Tag: 0-100

《Synthetic enzyme-based nanoparticles act as smart catalyst for glucose responsive release of insulin》 was written by Jana, Baishali A.; Shinde, Ujwala; Wadhwani, Ashish. Product Details of 7720-39-0 And the article was included in Journal of Biotechnology in 2020. The article conveys some information:

This study aimed to assess faster responsiveness of insulin release from this enzyme based nanoparticles which is self-regulated insulin delivery system constructed by loading with insulin, enzyme glucose oxidase into hyaluronic acid and 2-nitroimidazole forming enzyme-based nanoparticles which works in accordance to the blood glucose level. Enzyme-based nanoparticles were prepared by ionic gelation method. Insulin content in nanoparticles kept for stability study was estimated by human insulin enzyme based immunosorbent assay. In in-vitro studies; different concentrations of glucose were taken and the release study of insulin was recorded. This enzyme-based nanoparticles were having average diameter of around 193 nm and stability studies showed that nanoparticles were stable up to 30 days at 4°C. In-vitro studies showed the release of insulin from nanoparticle conjugates which was effectively correlated with the external glucose concentration created where different concentrations of glucose taken thus facilitating the stabilization of blood glucose levels in the hyperglycemia state which was achieved within 10 min. wherein drug release rate remarkably increased in hyperglycemia state and no specific changes or small amount of release was observed in normoglycemia state (100 mg/dL). Preliminary study of this enzyme-based nanoparticles formulation showed excellent rapid responsiveness towards hyperglycemia which might act as potential biomimetic system in triggering release of insulin in sustained manner. The experimental process involved the reaction of 1H-Imidazol-2-amine(cas: 7720-39-0Product Details of 7720-39-0)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Product Details of 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Effects of Atractylodes Oil on Inflammatory Response and Serum Metabolites in Adjuvant Arthritis Rats》 was published in Biomedicine & Pharmacotherapy in 2020. These research results belong to Qu, Linghang; Xu, Yiyi; Cao, Guosheng; Xu, Kang; Tu, Jiyuan; Lin, Xiong; Wang, Guangzhong; Li, Shuiqing; Liu, Yanju. Name: 1H-Imidazol-2-amine The article mentions the following:

Atractylodes Rhizoma is one of two principal components in Ermiaosan, a well-known traditional Chinese medicine for the treatment of rheumatoid arthritis (RA). Atractylodes oil (AO) represents a potential alternative treatment for RA. The purpose of this study was to investigate the effect of AO in rats with Adjuvant Arthritis (AA) by exploration of changes in serum metabolites using gas chromatog.-mass spectrometry (GC-MS). Foot thickness and arthritis score, ankle joint pathol. structure, the concentrations of TNF-α, IL-1β, IL-6, IL-17 and the expression of MMPs in ankle joint tissue were measured as indicators of efficacy of treatment using AO. In addition, multivariate statistical anal. was used to identify differential production of metabolites and biomarkers, and to analyze metabolic pathways. The results demonstrate that administration of AO resulted in a good therapeutic effect in the AA rat model, with significantly improved joint swelling, reduced joint score, and inhibition of inflammation, synovial pannus hyperplasia, and bone and cartilage destruction. Furthermore, AO was found to exert its effect against rheumatoid arthritis principally by differentially affecting 11 metabolites and six metabolic pathways, predominantly related to abnormal amino acid metabolism, in addition to energy-related metabolic pathways. This study evaluated the capability of AO to effectively treat AA rats, providing a novel strategy for the treatment of RA.1H-Imidazol-2-amine(cas: 7720-39-0Name: 1H-Imidazol-2-amine) was used in this study.

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Name: 1H-Imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Nanomaterials included an article by Khorasani, Media Ghasem Zadeh; Elert, Anna-Maria; Hodoroaba, Vasile-Dan; Jacome, Leonardo Agudo; Altmann, Korinna; Silbernagl, Dorothee; Sturm, Heinz. Reference of 1-Methyl-1H-imidazole. The article was titled 《Short- and long-range mechanical and chemical interphases caused by interaction of boehmite (γ-AlOOH) with anhydride-cured epoxy resins》. The information in the text is summarized as follows:

Understanding the interaction between boehmite and epoxy and the formation of their interphases with different mech. and chem. structures is crucial to predict and optimize the properties of epoxy-boehmite nanocomposites. Probing the interfacial properties with at. force microscopy-based methods, especially particle-matrix long-range interactions, is challenging. This is due to size limitations of various anal. methods in resolving nanoparticles and their interphases, the overlap of interphases, and the effect of buried particles that prevent the accurate interphase property measurement. Here, we develop a layered model system in which the epoxy is cured in contact with a thin layer of hydrothermally synthesized boehmite. Different microscopy methods are employed to evaluate the interfacial properties. With intermodulation at. force microscopy and amplitude dependence force spectroscopy, which contain information about stiffness, electrostatic, and van der Waals forces, a soft interphase was detected between the epoxy and boehmite. Surface potential maps obtained by scanning Kelvin probe microscopy revealed another interphase about one order of magnitude larger than the mech. interphase. The AFM-IR spectroscopy technique reveals that the soft interphase consists of unreacted curing agent. The long-range elec. interphase is attributed to the chem. alteration of the bulk epoxy and the formation of new absorption bands. In addition to this study using 1-Methyl-1H-imidazole, there are many other studies that have used 1-Methyl-1H-imidazole(cas: 616-47-7Reference of 1-Methyl-1H-imidazole) was used in this study.

1-Methyl-1H-imidazole(cas: 616-47-7) is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.Reference of 1-Methyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Quality Control of 1H-Imidazol-2-amineIn 2017 ,《Synthesis and characterization of S(-)1-phenyl-1,2,3,4-tetrahydro isoquinoline acetamide analogues》 was published in Asian Journal of Chemistry. The article was written by Krishna Rao, N.; Surendra Babu, M.; Basaveswara Rao, M. V.; Keshavi, R.; Sundara Rao, N.; Eswara Prasad, N. H.; Murthy, Y. L. N.. The article contains the following contents:

S(-)1-Phenyl-1,2,3,4-tetrahydroisoquinoline acetamide analogs are prepared by sequence of reactions which involve a metal hydride reduction of 3,4-dihydroisoquinoline followed by separation of S-form with mandelic acid (chiral reagent) by resolution The product S(-)1-phenyl-1,2,3,4-tetrahydroisoquinoline is treated with chloroacetyl chloride to obtain tetrahydroisoquinoline acetyl chloride which is further employed to synthesize acetamide derivatives of tetrahydroisoquinoline I [R = Ph, 4-hydroxyphenyl, pyrimidin-2-yl, etc.] using various substituted aryl amines RNH2. The products were characterized by advanced spectroscopic techniques.1H-Imidazol-2-amine(cas: 7720-39-0Quality Control of 1H-Imidazol-2-amine) was used in this study.

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Quality Control of 1H-Imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formula: C4H6N2In 2019 ,《Superhydrophilic, Underwater Directional Oil-Transport Fabrics with a Novel Oil Trapping Function》 was published in ACS Applied Materials & Interfaces. The article was written by Fu, Sida; Zhou, Hua; Wang, Hongxia; Niu, Haitao; Yang, Weidong; Shao, Hao; Wang, Jinnan; Lin, Tong. The article contains the following contents:

In this study, we have prepared a novel superhydrophilic fabric that has underwater directional oil-transport capability. The fabric was prepared using a two-step process consisting of dip-coating of a crosslinkable polymer, which comprises both oleophilic and hydrophilic groups, onto the fabric substrate and single-side UV irradiation of the coated fabric. The fabric had in-air superhydrophilicity on both sides, and it can be wetted easily once immersed in water. The treated fabric showed underwater oleophobicity on the UV-exposed surface, whereas the unexposed back side still maintained underwater oleophilicity. At the optimized condition, the fabric in water transports oil automatically from the UV-exposed to the unexposed back side but stops oil transport in the opposite direction. Such a directional oil transport takes place without the need for oil prewetting or formation of a plastron layer on fabric. The UV irradiation time showed an effect on oil-transport ability. We further showed that the underwater directional oil-transport fabric had a novel “”oil trapping”” ability. When used to seal a container, the fabric can trap oil into the container, and once trapped, the oil was kept without releasing. This underwater directional oil-transport fabric may be useful for the development of high-efficiency oil recovery systems.1-Methyl-1H-imidazole(cas: 616-47-7Formula: C4H6N2) was used in this study.

1-Methyl-1H-imidazole(cas: 616-47-7) is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate.Formula: C4H6N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 7720-39-0In 2021 ,《A scaffold hopping strategy to generate new aryl-2-amino pyrimidine MRSA biofilm inhibitors》 was published in RSC Medicinal Chemistry. The article was written by Weig, Alexander W.; Barlock, Samantha L.; O’Connor, Patrick M.; Marciano, Orry M.; Smith, Richard; Ernst, Robert K.; Melander, Roberta J.; Melander, Christian. The article contains the following contents:

Infections that stem from bacterial biofilms are difficult to eradicate. Within a biofilm state, bacteria are upwards of 1000-fold more resistant to conventional antibiotics, necessitating the development of alternative approaches to treat biofilm-based infections. One such approach is the development of small mol. adjuvants that can inhibit/disrupt bacterial biofilms. When such mols. are paired with conventional antibiotics, these dual treatments present a combination approach to eradicate biofilm-based infections. Previously, we have demonstrated that small mols. containing either a 2-amino pyrimidine (2-AP) or a 2-aminoimidazole (2-AI) heterocycle are potent anti-biofilm agents. Herein, we now report a scaffold hopping strategy to generate new aryl 2-AP analogs that inhibit biofilm formation by methicillin-resistant Staphylococcus aureus (MRSA). These mols. also suppress colistin resistance in colistin resistant Klebsiella pneumoniae, lowering the min. inhibitory concentration (MIC) by 32-fold. The results came from multiple reactions, including the reaction of 1H-Imidazol-2-amine(cas: 7720-39-0Related Products of 7720-39-0)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Related Products of 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Product Details of 7720-39-0In 2017 ,《Synthesis, dyeing performance on polyester fiber and antimicrobial studies of some novel pyrazolotriazine and pyrazolyl pyrazolone azo dyes》 appeared in Arabian Journal of Chemistry. The author of the article were Rizk, Hala F.; Ibrahim, Seham A.; El-Borai, Mohammed A.. The article conveys some information:

The 5-amino-4-heterylazo-3-phenyl-1H-pyrazoles (2a-d) were diazotized and coupled with malononitrile to give pyrazoloazo malononitrile which by heating in glacial acetic acid gave novel pyrazolo[5,1-c][1,2,4]triazine dyes (3a-d). Also, some diazopyrazolyl pyrazolone dyes (4a-h) were synthesized by diazotization of 2a-d and coupled with some pyrazolone derivatives The structure of the synthesized dyes was determined by elemental anal. and spectral data. All the synthesized compounds were applied as disperse dyes and their dyeing performance on polyester fabric was studied. The fastness and colorimetric properties were measured. The results revealed that the monoazo dyes have good fastness and good to moderate affinity to polyester fabric than diazo dyes. In addition, the synthesized dyes were screened for their antimicrobial activities against Staphylococcus aureus, Pseudomonas aeruginosa (Gram pos.), Bacillus subtitles, Escherichia coli (Gram neg.) and Candida albicans, Aspergillus niger (Fungi). The results revealed that most of the prepared dyes have high antibacterial activity. In the part of experimental materials, we found many familiar compounds, such as 1H-Imidazol-2-amine(cas: 7720-39-0Product Details of 7720-39-0)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Product Details of 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zaoui, Tayeb; Debdab, Mansour; Haddad, Boumediene; Belarbi, El Habib; Chaker, Yassine; Rahmouni, Mustapha; Bresson, Serge; Baeten, Vincent published an article in 2021. The article was titled 《Synthesis, vibrational and thermal properties of new functionalized 1-(2-hydroxyethyl)-3-methylimidazolium dihydrogenophosphate ionic liquid》, and you may find the article in Journal of Molecular Structure.COA of Formula: C4H6N2 The information in the text is summarized as follows:

Very recently, the hydroxyl-functionalized ionic liquids have gained immense interest and were developed for a number of interesting applications. In this work and for the first time new hydroxyl-functionalized namely; 1-(hydroxyethyl)-3-methylimidazolium dihydrogenophosphate ionic liquid [EtOHMIM+][H2PO4-] was synthesized. The synthesis is based on an alkylation reaction of 1-methylimidazole followed by anion exchange. The obtained IL is characterized by 1H-NMR, 13C-NMR spectroscopy. Their exptl. vibrational spectroscopy have been investigated using IR and Raman spectroscopy, based on the IR (IR) and Raman spectroscopies results, complete vibrational assignments have been performed. Besides, thermal properties of this hydroxyl-functionalized IL were investigated by using following techniques, (i) thermogravimetric anal. (TGA) and derivative thermogravimetry (DTG) in the temperature range from 20 to 600°, (ii) differential scanning calorimetry (DSC) from-100° to 200°. The thermogravimetry anal. was coupled with mass spectrometry in order to assess the influence of anion on the measured property. In addition to this study using 1-Methyl-1H-imidazole, there are many other studies that have used 1-Methyl-1H-imidazole(cas: 616-47-7COA of Formula: C4H6N2) was used in this study.

1-Methyl-1H-imidazole(cas: 616-47-7) is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.COA of Formula: C4H6N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of C4H6N2In 2020 ,《Novel bio-based epoxy thermosets based on triglycidyl phloroglucinol prepared by thiol-epoxy reaction》 appeared in Polymers (Basel, Switzerland). The author of the article were Guzman, Dailyn; Santiago, David; Serra, Angels; Ferrando, Francesc. The article conveys some information:

The pure trifunctional glycidyl monomer from phloroglucinol (3EPO-Ph) was synthesized and used as feedstock in the preparation of novel bio-based thermosets by thiol-epoxy curing. The monomer was crosslinked with different com. available thiols: tetrafunctional thiol (PETMP), trifunctional thiol (TTMP) and an aromatic dithiol (TBBT) as curing agents in the presence of a base. As catalyst, two different com. catalysts: LC-80 and 4-(N, N-dimethylamino) pyridine (DMAP) and a synthetic catalyst, imidazolium tetraphenylborate (base generator, BG) were employed. The curing of the reactive mixtures was studied by using DSC and the obtained materials by means of differential scanning calorimetry (DSC), thermogravimetric anal. (TGA) and dynamic mech. thermal anal. (DMTA). The results revealed that only the formulations catalyzed by BG showed a latent character. Already prepared thermosetting materials showed excellent thermal, thermomech. and mech. properties, with a high transparency. In addition to that, when compared with the diglycidyl ether of bisphenol A (DGEBA)/PETMP material, the thermosets prepared from the triglycidyl derivative of phloroglucinol have better final characteristics and therefore this derivative can be considered as a partial or total renewable substitute of DGEBA in technol. applications. In the part of experimental materials, we found many familiar compounds, such as 1-Methyl-1H-imidazole(cas: 616-47-7Electric Literature of C4H6N2)

1-Methyl-1H-imidazole(cas: 616-47-7) is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate.Electric Literature of C4H6N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Stitou, Mourad; Toufik, Hamid; Akabli, Taoufik; Lamchouri, Fatima published an article in Journal of Molecular Modeling. The title of the article was 《Virtual screening of PEBP1 inhibitors by combining 2D/3D-QSAR analysis, hologram QSAR, homology modeling, molecular docking analysis, and molecular dynamic simulations》.Category: imidazoles-derivatives The author mentioned the following in the article:

Human phosphatidylethanolamine binding protein 1 (hPEBP1) is a novel target affecting many cellular signaling pathways involved in the formation of metastases. It can be used in the treatment of many cases of cancer. For these reasons, pharmaceutical companies use computational approaches, including multi-QSAR (2D, 3D, and hologram QSAR) anal., homol. modeling, mol. docking anal., and mol. dynamic simulations, to speed up the drug discovery process. In this paper, QSAR modeling was conducted using two quantum chem. optimization methods (AM1 and DFT levels). As per PLS results, we found that the DFT/B3LYP method presents high predictability according to 2D-QSAR, CoMFA, CoMSIA, and hologram QSAR studies, with Q2 of 0.81, 0.67, 0.79, and 0.67, and external power with R2pred of 0.78, 0.58, 0.66, and 0.56, resp. This result has been validated by CoMFA/CoMSIA graphics, which suggests that electrostatic fields combined with hydrogen bond donor/acceptor fields are beneficial to the antiproliferative activity. While the hologram QSAR models show the contributions of each fragment in improving the activity. The results from QSAR analyses revealed that ursolic acids with heterocyclic rings could improve the activities. Ramachandran plot validated the modeled PEBP1 protein. Mol. docking and MD simulations revealed that the hydrophobic and hydrogen bond interactions are dominant in the PEBP1′s pocket. These results were used to predict in silico structures of three new compounds with potential anticancer activity. Similar mol. docking stability studies and mol. dynamics simulations were conducted. The results came from multiple reactions, including the reaction of 1-Methyl-1H-imidazole(cas: 616-47-7Category: imidazoles-derivatives)

1-Methyl-1H-imidazole(cas: 616-47-7) is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem