Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2302-25-2, name is 4-Bromo-1H-imidazole, A new synthetic method of this compound is introduced below., Quality Control of 4-Bromo-1H-imidazole
A solution of compound 126-1 (5.0 g, 34 mmol, 1.0 eq), compound 126- la (5.0 g, (1508) 58 mmol, 1.7 eq), Cu(OAc)2 (6.2 g, 34 mmol, 1.0 eq), 2,2′-bipyridine (5.3 g, 34 mmol, 1.0 eq) and potassium carbonate (9.4 g, 68 mmol, 2.0 eq) in 1,2-dichloroethane (150 mL) was stirred at 70 C for 16 hrs. TLC showed one new spot was formed. EA (220 mL) was added, and then the suspension was filtered. The organic layer was concentrated under reduced pressure. The mixture was diluted with water (80 mL) and the resultant mixture was extracted with EA (150 mL * 3). The combined organic layers were dried over Na2SC>4, filtered and concentrated to dryness under reduced pressure. The residue was purified by column chromatography over silica gel to afford the title compound 126-2 as a crude product. The residue was purified by Prep-TLC to obtain the title compound 126-2 (1.2 g, 18% yield). Ti NMR (400MHz, CDC13) delta 7.42 (s, 1H), 6.95 (d, J = 1.3 Hz, 1H), 3.36 -3.28 (m, 1H), 1.06 – 0.90 (m, 4H).
The synthetic route of 2302-25-2 has been constantly updated, and we look forward to future research findings.