Tag: 200-300

Iniya, Murugan;Vidya, Balasubramanian;Anand, Thangaraj;Sivaraman, Gandhi;Jeyanthi, Dharmaraj;Krishnaveni, Karuppiah;Chellappa, Duraisamy published 《Microwave-Assisted Synthesis of Imidazoquinazoline for Chemosensing of Pb²⁺ and Fe³⁺ and Living Cell Application》. The research results were published in《ChemistrySelect》 in 2018.COA of Formula: C13H11N3 The article conveys some information:

An efficient dual-responsive fluorescent probe based on imidazoquinazoline has been synthesized using microwave-assisted solvent-free condition. Its sensing behavior towards Pb²⁺ and Fe³⁺ has been investigated sep. through fluorescence, absorbance and visual fluorescence color changes in different solvent systems. Interestingly, the binding event triggers selective “turn-on” response to Pb²⁺ and ratiometric response to Fe³⁺ against other commonly coexistent metal ions. The observed exptl. data has been rationalized in terms of theor. calculations The living cell imaging experiment demonstrated the practical value of the sensor in mapping intracellular Fe³⁺ and Pb²⁺ distributions in biol. systems. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 COA of Formula: C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Si, Wei-Jie;Wang, Xiao-Bin;Chen, Min;Wang, Meng-Qi;Lu, Ai-Min;Yang, Chun-Long published 《Design, synthesis, antifungal activity and 3D-QSAR study of novel pyrazole carboxamide and niacinamide derivatives containing benzimidazole moiety》 in 2019. The article was appeared in 《New Journal of Chemistry》. They have made some progress in their research.Reference of 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

A series of novel pyrazole carboxamide I (R¹ = H, Cl, Me; R² = Me, CF₃), II (R¹ = H, Cl, Me; R² = Me, i-Bu) and niacinamide derivatives III (R¹ = H, Cl, Me; R² = H, Cl, SH) containing a benzimidazole moiety were designed and synthesized as antifungal candidate agents. The structure of compound I (R¹ = H; R² = Me) was confirmed by single crystal X-ray diffraction anal. The antifungal activities of the target compounds were evaluated in vitro against four phytopathogenic fungi (namely Botrytis cinerea, Rhizoctonia solani, Fusarium graminearum and Alternaria solani) by the mycelium growth inhibition method. The bioassay results indicated that some of the compounds exhibited good antifungal activity against B. cinerea at 100 μg ML^-1 compared to other three fungi. In order to better explore the structure-activity relationship (SAR), the EC₅₀ values of target compounds against B. cinerea were measured and assessed. Subsequently, a 3D quant. structure-activity relationship (3D-QSAR) study was carried out using the comparative mol. field anal. (CoMFA) technique based on the inhibitory activities of tested compounds against B. cinerea. Mol. modeling results revealed fine predictive ability with cross-validated q² and non-cross-validated r² values of 0.578 and 0.850, resp. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Reference of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sharada, Duddu S.;Shinde, Anand H.;Patel, Srilaxmi M.;Vidyacharan, Shinde published 《Scaffold Diversity through a Branching Double-Annulation Cascade Strategy: Iminium-Induced One-Pot Synthesis of Diverse Fused Tetrahydroisoquinoline Scaffolds》 in 2016. The article was appeared in 《Journal of Organic Chemistry》. They have made some progress in their research.Synthetic Route of C13H11N3 The article mentions the following:

A branching double-annulation cascade (BDAC) strategy for diverse and complex fused THIQ scaffolds via a highly reactive iminium-induced one-pot double-cyclization sequence involving Pictet-Spengler-type cyclization has been developed for the first time. The salient features of this protocol are that it allows direct and rapid access to unprecedented diverse fused THIQ skeletons, is metal/catalyst free, has a cleaner reaction profile, provides good to excellent yields, and is a convenient approach. This catalyst-free domino process facilitates the double annulation with a variety of scaffold building agents via two C-N and one C-X (X = C, N, O) bond formation in a single step under uniform reaction conditions. Furthermore, we reveal an unusual dual BDAC sequence leading to N-N-linked isoquinoline dimer. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Synthetic Route of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Odame, F.;Hosten, E. C.;Tshentu, Z. R. published 《Synthesis,characterization and computational studies of N-[(9E)-8,10,17-triazatetracyclo[8.7.0.0^2,7.0^11,16]heptadeca-1(17),2,4,6,11(16),12,14-heptaen-9-ylidene] benzamide》 in 2020. The article was appeared in 《Journal of Structural Chemistry》. They have made some progress in their research.SDS of cas: 5805-39-0 The article mentions the following:

N-[(9E)-8,10,17-Triazatetracyclo[8.7.0.0^2,7.0^11,16]heptadeca-1(17),2,4,6,11(16),12,14-heptaen-9-ylidene] benzamide (I) is synthesized and characterized by spectroscopy, microanal., and single crystal X-ray diffractometry. Compound I crystallizes in the monoclinic space group P2₁/c with a = 15.8980(7) Å, b = 4.8067(2) Å, c = 21.0455(10) Å, β = 101.153(2)°, and Z = 4. The exptl. bond lengths and bond angles are contrasted with computed bond lengths and bond angles.2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) were involved in the experimental procedure.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 SDS of cas: 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jeyanthi, D.;Joel, C.;Bennie, R. Biju;Livingston, D. Jim;Balakrishnan, C. published 《Crystal structure and chemosensing property of benzimidazole-based probe towards detection of multiple analytes – A combined experimental and DFT approach》 in 2022. The article was appeared in 《Journal of Photochemistry and Photobiology, A: Chemistry》. They have made some progress in their research.Name: 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

A benzimidazole derived probe [(6-(1H-indol-3-yl)-5,6-dihydrobenzo[4,5]imidazo [1,2-c]quinazoline) (IDBIQ)] was synthesized and structurally characterized by single-crystal X-ray diffraction anal. and spectroscopic methods. The probe IDBIQ crystallizes in a monoclinic P2_1/c space group which is found to be highly sensitive and also selective towards the analytes Hg^II, F^– and histidine. The probe exhibits turn-off fluorescence for Hg^II and histidine while it is ratiometric towards F^– ions. These quenching and ratiometric fluorescent changes have been further explored by ¹H NMR titrations and DFT/TD-DFT calculations The limit of detection of the probe towards the analytes was found to be in nano-molar range and the receptor was observed to bind with the analytes in 1:1 stoichiometric manner. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Name: 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 5805-39-0In 2018, Chen, Dong-Sheng;Liu, Shu-Jun;Lu, Wen-Qiang;Wang, Xiang-Shan published 《Green synthesis of 6-aryl-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline derivatives in ionic liquid under catalyst-free conditions》. 《Journal of Heterocyclic Chemistry》published the findings. The article contains the following contents:

Using ionic liquids as green media, a series of 6-arylbenzimidazolo[1,2-c]quinazoline derivatives I [R¹ = 3-Cl, 4-Br, 3,5-(MeO)₂, etc.] was synthesized via reaction of 2-(1H-benzo[d]imidazol-2-yl)aniline and benzaldehydes in the air. The intermediate products of 6-arylbenzimidazolo[1,2-c]quinazolines II [R² = 2,4-Cl₂, 2-Br, 3,5-(MeO)₂, etc.] were obtained in high yields at the same conditions under nitrogen protection. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Application of 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kanlayakan, Narissa;Kungwan, Nawee published 《Theoretical study of heteroatom and substituent effects on excited-state intramolecular proton transfers and electronic properties of amino-type hydrogen bonding molecules》 in 2021. The article was appeared in 《Journal of Luminescence》. They have made some progress in their research.Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

Excited-state intramol. proton transfer (ESIPT) reactions and electronic properties of the NH-type hydrogen bonding mols. (APBI, APBO, APBT, and APIP) and their derivatives have been theor. investigated. For the different heteroatoms at the same position, the oxygen (APBO) and sulfur (APBT) bring weak intra-HB leading to only normal emission while the nitrogen (APBI) makes moderatly strong intra-HB in APBI giving dual emission. For the nitrogen heteroatoms at the different positions, the tertiary nitrogen in APIP greatly enhances intramol. charge transfer (ICT) resulting in a tautomer emission maximum (driven by ESIPT) at much longer wavelength compared to that of APBI with secondary nitrogen. Moreover, the introduction of a tosyl (Ts) into one of amino protons of the NH-type mols. yielding Ts-substituted derivatives can ensure their ESIPT providing a single tautomer emission. Furthermore, the addition of a moderatly strong electron withdrawing group (cyano) in tosylaminophenyl causes a slight blue-shift of the tautomer emission maximum while the addition of a moderatly strong electron donating group (amino) makes a noticeable red-shift of the emission maximum compared to their parents. Among the designed derivatives, APIP-tosyl-NH2 photoexcited at around 360 nm exhibits the longest wavelength of tautomer emission in near IR region caused by strong ICT leading to large Stokes shift that can avoid self-reabsorption which is an important character for fluorescent probes.2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) were involved in the experimental procedure.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Odame, F.;Hosten, E. C.;Tshentu, Z. R. published 《Synthesis, Characterization, and Computional Studies of Triazatetracyclo Acetamide》 in 2018. The article was appeared in 《Journal of Structural Chemistry》. They have made some progress in their research.Recommanded Product: 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

N-[(9E)-8,0 10,0 17-triazatetracyclo[8.7.0.0^2,7.0^11,18]heptadeca-1(17),2(7),3,5,11,13,15-heptaen-9-ylidene] acetamide (I) was synthesized and characterized by spectroscopy, microanal., and single crystal X-ray diffractometry. Compound I crystallizes in the monoclinic space group P21/n with a = 17.5552(17) Å, b = 4.6163(4) Å, c = 17.7662(17) Å, β = 115.953(3)°, and Z = 4. The bond angles and bond lengths of the compound are computed using the d. functional theory with B3LYP, BPW91, and wB97XD functionals and the 6-31G++(d,p) basis set. The frontier orbitals that contribute to the reactivity of triazatetracyclics were discussed. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Recommanded Product: 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Xiong, Yucong;Wang, Kaizhi;Ma, Lei;Zhu, Jiukang;Miao, Yujia;Gong, Li;Mu, Xiao;Wan, Jiang;Li, Rong published 《Bimetallic CoMoO₄@C nanorod catalyzes one-pot synthesis of benzimidazoles from benzyl alcohol and o-phenylendiamine without alkali》 in 2022. The article was appeared in 《Applied Organometallic Chemistry》. They have made some progress in their research.Recommanded Product: 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

Benzimidazoles possess a series of applications for industrial chem. and biomedicine. However, the complicated synthetic steps and harsh reaction conditions limit its further development. Herein, authors reported an efficient, environmentally friendly, and stable bimetallic CoMoO4@C catalyst, which used low-cost cobalt and molybdenum as the basic raw material. In base-free conditions, it has been proved that the yield could achieve to 99.9% for the synthesis of benzimidazoles with liberating water as the sole byproduct, and the catalyst remains stable and efficient even after five successive cycle tests. Addnl., experiments and characterizations confirm the good oxidation activity of the catalyst benefits from the numerous oxygen vacancies provided by the high concentration of low-valent cobalt (Co²⁺) and the doping of carbon improves the intermol. transport of electrons. Furthermore, this strategy could potentially be applied in the industrial production of benzimidazoles. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Recommanded Product: 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

COA of Formula: C13H11N3《Synthesis, characterization, X-ray crystal structures of heterocyclic Schiff base compounds and in vitro cholinesterase inhibition and anticancer activity》 was published in 2017. The authors were Arafath, Azharul Md.;Adam, Farook;Al-Suede, Fouad Saleih R.;Razali, Mohd. R.;Ahamed, Mohamed B. Khadeer;Abdul Majid, Amin Malik Shah;Hassan, Mohd. Zaheen;Osman, Hasnah;Abubakar, Saifullah, and the article was included in《Journal of Molecular Structure》. The author mentioned the following in the article:

Four heterocyclic embedded Schiff base derivatives, (benzimidazo[1,2-c]quinazolin-6-yl)methoxyphenol I and II [R = 3-OH-4-OMe, 2-OH-5-OMe; R¹ = 5-methyl-2-pyridyl, 2-(1,3-benzothiazol-2-yl)phenyl] were synthesized and characterized by m.p., elemental anal., FTIR, ¹H, ¹³C NMR and UV-visible spectral data. The structures of compounds I and II [R = 2-OH-5-OMe, R¹ = 5-methyl-2-pyridyl; 3-OH-4-OMe, 2-(1,3-benzothiazol-2-yl)phenyl] were successfully established through single crystal X-ray diffraction anal. In-vitro cholinesterase inhibition assays showed that the cyclized derivative I displayed higher BuChE enzyme inhibitory activity with IC₅₀ value of 1.45 ± 0.09 μM. The anti-proliferative efficacies of the compounds were also evaluated using human colorectal HCT 116 and breast MCF-7 adenocarcinoma cell lines. In addition, a human normal endothelial cell line (Ea.hy926) was also tested to assess the safety and selectivity of the compounds towards normal and cancer cells, resp. Among the compounds tested, compound II [R = 3-OH-4-OMe, 2-(1,3-benzothiazol-2-yl)phenyl] displayed potent cytotoxic effect (IC₅₀ = 34 μM) against HCT 116 cells with highest selectivity index of 3.1 with respect to the normal endothelial cells. Whereas, compound II [R = 2-OH-5-OMe, R¹ = 5-methyl-2-pyridyl] exhibited significant anti-proliferative effect (IC₅₀ = 21.1 μM) against MCF-7 cells with highest selectivity index of 3.3 with respect to the normal endothelial cells. The docking result of these compounds against hAChE showed potent activities with different binding modes. These compounds could be a promising pharmacol. agent to treat cancer and Alzheimer’s disease. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 COA of Formula: C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem