Imidazoles-derivatives

Preparation and evaluation of solid supersaturable self-nanoemulsifying drug delivery system of candesartan cilexetil was written by Albaidhani, Safa F.;Hussein, Ahmed A.. And the article was included in Journal of Pharmaceutical Sciences and Research in 2019.Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

Solubility problem of many effective pharmaceutical mols. is still one of the major challenges in the formulation of these mols. Candesartan cilexetil (CC) is angiotensin II receptor antagonist and has very low water solubility and as a result of that low and variable bioavailability was produced. Supersaturable solid self- emulsifying drug delivery system (S-SSEDDS) showed a promising result in overcome solubility problem of many drug mols. with significant improvement in in-vivo bioavailability of drug mols. CC was prepared as S-SSEDDS by using novel combination of two surfactants (tween 80 and cremophore EL) and tetraglycol as cosurfactant, in addition to use of triacetin as oil and solidify using different adsorbents (Avicel PH101, Avicel PH102, Aerosil and dibasic calcium phosphate), after that a suitable precipitation inhibitor was used (HPMC K100). Different tests were performed to confirm the stability of the final product which includes; measurement of micrometric properties of the resultant powder, in-vitro drug release, SPM, FTIR, X-ray powder diffraction, DSC and in-vivo plasma level measurement. The results suggest that preparation of CC. as S-SSEDDS is a promising technique for oral delivery of CC. in order to improve its bioavailability. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Crystal structures and solution spectroscopy of lophine derivatives was written by Fridman, Natalya;Kaftory, Menahem;Eichen, Yoav;Speiser, Shammai. And the article was included in Journal of Molecular Structure in 2009.Category: imidazoles-derivatives This article mentions the following:

Lophine (2,4,5-triphenylimidazole) derivatives were synthesized and their physicochem. properties were determined Spectroscopic and fluorescence behavior of lophine derivatives in methanol at different pH and various solvents were presented. The observed spectroscopic features in the solution are determined by specific interactions of the NH hydrogen. These kinds of interactions are manifested both in the solid state and in solution The crystal and mol. structures of lophine derivatives with different solvents of crystallization are presented and discussed. In all solvates the solvent mols. link host mols. through hydrogen bonds. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Category: imidazoles-derivatives).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Syntheses of formamidines and benzimidazoles was written by Mathias, L. J.;Overberger, C. G.. And the article was included in Synthetic Communications in 1975.SDS of cas: 58442-17-4 This article mentions the following:

The benzimidazoles I (R = 5(6)-Cl, 5(6)-Me, 5(6)-CO2H, 5(6)-benzimidazol-5(6)-yl) were prepared by cyclization of 4-RC6H3(NH2)2-1,2 with HCO2H in the presence of HCl and a strong acid resin. RNHCH:NR (R = p-O2NC6H4, p-H2NC6H4, 2-thiazolyl, 2-pyridyl) and I (R = 5(6)-Me, 4(7)-Me, 5(6)-NO2, 5(6)-COMe, 5(6)-CHO, 5(6)-Cl) were prepared by treating RNH2 or RC6H4(NH2)2-1,2 with Cl2CHOMe containing (Me3C)3N. In the experiment, the researchers used many compounds, for example, 1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4SDS of cas: 58442-17-4).

1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.SDS of cas: 58442-17-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

One-step radiation synthesis of novel star-shaped polymeric ionic liquid-POSS gel electrolytes with high ionic conductivity and mechanical properties for supercapacitor was written by Shi, Mengni;Lin, Tingrui;Wang, Yue;Hu, Yang;Peng, Jing;Li, Jiuqiang;Zhai, Maolin. And the article was included in Journal of Materials Science in 2020.Synthetic Route of C9H15F6N2P This article mentions the following:

Polymeric ionic liquids (PILs) not only have the unique properties of ionic liquid, but also possess diverse mech. properties of polymers. Due to their safety and conductivity, PILs-based gel polymer electrolytes (GPEs) are the promising candidates for the design of the devices. Here, we reported a facile approach to synthesize novel star-shaped GPE (named PIL-POSS-Li GPE) based on 1-vinyl-3-butylimidazolium hexafluorophosphate ionic liquid, octavinyl polyhedral oligomeric silsesquioxane (POSS) and LiPF6 solution in one step via gamma-ray radiation. Compared with PIL-Li GPE without POSS, the incorporation of POSS into the PIL-Li GPE can improve properties of PIL-POSS-Li GPE due to the formation of a star-shaped structure, and the as-prepared PIL-POSS-Li GPE showed excellent compressive strength of 1617 kPa, high fracture compression stain of 79% and high ionic conductivity of 3.88 mS cm^-1 at 25掳C. What is more, the PIL-POSS-Li supercapacitor (SC) showed better electrochem. performance than PIL-Li SC. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9Synthetic Route of C9H15F6N2P).

1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Synthetic Route of C9H15F6N2P

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Copper(II)-catalyzed dehydrogenative cross-coupling between two azoles was written by Qin, Xurong;Feng, Boya;Dong, Jiaxing;Li, Xiaoyu;Xue, Ying;Lan, Jingbo;You, Jingsong. And the article was included in Journal of Organic Chemistry in 2012.Computed Properties of C4H5N3O2 This article mentions the following:

The copper(II)-catalyzed dehydrogenative coupling between two different azoles for the preparation of unsym. biazoles e. g., I has been developed. The current catalytic system can effectively control the chemoselectivity for heterocoupling over homocoupling. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Computed Properties of C4H5N3O2).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Computed Properties of C4H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Crystal structure of the triclinic modification of 1-methyl-4-nitroimidzole, C₄H₅N₃O₂ was written by Wang, Jianlong;Lian, Pengbao;Chen, Lizhen. And the article was included in Zeitschrift fuer Kristallographie – New Crystal Structures in 2017.Reference of 3034-41-1 This article mentions the following:

C₄H₅N₃O₂, triclinic, P1 (number 1), a = 3.8976(6) 脜, b = 5.7235(8) 脜, c = 6.2670(10) 脜, 伪 = 89.630(12)掳, 尾 = 84.800(13)掳, 纬 = 76.970(13)掳, V = 135.63(4) 脜³, Z = 1, R _gt(F) = 0.0519, wR _ref(F ²) = 0.1303, T = 104.8 K. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Reference of 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

How does methylation suppress the electron-induced decomposition of 1-methyl-nitroimidazoles? was written by Kossoski, F.;Varella, M. T. do N.. And the article was included in Journal of Chemical Physics in 2017.Safety of 1-Methyl-4-nitroimidazole This article mentions the following:

The efficient decomposition of nitroimidazoles (NIs) by low energy electrons is believed to underlie their radiosensitizing properties. Recent dissociative electron attachment (DEA) measurements showed that methylation at the N1 site unexpectedly suppresses the electron-induced reactions in 4(5)-NI. We report theor. results that provide a clear interpretation of that astounding finding. Around 1.5 eV, DEA reactions into several fragments are initiated by a 蟺^* resonance, not considered in previous studies. The autoionization lifetime of this anion state, which limits the predissociation dynamics, is considerably shorter in the methylated species, thereby suppressing the DEA signals. On the other hand, the lifetime of the 蟺^* resonance located around 3 eV is less affected by methylation, which explains why DEA is still observed at these energies. Our results demonstrate how even a simple methylation can significantly modify the probabilities for DEA reactions, which may be significant for NI-based cancer therapy. (c) 2017 American Institute of Physics. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Safety of 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Safety of 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Heterocyclic compounds. Ultraviolet absorption spectra and chromophoric properties. I. Imidazoles, benzimidazoles, and phenylbenzimidazoles was written by Leandri, Guiseppe;Mangini, Angelo;Montanari, Fernando;Passerini, Riccardo. And the article was included in Gazzetta Chimica Italiana in 1955.COA of Formula: C7H5BrN2 This article mentions the following:

The ultraviolet absorption spectra of imidazole, some methylimidazoles, 2-phenylimidazole (I), and of 20 methyl, halo, methoxy, amino and nitro derivatives of I, of 1- and 2-phenylbenzylimidazoles (III and IV) and 72 methylhalo, methoxy, amino, and nitro derivatives of III and IV are presented. The spectra are discussed in the light of the theory of localized chromophoric groups, and the essential chromophores are characterized in relation to their primary absorption bands. Some of the conclusions derived by the authors from their data are: (1) The absorption of imidazole and methylimidazole in the region of 200-2掳 m渭 is attributed to “cyclic” excitation, that is, a transition which involves the passage from a sym. compound structurally covalent, to one which is antisym. and polar; (2) in the case of the nitrobenzimidazoles, the tendency of the spectra toward lower frequencies (300 m渭 region) is attributed to the chromophonic nitrobenzenoid group and the differences in the absorption bands of the derivatives with a NO₂ group in the 4-, 7-, 5-, and 6-position are attributed to the particular effect resulting from the substitution. Further conclusions are presented with regards to inductive, mesomeric, and steric effects of the various substituents. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-benzoimidazole (cas: 83741-35-9COA of Formula: C7H5BrN2).

4-Bromo-1H-benzoimidazole (cas: 83741-35-9) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.COA of Formula: C7H5BrN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Modular design of G-quadruplex metalloDNAzymes for catalytic C-C bond formations with switchable enantioselectivity was written by Punt, Philip M.;Langenberg, Marie D.;Altan, Okan;Clever, Guido H.. And the article was included in Journal of the American Chemical Society in 2021.COA of Formula: C6H8N2O This article mentions the following:

Metal-binding DNA structures with catalytic function are receiving increasing interest. Although a number of metalloDNAzymes have been reported to be highly efficient, the exact coordination/position of their catalytic metal center is often unknown. Here, we present a new approach to rationally develop metalloDNAzymes for Lewis acid-catalyzed reactions such as enantioselective Michael additions Our strategy relies on the predictable folding patterns of unimol. DNA G-quadruplexes, combined with the concept of metal-mediated base-pairing. Transition-metal coordination environments were created in G-quadruplex loop regions, accessible by substrates. Therefore, protein-inspired imidazole ligandoside L was covalently incorporated into a series of G-rich DNA strands by solid-phase synthesis. Iterative rounds of DNA sequence design and catalytic assays allowed us to select tailored metalloDNAzymes giving high conversions and excellent enantioselectivities (鈮?9%). Based on their primary sequence, folding pattern, and metal coordination mode, valuable information on structure-activity relationships could be extracted Variation of the number and position of ligand L within the sequence allowed us to control the formation of (S) and (R) enantiomeric reaction products, resp. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1COA of Formula: C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. COA of Formula: C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Supercritical methanol as solvent and carbon source in the catalytic conversion of 1,2-diaminobenzenes and 2-nitroanilines to benzimidazoles was written by Sun, Zhuohua;Bottari, Giovanni;Barta, Katalin. And the article was included in Green Chemistry in 2015.HPLC of Formula: 4887-83-6 This article mentions the following:

Benzimidazoles and N-methylbenzimidazoles were synthesized by simply heating 1,2-diaminobenzenes in supercritical methanol over copper-doped porous metal oxides. These catalysts were derived from synthetic hydrotalcites that only contain earth-abundant starting materials. The carbon equivalent needed for the construction of the benzimidazole core originated from the solvent itself, which is known to undergo reforming to hydrogen and carbon monoxide through the formation of a formaldehyde intermediate. A variety of 1,2-diaminobenzenes were converted to the corresponding mixtures of benzimidazoles and N-methylated analogs in good yields. Interestingly, the more challenging, but readily available 2-nitroanilines, which require an addnl. reduction step prior to cyclization, could also be successfully converted to benzimidazoles in high selectivity. Furthermore, various other alcs. were applied besides methanol, to obtain 2-alkyl- and 1,2-dialkylbenzimidazoles. Preliminary mechanistic insights into the origins of N-alkylation as well as the reactivity of the nitro derivatives are discussed. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6HPLC of Formula: 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.HPLC of Formula: 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem