Tag: 0-100

In 2018,Ghanbarimasir, Zahra; Bekhradnia, Ahmadreza; Morteza-Semnani, Katayoun; Rafiei, Alireza; Razzaghi-Asl, Nima; Kardan, Mostafa published 《Design, synthesis, biological assessment and molecular docking studies of new 2-aminoimidazole-quinoxaline hybrids as potential anticancer agents》.Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published the findings.HPLC of Formula: 7720-39-0 The information in the text is summarized as follows:

In a search for novel antiproliferative agents, a series of quinoxaline derivatives containing 2-aminoimidazole (8a-8x) were designed and synthesized. The structures of synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, Mass Spectroscopy and analyzed using HSQC, COSY, ROESY, HMBC techniques. The anticancer activity of all derivatives were evaluated for colon cancer and breast cancer cell lines by the MTT assay and acridine orange/ethidium bromide double staining method. The anti-cancer effect in human colon cancer (HCT-116) and breast cancer (MCF-7) cell lines exhibited that compounds 8a, 8s, 8t, 8w, 8x appeared as potent antiproliferative agents and especially inhibited the human colon cancer cell proliferation with percentage of inhibition by over 50%. The most active compound was (E)-4-phenyl-1-((quinoxalin-2-ylmethylene)amino)-1H-imidazol-2-amine (8a) with the highest inhibition for MCF-7 (83.3%) and HCT-116 (70%) cell lines after 48 and 24 h, resp. Mol. docking studies of these derivatives within c-kit active site as a validated target might be suggested them as appropriate candidates for further efforts toward more potent anticancer compounds After reading the article, we found that the author used 1H-Imidazol-2-amine(cas: 7720-39-0HPLC of Formula: 7720-39-0)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.HPLC of Formula: 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Molecular-level electrochemical doping for fine discrimination of volatile organic compounds in organic chemiresistors》 was written by Kwon, Sooncheol; Pak, Yusin; Kim, Bongseong; Park, Byoungwook; Kim, Jehan; Kim, Geunjin; Jo, Yong-Ryun; Limbu, Saurav; Stewart, Katherine; Kim, Hyeonghun; Kim, Bong-Joong; Jang, Soo-Young; Kang, Hongkyu; Min, Jung-Wook; Kim, Ji-Seon; Jung, Gun Young; Lee, Kwanghee. Electric Literature of C4H6N2 And the article was included in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2020. The article conveys some information:

Printable organic sensors fabricated from solution-processed π-conjugated polymers (π-CPs) are promising candidates to detect volatile organic compounds (VOCs) due to the intriguing phys., chem. and electronic properties of π-CPs. These devices, often termed organic chemiresistors, require good sensing capabilities to transduce stimuli from specific VOCs at low concentrations into anal. elec. signals. However, discriminating such VOCs using organic chemiresistors proved very challenging. Herein, the authors report that the mol.-level electrochem. doping of π-CPs with solid-state ionic liquids (SILs) significantly improves their elec. conductivity (~10-1 S cm-1) and selective VOC interactions, which can be manipulated through different π-CPs:SIL blend ratios. These characteristics enable the fine discrimination of VOCs at concentrations in the parts-per-billion (ppb) range under low power consumption (<0.1 μW) and room temperature conditions. The authors′ result provides a new opportunity for developing highly sensitive and selective VOC monitoring platform technologies that are printable on large-area, wearable, flexible and transparent substrates. The experimental process involved the reaction of 1-Methyl-1H-imidazole(cas: 616-47-7Electric Literature of C4H6N2)

1-Methyl-1H-imidazole(cas: 616-47-7) is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.Electric Literature of C4H6N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem