Tag: 186.1819

Related Products of 123470-47-3,Some common heterocyclic compound, 123470-47-3, name is 5,6-Difluoro-1H-benzo[d]imidazole-2(3H)-thione, molecular formula is C7H4F2N2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 1-tert-butoxycarbonyl-4-(2-hydroxyethyl)piperazine (7.40 g, 32.13 mmol) in THF (100 mL), while stirring in an ice-bath, triethylamine (4.36 g, 43.09 mmol), 4-dimethylaminopyridine (200 mg, 1.64 mmol), and methanesulfonyl chloride (7.40 g, 38.76 mmol) were sequentially added. The temperature of the mixture was allowed to room temperature, and the mixture was stirred for 50 minutes. The reaction mixture was filtrated, and the filtrate was concentrated under reduced pressure. The residue was dissolved in DMF (200 mL), and, at room temperature, 5,6-difluoro-2-mercaptobenzimidazole (5.00 g, 26.86 mmol), potassium carbonate (8.64 g, 62.51 mmol), and 18-crown-6 (500 mg, 1.92 mmol) were sequentially added to the solution, followed by stirring for 90 minutes at 80 C. The reaction mixture was concentrated under reduced pressure, and the residue was purified through silica gel column chromatography (silica gel 200 g, hexane: acetone=8:1 to 1:1). The product was crystallized from acetone-ether-hexane, to thereby yield 1-tert-butoxycarbonyl-4-[2-(5,6-difluorobenzimidazol-2-ylthio)ethyl]piperazine (7.26 g, yield 68%) as colorless crystals. mp: 192.3-193.0 C. IR (KBr): 3061, 2976, 2836, 1672, 1475, 1427(cm-1). 1H-NMR (400 MHz, CDCl3) delta: 1.50 (9H, s), 2.51-2.68 (4H, m), 2.94 (2H, t, J=5.4 Hz), 3.28 (2H, t, J=5.4 Hz), 3.45-3.65 (4H, m), 6.85-7.62 (2H, m).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,6-Difluoro-1H-benzo[d]imidazole-2(3H)-thione, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 123470-47-3, name is 5,6-Difluoro-1H-benzo[d]imidazole-2(3H)-thione, A new synthetic method of this compound is introduced below., Quality Control of 5,6-Difluoro-1H-benzo[d]imidazole-2(3H)-thione

Subsequently, 93.1 mg of 5,6-difluorobenzimidazole-2-thiol (0.5 mmol) was dissolved in 2 ml of N,N-dimethylformamide, and the solution was heated at 80 C. for 12 hr after the addition of 104 mul of triethylamine and 117 mg of ethyl 4-bromobutyrate. The reaction mixture was cooled, water was added, the mixture was extracted with diethyl ether, and the organic layer was concentrated in vacuo. The residue was purified by preparative thin layer chromatography (hexane-ethyl acetate=1:1), and the product was collected and dried to yield 113 mg of 4-(5,6-difluorobenzimidazole-2-ylthio)butyric acid ethyl ester (75% yield).

The synthetic route of 123470-47-3 has been constantly updated, and we look forward to future research findings.