Category: https://en.wikipedia.org/wiki/Imidazole

Some common heterocyclic compound, 24134-26-7, name is 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole, molecular formula is C9H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C9H9N3

General procedure: A solution of 2 mmol of compound 1-3 and 2.1 mmol of BrCH2C6H4C6H4R-o or ethyl 4-(bromomethyl)benzoate in 10 ml of CH3NO2 was boiled for 7.5 h. The reaction mixture was cooled and left for two days at 5 C. The precipitated hydrobromide was filtered and washed with acetone.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 24134-26-7, its application will become more common.

Synthetic Route of 288-32-4,Some common heterocyclic compound, 288-32-4, name is 1H-Imidazole, molecular formula is C3H4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 1 Ethyl 5-(4-(lH-imidazol- l-yl)phenyl)-4H-thieno[3,2-^]pyrrole-2-carboxylate Step- 1 : Preparation of 4-(lH-imidazol-l-yl)benzaldehyde To a solution of 4-fluorobenzaldehyde (1.0 g, 8.06 mmol) in DMF (3 mL) were added 1H- imidazole (2.1 g, 32.2 mmol) and K2C03 (2.2 g, 16.12 mmol). The reaction mass was heated at reflux for 6 h before it was diluted with water and was extracted with EtOAc. The organic layer was separated, dried, filtered and concentrated. The residue was purified by column chromatography to afford 1.0 g of the title product. 1H NMR (300 MHz, DMSO d6) delta 10.03 (s, 1H), 8.47 (s, 1H), 8.07-8.04 (d, = 8.4 Hz, 2H), 7.95-7.93 (m, 3H), 7.17 (s, 1H); MS (m/z): 173 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Imidazole, its application will become more common.

Electric Literature of 26663-77-4, A common heterocyclic compound, 26663-77-4, name is Methyl benzimidazole-5-carboxylate, molecular formula is C9H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of methyl 1H-benzo[d]imidazole-5-carboxylate (0.90 g, 5.1 mmol) in DMF(20 ml) was added NaH (0.25 g, 6.2 mmol), and the reaction mixture was stirred at room temperature for 30 mm. Then (2-(chloromethoxy)ethyl)trimethylsilane (0.94 g, 5.6 mmol) wasadded and the reaction mixture was stirred at room temperature for 2 hours. When LCMS showed that the reaction completed, the reaction mixture was diluted with EtOAc (100 mL), washed with H20 (100 mL x 2) and brine (100 mL), dried over Na2504 and concentrated under reduced pressure to afford crude product as an oil, which was purified by column chromatography on silica gel (eluted with petroleum ether/EtOAc = 1:1) to afford mixture ofmethyl 1 -((2-(trimethylsilyl)ethoxy)methyl)- 1 H-benzo[d]imidazole-5-carboxylate and methyl 1- ((2-(trimethylsilyl)ethoxy) methyl)- 1 H-benzo [d] imidazole-6-carboxylate as an oil. LC/MS (m/z): 307 (M+H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 1402838-08-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1402838-08-7 as follows.

To a solution of (l-(3-bromophenyl)ethoxy)(tert-butyl)dimethylsilane (1.10 g, 3.47 mmol) in THF (15 mL) at -78 C was added n-BuLi (1.58 mL, 1.59 mmol; 2.2 M solution in hexanes). After stirring for 1.5 h, 2-(l-trityl-lH-imidazol-4-yl)benzaldehyde (900 mg, 2.17 mmol) was added as a solution in THF (6 mL). The mixture was allowed to warm to rt and stirred overnight. The reaction was diluted with water (30 mL) and the product was extracted with EtOAc (3 x 50 mL). The combined organic extract was washed with water (50 mL), dried over Na2S04 and concentrated under reduced pressure to afford the crude mixture. The crude was purified by CombiFlash to afford the desired product as white solid (1.28 g, 90.5 %). NMR (400 MHz, Chloroform-^ delta 7.47 – 7.01 (m, 24H), 6.88 (d, J = 10.9 Hz, 1H), 5.91 (s, 1H), 4.91 – 4.70 (m, 1H), 1.31 (dd, J = 6.2, 3.9 Hz, 3H), 0.84 (d, J = 20.4 Hz, 9H), -0.00 – -0.20 (m, 6H).

According to the analysis of related databases, 1402838-08-7, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4857-06-1, name is 2-Chloro-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below., Safety of 2-Chloro-1H-benzo[d]imidazole

[1372] mel (6.1 ml, 98.3 mmol) was added to a mixture of 2-chloro-1H-benzo[d]imidazole (5.0 g, 32.8 mmol) and K2CO3 (13.6 g, 98.3 mmol) in DMF(20 ml). The mixture was stirred at 25 C for lh. The insoluble substance was removed by filtration and the filtrate was treated with ea (50 ml), H2O (50 ml). The organic layer was separated and the aqueous layer was extracted with ea (35 ml x 3). The combined organic layer was washed with H2O (35 ml x 2), brine (35 ml x 2), dried over mgs04, filtered and concentrated. The residue was triturated with tbme/pe (v/v = 1/1, -20 ml) to afford compound 294a (3.3 g, yield 60.38%) as pale yellow solid. 1H NMR (DMSO-d6, 400 mhz) delta .60 – 7.56 (m, 2h), 7.31 – 7.24 (m, 2h), 3.80 (s, 3h). MS (ESI) m/z (M+H)+ 167.0.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2302-25-2, name is 4-Bromo-1H-imidazole, A new synthetic method of this compound is introduced below., Quality Control of 4-Bromo-1H-imidazole

A solution of compound 126-1 (5.0 g, 34 mmol, 1.0 eq), compound 126- la (5.0 g, (1508) 58 mmol, 1.7 eq), Cu(OAc)2 (6.2 g, 34 mmol, 1.0 eq), 2,2′-bipyridine (5.3 g, 34 mmol, 1.0 eq) and potassium carbonate (9.4 g, 68 mmol, 2.0 eq) in 1,2-dichloroethane (150 mL) was stirred at 70 C for 16 hrs. TLC showed one new spot was formed. EA (220 mL) was added, and then the suspension was filtered. The organic layer was concentrated under reduced pressure. The mixture was diluted with water (80 mL) and the resultant mixture was extracted with EA (150 mL * 3). The combined organic layers were dried over Na2SC>4, filtered and concentrated to dryness under reduced pressure. The residue was purified by column chromatography over silica gel to afford the title compound 126-2 as a crude product. The residue was purified by Prep-TLC to obtain the title compound 126-2 (1.2 g, 18% yield). Ti NMR (400MHz, CDC13) delta 7.42 (s, 1H), 6.95 (d, J = 1.3 Hz, 1H), 3.36 -3.28 (m, 1H), 1.06 – 0.90 (m, 4H).

The synthetic route of 2302-25-2 has been constantly updated, and we look forward to future research findings.

Reference of 33529-02-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33529-02-1, name is 1-Decyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Under an atmosphere of nitrogen, the alpha,omega-bis(methanesulfonyloxy)alkane (0.36 mmol, 1 equiv) was mixed with the appropriate 1-alkylimidazole(5 equiv) and the mixture was heated at 80-90 C for 1 h;acetone (20 mL) was then added and the mixture was stirred at refluxtemperature overnight, concentrated, and dried under high vacuum.The resulting golden oil was dissolved in methanol, the solution wasconcentrated, and the residual oil was washed with diethyl ether(10 mL). This dissolution/concentration/washing procedure was repeatedtwo more times. The solid material was dried under high vacuumto give the product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Decyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Reference of 109012-24-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 109012-24-0, name is 1-Methyl-4-nitro-1H-imidazole-2-carboxylic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 2 Synthesis of N-(N’,N’-dimethylaminoethyl)-1-methyl-4-{4-[4,4-bis(2-chloroethyl)aminobenzamido]-1-methylimidazole-2-carboxamido}imidazole-2-carboxamide (Compound 6) To a suspension of 1-methyl-4-nitroimidazole-2-carboxylic acid (3.00 g, 17.5 mmol) in dry THF (30 mL) was slowly added oxalyl chloride (12 mL). The reaction mixture was heated to reflux under a drying tube for 45 minutes at which time the excess oxalyl chloride and THF were removed under reduced pressure and the acid chloride coevaporated twice with dry CH2 Cl2 (20 mL each) yielding 1-methyl-4-nitroimidazole-2-carbonyl chloride as a yellow powder.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-4-nitro-1H-imidazole-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3034-38-6, name is 5-Nitro-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C3H3N3O2

To a solution of 4-nitro- 1 H-imidazole (5.0 g, 44 mmol, 1 eq.) in ACN (50 ml) was added K2C03 (9.17 g, 66 mmol). Methyl iodide (7.53 g, 53 mmol, 3.30 ml) was added slowly to the mixture at rt, then the mixture was warmed to 60 C for 14 h. The solvent was removed under reduced pressure, then the residue was diluted with water (30 ml), extracted with DCM (5 x 30 ml) and the combined organic layers dried over Na2S04. The organic phase was concentrated in vacuo to give the title compound as a yellow solid. ‘H NMR (400 MHz, DMSO-de) d = 8.35 (s, 1H), 7.80 (s, 1H), 3.75 (s, 3H).

The synthetic route of 3034-38-6 has been constantly updated, and we look forward to future research findings.