Category: https://en.wikipedia.org/wiki/Imidazole

Application of 1457-58-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1457-58-5, name is 2-Methyl-1H-imidazole-5-carboxylic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 7 Synthesis of 6-(4-tert-butyl-phenyl)-3-methyl-7H-imidazo[1 ,5-a]pyrazin-8- (“A7”) 2-Meth l-1H-imidazole-4-carboxylic acid ethyl ester 2-Methyl-1H-imidazole-4-carboxylic acid (1.43 g; 11.299 mmol) was dissolved in ethanol (90.0 ml_). HCI in dioxane (4 M, 7.50 ml_) was added and the mixture was heated at 90 C for 18 h. The solution was concentrated. The residue was partitioned between ethyl acetate and saturated NaHC03 solution. The aqueous layer was extracted twice with ethyl acetate. The combined organic layers were washed with brine and dried over Na2S04, filtered and evaporated to dryness; yield: 1.43 g (82%).

The synthetic route of 2-Methyl-1H-imidazole-5-carboxylic acid has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 36947-68-9, name is 2-Isopropyl-1H-imidazole, molecular formula is C6H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 2-Isopropyl-1H-imidazole

EXAMPLE 3 2-Isopropyl-4,5-dihydroxymethylimidazole 110 g (1 mole) of 2-isopropylimidazole and 220 g (2.2 moles) of a 30% strength aqueous formaldehyde solution are stirred for 1 hour at 60 C., 50.4 g (0.44 mole) of triethylamine are added to the mixture, and stirring is continued under reflux at about 78 C. The product crystallizes out from the mixture. After 48 hours, the mixture is cooled to 5 C. After 1 hour, the product is isolated by filtration. 136.8 g of crude product are obtained, and this is washed with twice 200 ml of acetone and dried in a drying oven under reduced pressure at 450 C. to give 126.1 g of 2-isopropyl-4,5-dihydroxymethylimidazole of melting point 199.5-201.0 C. Evaporating down the filtrate gives 107 g of a crude product from which a further 18.5 g of 2-isopropyl-4,5-dihydroxymethylimidazole can be obtained by stirring with 107 g of methanol at 50 C. for 30 minutes and then cooling at 5 C. for 30 minutes, filtering and drying. The total yield is 84.8%. Elemental analysis: Mass spectrum: M+ 170. 1 H-NMR spectrum (solvent DDMSO): 1.12 1.24 (d, 6p) 2.9 (septet, 1p) 4.35 (s, 4p).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 36947-68-9, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 123470-47-3, name is 5,6-Difluoro-1H-benzo[d]imidazole-2(3H)-thione, A new synthetic method of this compound is introduced below., Quality Control of 5,6-Difluoro-1H-benzo[d]imidazole-2(3H)-thione

Subsequently, 93.1 mg of 5,6-difluorobenzimidazole-2-thiol (0.5 mmol) was dissolved in 2 ml of N,N-dimethylformamide, and the solution was heated at 80 C. for 12 hr after the addition of 104 mul of triethylamine and 117 mg of ethyl 4-bromobutyrate. The reaction mixture was cooled, water was added, the mixture was extracted with diethyl ether, and the organic layer was concentrated in vacuo. The residue was purified by preparative thin layer chromatography (hexane-ethyl acetate=1:1), and the product was collected and dried to yield 113 mg of 4-(5,6-difluorobenzimidazole-2-ylthio)butyric acid ethyl ester (75% yield).

The synthetic route of 123470-47-3 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7189-69-7, name is 1,1′-Sulfonyldiimidazole, A new synthetic method of this compound is introduced below., category: imidazoles-derivatives

A solution of 1,1′-sulfonylbis(1H-imidazole) (10.000 g, 50.454 mmol) in dichloromethane (120 mL) was mixed at 0 C with trifluoromethanesulfonate (MeOTf, 5.710 mL, 50.454 mmol), and stirred at the same temperature for 3 hr. The precipitates were collected by filtration, washed by dichloromethane, and dried to give 1-((1H-imidazol-1-yl)sulfonyl)-3-methyl-1H-imidazol-3-ium trifluoromethanesulfonate as white solid (16.720 g, 91.5 %).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 17289-30-4,Some common heterocyclic compound, 17289-30-4, name is 4-(Chloromethyl)-1-methyl-1H-imidazole hydrochloride, molecular formula is C5H8Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 4-(6-fluoropyridin-3-yl)-6-hydroxypyrazolo[l,5-a]pyridine-3- carbonitrile (Intermediate P66, 103.6 mg, 0.4075 mmol), 4-(chloromethyl)-l-methyl-lH- imidazole hydrochloride (199.7 mg, 1.196 mmol) and Cs2CCb(s) (1.328 g, 4.075 mmol) in DMA (2.0 mL) was stirred for 1 d at 60 C, then for an additional 1 d at 110 C. After cooling to ambient temperature, the reaction mixture was acidified with 2 M HCl(aq), and purified directly by C18 reverse phase chromatography (using 0-70% water/ ACN with 0.1% TFA as the gradient eluent). Fractions containing the desired product were combined, partially concentrated in vacuo to remove the ACN, then partitioned between saturated NaHC03(aq) and 4: 1 DCM:iPrOH. The biphasic mixture was extracted with additional 4: 1 DCM:iPrOH (3x). The combined organic extracts were dried over anhydrous Na2S04(S), filtered and concentrated in vacuo to afford the title compound (26.0 mg, 18% yield). MS (apci) m/z = 349.10 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Chloromethyl)-1-methyl-1H-imidazole hydrochloride, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1849-02-1, name is 2-Chloro-1-methyl-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 1849-02-1

The product of preparation 16 (50mg, 0.19mmol), 2-chloro-1-methyl-1H-benzimidazole [(32mg, 0.19mmol), J. Heterocyclic. Chem, 34(6) 1781-1788; 1997] potassium phosphate, (45mg, 0.21mmol), palladium trifluoroacetate (cat.) and tri-tbutylphosphine (cat) were added to xylene (1mL) and the mixture was heated at 120C for 3 hours in a sealed Reactivial tube. Additional tri-tbutylphosphine (1.8mg) was added and the mixture was heated for a further 18 hours. The reaction mixture was then dissolved in methanol and was purified by column chromatography on silica gel, eluding with ethyl acetate:methanol:0.88 ammonia, 100:0:0 to 80:20:2. The crude product was purified further by column chromatography on Biotage amino silica gel, eluding with pentane:ethyl acetate 100:0 to 0:100, to afford the title compound as a colourless oil in 9% yield, 7mg. 1H-NMR(CDCl3, 400MHz) delta: 1.79-1.90(m, 4H), 1.99-2.05(m, 2H), 2.50-2.65(brm, 6H), 3.10(m, 2H), 3.60(m, 2H), 3.64(s, 3H), 4.30(m, 2H), 4.48(s, 2H), 6.60(d, 1H), 7.19(m, 3H), 7.38(d, 1H), 7.60(m, 1H) MS APCI+ m/z 392 [MH]+

According to the analysis of related databases, 1849-02-1, the application of this compound in the production field has become more and more popular.

152628-03-0, name is 4-Methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C12H14N2O2

A mixture of 4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid (2) (5.2 g, 23.8 mmol) and thionyl dichloride (30 mL) was refluxed for 4 h, then thionyl dichloride was evaporated under reduced pressure to obtain off-white solid (5.64 g). It was used for the next step directly.

The synthetic route of 152628-03-0 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 1402838-08-7,Some common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, molecular formula is C29H22N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 13a (52 mg, 0.363 mmol) in anhydrous THF (5 mL) was added LDA (2 M in THF, 0.2 mL, 0.40 mmol) dropwise at -78 under nitrogen. The reaction mixture was stirred at -78 for 1 h, a solution of 10a (100 mg, 0.242 mmol) in anhydrous THF (1 mL) was added dropwise. The resulting reaction mixture was warmed slowly to room temperature, and stirred for another 3 h. The reaction mixture was quenched with water and extracted with EtOAc (5 mL x 3) . The combined organic layers were washed with brine (10 mL) , dried over anhydrous Na2SO4, filtered and concentrated in vacuo to give a residue, which was purified by preparative TLC (petroleum ether : EtOAc 4 : 1) to afford compound 13b (70 mg, 52yield) as a white solid.1H NMR (CD3OD, 400 MHz) : delta 7.62-7.55 (m, 3H) , 7.45-7.36 (m, 9H) , 7.32-7.20 (m, 8H) , 7.15 (s, 1H) , 5.65 (s, 1H) , 1.15 (s, 9H) , 1.01-0.87 (m, 3H) , 0.54-0.47 (m, 1H) MS 557.3 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(1-Trityl-4-imidazolyl)benzaldehyde, its application will become more common.

Reference of 137049-00-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 137049-00-4, name is 1-Methyl-1H-imidazole-4-sulfonyl chloride belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To 5-phenyl-3-(4-piperidinyl)-1 H-indole-7-carboxamide (40 mg, 0.12 mmol) in methylene chloride (5mL) at O0C, 1 -methyl-1 H-imidazoie-4-sulfonyl chloride (27.1 mg, 0.14 mmol) and triethylamine (0.07 ml_, 0.50 mmol) were added. The reaction mixture was stirred at O0C for 30 min. Then the reaction mixture was partitioned between methylene chloride and water, the aqueous layer was extracted with methylene chloride (25 ml_x2) and combined organic phase was dried with Mg2SO4 and concentrated by reduce pressure, and purified by Gilson HPLC (reverse phase, eluting with CH3CN/Water, 0.1 % TFA, 10/90, v/v, over 15 min) to give the title compound (22.5 mg, 39%). LC/MS: m/z, 463.4 (M+H), 1.72 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-4-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.

Related Products of 123470-47-3,Some common heterocyclic compound, 123470-47-3, name is 5,6-Difluoro-1H-benzo[d]imidazole-2(3H)-thione, molecular formula is C7H4F2N2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 1-tert-butoxycarbonyl-4-(2-hydroxyethyl)piperazine (7.40 g, 32.13 mmol) in THF (100 mL), while stirring in an ice-bath, triethylamine (4.36 g, 43.09 mmol), 4-dimethylaminopyridine (200 mg, 1.64 mmol), and methanesulfonyl chloride (7.40 g, 38.76 mmol) were sequentially added. The temperature of the mixture was allowed to room temperature, and the mixture was stirred for 50 minutes. The reaction mixture was filtrated, and the filtrate was concentrated under reduced pressure. The residue was dissolved in DMF (200 mL), and, at room temperature, 5,6-difluoro-2-mercaptobenzimidazole (5.00 g, 26.86 mmol), potassium carbonate (8.64 g, 62.51 mmol), and 18-crown-6 (500 mg, 1.92 mmol) were sequentially added to the solution, followed by stirring for 90 minutes at 80 C. The reaction mixture was concentrated under reduced pressure, and the residue was purified through silica gel column chromatography (silica gel 200 g, hexane: acetone=8:1 to 1:1). The product was crystallized from acetone-ether-hexane, to thereby yield 1-tert-butoxycarbonyl-4-[2-(5,6-difluorobenzimidazol-2-ylthio)ethyl]piperazine (7.26 g, yield 68%) as colorless crystals. mp: 192.3-193.0 C. IR (KBr): 3061, 2976, 2836, 1672, 1475, 1427(cm-1). 1H-NMR (400 MHz, CDCl3) delta: 1.50 (9H, s), 2.51-2.68 (4H, m), 2.94 (2H, t, J=5.4 Hz), 3.28 (2H, t, J=5.4 Hz), 3.45-3.65 (4H, m), 6.85-7.62 (2H, m).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,6-Difluoro-1H-benzo[d]imidazole-2(3H)-thione, its application will become more common.