has the treatment of VTE. Therapeutic options for the treatment of cancer-associated VTE have expanded from only warfarin and low-mol.-weight heparins (LMWHs) to include the direct oral anticoagulants (DOACs) apixaban, edoxaban and rivaroxaban. There have been no head-to-head trials comparing different DOACs in this setting, and randomized trials comparing a DOAC with LMWH dalteparin differ in trial design and results. Drug-drug interactions, drug-specific side effects, and patient selection are important considerations when prescribing anticoagulant therapy. In all patients, the relative risks of thrombosis and bleeding, the availability of the anticoagulant, and the life expectancy of the patient are vital elements in selecting the most appropriate anticoagulant (which can vary over time) for the individual patient. We describe the intricacies and challenges of treating thrombotic complications in patients with lymphoma with an emphasis on evidence and guideline-based care. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Quality Control of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Quality Control of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electrochemical determination of anticancer drug Bendamustine and its interaction with double strand DNA in the absence and presence of quercetin was written by Erol, Aylin;Akpinar, Fatma;Muti, Mihrican. And the article was included in Colloids and Surfaces, B: Biointerfaces in 2021.Synthetic Route of C16H21Cl2N3O2 The following contents are mentioned in the article:

Studies based on drug-DNA interactions, especially anticancer drug-DNA interactions, are of great importance for the method development. It is thought that single-use electrodes, which give fast, cheap and reproducible results, will make a great contribution to the chip technol. for the development of individual patient anal. in the future. It is known that antioxidants reduce carcinogenesis caused by oxidative stress with their radical scavenging effects. Literature shows that quercetin (QRCT) exhibits anticancer activity by preventing oxidative cell damage as an effective radical scavenger. In this study, Bendamustine (BND), an anticancer drug, which is used in different blood cancer types, was electrochem. determined and the toxicity degree was calculated by examining the interaction of the drug with DNA in the absence and presence of QRCT, which is the first examination in the literature. Limit of detection and quantification for BND was calculated as 6.0 and 20.0渭g/mL resp. by using the equation I = 0.029 x CBND+ 1.197, (R2 = 0.997). We found that QRCT prevents the interaction between BND and DNA because of its strong interaction with DNA. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Synthetic Route of C16H21Cl2N3O2).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Synthetic Route of C16H21Cl2N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Novel potassium-competitive acid blocker, tegoprazan, protects against colitis by improving gut barrier function was written by Son, Mijeong;Park, I. Seul;Kim, Soochan;Ma, Hyun Woo;Kim, Ji Hyung;Kim, Tae Il;Kim, Won Ho;Han, Jaeyong;Kim, Seung Won;Cheon, Jae Hee. And the article was included in Frontiers in Immunology in 2022.Computed Properties of C18H20N3NaO3S The following contents are mentioned in the article:

Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder characterized by prolonged inflammation of the gastrointestinal tract. IBD can result from gut barrier dysfunction, altered gut microbiota, and abnormal intestinal immunity induced by environmental factors in genetically susceptible individuals. Proton pump inhibitors (PPIs) such as rabeprazole are frequently employed for gastric acid inhibition. However, long-term PPI administration can alter the intestinal microbiome composition, possibly worsening IBD severity. The present study revealed that tegoprazan, a potassiumcompetitive acid blocker, significantly improved colitis in mice and enhanced the intestinal epithelial barrier function. Tegoprazan alleviated gut microbiota dysbiosis and enhanced the growth of Bacteroides vulgatus. In turn, B. vulgatus alleviated intestinal inflammation by inhibiting epithelial adhesion of pathogenic bacteria. Unlike rabeprazole, tegoprazan did not induce gut dysbiosis. Our findings provide novel insights into the potential role of tegoprazan as an intestinal protectant for IBD and as a therapeutic agent for gastric acid-related diseases. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Computed Properties of C18H20N3NaO3S).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Computed Properties of C18H20N3NaO3S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Management of Waldenstrom’s macroglobulinemia on the basis of cytogenetic abnormality was written by Sekiguchi, Naohiro. And the article was included in Ketsueki Naika in 2022.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

Indeed, in the last decade, the mol. pathogenesis of WM, such as chromosomal abnormalities, gene mutations, and signal transduction, has progressed rapidly, and new drugs, including BTK inhibitors, have been vigorously developed. While there are reports indicating that searching for chromosomal/genetic abnormalities at the time of diagnosis is highly significant in predicting the response rate and long-term prognosis in the therapeutic intervention of WM, in Japan, it is difficult to say that such searches are sufficiently performed in routine clin. practice. At present, there are no high-evidence-level clin. practice guidelines or prognostic models based on chromosomal/genetic abnormalities. It is hoped that in the next 10 years established a stratification of clin. practice based on chromosomal/genetic abnormalities in WM. In this article, the author like to explain the chromosomal/genetic abnormalities that can be detected by WM, and also discuss the prognostic significance of chromosomal/genetic abnormalities, proposed treatment algorithms based on chromosomal/genetic abnormalities, and issues, including my personal views. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem