Fridman, Natalya et al. published their research in Journal of Molecular Structure in 2009 | CAS: 5496-35-5

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Category: imidazoles-derivatives

Crystal structures and solution spectroscopy of lophine derivatives was written by Fridman, Natalya;Kaftory, Menahem;Eichen, Yoav;Speiser, Shammai. And the article was included in Journal of Molecular Structure in 2009.Category: imidazoles-derivatives This article mentions the following:

Lophine (2,4,5-triphenylimidazole) derivatives were synthesized and their physicochem. properties were determined Spectroscopic and fluorescence behavior of lophine derivatives in methanol at different pH and various solvents were presented. The observed spectroscopic features in the solution are determined by specific interactions of the NH hydrogen. These kinds of interactions are manifested both in the solid state and in solution The crystal and mol. structures of lophine derivatives with different solvents of crystallization are presented and discussed. In all solvates the solvent mols. link host mols. through hydrogen bonds. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Category: imidazoles-derivatives).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kortagere, Sandhya et al. published their research in Journal of Virology in 2012 | CAS: 5496-35-5

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.HPLC of Formula: 5496-35-5

Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid was written by Kortagere, Sandhya;Madani, Navid;Mankowski, Marie K.;Schon, Arne;Zentner, Isaac;Swaminathan, Gokul;Princiotto, Amy;Anthony, Kevin;Oza, Apara;Sierra, Luz-Jeannette;Passic, Shendra R.;Wang, Xiaozhao;Jones, David M.;Stavale, Eric;Krebs, Fred C.;Martin-Garcia, Julio;Freire, Ernesto;Ptak, Roger G.;Sodroski, Joseph;Cocklin, Simon;Smith, Amos B. III. And the article was included in Journal of Virology in 2012.HPLC of Formula: 5496-35-5 This article mentions the following:

The HIV-1 capsid (CA) protein plays essential roles in both early and late stages of virl replication and has emerged as a novel drug target. We report hybrid structure-based virtual screening to identify small mols. with the potential to interact with the N-terminal domain (NTD) of HIV-1 CA and disrupt early, preintegration steps of the HIV-1 replication cycle. The small mol. 4,4′-[dibenzo[b,d]furan-2,8-diylbis(5-phenyl-1H-imidazole-4,2-diyl)]dibenzoic acid (CK026), which had anti-HIV-1 activity in single- and multiple-round infections but failed to inhibit viral replication in peripheral blood mononuclear cells (PBMCs), was identified. Three analogs of CK026 with reduced size and better drug-like properties were synthesized and assessed. Compound I-XW-053 (4-(4,5-diphenyl-1H-imidazol-2-yl)benzoic acid) retained all of the antiviral activity of the parental compound and inhibited the replication of a diverse panel of primary HIV-1 isolates in PBMCs, while displaying no appreciable cytotoxicity. This antiviral activity was specific to HIV-1, as I-XW-053 displayed no effect on the replication of SIV or against a panel of nonretroviruses. Direct interaction of I-XW-053 was quantified with wild-type and mutant CA protein using surface plasmon resonance and isothermal titration calorimetry. Mutation of Ile37 and Arg173, which are required for interaction with compound I-XW-053, crippled the virus at an early, preintegration step. Using quant. PCR, we demonstrated that treatment with I-XW-053 inhibited HIV-1 reverse transcription in multiple cell types, indirectly pointing to dysfunction in the uncoating process. In summary, we have identified a CA-specific compound that targets and inhibits a novel region in the NTD-NTD interface, affects uncoating, and possesses broad-spectrum anti-HIV-1 activity. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5HPLC of Formula: 5496-35-5).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.HPLC of Formula: 5496-35-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ali, Rashid et al. published their research in New Journal of Chemistry in 2016 | CAS: 5496-35-5

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Name: 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid

An efficient ICT based fluorescent turn-on dyad for selective detection of fluoride and carbon dioxide was written by Ali, Rashid;Razi, Syed S.;Gupta, Ramesh C.;Dwivedi, Sushil K.;Misra, Arvind. And the article was included in New Journal of Chemistry in 2016.Name: 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid This article mentions the following:

A new intramol. charge transfer (ICT) based fluorescent turn-on ratiometric probe 2 (D-蟺-A type) has been designed and synthesized by bridging imidazole (donor, D) and benzothiazole (acceptor, A) moieties through a Ph ring. The photophys. behavior of probe 2 in solvents of different polarities and at different pH values has been investigated. Upon interaction with different types of anions probe 2 showed selective high affinity for fluoride anions (F) in aqueous DMSO (20%) solution The ratiometric fluorescence turn-on behavior displayed by 2 with F is attributed to changes in the ICT process. Job’s plot anal. revealed a 1 : 1 binding stoichiometry for 2 + F interactions with a high binding constant and detection sensitivity (30 ppb). Moreover, a solution of 2 + F enabled the detection of CO2 (鈭?00 ppb; 2.29 渭M) through enhanced emission. The mode of interaction has been confirmed by 1H NMR titration studies which suggested the deprotonation of the -NH fragment of an imidazolyl unit in the presence of F. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Name: 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Name: 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Philbrook, G. E. et al. published their research in Tetrahedron Letters in 1964 | CAS: 5496-35-5

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Formula: C22H16N2O2

Chemiluminescent intensities from substituted lophines was written by Philbrook, G. E.;Maxwell, M. A.. And the article was included in Tetrahedron Letters in 1964.Formula: C22H16N2O2 This article mentions the following:

Chemiluminescent intensities of 14 lophine derivatives, substituted in the 3 and (or) 4 position(s) of the 2-phenyl group, were determined in 7:3 Me2SO-H2O solution, N in NaOH. O was passed through the solution continuously. The intensity of emission passed through a maximum (Imaximum) after 1-2 min. and then declined. A Hammett plot of Imaximum/I0 against 蟽 values was reported, where I0 is the intensity maximum for lophine (I). The observed slope, -1.96 卤 0.06, compares with a value of -1.16 卤 0.06 obtained when similar plots were constructed with 蟽+ values (Brown and Okamoto, CA 53, 9120f). The emission intensity was a linear function of concentration for I, and the 4-carboxy, 4-MeO, 3,4-dimethoxy, and 4-Cl derivatives over the concentration range 3 脳 10-3 to 3 脳 10-5 M. The chemiluminescent maximum for all the compounds, except the nitro derivative, fell at 5300 A. It appeared that the chemiluminescent processes in all cases examined yield the same mol. fragment. Probably the substituent present in the original derivative was not present in this fragment. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Formula: C22H16N2O2).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Formula: C22H16N2O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Fridman, Natalya et al. published their research in Sensors and Actuators, B: Chemical in 2007 | CAS: 5496-35-5

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 5496-35-5

Structures and photophysics of lophine and double lophine derivatives was written by Fridman, Natalya;Kaftory, Menahem;Speiser, Shammai. And the article was included in Sensors and Actuators, B: Chemical in 2007.SDS of cas: 5496-35-5 This article mentions the following:

Novel lophine (2,4,5-triphenylimidazole) derivatives, ortho-, meta- and para-substituted in the 2-Ph ring and p-Ph, p-tolyl, and p-anisyl rings in the 4- and 5-aryl rings and double lophine derivatives were synthesized and their physico-chem. properties were determined We included arylimidazoles, derivatives substituted with electron-donating and electron attracting groups. MeO- and OH-groups release electrons and activate the ring. In contrast, COOH- and CN-groups withdraw electrons and deactivate the ring. Nitro derivatives of imidazole, phenol, 2-[4,5-bis(4-methoxyphenyl)-1H-imidazole-2-yl]-4-nitro 23 and phenol, 2-[4,5-bis(4-methyl-phenyl)-1H-imidazole-2-yl]-4-nitro 24 crystallize with guest mols. in various colors. Double imidazole derivatives of lophine, 2,2′-(2,5-thiophenediyl)bis[4,5-diphenyl-1H-imidazole] 27 and 2,2′-(1,4-phenylene)bis[4,5-diphenyl-1H-imidazole] 29 show piezochromism, photochromism and thermochromism in the solid state and form inclusion compounds in various colors. Four inclusion compounds in two different colors: yellow and green, depending on the solvent mols. were found for 27 and two different colors: light yellow and colorless were obtained for 29. The fluorescence intensity for 27 substituted with MeO-group in the 4,5-Ph rings is decreased and it is increased for 29 by changing Ph rings to MeO-substituent in the 4,5-Ph rings. Upon irradiation with UV light at room temperature, green solution of 29 turned into orange and colorless solution of 29 turned into light yellow. The photochem. properties of 27 and 29 and their derivatives were studied by irradiating basic and neutral degassed acetonitrile solutions with medium pressure xenon lamp and their photochem. quantum yields, ranging from 0.0011 to 0.0024, together with the corresponding fluorescence quantum yields, ranging from 0.52 to 0.90 and lifetimes, ranging from 1.03 to 1.42 ns were determined These compounds are sensitive to different external stimulations, such as UV irradiation, heat, increasing pressure, and changing of the environmental pH, causing spectral changes. Our results suggest potential applications of these compounds in mol. photonics and sensing. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5SDS of cas: 5496-35-5).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 5496-35-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mohamed, Shaaban K. et al. published their research in Acta Crystallographica, Section E: Structure Reports Online in 2013 | CAS: 5496-35-5

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Category: imidazoles-derivatives

Prop-2-en-1-yl 4-(4,5-diphenyl-1H-imidazol-2-yl)benzoate was written by Mohamed, Shaaban K.;Akkurt, Mehmet;Marzouk, Adel A.;Abdelhamid, Antar A.;Santoyo-Gonzalez, Francisco. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2013.Category: imidazoles-derivatives This article mentions the following:

Prop-2-en-1-yl 4-(4,5-diphenyl-1H-imidazol-2-yl)benzoate, C25H20N2O2, crystallized with 2 mols. in the asym. unit, in 1 of which the atoms of the terminal propenyl group are disordered over 2 sets of sites, with a refined occupancy ratio of 0.870(4):0.130(4). The central imidazole ring makes dihedral angles of 25.51(11), 40.73(11) and 27.36(11)掳 with the 3 pendant rings in 1 mol. and 22.56(10), 60.72(10) and 5.85(10)掳 in the other. In the crystal, mols. are linked by N-H路路路N and C-H路路路O H bonds, forming a 3-dimensional network. The crystal structure also features C-H路路路蟺 interactions and 蟺-蟺 stacking [centroid-centroid distances = 3.8834(18) and 3.9621(17) 脜] interactions. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Category: imidazoles-derivatives).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Nemati, Firouzeh et al. published their research in Inorganic and Nano-Metal Chemistry in 2017 | CAS: 5496-35-5

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. HPLC of Formula: 5496-35-5

Synthesis and characterization of nano-copper ferrite as a magnetically separable catalyst for the one-pot synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles under solvent-free condition was written by Nemati, Firouzeh;Elhampour, Ali;Natanzi, Mahshid Bagheri. And the article was included in Inorganic and Nano-Metal Chemistry in 2017.HPLC of Formula: 5496-35-5 This article mentions the following:

Synthesis and characterization of nano-copper ferrite as a recoverable, eco-friendly, inexpensive and readily available catalyst for efficient, simple and green synthesis of multi-substituted imidazoles I [Ar1 = H, Ph, 2-thiophene, etc.; Ar2 = Ph, 4-MeC6H4, 4-ClC6H4] was reported. Short reaction times, high yields, easy workup and mild condition were the advantages of this protocol. The catalyst could be reused without evident loss of the catalytic activity. Characterization of the catalyst was performed fully by Fourier transform IR spectra, X-ray diffraction, FESEM, electron dispersive X-ray and vibration sampling magnetometer anal. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5HPLC of Formula: 5496-35-5).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. HPLC of Formula: 5496-35-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Philbrook, George E. et al. published their research in Tetrahedron Letters in 1964 | CAS: 5496-35-5

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 5496-35-5

Chemiluminescence intensities of substituted lophines was written by Philbrook, George E.;Maxwell, Michael A.. And the article was included in Tetrahedron Letters in 1964.Reference of 5496-35-5 This article mentions the following:

The intensities of the chemiluminescence and the ir and uv absorption spectra were investigated for lophine, 4-dimethylamino-, 4-acetamino, 4-methoxy, 3,4-dimethoxy, 3,4-diethoxy, 4-methyl, 4-isopropyl-, 4-chloro-, 4-fluoro-, 4-bromo-, 3-nitro, 4-nitro-, 4-phenoxy-, and 4-carboxylophine (substituents in the 2 position on the ring) in 70% Me2SO in 30% N NaOH. The curves, log I/I0 = f(σ) (Hammett) were plotted; I depended linearly on the lophine concentration and could be increased by H2O2. Spontaneous evaporation and spontaneous absorption were not found. All the chemiluminescence processes investigated were explained by the fact that, at times, the same mol. fragment was formed. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Reference of 5496-35-5).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 5496-35-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kapale, Suraj S. et al. published their research in Journal of Asian Natural Products Research in 2021 | CAS: 5496-35-5

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.HPLC of Formula: 5496-35-5

A sustainable approach towards the three-component synthesis of unsubstituted 1H-imidazoles in the water at ambient conditions was written by Kapale, Suraj S.;Chaudhari, Hemchandra K.;Mali, Suraj N.;Takale, Balaram S.;Pawar, Hitesh. And the article was included in Journal of Asian Natural Products Research in 2021.HPLC of Formula: 5496-35-5 This article mentions the following:

A green protocol for the synthesis of imidazoles I [R = Ph, 4-BrC6H4, 2-furyl, etc.; R1 = R2 = H, Ph] was demonstrated. The reaction was realized using com. available lipase enzyme, porcine pancreas lipase (PPL) in water. The reaction conditions were selective and mild which helped to tolerate a wide variety of functional groups to gave desired products I in good chem. yields. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5HPLC of Formula: 5496-35-5).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.HPLC of Formula: 5496-35-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kortagere, Sandhya et al. published their research in Journal of Chemical Information and Modeling in 2014 | CAS: 5496-35-5

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: 5496-35-5

Structure-Activity Relationships of a Novel Capsid Targeted Inhibitor of HIV-1 Replication was written by Kortagere, Sandhya;Xu, Jimmy P.;Mankowski, Marie K.;Ptak, Roger G.;Cocklin, Simon. And the article was included in Journal of Chemical Information and Modeling in 2014.Recommanded Product: 5496-35-5 This article mentions the following:

Despite the considerable successes of highly active antiretroviral therapy (HAART) for the treatment of HIV/AIDS, cumulative drug toxicities and the development of multidrug-resistant virus necessitate the search for new classes of antiretroviral agents with novel modes of action. The HIV-1 capsid (CA) protein has been structurally and functionally characterized as a druggable target. We have recently designed a novel small mol. inhibitor I-XW-053 using the hybrid structure based method to block the interface between CA N-terminal domains (NTD-NTD interface) with micromolar affinity. In an effort to optimize and improve the efficacy of I-XW-053, we have developed the structure activity relationship of I-XW-053 compound series using ligand efficiency methods. Fifty-six analogs of I-XW-053 were designed that could be subclassified into four different core domains based on their ligand efficiency values computed as the ratio of binding efficiency (BEI) and surface efficiency (SEI) indexes. Compound 34 belonging to subcore-3 showed an 11-fold improvement over I-XW-053 in blocking HIV-1 replication in primary human peripheral blood mononuclear cells (PBMCs). Surface plasmon resonance experiments confirmed the binding of compound 34 to purified HIV-1 CA protein. Mol. docking studies on compound 34 and I-XW-053 to HIV-1 CA protein suggested that they both bind to NTD-NTD interface region but with different binding modes, which was further validated using site-directed mutagenesis studies. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Recommanded Product: 5496-35-5).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: 5496-35-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem