Tag: 0-100

In 2017,Abdellattif, Magda H.; Eissa, A. M. F.; Mohamed, H. M. published 《Synthesis of anionic surface active agents containing heterocyclic moiety from long chain fatty alcohols》.Journal of Advances in Chemistry published the findings.Safety of 1H-Imidazol-2-amine The information in the text is summarized as follows:

A series of novel groups of anionic surface active agent were synthesized. Synthesis of these surfactants via the reaction of long chain fatty alcs. (octyl, decyl and dodecyl) with maleic anhydride to give monoester. The monoester chloride reacted with amino derivatives of heterocyclic rings followed by addition of NaHSO3. The surface tension, interfacial tension; Kraft point, emulsifying and wetting power were evaluated. Stability to hydrolysis, biodegradability and biol. activities were measured. A comparison studies between the chem. structures and the results were done. After reading the article, we found that the author used 1H-Imidazol-2-amine(cas: 7720-39-0Safety of 1H-Imidazol-2-amine)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Safety of 1H-Imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2017,Draughn, G. Logan; Allen, C. Leigh; Routh, Patricia A.; Stone, Maria R.; Kirker, Kelly R.; Boegli, Laura; Schuchman, Ryan M.; Linder, Keith E.; Baynes, Ronald E.; James, Garth; Melander, Christian; Pollard, Angela; Cavanagh, John published 《Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections》.Drug Design, Development and Therapy published the findings.Quality Control of 1H-Imidazol-2-amine The information in the text is summarized as follows:

2-Aminoimidazole (2-AI)-based compounds have been shown to efficiently disrupt biofilm formation, disperse existing biofilms, and resensitize numerous multidrug-resistant bacteria to antibiotics. Using Pseudomonas aeruginosa and Staphylococcus aureus, we provide initial pharmacol. studies regarding the application of a 2-AI as a topical adjuvant for persistent dermal infections. In vitro assays indicated that the 2-AI H10 is nonbactericidal, resensitizes bacteria to antibiotics, does not harm the integument, and promotes wound healing. Furthermore, in vivo application of H10 on swine skin caused no gross abnormalities or immune reactions. Taken together, these results indicate that H10 represents a promising lead dermal adjuvant compound The experimental process involved the reaction of 1H-Imidazol-2-amine(cas: 7720-39-0Quality Control of 1H-Imidazol-2-amine)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Quality Control of 1H-Imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

COA of Formula: C3H5N3In 2017 ,《2-Aminoimidazoles: synthesis by ring transformation reactions》 appeared in Studies in Natural Products Chemistry. The author of the article were Babaev, Eugene V.. The article conveys some information:

A review. Marine sponges belonging to the Calcarea family have been proven to be a source of biol. active alkaloids and their metabolites. Two Calcarea genera, Leucetta and Clathrina, have been found to contain more than 60 examples of imidazole alkaloids during the last 30 years. Since the first discovery of 2-aminoimidazole (2-Al) alkaloids in marine sponges by Kashman’s group in 1987. A number of preclathridine and isonaamine alkaloids, representing a family of 1,4-substituted 2-aminoimidazoles bearing one or two substituted benzyl moieties, have been isolated and synthesized in the last decades (see Scheme 2.1) [2]. Of course, the number of 2-AI is not exhausted by these examples; the series is much broader [3]. Many 2-AI alkaloids have been reported to have cytotoxic, antimicrobial, or antifungal properties [4,5],and this topic was recently well reviewed. In addition to this study using 1H-Imidazol-2-amine, there are many other studies that have used 1H-Imidazol-2-amine(cas: 7720-39-0COA of Formula: C3H5N3) was used in this study.

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.COA of Formula: C3H5N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Enhancing the Recyclability of a Vegetable Oil-Based Epoxy Thermoset through Initiator Influence》 was written by di Mauro, Chiara; Tran, Thi-Nguyet; Graillot, Alain; Mija, Alice. Synthetic Route of C4H6N2 And the article was included in ACS Sustainable Chemistry & Engineering in 2020. The article conveys some information:

Bisphenol A based epoxy thermosets involve both environmental and health risks. By reacting a vegetal oil-based epoxide with an aromatic diacid containing S-S bonds a thermoset is produced. Herein, reprocessable thermosets were synthesized, the recyclability being designed through a dual mechanism: that of disulfide metathesis and of transesterifications. To assess the feasibility of the reprocessing, a series of ten initiators were tested to probe their effect not only on the crosslinking reaction but also on the recyclability. This study introduces for the first time the key role of the initiator on the material performances and on their reprocessing. A very good reprocessability was obtained for thermosets prepared using as initiator the imidazole. Moreover, the thermosets exhibit complete chem. recyclability in 1N NaOH at 80°C, after 3 days, without needing addnl. chems. The reprocessed materials have similar performances with the virgin ones, even after 10 cycles of reprocessing. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazole(cas: 616-47-7Synthetic Route of C4H6N2)

1-Methyl-1H-imidazole(cas: 616-47-7) is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.Synthetic Route of C4H6N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Enhanced Menshutkin SN2 Reactivity in Mesoporous Silica: The Influence of Surface Catalysis and Confinement》 was written by Zheng, Weizhong; Yamada, Steven A.; Hung, Samantha T.; Sun, Weizhen; Zhao, Ling; Fayer, Michael D.. HPLC of Formula: 616-47-7 And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

A significant enhancement in the Menshutkin SN2 reaction between 1-methylimidazole (MeIm) and Me thiocyanate (MeSCN) is observed when the reaction is confined in the nanoscale silica pores of MCM41 and SBA15. The experiments in the silica pores are conducted without the surrounding bulk reaction mixture The influences of temperature, pore radius, and surface chem. on the kinetics of the confined reaction are analyzed with time-dependent IR spectroscopy, mol. dynamics simulations, and ab initio calculations The rate constant of the pseudo-first order reaction increases with decreasing pore size, and the activation energy is found to decrease by 5.6 kJ/mol in the smallest pore studied (2.8 nm) relative to the bulk reaction. The rate constant dependence on pore size is accurately described by a two-state model in which mols. within the 4.6 Å interfacial layer experience a 2.4-fold rate constant increase relative to those reacting at the bulk rate further away from the interface. The removal of polar silanol groups from the silica surface via passivation with trimethylsilyl chloride results in bulk-like kinetics despite a reduction in the pore diameter, demonstrating the role of silanols as catalytic sites. Electronic structure calculations of the energy profile on a model silica surface confirm that silanol groups, particularly those of the vicinal type, can reduce the activation energy and reaction endothermicity through the donation of hydrogen bonds to the reactant, transition state, and product complexes. In the experiment, the researchers used 1-Methyl-1H-imidazole(cas: 616-47-7HPLC of Formula: 616-47-7)

1-Methyl-1H-imidazole(cas: 616-47-7) is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.HPLC of Formula: 616-47-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Design, synthesis and nematicidal activitives of trifluorobutene amide derivatives against Meloidogyne incognita》 was written by Yang, Haiping; Zhang, Ruifeng; Li, Zhong; Maienfisch, Peter; Xu, Xiaoyong. SDS of cas: 7720-39-0This research focused ontrifluorobutene amide derivative synthesis treatment nematode nematicide; Amide; In vitro; In vivo; Nematicidal activity; Trifluorobutene. The article conveys some information:

Plant parasitic nematodes have always been a pressing problem in the field of plant protection. Well-established chem. nematicides, especially organophosphorus and carbamates are the most used products for nematode control worldwide. Due to long-term overuse, they have developed serious resistance and new innovative solutions are urgently required. In this study, thirty-one novel trifluorobutene amide derivatives were designed and synthesized, and their nematicidal activities were determined Three different synthetic methods have been developed for the final amidation reaction enabling the successfully syntheses of the target compounds independently from the nucleophilicities of the substrate amino group. Most target compounds showed good nematicidal activity in our in vitro test. Among all the compounds, compounds I and II exhibited excellent nematicidal activity against Meloidogyne incognita, their LC50 values are 2.02 mg L-1 and 0.76 mg L-1, resp. In particular, compound II has found to be almost as active as the com. nematicide fluensulfone. Furthermore, most compounds gave full control (100% inhibition) of M. incognita at 40 mg L-1 in the in vivo tests in sandy soil, the best compounds were further investigated for in vivo activity in matrix soil. Among the compound tested, compound I showed excellent in vivo nematicidal activity. At a concentration of 5 mg L-1 still 56% inhibition was observed The results of our study indicate that compound I possesses excellent in vitro and in vivo nematicidal activity, and can be considered as promising lead mol. for further modification. In the part of experimental materials, we found many familiar compounds, such as 1H-Imidazol-2-amine(cas: 7720-39-0SDS of cas: 7720-39-0)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.SDS of cas: 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Angewandte Chemie, International Edition included an article by Hedges, Jason B.; Ryan, Katherine S.. Category: imidazoles-derivatives. The article was titled 《In vitro reconstitution of the biosynthetic pathway to the nitroimidazole antibiotic azomycin》. The information in the text is summarized as follows:

Nitroimidazoles are one of the most effective ways to treat anaerobic bacterial infections. Synthetic nitroimidazoles are inspired by the structure of azomycin, isolated from Streptomyces eurocidicus in 1953. Despite its foundational role, no biosynthetic gene cluster for azomycin has been found. Guided by bioinformatics, we identified a cryptic biosynthetic gene cluster in Streptomyces cattleya and then carried out in vitro reconstitution to deduce the enzymic steps in the pathway linking L-arginine to azomycin. The gene cluster we discovered is widely distributed among soil-dwelling actinobacteria and proteobacteria, suggesting that azomycin and related nitroimidazoles may play important ecol. roles. Our work sets the stage for development of biocatalytic approaches to generate azomycin and related nitroimidazoles. In the experiment, the researchers used many compounds, for example, 1H-Imidazol-2-amine(cas: 7720-39-0Category: imidazoles-derivatives)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Angewandte Chemie, International Edition included an article by Hedges, Jason B.; Ryan, Katherine S.. Category: imidazoles-derivatives. The article was titled 《In vitro reconstitution of the biosynthetic pathway to the nitroimidazole antibiotic azomycin》. The information in the text is summarized as follows:

Nitroimidazoles are one of the most effective ways to treat anaerobic bacterial infections. Synthetic nitroimidazoles are inspired by the structure of azomycin, isolated from Streptomyces eurocidicus in 1953. Despite its foundational role, no biosynthetic gene cluster for azomycin has been found. Guided by bioinformatics, we identified a cryptic biosynthetic gene cluster in Streptomyces cattleya and then carried out in vitro reconstitution to deduce the enzymic steps in the pathway linking L-arginine to azomycin. The gene cluster we discovered is widely distributed among soil-dwelling actinobacteria and proteobacteria, suggesting that azomycin and related nitroimidazoles may play important ecol. roles. Our work sets the stage for development of biocatalytic approaches to generate azomycin and related nitroimidazoles. In the experiment, the researchers used many compounds, for example, 1H-Imidazol-2-amine(cas: 7720-39-0Category: imidazoles-derivatives)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of C4H6N2In 2022 ,《Revealing the Organization of Catalytic Sequence-Defined Oligomers via Combined Molecular Dynamics Simulations and Network Analysis》 appeared in Journal of Chemical Information and Modeling. The author of the article were Kardas, Sinan; Fossepre, Mathieu; Lemaur, Vincent; Fernandes, Antony E.; Glinel, Karine; Jonas, Alain M.; Surin, Mathieu. The article conveys some information:

Similar to biol. macromols. such as DNA and proteins, the precise control over the monomer position in sequence-defined polymers is of paramount importance for tuning their structures and properties toward achieving specific functions. Here, we apply mol. network anal. on three-dimensional structures issued from mol. dynamics simulations to decipher how the chain organization of trifunctional catalytic oligomers is influenced by the oligomer sequence and the length of oligo(ethylene oxide) spacers. Our findings demonstrate that the tuning of their primary structures is crucial for favoring cooperative interactions between the catalytic units and thus higher catalytic activities. This combined approach can assist in establishing structure-property relationships, leading to a more rational design of sequence-defined catalytic oligomers via computational chem. In the part of experimental materials, we found many familiar compounds, such as 1-Methyl-1H-imidazole(cas: 616-47-7Synthetic Route of C4H6N2)

1-Methyl-1H-imidazole(cas: 616-47-7) is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate.Synthetic Route of C4H6N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of C3H5N3In 2021 ,《Prebiotic Phosphorylation and Concomitant Oligomerization of Deoxynucleosides to form DNA》 appeared in Angewandte Chemie, International Edition. The author of the article were Jimenez, Eddy I.; Gibard, Clementine; Krishnamurthy, Ramanarayanan. The article conveys some information:

Recent demonstrations of RNA-DNA chimeras (RDNA) enabling RNA and DNA replication, coupled with prebiotic co-synthesis of deoxyribo- and ribo-nucleotides, have resurrected the hypothesis of co-emergence of RNA and DNA. As further support, we show that diamidophosphate (DAP) with 2-aminoimidazole (amido)phosphorylates and oligomerizes deoxynucleosides to form DNA-under conditions similar to those of ribonucleosides. The pyrimidine deoxynucleoside 5′-O-amidophosphates are formed in good (≈60 %) yields. Intriguingly, the presence of pyrimidine deoxynucleos(t)ides increased the yields of purine deoxynucleotides (≈20 %). Concomitantly, oligomerization (≈18-31 %) is observed with predominantly 3′,5′-phosphodiester DNA linkages, and some (<5 %) pyrophosphates. Combined with previous observations of DAP-mediated chemistries and the constructive role of RDNA chimeras, the results reported here help set the stage for systematic investigation of a systems chem. approach of RNA-DNA co-evolution. In the experiment, the researchers used 1H-Imidazol-2-amine(cas: 7720-39-0Synthetic Route of C3H5N3)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Synthetic Route of C3H5N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem