Imidazoles-derivatives

Dual Heterogeneous Catalysis for a Regioselective Three- Component Synthesis of Bi- and Tri(hetero)arylpyridines was written by Allais, Christophe;Lieby-Muller, Frederic;Constantieux, Thierry;Rodriguez, Jean. And the article was included in Advanced Synthesis & Catalysis in 2012.HPLC of Formula: 85692-37-1 This article mentions the following:

We have designed a new, user-friendly oxidative dual heterogeneous catalytic system capable of promoting polysubstituted pyridines as unique products from simple activated Michael acceptors, 1,3-dicarbonyls, and ammonium acetate. This metal-free environmentally respectful, and totally regioselective domino reaction proved to be a great strategy to access bi- and triaryl-type pyridines as well as challenging bi- and triheteroaryl-type pyridines in a single operation. E.g., in presence of 4Å mol. sieves, activated carbon, and O₂, reaction of PhCH:CHCO₂Me and Me acetoacetate gave 91% biarylpyridine (I). In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1HPLC of Formula: 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.HPLC of Formula: 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Two low-dimensional metal halides: ionothermal synthesis, photoluminescence, and nonlinear optical properties was written by Deng, Yuandan;Dong, Xuehua;Yang, Meng;Zeng, Hongmei;Zou, Guohong;Lin, Zhien. And the article was included in Dalton Transactions in 2019.Reference of 92507-97-6 This article mentions the following:

Two new organic-inorganic hybrid metal halides, formulated as (C₇H₁₃N₂)₂MnCl₄ (1) and (C₆H₁₁N₂)PbBr₃ (2), were prepared by a two-component ionothermal approach using multifunctional ionic liquids as solvents, charge-balancing agents, and halide sources. Compound 1 has an ionic zero-dimensional structure showing bright green luminescence with a high quantum yield of up to 70.78%. Compound 2 has a chain-like structure with a large second harmonic generation efficiency which is approx. 8脳 that of KH₂PO₄. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Reference of 92507-97-6).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 92507-97-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Group contribution and parachor analysis of experimental data on density and surface tension for members of the homologous series of 1-C_n-3-methylimidazolium chlorides was written by Souckova, Monika;Klomfar, Jaroslav;Patek, Jaroslav. And the article was included in Fluid Phase Equilibria in 2017.Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

The d. and surface tension values are presented that represent the best current knowledge of these properties for members of the homologous series of 1-C_n-3-methylimidazolium chlorides. To identify these values, a method was used based on the consistency requirement between selected background exptl. data and group contribution models of known best achievable accuracy. The models have been developed using our own and other authors data. For this purpose 64 and 119 new exptl. data on the d. and surface tension, resp., have been measured for [C₁IM][Cl] and [C_nMIM][Cl] with n = 2, 3, 4, 6, and 10 at temperatures from (263 to 365) K and at the pressure of 0.1 MPa. The d. was measured using the buoyancy method while the surface tension was measured by the Wilhelmy plate and du Nouy ring method in parallel. The resp. expanded combined uncertainties at the 0.95 confidence level of the resultant means of sets of individual measurements performed at a given temperature do not exceed 1 kg路m^-3, 0.07 mN路m^-1 and 1 mN路m^-1. The estimated maximum deviations of the obtained recommended values from the true d. and surface tension values are 0.1 kg路m^-3 and 0.15 mN路m^-1, resp. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Stop-Flow Microtubing Reactor-Assisted Visible Light-Induced Hydrogen-Evolution Cross Coupling of Heteroarenes with C(sp³)-H Bonds was written by Li, Dong-Sheng;Liu, Tao;Hong, Yang;Cao, Chen-Lin;Wu, Jie;Deng, Hong-Ping. And the article was included in ACS Catalysis in 2022.COA of Formula: C8H8N2 This article mentions the following:

Herein, assisted by stop-flow microtubing reactors, an operationally simple protocol for the visible light-induced hydrogen-evolution cross coupling of heteroarenes Ar-H (Ar = 4-methylquinolin-2-yl, phenanthridin-6-yl, 1,3-benzothiazol-2-yl, etc.) with unactivated C(sp³)-H bonds was developed in a metal- and external oxidant-free manner. A wide range of alkylated heteroarenes ArR¹ (R¹ = oxan-2-yl, Me, (1R,4S)-bicyclo[2.2.1]heptan-2-yl, etc.) was generated with common feedstock chems., including ethane. Mechanistic studies indicated that photoredox-induced hydrogen atom transfer processes followed by dehydrogenative rearomatization delivered the desired coupling products. The merits of this strategy were further demonstrated by the late-stage functionalization of various complex bioactive mols. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3COA of Formula: C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. COA of Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Oxazolidine Formation, or Loss of Acid, from Attempted Fluorination of Amide Side-Chain in 2-Nitroimidazoles was written by Baird, Ian R.;Patrick, Brian O.;Skov, Kirsten A.;James, Brian R.. And the article was included in Journal of Heterocyclic Chemistry in 2018.Formula: C5H5N3O4 This article mentions the following:

Reaction of Etanidazole (a 2-nitroimidazole derivative with an amide side-chain containing a hydroxyethyl group) with triflic anhydride gives, depending on conditions, a trifluoromethyl(sulfonyl)oxazolidine via a cyclization reaction, or a fluorine-free formate derivative; reaction with tosyl chloride gives only a chloroethyl derivative An attempt to replace a Br-atom in a related propyl-containing amide side-chain by a F-atom forms instead a propylene derivative via loss of HBr. The studies stem from interest in use of 2-nitroimidazoles with fluorine-containing amide side-chains as hypoxia markers. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Formula: C5H5N3O4).

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Formula: C5H5N3O4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Manganese-zeolitic imidazolate frameworks-90 with high blood circulation stability for MRI-guided tumor therapy was written by Jiang, Zhenqi;Yuan, Bo;Qiu, Nianxiang;Wang, Yinjie;Sun, Li;Wei, Zhenni;Li, Yanyin;Zheng, Jianjun;Jin, Yinhua;Li, Yong;Du, Shiyu;Li, Juan;Wu, Aiguo. And the article was included in Nano-Micro Letters in 2019.Recommanded Product: 1H-Imidazole-4-carboxamide This article mentions the following:

Zeolitic imidazolate frameworks (ZIFs) as smart drug delivery systems with microenvironment-triggered release have attracted much attention for tumor therapy. However, the exploration of ZIFs in biomedicine still encounters many issues, such as inconvenient surface modification, fast drug release during blood circulation, undesired damage to major organs, and severe in vivo toxicity. To address the above issues, we developed an Mn-ZIF-90 nanosystem functionalized with an originally designed active-targeting and pH-responsive magnetic resonance imaging (MRI) Y₁ receptor ligand [Asn²⁸, Pro³⁰, Trp³²]-NPY (25-36) for imaging-guided tumor therapy. After Y₁ receptor ligand modification, the Mn-ZIF-90 nanosystem exhibited high drug loading, better blood circulation stability, and dual breast cancer cell membrane and mitochondria targetability, further favoring specific microenvironment-triggered tumor therapy. Meanwhile, this nanosystem showed promising T1-weighted magnetic resonance imaging contrast in vivo in the tumor sites. Especially, this nanosystem with fast clean-up had almost no obvious toxicity and no damage occurred to the major organs in mice. Therefore, this nanosystem shows potential for use in imaging-guided tumor therapy. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Recommanded Product: 1H-Imidazole-4-carboxamide).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Recommanded Product: 1H-Imidazole-4-carboxamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Amino acids. I. Preparation and properties of glycocyamidine was written by McKay, A. F.;Braun, R. O.;Hatton, W. G.. And the article was included in Canadian Journal of Chemistry in 1954.COA of Formula: C6H8N2O2S This article mentions the following:

Free guanidine with Et glycinate gave 29% glycocyamidine (I). Heating guanidine carbonate with glycine produced no I, but 55% guanidinoacetic acid (II). This was esterified with EtOH by azeotropic removal of H₂O by C₆H₆ from an alc. HCl solution to produce Et guanidinoacetate-HCl (III); picrate, m. 189.5-90.5掳. Aqueous III treated with Amberlite IRA-400 and the resulting solution evaporated gave a mixture of I (identified as its picrate, m. 214.5-15.5掳) and II. I was nitrated in Ac₂O-HNO₃ to glycocyamidine nitrate, m. 145掳 (from EtOH). I and II may be separated and identified by paper chromatog. with BuOH-H₂O-HOAc (4.2:4.2:1) as eluent. In the experiment, the researchers used many compounds, for example, Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8COA of Formula: C6H8N2O2S).

Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C6H8N2O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Energies of isomerization in nitro derivatives of diazole was written by Lebedev, Vyacheslav P.;Matyushin, Yuriy N.;Miroshnichenko, Evgeniy A.;Konkova, Tatyana S.;Vorobev, Aleksei B.;Inozemtsev, Yaroslav O.. And the article was included in International Annual Conference of ICT in 2008.Formula: C4H5N3O2 This article mentions the following:

Energy of combustion of nitro derivatives of pyrazole and imidazole are measured. The energy of isomerization is estimated as the difference between enthalpies of formation of corresponding isomers. The influence of number, place of connection and chem. nature of substituents on energy of isomerization is considered. The obtained exptl. magnitudes will essentially fill up a database on enthalpies of formation and energies of isomerization of heterocyclic aromatic five-membered rings. These data are necessary for the further development of calculated methods that will allow purposeful search of structures with the set energetic properties. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Formula: C4H5N3O2).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Formula: C4H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Development of a novel gastric process simulation model: the successful assessment of bioequivalence and bioinequivalence of a biopharmaceutics classification system class II weak acid drug was written by Zenda, Naoki;Tagami, Tatsuaki;Ozeki, Tetsuya. And the article was included in Biological & Pharmaceutical Bulletin in 2022.Application of 145040-37-5 This article mentions the following:

Bioequivalence has been assessed using in vitro dissolution testing, such as in vivo predictive dissolution methodol. However, the assessment of bioequivalence should be performed carefully, considering the effect of the in vivo environment and according to the properties of the drug. The gastric emptying process is a key factor for the assessment of biopharmaceutics classification system class II (BCS class IIa) drugs with acidic properties since they cannot dissolve in the acidic stomach, but do dissolve in the small intestine (SI). The disintegration of a tablet in the stomach affects the distribution/dissolution in the SI due to the difference in the gastric emptying step, which in turn is a result of the varying formulation of the drugs. In this study, we used the reported dynamic pH change method and a novel gastric process simulation (GPS) model, which can compare the gastric emptying of particular-sized drug particles. The in vitro results were compared to clin. data using bioequivalent and bioinequivalent products of candesartan cilexetil. It was revealed that the dynamic pH change method was inappropriate, whereas the amount of filtered drug in GPS studies with 20 and 50 渭m pore size filters could reflect the clin. results of all products. The evaluation of the gastric emptying process of drug particles less than 50 渭m enabled us to assess the bioequivalence because they probably caused the difference in the distribution in the SI. This study demonstrated the utility of the GPS model for the assessment of bioequivalence of BCS class IIa drugs. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Application of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem