Category: 95470-42-1

Electric Literature of 95470-42-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 95470-42-1 as follows.

To a solution of ethyl vinylether (6.6 ml, 68.65 mmol) in methylene chloride (CH2Cl2, 20 ml) was added trifluoroacetic acid (3 mmolpercent) at 00C at which reaction was conducted for 5 min, followed by mixing with a solution of the compound (8 g, 34.33 mmol) of Preparation Example 1 in CH2Cl2OO ml) . Reaction at room temperature for 3 hrs was precedent to the addition of water to the reaction mixture which was then extracted twice with CH2Cl2 and washed with saturated brine . The extract was dried over magnesium sulfate (MgSO4) and filtered, followed by the vacuum concentration of the filtrate. The purification of the concentrate through silica gel column chromatography (hexene:ethylacetate=2 : 1) afforded the title compound as a colorless oil (9.8 g, 93percent).1H-NMROOO MHz, CDCl3) sigma 5.68(q, IH), 4.37 (q, 2H), 3.44-3.35(m, 2H), 2.71(s, 3H), 1.67 (d, 3H), 1.39(t, 3H), 1.20 (t, 3H) ;MS 304 (M+) .

According to the analysis of related databases, 95470-42-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KOREA RESERACH INSTITUTE OF CHEMICAL TECHNOLOGY; WO2008/111794; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 95470-42-1, name is Ethyl 2-bromo-4-methyl-1H-imidazole-5-carboxylate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 95470-42-1, Recommanded Product: Ethyl 2-bromo-4-methyl-1H-imidazole-5-carboxylate

(2) Ethyl 2-bromo-4-methyl-i H-imidazole-5-carboxylate (5lene (4.56 g, 25.8 nmol) were added thereto, and the mixmre g, 21.45 mmol) was dissolved in DMF (40 mE), potassium carbonate (5.93 g, 42.9 mmol) and 1 -(chloromethyl)naphthaNwas stirred at 80¡ã C. for 2 hours. After the reaction, water wasThe organic layer was washed with samrated aqueous sodiumadded and the mixture was extracted twice with ethyl acetate.chloride and dried over anhydrous sodium sulfate. Afier con-centrating the organic layer, the residue was purified by column chromatography to obtain ethyl 2-bromo-4-methyl-1 – (naphthalen-1 -ylmethyl)-i H-imidazole-5-carboxylate (3.2510129] ?H-NMR (CDC13) oe: 8.01 (1H, d, J=8.3 Hz), 7.91(1H, d, J=7.8 Hz), 7.77 (1H, d, J 8.3 Hz), 7.63-7.53 (2H, m),7.33 (1H, t, J=7.6 Hz), 6.43 (1H, dd, J=7.3, 1.0Hz), 6.07 (2H,s), 4.13 (2H, q, J=7.i Hz), 2.58 (3H, s), 1.11 (3H, t, J=7.i Hz);10130] ESI-MS mlz=373 (M+H).

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Reference:
Patent; Teijin Pharma Limited; Maruyama, Akinobu; Kamada, Hirofumi; Fujinuma, Mika; Takeuchi, Susumu; Saitoh, Hiroshi; Takahashi, Yoshimasa; US2015/284358; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem