Category: imidazoles-derivatives

Dual Heterogeneous Catalysis for a Regioselective Three- Component Synthesis of Bi- and Tri(hetero)arylpyridines was written by Allais, Christophe;Lieby-Muller, Frederic;Constantieux, Thierry;Rodriguez, Jean. And the article was included in Advanced Synthesis & Catalysis in 2012.HPLC of Formula: 85692-37-1 This article mentions the following:

We have designed a new, user-friendly oxidative dual heterogeneous catalytic system capable of promoting polysubstituted pyridines as unique products from simple activated Michael acceptors, 1,3-dicarbonyls, and ammonium acetate. This metal-free environmentally respectful, and totally regioselective domino reaction proved to be a great strategy to access bi- and triaryl-type pyridines as well as challenging bi- and triheteroaryl-type pyridines in a single operation. E.g., in presence of 4Å mol. sieves, activated carbon, and O₂, reaction of PhCH:CHCO₂Me and Me acetoacetate gave 91% biarylpyridine (I). In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1HPLC of Formula: 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.HPLC of Formula: 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Two low-dimensional metal halides: ionothermal synthesis, photoluminescence, and nonlinear optical properties was written by Deng, Yuandan;Dong, Xuehua;Yang, Meng;Zeng, Hongmei;Zou, Guohong;Lin, Zhien. And the article was included in Dalton Transactions in 2019.Reference of 92507-97-6 This article mentions the following:

Two new organic-inorganic hybrid metal halides, formulated as (C₇H₁₃N₂)₂MnCl₄ (1) and (C₆H₁₁N₂)PbBr₃ (2), were prepared by a two-component ionothermal approach using multifunctional ionic liquids as solvents, charge-balancing agents, and halide sources. Compound 1 has an ionic zero-dimensional structure showing bright green luminescence with a high quantum yield of up to 70.78%. Compound 2 has a chain-like structure with a large second harmonic generation efficiency which is approx. 8脳 that of KH₂PO₄. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Reference of 92507-97-6).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 92507-97-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Group contribution and parachor analysis of experimental data on density and surface tension for members of the homologous series of 1-C_n-3-methylimidazolium chlorides was written by Souckova, Monika;Klomfar, Jaroslav;Patek, Jaroslav. And the article was included in Fluid Phase Equilibria in 2017.Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

The d. and surface tension values are presented that represent the best current knowledge of these properties for members of the homologous series of 1-C_n-3-methylimidazolium chlorides. To identify these values, a method was used based on the consistency requirement between selected background exptl. data and group contribution models of known best achievable accuracy. The models have been developed using our own and other authors data. For this purpose 64 and 119 new exptl. data on the d. and surface tension, resp., have been measured for [C₁IM][Cl] and [C_nMIM][Cl] with n = 2, 3, 4, 6, and 10 at temperatures from (263 to 365) K and at the pressure of 0.1 MPa. The d. was measured using the buoyancy method while the surface tension was measured by the Wilhelmy plate and du Nouy ring method in parallel. The resp. expanded combined uncertainties at the 0.95 confidence level of the resultant means of sets of individual measurements performed at a given temperature do not exceed 1 kg路m^-3, 0.07 mN路m^-1 and 1 mN路m^-1. The estimated maximum deviations of the obtained recommended values from the true d. and surface tension values are 0.1 kg路m^-3 and 0.15 mN路m^-1, resp. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Stop-Flow Microtubing Reactor-Assisted Visible Light-Induced Hydrogen-Evolution Cross Coupling of Heteroarenes with C(sp³)-H Bonds was written by Li, Dong-Sheng;Liu, Tao;Hong, Yang;Cao, Chen-Lin;Wu, Jie;Deng, Hong-Ping. And the article was included in ACS Catalysis in 2022.COA of Formula: C8H8N2 This article mentions the following:

Herein, assisted by stop-flow microtubing reactors, an operationally simple protocol for the visible light-induced hydrogen-evolution cross coupling of heteroarenes Ar-H (Ar = 4-methylquinolin-2-yl, phenanthridin-6-yl, 1,3-benzothiazol-2-yl, etc.) with unactivated C(sp³)-H bonds was developed in a metal- and external oxidant-free manner. A wide range of alkylated heteroarenes ArR¹ (R¹ = oxan-2-yl, Me, (1R,4S)-bicyclo[2.2.1]heptan-2-yl, etc.) was generated with common feedstock chems., including ethane. Mechanistic studies indicated that photoredox-induced hydrogen atom transfer processes followed by dehydrogenative rearomatization delivered the desired coupling products. The merits of this strategy were further demonstrated by the late-stage functionalization of various complex bioactive mols. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3COA of Formula: C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. COA of Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Syntheses of formamidines and benzimidazoles was written by Mathias, L. J.;Overberger, C. G.. And the article was included in Synthetic Communications in 1975.SDS of cas: 58442-17-4 This article mentions the following:

The benzimidazoles I (R = 5(6)-Cl, 5(6)-Me, 5(6)-CO2H, 5(6)-benzimidazol-5(6)-yl) were prepared by cyclization of 4-RC6H3(NH2)2-1,2 with HCO2H in the presence of HCl and a strong acid resin. RNHCH:NR (R = p-O2NC6H4, p-H2NC6H4, 2-thiazolyl, 2-pyridyl) and I (R = 5(6)-Me, 4(7)-Me, 5(6)-NO2, 5(6)-COMe, 5(6)-CHO, 5(6)-Cl) were prepared by treating RNH2 or RC6H4(NH2)2-1,2 with Cl2CHOMe containing (Me3C)3N. In the experiment, the researchers used many compounds, for example, 1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4SDS of cas: 58442-17-4).

1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.SDS of cas: 58442-17-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Crystal structures and solution spectroscopy of lophine derivatives was written by Fridman, Natalya;Kaftory, Menahem;Eichen, Yoav;Speiser, Shammai. And the article was included in Journal of Molecular Structure in 2009.Category: imidazoles-derivatives This article mentions the following:

Lophine (2,4,5-triphenylimidazole) derivatives were synthesized and their physicochem. properties were determined Spectroscopic and fluorescence behavior of lophine derivatives in methanol at different pH and various solvents were presented. The observed spectroscopic features in the solution are determined by specific interactions of the NH hydrogen. These kinds of interactions are manifested both in the solid state and in solution The crystal and mol. structures of lophine derivatives with different solvents of crystallization are presented and discussed. In all solvates the solvent mols. link host mols. through hydrogen bonds. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Category: imidazoles-derivatives).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Preparation and evaluation of solid supersaturable self-nanoemulsifying drug delivery system of candesartan cilexetil was written by Albaidhani, Safa F.;Hussein, Ahmed A.. And the article was included in Journal of Pharmaceutical Sciences and Research in 2019.Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

Solubility problem of many effective pharmaceutical mols. is still one of the major challenges in the formulation of these mols. Candesartan cilexetil (CC) is angiotensin II receptor antagonist and has very low water solubility and as a result of that low and variable bioavailability was produced. Supersaturable solid self- emulsifying drug delivery system (S-SSEDDS) showed a promising result in overcome solubility problem of many drug mols. with significant improvement in in-vivo bioavailability of drug mols. CC was prepared as S-SSEDDS by using novel combination of two surfactants (tween 80 and cremophore EL) and tetraglycol as cosurfactant, in addition to use of triacetin as oil and solidify using different adsorbents (Avicel PH101, Avicel PH102, Aerosil and dibasic calcium phosphate), after that a suitable precipitation inhibitor was used (HPMC K100). Different tests were performed to confirm the stability of the final product which includes; measurement of micrometric properties of the resultant powder, in-vitro drug release, SPM, FTIR, X-ray powder diffraction, DSC and in-vivo plasma level measurement. The results suggest that preparation of CC. as S-SSEDDS is a promising technique for oral delivery of CC. in order to improve its bioavailability. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The Ionic Liquid-H₂O Interface: A New Platform for the Synthesis of Highly Crystalline and Molecular Sieving Covalent Organic Framework Membranes was written by Gao, Shuaiqi;Li, Zhiyong;Yang, Yingying;Wang, Zhenzhen;Wang, Yanlei;Luo, Shuangjiang;Yao, Kaisheng;Qiu, Jikuan;Wang, Huiyong;Cao, Li;Lai, Zhiping;Wang, Jianji. And the article was included in ACS Applied Materials & Interfaces in 2021.Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

Covalent organic frameworks (COFs) are highly porous crystalline polymers with uniform pores and large surface areas. Combined with their modular design principle and excellent properties, COFs are an ideal candidate for separation membranes. Liquid-liquid interfacial polymerization is a well-known approach to synthesize membranes by reacting two monomers at the interface. However, volatile organic solvents are usually used, which may disturb the liquid-liquid interface and affect the COF membrane crystallinity due to solvent evaporation Simultaneously, the domain size of the organic solvent-water interface, named the reaction zone, can hardly be regulated, and the diffusion control of monomers for favorable crystallinity is only achieved in the water phase. These drawbacks may limit the widespread applications of liquid-liquid interfacial polymerization to synthesize diverse COF membranes with different functionalities. Here, we report a facile strategy to synthesize a series of imine-linked freestanding COF membranes with different thicknesses and morphologies at tunable ionic liquid (IL)-H₂O interfaces. Due to the H-bonding of the catalysts with amine monomers and the high viscosity of the ILs, the diffusion of the monomers was simultaneously controlled in water and in ILs. This resulted in the exceptionally high crystallinity of freestanding COF membranes with a Brunauer-Emmett-Teller (BET) surface area up to 4.3 times of that synthesized at a dichloromethane-H₂O interface. By varying the alkyl chain length of cations in the ILs, the interfacial region size and interfacial tension could be regulated to further improve the crystallinity of the COF membranes. As a result, the as-fabricated COF membranes exhibited ultrahigh permeance toward water and organic solvents and excellent selective rejection of dyes. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

1-Ethyl-2,3-dimethylimidazolium paramagnetic ionic liquids with 3D magnetic ordering in its solid state: synthesis, structure and magneto-structural correlations was written by Garcia-Saiz, Abel;de Pedro, Imanol;Vallcorba, Oriol;Migowski, Pedro;Hernandez, Ignacio;Fernandez Barquin, Luis;Abrahams, Isaac;Motevalli, Majid;Dupont, Jairton;Gonzalez, Jesus Antonio;Fernandez, Jesus Rodriguez. And the article was included in RSC Advances in 2015.Product Details of 92507-97-6 This article mentions the following:

Two novel paramagnetic ionic liquids, comprised of a 1-ethyl-2,3-dimethylimidazolium (Edimim) cation and a tetrahaloferrate(III) (FeX₄) (X = Cl and Br) anion were synthesized and characterized by thermal, structural, Raman spectroscopy and magnetic studies. The crystal structures, determined by synchrotron X-ray powder diffraction and single crystal X-ray diffraction at 100 K for Edimim[FeCl₄] and Edimim[FeBr₄] resp., are characterized by layers of cations (in non-planar configuration) and anions stacked upon one another in a three-dimensional (3D) manner with several non-covalent interactions: halide-halide, hydrogen bond and anion-蟺. Magnetization measurements show the presence of three-dimensional antiferromagnetic ordering below the N茅el temperature (T_N) with the existence of a noticeable magneto-crystalline anisotropy in the bromide compound The corresponding magneto-structural correlations evidence that the 3D magnetic ordering mainly takes place via Fe-X路路路X-Fe (X = Cl and Br) interactions, displaying a higher superexchange magnetic interaction between the planes. Comparison with the Emim[FeX₄] (X = Cl and Br) phases (Emim: 1-ethyl-3-methylimidazolium) reveals that the methylation at the C(2) position onto the imidazolium cation ring causes an increase of the m.p. and a decrease of the T_N. In contrast, the comparative study with Dimim[FeX₄] (X = Cl and Br) compounds (Dimim: 1,3-dimethylimidazolium) shows a lower T_N in the chloride compound, Edimim[FeCl₄], whereas it is higher for the bromide, Edimim[FeBr₄]. This fact is attributed to the spin delocalization of iron atoms in [FeBr₄]^– and discards the hypothesis that a bigger imidazolium ion size causes a weaker magnetic coupling in paramagnetic ionic liquids based on tetrahaloferrate anions and imidazolium cations with 3D magnetic ordering in its solid state. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Product Details of 92507-97-6).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Product Details of 92507-97-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Estimation of Heat Capacity of 143 Pure Ionic Liquids Using Artificial Neural Network was written by Azadfar, Roohollah;Shaabanzadeh, Masoud;Hashemi-Moghaddam, Hamid;Nafchi, Abdorreza Mohammadi. And the article was included in International Journal of Thermophysics in 2022.COA of Formula: C18H31F6N3O4S2 This article mentions the following:

Based on artificial neural network (ANN), a new model is presented to estimate the heat capacity of pure ionic liquids A database for the heat capacity of ionic liquids created by extracting exptl. data from literature covering the period from 1971 to 2021 is reported. With the presented approach, heat capacity is calculated and evaluated by source data bank for 7059 data points of 143 ionic liquids The accuracies of new ANN model are evaluated by comparing with the most commonly used correlations in the literatures, and the results reveal that the proposed network provides more accurate results than other literature correlations considered in this work. The average absolute percentage deviation from the new model is only 1.14%. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5COA of Formula: C18H31F6N3O4S2).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C18H31F6N3O4S2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem