Tag: 300-400

Rabeprazole: A comprehensive profile. was written by Bakheit, Ahmed H;Al-Kahtani, Hamad M;Albraiki, Salem. And the article was included in Profiles of drug substances, excipients, and related methodology in 2021.Reference of 117976-90-6 The following contents are mentioned in the article:

Rabeprazole belongs to the class of anti-secretory drugs, with benzimidazoles substitution. These drugs induce gastric acid secretion through precise inhibition of the enzyme H⁺/K⁺-ATPase (acid or proton pump). This effect helps to treat and prevent conditions in which gastric acid directly aggravates symptoms such as duodenal and gastric ulcers. This chapter includes a comprehensive review of rabeprazole in terms of nomenclature, its physical-chemical properties, methods of preparation and ADME profiles. In addition, the chapter also includes a review of several methods for analysis of rebeprazole in its dosage forms and biological fluids. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Reference of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Development of pharmacists’ work support system using vibrational spectroscopy was written by Moriyama, Kei. And the article was included in Kagaku Kogyo in 2020.Electric Literature of C18H20N3NaO3S The following contents are mentioned in the article:

This paper focuses on application of Raman spectroscopy in development of device for drug identification useful in prescription drug preparation process or consultation process with patients with pre-prescribed medicines. First, the authors developed a Raman spectra database of 210 common tablets, and then, 46 tablets were analyzed with Raman spectroscopy and collated with the database to obtain a quality index. Also, addnl. use of near-IR spectroscopy was investigated. The results showed that tablets can be identified non-destructively by measuring the Raman spectrum, and the accuracy was increased with the combinational use of near-IR spectra. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Electric Literature of C18H20N3NaO3S).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Electric Literature of C18H20N3NaO3S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Brentuximab vedotin in combination with bendamustine in pediatric patients or young adults with relapsed or refractory Hodgkin lymphoma was written by Vinti, Luciana;Pagliara, Daria;Buffardi, Salvatore;Di Ruscio, Valentina;Stocchi, Francesca;Mariggio, Elena;Parasole, Rosanna;Di Matteo, Antonia;Petruzziello, Fara;Paganelli, Valeria;De Vito, Rita;Del Bufalo, Francesca;Strocchio, Luisa;Locatelli, Franco. And the article was included in Pediatric Blood & Cancer in 2022.Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

Although children and young adults with Hodgkin’s lymphoma usually have a favorable prognosis, patients with primary refractory disease and some subsets of relapsed patients still have a dismal outcome. Brentuximab vedotin (BV) in combination with bendamustine may represent a suitable salvage therapy; data on 32 patients aged less than 25 years were retrospectively analyzed. Patients received up to six cycles of treatment of BV 1.8 mg/kg on day 1 and bendamustine 90-120 mg/m² on days 2 and 3. At the end of treatment, the overall response rate was 81. The 3-yr overall and progression-free survivals are 78.1and 67, resp. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Case report: unremitting COVID-19 pneumonia, viral shedding, and failure to develop anti-SARS-CoV-2 antibodies for more than 6 months in patient with mantle cell lymphoma treated with rituximab was written by Berktas, Bahadir M.;Koyuncu, Adem. And the article was included in American Journal of Tropical Medicine and Hygiene in 2022.Related Products of 16506-27-7 The following contents are mentioned in the article:

Severe cases of COVID-19 are being reported in patients with comorbidities and drug-induced immunosuppression. The risk seems to depend on the type of immunosuppressive agents used, and it is particularly high with rituximab because of its long-lasting effects. We report a 71-yr-old man with COVID-19, mantle cell lymphoma, and rituximab-associated immunodeficiency. His COVID-19 clin. course was severe, unremitting, prolonged, and with frequent acute exacerbations requiring hospitalization. Viral shedding and failure to develop anti-severe acute respiratory syndrome coronavirus 2 antibodies continued for at least 6 mo. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Related Products of 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Related Products of 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A Fatal Breakthrough COVID-19 Case Following Bendamustine-Rituximab Therapy was written by Kamegai, Kohei;Iwamoto, Noriko;Togano, Tomiteru;Maeda, Kenji;Takamatsu, Yuki;Miyazato, Yusuke;Ishikane, Masahiro;Mizokami, Masashi;Sugiyama, Masaya;Iida, Shun;Miyamoto, Sho;Suzuki, Tadaki;Ohmagari, Norio. And the article was included in International Journal of Infectious Diseases in 2022.Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

Although mRNA vaccines are substantially effective toward SARS-CoV-2 infection, patients with hematol. malignancies are still prone to the virus. Herein, we report a fatal case of breakthrough SARS-CoV-2 Delta variant infection in a patient with mucosa-associated lymphoid tissue lymphoma with remission by bendamustine-rituximab (BR) therapy completed a year ago. The serol. study revealed impaired responsiveness toward vaccines and prolonged high viral load after infection. BR therapy seemingly induced an immune escape. Prevention and treatment strategies for such vulnerable patients should be clarified immediately. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Treatment of relapsed/refractory follicular lymphoma was written by Fukuhara, Noriko. And the article was included in Ketsueki Naika in 2021.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

A review. Follicular Iymphoma (FL) is a typical type of so-called indolent lymphoma that progresses on a yearly basis, accounting for about 20% of all B-cell lymphoma, and has increased in recent years in Japan as well as in Europe and the United States. In the normal recurrence group, there is no change in transformation, and most of the transformation is DLBCLNOS, but high grade Iymphoma with MYC locus is also observed in some cases. At that point, it will be necessary to further elucidate the pathophysiol. of follicular lymphoma with the new treatment opening 56 in order to judge the situation and select a better move. The addnl. effect of obinutuzumab on bendamustine therapy is verified in the case of rituximab resistance. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In vitro, in vivo and in silico-driven identification of novel benzimidazole derivatives as anticancer and anti-inflammatory agents was written by Sathyanarayana, Reshma;Poojary, Boja;Srinivasa, Sudhanva M.;Merugumolu, Vijay K.;Chandrashekarappa, Revanasiddappa B.;Rangappa, Shobith. And the article was included in Journal of the Iranian Chemical Society in 2022.Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

The synthesis of novel benzimidazole derivatives with varied carbon chain length was achieved via ′′one-pot′â€?nitro reductive cyclization (6a-o). In each case, compounds were determined by the elemental analyses, FT-IR, mass, ¹H and ¹³C NMR spectroscopy. Further, these derivatives were screened for their in vitro anticancer, in vitro and in vivo anti-inflammatory activities. The results revealed that the length of the carbon chain greatly affects the activity. Among the 15 derivatives, compound 6d induced maximum cell death in HeLa and A549 cell lines and compound 6a emerged as a potent anti-inflammatory agent. Also, the physicochem. properties of potent compounds were studied. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Indolent T cell lymphoma involving the central nervous system and successfully treated by bendamustine was written by Hui, Min;Chen, Miao. And the article was included in Annals of Hematology in 2022.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

Peripheral T-cell lymphoma, not otherwise unspecified (PTCL-NOS), was most common among the peripheral T-cell lymphomas (PTCL) subtypes. The central nervous system (CNS) is rarely involved as the primary site, making it especially challenging for diagnosis and treatment. The present report describes a rare case of indolent PTCL involving the central nervous system, bone marrow, s.c. tissue, and muscles, which was successfully treated by the bifunctional alkylating agent bendamustine and allogeneic hematopoietic stem cell transplantation. This report describes the first known experience of patients with indolent T cell lymphoma involving the central nervous system treated with bendamustine. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Heterologous SARS-CoV -2 vaccinations in patients with B-cell lymphoid malignancies was written by Ujjani, Chaitra;Greninger, Alexander L.;Shadman, Mazyar;Hill, Joshua A.;Lynch, Ryan C.;Warren, Edus H.;Gopal, Ajay K.. And the article was included in American Journal of Hematology in 2022.Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

This article deals about heterologous SARS-CoV-2 vaccinations in patients with B-cell lymphoid malignancies. The majority of patients subsequently received another mRNA vaccine for a total of four vaccinations. The median IgG, absolute lymphocyte count, and normal CD19+ B-cell counts were 597 mg/dL (range 180-1007), 0.97-103/mL (range 0.61-2.56), and 0.6 cells/mL (range 0-121), resp. Nucleocapsid antibody was nonreactive in all patients, indicating no evidence of prior SARS-CoV-2 infection. A number of variables such as type of B-cell directed therapy, length of and time from exposure, sequence of and duration between vaccinations, and underlying disease biol. may have had impact. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of 1,2-diaryl- and 1-aryl-2-alkylimidazoles with sterically demanding substituents was written by Micksch, Maik;Tenne, Mario;Strassner, Thomas. And the article was included in European Journal of Organic Chemistry in 2013.Electric Literature of C21H24N2 The following contents are mentioned in the article:

1,2-Diarylimidazoles are an important class of compounds They are frequently used as ligands for photophys. active metal complexes and also display physiol. activity. We developed a new, high-yielding procedure for the synthesis of 1,2-diaryl-substituted imidazoles with sterically demanding substituents at the resp. ortho positions by starting from com. available anilines and benzoic acids through the corresponding acid chlorides. The metal-free method provides access to a variety of different substituents on the Ph rings at N-1 and C-2 as well as at the 4,5-positions of the imidazole backbone. Our new method is also suitable for the preparation of 1-aryl-2-alkylimidazoles. This study involved multiple reactions and reactants, such as 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6Electric Literature of C21H24N2).

1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C21H24N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem