Category: https://en.wikipedia.org/wiki/Imidazole

Synthetic Route of 10394-38-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10394-38-4, name is 1-Methylbenzoimidazol-5-amine belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

1.76 g (6.79 mmol) of ethyl 3-ethoxy-2-[(ethoxycarbonyl)carbamoyl]acrylate and 1.00 g (6.79 mmol) of 1-methyl-1H-benzimidazol-5-amine [for preparation see: US 2008/0090856, Ex. B23] in 51 ml of ethanol were heated to reflux for 2 h. Thereafter, at RT, 0.76 g (6.79 mmol) of potassium tert-butoxide were added and the reaction mixture was heated to reflux for a further 3 h. For workup, the reaction mixture was admixed with water and acidified with 1N hydrochloric acid. The aqueous phase was concentrated, dichloromethane/ methanol (1:1) was added and the solid formed was filtered off. The filtrate was concentrated, MTBE/ ethyl acetate (1:1) was added, and the solid formed was filtered off, washed with ethyl acetate and then dried at 50 C. under reduced pressure. This gave 1.55 g (73% of theory) of the title compound. LC-MS (Method 2): Rt=1.00 min; MS (ESIpos): m/z=315 (M+H)+. 1H NMR (400 MHz, DMSO-d6): delta [ppm]=1.22 (t, 3H), 4.03 (s, 3H), 4.18 (q, 2H), 7.62-7.68 (m, 1H), 7.94-8.00 (m, 1H), 8.00-8.03 (m, 1H), 8.35 (s, 1H), 9.24 (br.s, 1H), 11.73 (s, 1H).

The synthetic route of 1-Methylbenzoimidazol-5-amine has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2849-93-6, name is 1H-Benzimidazole-2-carboxylic acid, A new synthetic method of this compound is introduced below., Computed Properties of C8H6N2O2

General procedure: To the acid (1 eq) in 1 mL of THF and 1 drop of DMF at 0C, oxalyl chloride (1.2 eq) was added. The reaction was stirred under nitrogen for 1.5 hours and then the solution was concentrated. The acid chloride was continued to the next step.

The synthetic route of 2849-93-6 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 1072-63-5, name is 1-Vinyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 1072-63-5

General procedure: Bis-vinylimidazolium bromoethane ([CnDVIM]Br) were synthesized by the reaction between 1-vinylimidazole and (CH2)2Br2, (CH2)4Br2, or (CH2)8Br2 [20]. Typically, 1-vinylimidazole (4.20g, 44.6mmol) and (CH2)nBr2 (21.7mmol) were dissolved in 5.0mL methanol. Then, the mixture was continuously magnetic stirred for 5min to get a homogenous solution and poured into a 50mL single-necked flask. After aerated nitrogen for about 3min, the flask was sealed and placed into 65C oil bath with a continuously magnetic stirring for 24h. After cooling to room temperature, excess diethyl ether (200mL) was poured into the solution and the crude salt was obtained. The obtained salt was washed with diethyl ether three times and dried under vacuum to get the yellow [CnDVIM]Br.

The synthetic route of 1-Vinyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2849-93-6, name is 1H-Benzimidazole-2-carboxylic acid, A new synthetic method of this compound is introduced below., category: imidazoles-derivatives

A mixture of 1H-benzimidazole-2-carboxylic acid (4.0g, 24.6mmol), aminoethanol (1.48mL, 24.6mmol), 1-hydroxybenzotriazole (4.14g, 27.1mmol) and N-(3-dimethylaminopropyl)-N?-ethylcarbodiimide hydrochloride (5.19g, 27.1mmol) in 80mL dimethylformamide was stirred for 12hat room temperature then concentrated in vacuo. The residue could be crystallized from ethanol (35mL). Yield: 3.13g (62%), EI-LRMS m/z 206.1= (M+H)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33016-47-6, name is 1-Trityl-1H-imidazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-Trityl-1H-imidazole-4-carbaldehyde

(i) Production of (4-bromophenyl) (1-trityl-1H-imidazol-4-yl)methanol By the reaction in the same manner as in Example 4-(i) using p-dibromobenzene (54.7 g), a solution (1.6 M; 94.7 ml) of n-butyllithium in hexane and 1-trityl-1H-imidazole-4-carbaldehyde (34.2 g), the title compound (27.8 g) was obtained as colorless powder crystals. 1H-NMR (CDCl3) delta: 3.56 (1H, br s), 5.71 (2H, d, J=4.4 Hz), 6.58 (1H, s), 7.07-7.13 (7H, m), 7.25-7.44 (12H, m). IR (KBr): 1493, 1445, 1128, 1011, 909, 747, 733, 702 cm-1.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 33016-47-6.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3012-80-4, name is 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Prepared a 2 M stock solution of (1S,5R,6R)-tert-butyl 6-(hydroxymethyl)-3-aza- bicyclo[3.1.0]hexane-3-carboxyiate (Preparation 1 ) in THF. Prepared 2 M stock solutions of varying phenols of a general formula (III) in THF. Prepared a 0.5 M stock solution of DEAD in toluene. To each reaction vial, added 0.200 ml_ of the varying phenol followed by 0.075 mL of (1S,5R,6R)-tert-butyl 6- (hydroxymethyl)-3-aza-bicyclo[3.1.0]hexane-3-carboxylate. Added 0.600 mL of the DEAD solution, followed by 0.750 mL of toluene. Added 140 mg of triphenylphosphine-polystyrene resin. Vials were capped and shaken at room temperature for 17 hours. Added 2.5 mL of THF to each reaction vial. The top layer was transferred to empty 6 mL SPE cartridges over collection tubes. Added 3.0 mL of THF to the reaction vials and then aspirated the top layer to the SPE cartridges over collection tubes. Transferred solutions from collection tubes to new reaction vials and evaporated. Added 0.600 mL of CH3OH followed by 0.300 mL of 4 M HCI in 1 ,4-dioxane to each reaction vial. Vials were capped and shaken at room temperature for 24 hours. The solvent was evaporated and the intermediates used without further purification in the next reaction.Prepared a 0.25 M solution of an aldehyde of general formula (V) in 1 ,2- dichloroethane. Prepared a 0.25 M solution of sodium triacetoxyborohydride in 1 ,2- dichloroethane. Added 0.600 mL of the aldehyde solution to each of the reaction vials from the step above, followed by 0.070 mL of DIPEA. Added 2.0 mL of the sodium triacetoxyborohydride solution, capped vials and shaken at room temperature for 17 hours. Added 1.0 mL of 1 ,2-dichloroethane followed by 2.0 mL of 10percent NaOH. Vials were vortexed and/or shaken and removed top layer. Added 2.0 mL of 10percent NH4OH, with vials shaken well and/ or vortexed. The bottom layers were aspirated to empty 6 mL SPE cartridges over tared collection tubes. Added 1.0 mL of 1 ,2-dichloroethane to the aqueous layer and aspirated the bottom layer to the SPE cartridge over the collection tubes. Evaporated solutions to dryness. The resulting crude mixtures were purified via preparative LC/MS chromatography to yield compounds of general formula (Vl) Alternatively, compounds of formula I can be prepared as highlighted below in method D utilizing parallel chemistry or high-speed synthesis methods.

The synthetic route of 3012-80-4 has been constantly updated, and we look forward to future research findings.

Related Products of 104619-51-4, A common heterocyclic compound, 104619-51-4, name is Di(1H-imidazol-1-yl)methanimine, molecular formula is C7H7N5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 3-((2-hydroxy-3-nitrobenzyl)amino)propanenitrile (KR-400428) (3.87 mmol, 0.91 g) in methanol (125 mL), PtO2 (0.19 mmol, 0.04 g) was added. The reaction was flushed with argon followed by hydrogen for fifteen minutes each with constant magnetic stirring. The reaction was then stirred under hydrogen atmosphere at ordinary pressure (15 psi) for two hours. Argon was again flushed through the reaction vessel for 15 minutes. Then the reaction contents were filtered quickly over a thin pad of celite which was then immediately washed with methanol (75 mL). The filtrate was concentrated in vacuo yielding a brown oil. The oil was quickly re-dissolved in acetonitrile (175 mL) and di(imidazole-1-yl)methanimine (7.74 mmol, 1.25 g) was added with constant magnetic stirring. The reaction was then placed under argon atmosphere and refluxed for six hours. The reaction was concentrated under reduced pressure and silica gel column chromatography (20:1 ethyl acetate/methanol) provided faint brown crystals in a 67% yield. The product of the reduction (3-((3-amino-2-hydroxybenzyl)(methyl)amino)propanenitrile) is air sensitive and appropriate measures should be taken to minimize air exposure.

The synthetic route of 104619-51-4 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 5851-46-7, These common heterocyclic compound, 5851-46-7, name is 2-Pentyl-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The respective 1H-benz[d]imidazole(2.50 mmol) was dissolved in 10 ml of abs. DMF. Sodium hydride(60 % dispersion in mineral oil) (0.2 g, 5 mmol) was added withcooling. After the gas formation stopped, 4?-bromomethyl-[1,1?-biphenyl]-2-carbonitrildissolved in 2 ml of abs. DMF was added dropwise and the solution wasstirred for 1 h under cooling in an ice bath and further 2h at RT. Water wasadded and after the solution was acidified with HCl the product was extractedthree times with methylene chloride. The combined organic layers were driedover Na2SO4 and evaporated to dryness in vacuo. The crudeproduct was purified by column chromatography on silica gel with methylenechloride/methanol (95:5) and if necessary recrystallized from diethyl ether/methanol.

Statistics shows that 2-Pentyl-1H-benzo[d]imidazole is playing an increasingly important role. we look forward to future research findings about 5851-46-7.

Reference of 172499-76-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 172499-76-2, name is Ethyl 3-(1H-imidazol-2-yl)propanoate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A suspension of tBuOK (1.1 equiv. or 2.2 equiv.) and the imidazole derivative (1.0 equiv.) in DMF (6 mL/mmol) was stirred at rt for 1 h. The reaction mixture was treated with the corresponding alkyl bromide or alkyl mesylate (1.3 equiv. or 2.0 equiv.) and the temperature was raised up to 60 C and stirred at this temperature for 72 h. The solution was then diluted with EtOAc (20 mL/mmol) and washed three times with brine and H2O. The organic layers were dried over MgSO4, filtered, and concentrated. The crude product was purified by CC.

The synthetic route of Ethyl 3-(1H-imidazol-2-yl)propanoate has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 124750-59-0, name is 2-Propyl-1H-imidazole-4,5-dicarboxylic acid dimethyl ester belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 124750-59-0

PART A: Preparation of 4,5-Bis(methoxycarbonyl)-1-(4-bromophenyl)methyl-2-propylimidazole A solution of 40.0 g (0.177 mole) of 2-propyl-4,5-bis(methoxycarbonyl)-imidazole and 44.6 g (0.178 mole) of 4-bromobenzyl bromide in 350 mL of DMF was stirred in the presence of 37.5 g (0.271 mole) of K2 CO3 overnight at room temperature. The reaction mixture was then poured into 1200 mL of water and extracted with 3*300 mL of ether. The combined ether extracts were washed with 8*1000 mL of water and once with brine, then dried over MgSO4. The solvent was removed under reduced pressure to yield 61.8 g (88%) of the title compound as a solid. 1 H NMR (300 MHz, CDCl3): delta0.94 (t, J=7.6 Hz, 3H); 1.73 (m, 2H); 2.63 (t, J=7.9 Hz, 2H); 3.81 (s, 3H); 3.93 (s, 3H); 5.37 (s, 2H); 6.86 (d, J=8.8 Hz, 2H); 7.45 (d, J=8.8 Hz, 2H). MS [DCI (NH3)]: m/z 395/397 (M+H, 1 Br).

The synthetic route of 124750-59-0 has been constantly updated, and we look forward to future research findings.